{"id":"https://openalex.org/W2886535511","doi":null,"title":"Abstract 19364: C-Kit+ Cardiac Progenitor Cells are Important in Cardiomyocytes Generation in vivo in Response to Sfrp2","display_name":"Abstract 19364: C-Kit+ Cardiac Progenitor Cells are Important in Cardiomyocytes Generation in vivo in Response to Sfrp2","publication_year":2015,"publication_date":"2015-11-10","ids":{"openalex":"https://openalex.org/W2886535511","mag":"2886535511"},"language":"en","primary_location":{"id":"mag:2886535511","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/circ.132.suppl_3.19364?rss=1","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null},"volume":null,"type":"conference-abstract","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jos\u00e9 A. G\u00f3mez","orcid":"https://orcid.org/0000-0001-8148-8308","observed_orcids":["https://orcid.org/0000-0001-8148-8308"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jos\u00e9 A. G\u00f3mez","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8148-8308","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054437328","display_name":"Conrad P. Hodgkinson","orcid":"https://orcid.org/0000-0002-6460-7333","observed_orcids":["https://orcid.org/0000-0002-6460-7333"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Conrad P. Hodgkinson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6460-7333","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021805588","display_name":"Alan J. Payne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan Payne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058498462","display_name":"Jeffrey Scmeckpeper","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey Scmeckpeper","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032857374","display_name":"Lunan Zhang","orcid":"https://orcid.org/0000-0002-9857-3055","observed_orcids":["https://orcid.org/0000-0002-9857-3055"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lunan Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9857-3055","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106486813","display_name":"Lan Mao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lan Mao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5090663343","display_name":"Victor J. Dzau","orcid":"https://orcid.org/0000-0002-8280-519X","observed_orcids":["https://orcid.org/0000-0002-8280-519X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Victor J. Dzau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sfrp2","display_name":"SFRP2","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cardiomyocyte-differentiation","display_name":"cardiomyocyte differentiation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.9160000085830688},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cardiac-recovery","display_name":"cardiac function recovery","score":0.5630000233650208},{"id":"https://openalex.org/keywords/lineage-tracing","display_name":"lineage tracing","score":0.8460000157356262},{"id":"https://openalex.org/keywords/creert2","display_name":"CreERT2","score":0.5669999718666077},{"id":"https://openalex.org/keywords/diphtheria-toxin-receptor","display_name":"diphtheria toxin receptor","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6532124280929565},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6530072093009949},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5857149958610535},{"id":"https://openalex.org/C33057221","wikidata":"https://www.wikidata.org/wiki/Q421580","display_name":"Diphtheria toxin","level":3,"score":0.5692877769470215},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.5320015549659729},{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.5161365270614624},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.46291548013687134},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4318616986274719},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4312208890914917},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3737468123435974},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25944048166275024},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23950737714767456},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.19553449749946594},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.16639533638954163},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14718225598335266},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.1373620629310608},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2886535511","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/circ.132.suppl_3.19364?rss=1","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3192290017","https://openalex.org/W2889270927","https://openalex.org/W40001068","https://openalex.org/W2942874587","https://openalex.org/W2148402694","https://openalex.org/W2046027917","https://openalex.org/W2139982097","https://openalex.org/W2010368308","https://openalex.org/W6989175443","https://openalex.org/W7100882081"],"abstract_inverted_index":{"Introduction:":[0],"Resident":[1],"c-Kit+":[2,33],"cardiac":[3,42],"progenitor":[4],"cells":[5],"(CPCs)":[6],"differentiation":[7,31],"into":[8,35],"cardiomyocytes":[9,36],"in":[10,37,70,138],"vivo":[11],"is":[12],"controversial.":[13],"Using":[14],"lineage":[15],"tracing":[16],"and":[17,40,122],"gene":[18],"ablation":[19],"techniques":[20],"we":[21],"documented":[22],"that":[23],"the":[24,50,108],"Wnt":[25],"signaling":[26],"modulator":[27],"Sfrp2":[28,102],"substantially":[29],"increased":[30],"of":[32,55,67],"CPCs":[34],"post-MI":[38,118],"heart":[39,86],"restored":[41],"function.":[43],"Methods:":[44],"c-Kit-CreERT2/mTeG":[45,128],"mice":[46,98],"were":[47,74,90,99],"used":[48],"where":[49],"c-Kit":[51,71,87,140],"promoter":[52],"drives":[53,65],"expression":[54,66,121,133],"a":[56,77],"tamoxifen":[57],"(TX)-inducible":[58],"Cre.":[59],"Upon":[60],"TX":[61],"treatment":[62],"Cre-mediated":[63],"recombination":[64],"eGFP":[68,120,132],"exclusively":[69],"cells.":[72,88],"Mice":[73,89],"crossed":[75],"with":[76,101],"Diphtheria":[78],"toxin":[79],"receptor":[80],"(DT)":[81],"strain":[82],"to":[83,92],"selectively":[84],"ablate":[85],"subjected":[91],"myocardial":[93],"infarction.":[94],"2":[95,116],"days":[96],"later,":[97],"injected":[100],"(0.5":[103],"\u03bcg)":[104],"or":[105],"saline":[106],"at":[107],"infarct":[109],"border":[110],"zone.":[111],"Heart":[112],"tissue":[113],"was":[114,130],"analyzed":[115],"months":[117],"for":[119],"various":[123],"markers":[124],"by":[125],"microscopy.":[126],"Results:":[127],"model":[129],"tested.":[131],"had":[134],"no":[135],"effect":[136],"on":[137],"vitro":[139],"CPC":[141],"differentiat...":[142]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2018-08-22T00:00:00"}
