{"id":"https://openalex.org/W2886480677","doi":"https://doi.org/10.3390/nu10081053","title":"Neuroprotective Properties of Asiatic Acid against 5-Fluorouracil Chemotherapy in the Hippocampus in an Adult Rat Model","display_name":"Neuroprotective Properties of Asiatic Acid against 5-Fluorouracil Chemotherapy in the Hippocampus in an Adult Rat Model","publication_year":2018,"publication_date":"2018-08-09","ids":{"openalex":"https://openalex.org/W2886480677","doi":"https://doi.org/10.3390/nu10081053","mag":"2886480677","pmid":"https://pubmed.ncbi.nlm.nih.gov/30096914","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6115773"},"language":"en","primary_location":{"id":"doi:10.3390/nu10081053","doi":"https://doi.org/10.3390/nu10081053","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/nu10081053","pdf_url":"https://www.mdpi.com/2072-6643/10/8/1053/pdf","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6643/10/8/1053/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079907583","display_name":"Jariya Umka Welbat","orcid":"https://orcid.org/0000-0002-2872-1542","observed_orcids":["https://orcid.org/0000-0002-2872-1542"]},"institutions":[{"id":"https://openalex.org/I179193067","display_name":"Khon Kaen University","ror":"https://ror.org/03cq4gr50","country_code":"TH","type":"education","lineage":["https://openalex.org/I179193067"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Jariya Umka Welbat","raw_affiliation_strings":["Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand","Neuroscience Research and Development Group, Khon Kaen University, Khon Kaen 40002, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand","institution_ids":["https://openalex.org/I179193067"]},{"raw_affiliation_string":"Neuroscience Research and Development Group, Khon Kaen University, Khon Kaen 40002, Thailand","institution_ids":["https://openalex.org/I179193067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074769100","display_name":"Pornthip Chaisawang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I179193067","display_name":"Khon Kaen University","ror":"https://ror.org/03cq4gr50","country_code":"TH","type":"education","lineage":["https://openalex.org/I179193067"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Pornthip Chaisawang","raw_affiliation_strings":["Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand","institution_ids":["https://openalex.org/I179193067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072173213","display_name":"Wanassanun Pannangrong","orcid":"https://orcid.org/0000-0002-8820-5873","observed_orcids":["https://orcid.org/0000-0002-8820-5873"]},"institutions":[{"id":"https://openalex.org/I179193067","display_name":"Khon Kaen University","ror":"https://ror.org/03cq4gr50","country_code":"TH","type":"education","lineage":["https://openalex.org/I179193067"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Wanassanun Pannangrong","raw_affiliation_strings":["Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand","institution_ids":["https://openalex.org/I179193067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064469661","display_name":"Peter M. Wigmore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I4210137227","display_name":"Queen's Medical Centre","ror":"https://ror.org/03ap6wx93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I4210137227"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter Wigmore","raw_affiliation_strings":["School of Life Sciences, Medical School, Queen\u2019s Medical Centre, Nottingham University, Nottingham NG7 2RD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Medical School, Queen\u2019s Medical Centre, Nottingham University, Nottingham NG7 2RD, UK","institution_ids":["https://openalex.org/I142263535","https://openalex.org/I4210137227"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5079907583"],"corresponding_institution_ids":["https://openalex.org/I179193067"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":1.4613,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.85184002,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"10","issue":"8","first_page":"1053","last_page":"1053"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.6753000020980835,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.6753000020980835,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.10660000145435333,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.10440000146627426,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asiatic-acid","display_name":"asiatic