{"id":"https://openalex.org/W2886498706","doi":"https://doi.org/10.1038/s41598-018-29789-6","title":"COPD is accompanied by co-ordinated transcriptional perturbation in the quadriceps affecting the mitochondria and extracellular matrix","display_name":"COPD is accompanied by co-ordinated transcriptional perturbation in the quadriceps affecting the mitochondria and extracellular matrix","publication_year":2018,"publication_date":"2018-08-09","ids":{"openalex":"https://openalex.org/W2886498706","doi":"https://doi.org/10.1038/s41598-018-29789-6","mag":"2886498706","pmid":"https://pubmed.ncbi.nlm.nih.gov/30111857","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6093887"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-018-29789-6","doi":"https://doi.org/10.1038/s41598-018-29789-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-29789-6","pdf_url":"https://www.nature.com/articles/s41598-018-29789-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-018-29789-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061421688","display_name":"Saffron A.G. Willis\u2010Owen","orcid":"https://orcid.org/0000-0003-2633-1150","observed_orcids":["https://orcid.org/0000-0003-2633-1150"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Saffron A. G. Willis-Owen","raw_affiliation_strings":["Centre for Genomic Medicine, National Heart and Lung Institute, Imperial College London, SW3 6LY, London, United Kingdom. s.willis-owen@imperial.ac.uk","Centre for Genomic Medicine, National Heart and Lung Institute, Imperial College London, SW3 6LY, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Genomic Medicine, National Heart and Lung Institute, Imperial College London, SW3 6LY, London, United Kingdom. s.willis-owen@imperial.ac.uk","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Centre for Genomic Medicine, National Heart and Lung Institute, Imperial College London, SW3 6LY, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020146347","display_name":"Anna Thompson","orcid":"https://orcid.org/0000-0001-5926-1983","observed_orcids":["https://orcid.org/0000-0001-5926-1983"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anna Thompson","raw_affiliation_strings":["Centre for Genomic Medicine, National Heart and Lung Institute, Imperial College London, SW3 6LY, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Genomic Medicine, National Heart and Lung Institute, Imperial College London, SW3 6LY, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007429139","display_name":"Paul Robert Kemp","orcid":"https://orcid.org/0000-0001-8975-7293","observed_orcids":["https://orcid.org/0000-0001-8975-7293"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul R. Kemp","raw_affiliation_strings":["Respiratory Sciences, National Heart and Lung Institute, Imperial College London, SW3 6NP, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Sciences, National Heart and Lung Institute, Imperial College London, SW3 6NP, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004128310","display_name":"Michael Iain Polkey","orcid":"https://orcid.org/0000-0003-1243-8571","observed_orcids":["https://orcid.org/0000-0003-1243-8571"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael I. Polkey","raw_affiliation_strings":["Respiratory Sciences, National Heart and Lung Institute, Imperial College London, SW3 6NP, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Sciences, National Heart and Lung Institute, Imperial College London, SW3 6NP, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004017860","display_name":"William Cookson","orcid":"https://orcid.org/0000-0001-9551-4677","observed_orcids":["https://orcid.org/0000-0001-9551-4677"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"William O. C. M. Cookson","raw_affiliation_strings":["Centre for Genomic Medicine, National Heart and Lung Institute, Imperial College London, SW3 6LY, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-9551-4677","affiliations":[{"raw_affiliation_string":"Centre for Genomic Medicine, National Heart and Lung Institute, Imperial College London, SW3 6LY, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055256960","display_name":"Miriam F. Moffatt","orcid":"https://orcid.org/0000-0001-7623-5840","observed_orcids":["https://orcid.org/0000-0001-7623-5840"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Miriam F. Moffatt","raw_affiliation_strings":["Centre for Genomic Medicine, National Heart and Lung Institute, Imperial College London, SW3 6LY, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Genomic Medicine, National Heart and Lung Institute, Imperial College London, SW3 6LY, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111969790","display_name":"Samantha Amanda Natanek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Samantha A. Natanek","raw_affiliation_strings":["Respiratory Sciences, National Heart and Lung Institute, Imperial College London, SW3 6NP, London, United Kingdom. a.natanek@imperial.ac.uk","Respiratory Sciences, National Heart and Lung Institute, Imperial College London, SW3 