acid","score":0.9860000014305115},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chemotherapy-induced-neurotoxicity","display_name":"chemotherapy-induced neurotoxicity","score":0.9380000233650208},{"id":"https://openalex.org/keywords/hippocampal-neurogenesis","display_name":"hippocampal neurogenesis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7459999918937683},{"id":"https://openalex.org/keywords/memory-impairment","display_name":"memory impairment","score":0.6869999766349792},{"id":"https://openalex.org/keywords/notch1","display_name":"Notch1","score":0.8759999871253967},{"id":"https://openalex.org/keywords/sox2","display_name":"SOX2","score":0.9909999966621399},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.8429999947547913},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.8450000286102295},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.8930000066757202},{"id":"https://openalex.org/keywords/subgranular-zone","display_name":"subgranular zone","score":0.7760000228881836},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.843999981880188}],"concepts":[{"id":"https://openalex.org/C2781461022","wikidata":"https://www.wikidata.org/wiki/Q14912973","display_name":"Doublecortin","level":4,"score":0.9341488480567932},{"id":"https://openalex.org/C2781176699","wikidata":"https://www.wikidata.org/wiki/Q4445017","display_name":"Subgranular zone","level":5,"score":0.7761141061782837},{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.6830374002456665},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6199358701705933},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.576619029045105},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5764453411102295},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5222300291061401},{"id":"https://openalex.org/C2777738006","wikidata":"https://www.wikidata.org/wiki/Q14906812","display_name":"Nestin","level":4,"score":0.4688996374607086},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.44982263445854187},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3665097951889038},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35826778411865234},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.3293234705924988},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29136213660240173},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.2129419445991516},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.19905656576156616},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.10083138942718506},{"id":"https://openalex.org/C2777542384","wikidata":"https://www.wikidata.org/wiki/Q937403","display_name":"Subventricular zone","level":4,"score":0.088380366563797},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.060394287109375}],"mesh":[{"descriptor_ui":"D000089662","descriptor_name":"Doublecortin Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D053978","descriptor_name":"Pentacyclic Triterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059447","descriptor_name":"Cell Cycle Checkpoints","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.3390/nu10081053","doi":"https://doi.org/10.3390/nu10081053","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/nu10081053","pdf_url":"https://www.mdpi.com/2072-6643/10/8/1053/pdf","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5073556","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6115773","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6115773","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6115773","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"Text"},{"id":"pmid:30096914","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30096914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:598ab1eda674408aa5f2969f61ac9771","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/598ab1eda674408aa5f2969f61ac9771","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nutrients, Vol 10, Iss 8, p 1053 (2018)","raw_type":"article"},{"id":"doi:10.60692/3nhvk-5ne63","doi":"https://doi.org/10.60692/3nhvk-5ne63","is_oa":true,"landing_page_url":"https://doi.org/10.60692/3nhvk-5ne63","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/pkr0r-2dj18","doi":"https://doi.org/10.60692/pkr0r-2dj18","is_oa":true,"landing_page_url":"https://doi.org/10.60692/pkr0r-2dj18","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.3390/nu10081053","doi":"https://doi.org/10.3390/nu10081053","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/nu10081053","pdf_url":"https://www.mdpi.com/2072-6643/10/8/1053/pdf","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2923676663","display_name":null,"funder_award_id":"TRG5780086","funder_id":"https://openalex.org/F4320322614","funder_display_name":"Thailand Research Fund"}],"funders":[{"id":"https://openalex.org/F4320322335","display_name":"Khon Kaen University","ror":"https://ror.org/03cq4gr50"},{"id":"https://openalex.org/F4320322614","display_name":"Thailand Research Fund","ror":"https://ror.org/03gd1bh37"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2886480677.pdf","grobid_xml":"https://content.openalex.org/works/W2886480677.