6NP, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Sciences, National Heart and Lung Institute, Imperial College London, SW3 6NP, London, United Kingdom. a.natanek@imperial.ac.uk","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Respiratory Sciences, National Heart and Lung Institute, Imperial College London, SW3 6NP, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5061421688","https://openalex.org/A5111969790"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":1580,"currency":"EUR","value_usd":1704},"fwci":0.9366,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.72270941,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"12165","last_page":"12165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.5570999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.5570999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.42989999055862427,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.984000027179718},{"id":"https://openalex.org/keywords/skeletal-muscle-dysfunction","display_name":"skeletal muscle dysfunction","score":0.8529999852180481},{"id":"https://openalex.org/keywords/quadriceps","display_name":"quadriceps","score":0.8510000109672546},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8579999804496765},{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.5950000286102295},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9980000257492065},{"id":"https://openalex.org/keywords/idh2","display_name":"IDH2","score":0.800000011920929},{"id":"https://openalex.org/keywords/gene-co-expression-modules","display_name":"gene co-expression modules","score":0.8920000195503235},{"id":"https://openalex.org/keywords/fam13a","display_name":"FAM13A","score":0.7170000076293945},{"id":"https://openalex.org/keywords/extrapulmonary-manifestations","display_name":"extrapulmonary manifestations","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.7525413036346436},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6028457283973694},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5911524295806885},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5157759189605713},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4931308925151825},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.45017218589782715},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.43066126108169556},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4219058156013489},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4157434403896332},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3857863247394562},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35371071100234985},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3501821756362915},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33598777651786804},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3250102698802948}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D052097","descriptor_name":"Quadriceps Muscle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41598-018-29789-6","doi":"https://doi.org/10.1038/s41598-018-29789-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-29789-6","pdf_url":"https://www.nature.com/articles/s41598-018-29789-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5044846","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6093887","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6093887","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6093887","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:30111857","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30111857","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e57839f767084b7bba449995c0d5109b","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e57839f767084b7bba449995c0d5109b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)","raw_type":"article"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/62792","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/62792","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s41598-018-29789-6","doi":"https://doi.org/10.1038/s41598-018-29789-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-29789-6","pdf_url":"https://www.nature.com/articles/s41598-018-29789-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G185887985","display_name":null,"funder_award_id":"WT09694","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G2756042029","display_name":null,"funder_award_id":"WT 079686/Z/06/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3858608197","display_name":"Is the anaerobic quadriceps muscle phenotype in COPD mediated by reduced muscle concentrations of Peroxisome Proliferator-Activated Receptors a and d?","funder_award_id":"079686/Z/06/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6092178110","display_name":null,"funder_award_id":"WT097117","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6900387849","display_name":"Is the anaerobic quadriceps muscle phenotype in COPD mediated by reduced muscle concentrations of Peroxisome Proliferator-Activated Receptors a and d?","funder_award_id":"079686","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G8859056213","display_name":"Genetics and Genomics and Respiratory Disease.","funder_award_id":"096964/Z/11/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320313317","display_name":"Royal Brompton and Harefield NHS Foundation Trust","ror":"https://ror.org/02218z997"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320283","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2886498706.pdf","grobid_xml":"https://content.openalex.org/works/W2886498706.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1564209005","https://openalex.org/W1573544812","https://openalex.org/W1877128102","https://openalex.org/W1950113648","https://openalex.org/W1965498876","https://openalex.org/W1966327575","https://openalex.org/W1971000546","https://openalex.org/W1987107036","https://openalex.org/W1999867744","https://openalex.org/W2005623173","https://openalex.org/W2014958679","https://openalex.org/W2016353157","https://openalex.org/W2026946978","https://openalex.org/W2037367656","https://openalex.org/W2038045721","https://openalex.org/W2040574121","https://openalex.org/W2044592603","https://openalex.org/W2061873776","https://openalex.org/W2065691491","https://openalex.org/W2082836483","https://openalex.org/W2088240660","https://openalex.org/W2093200002","https://openalex.org/W2098170299","https://openalex.org/W2100006057","https://openalex.org/W2105524929","https://openalex.org/W2106506181","https://openalex.org/W2107264101","https://openalex.org/W2107826773","https://openalex.org/W2110065044","https://openalex.org/W2112348866","https://openalex.org/W2131423215","https://openalex.org/W2136917709","https://openalex.org/W2140099276","https://openalex.org/W2141536507","https://openalex.org/W2149343603","https://openalex.org/W2151850247","https://openalex.org/W2152073286","https://openalex.org/W2157090335","https://openalex.org/W2166354223","https://openalex.org/W2187583278","https://openalex.org/W2193288511","https://openalex.org/W2266228206","https://openalex.org/W2316927045","https://openalex.org/W2535683493","https://openalex.org/W2558208069","https://openalex.org/W2559028527","https://openalex.org/W2573109541","https://openalex.org/W2784822221","https://openalex.org/W2796186950","https://openalex.org/W3105003467","https://openalex.org/W4246117717"],"related_works":["https://openalex.org/W4417117139","https://openalex.org/W7221802001","https://openalex.org/W4395047620","https://openalex.org/W3092447922","https://openalex.org/W2123567288","https://openalex.org/W2066569687","https://openalex.org/W2042660834","https://openalex.org/W4396503990","https://openalex.org/W2118581168","https://openalex.org/W2136598956"],"abstract_inverted_index":{"Skeletal":[0],"muscle":[1],"dysfunction":[2],"is":[3,150],"a":[4,109,129,139],"frequent":[5],"extra-pulmonary":[6],"manifestation":[7],"of":[8,19,46,97,114,126,132,155],"Chronic":[9],"Obstructive":[10],"Pulmonary":[11],"Disease":[12],"(COPD)":[13],"with":[14,120],"implications":[15],"for":[16],"both":[17],"quality":[18],"life":[20],"and":[21,54,58,89,122,137,144,163,166],"survival.":[22],"The":[23],"underlying":[24],"biology":[25],"nevertheless":[26],"remains":[27],"poorly":[28],"understood.":[29],"We":[30,61,117],"measured":[31],"global":[32],"gene":[33],"transcription":[34,156],"in":[35,42,51,99,157,171],"the":[36,133,158,161],"quadriceps":[37,159],"using":[38],"Affymetrix":[39],"HuGene1.1ST":[40],"arrays":[41],"an":[43],"unselected":[44],"cohort":[45],"79":[47],"stable":[48],"COPD":[49,100,149],"patients":[50],"secondary":[52],"care":[53],"16":[55],"healthy":[56],"age-":[57],"gender-matched":[59],"controls.":[60],"detected":[62],"1,826":[63],"transcripts":[64,92],"showing":[65],"COPD-related":[66],"variation.":[67],"Eighteen":[68],"exhibited":[69],"\u22652fold":[70],"changes":[71],"(SLC22A3,":[72],"FAM184B,":[73],"CDKN1A,":[74],"FST,":[75],"LINC01405,":[76],"MUSK,":[77],"PANX1,":[78],"ANKRD1,":[79],"C12orf75,":[80],"MYH1,":[81],"POSTN,":[82],"FRZB,":[83],"TNC,":[84],"ACTC1,":[85],"LINC00310,":[86],"MYH3,":[87],"MYBPH":[88],"AREG).":[90],"Thirty-one":[91],"possessed":[93],"previous":[94],"reported":[95],"evidence":[96],"involvement":[98],"through":[101],"genome-wide":[102],"association,":[103],"including":[104,167],"FAM13A.":[105],"Network":[106],"analysis":[107],"revealed":[108],"substructure":[110],"comprising":[111],"6":[112],"modules":[113,119],"co-expressed":[115],"genes.":[116],"identified":[118],"mitochondrial":[121,134],"extracellular":[123,164],"matrix":[124,165],"features,":[125],"which":[127],"IDH2,":[128],"central":[130],"component":[131],"antioxidant":[135],"pathway,":[136],"ABI3BP,":[138],"proposed":[140],"switch":[141],"between":[142],"proliferation":[143],"differentiation,":[145],"represent":[146],"hubs":[147],"respectively.":[148],"accompanied":[151],"by":[152],"coordinated":[153],"patterns":[154],"involving":[160],"mitochondria":[162],"genes":[168],"previously":[169],"implicated":[170],"primary":[172],"disease":[173],"processes.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-08-22T00:00:00"}