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W154375584","https://openalex.org/W1624064684","https://openalex.org/W1648834533","https://openalex.org/W1748580760","https://openalex.org/W1775250759","https://openalex.org/W1926911592","https://openalex.org/W1936143294","https://openalex.org/W1970630658","https://openalex.org/W1974951849","https://openalex.org/W1979340756","https://openalex.org/W1980303048","https://openalex.org/W1980924523","https://openalex.org/W1981563641","https://openalex.org/W1981989609","https://openalex.org/W1984328540","https://openalex.org/W1985141465","https://openalex.org/W1995234317","https://openalex.org/W2000305671","https://openalex.org/W2005613383","https://openalex.org/W2009872288","https://openalex.org/W2011154028","https://openalex.org/W2021551531","https://openalex.org/W2028916975","https://openalex.org/W2029372290","https://openalex.org/W2030378354","https://openalex.org/W2031685110","https://openalex.org/W2052483400","https://openalex.org/W2052554888","https://openalex.org/W2053030019","https://openalex.org/W2053326179","https://openalex.org/W2068288514","https://openalex.org/W2073345047","https://openalex.org/W2074764259","https://openalex.org/W2077315330","https://openalex.org/W2078504009","https://openalex.org/W2079678859","https://openalex.org/W2081050947","https://openalex.org/W2087953568","https://openalex.org/W2095173648","https://openalex.org/W2103504457","https://openalex.org/W2103846273","https://openalex.org/W2104230351","https://openalex.org/W2115073963","https://openalex.org/W2126676759","https://openalex.org/W2135046848","https://openalex.org/W2139669634","https://openalex.org/W2143088276","https://openalex.org/W2143337494","https://openalex.org/W2146943422","https://openalex.org/W2151411994","https://openalex.org/W2151643037","https://openalex.org/W2168388707","https://openalex.org/W2343599709","https://openalex.org/W2399342557","https://openalex.org/W2481624906","https://openalex.org/W2519131942","https://openalex.org/W2558267228","https://openalex.org/W2732818861","https://openalex.org/W2736110790","https://openalex.org/W2738575330","https://openalex.org/W2752633538","https://openalex.org/W6637873345","https://openalex.org/W6645551665"],"related_works":["https://openalex.org/W2736110790","https://openalex.org/W1550863054","https://openalex.org/W1578517655","https://openalex.org/W3007134000","https://openalex.org/W7117250323","https://openalex.org/W1980303048","https://openalex.org/W2011154028","https://openalex.org/W2070400315","https://openalex.org/W2052554888","https://openalex.org/W4404549958"],"abstract_inverted_index":{"This":[0,30],"compound":[1],"can":[2],"ameliorate":[3],"intracellular":[4],"oxidative":[5,227],"stress":[6,228],"caused":[7,113,182,222],"by":[8,27,65,183,223],"chemotherapy":[9],"drugs.":[10],"Recent":[11],"studies":[12],"have":[13],"shown":[14],"that":[15,205],"AA":[16,39,56,74,86,99,163,187,206],"is":[17],"capable":[18],"of":[19,38,103,214],"inhibiting":[20,226],"neuronal":[21],"generation":[22],"and":[23,44,60,79,94,127,153,164,168,180,196,219,229],"memory":[24,45,220],"deficit":[25],"produced":[26],"5-FU":[28,62,91,112,141,165,224],"chemotherapy.":[29],"study":[31],"aimed":[32],"to":[33,41,172,190,210],"assess":[34],"the":[35,101,104,137,149,158,200,208,212,217],"molecular":[36],"mechanisms":[37],"related":[40],"hippocampal":[42],"neurogenesis":[43,215],"in":[46,116,148,157,166,175,192,199],"rats":[47,53,71],"receiving":[48],"5-FU.":[49,184],"Male":[50],"Sprague":[51],"Dawley":[52],"were":[54,72],"given":[55,61,73],"(30":[57],"mg/kg)":[58,64],"orally":[59],"(25":[63],"i.v.":[66],"injection":[67],"5":[68],"times.":[69],"Some":[70],"for":[75,87,107],"20":[76,88],"days":[77,89],"before":[78],"during":[80],"15-FU":[81],"treatment":[82,92,97],"(preventive),":[83],"some":[84,95],"received":[85],"after":[90],"(recovery),":[93],"underwent":[96],"with":[98,111,161,186],"throughout":[100,169],"time":[102],"experiment":[105],"(throughout)":[106],"40":[108],"days.":[109],"Treatment":[110,185],"significant":[114],"reductions":[115],"Notch1,":[117],"sex":[118],"determining":[119],"region":[120],"Y-box":[121],"2":[122,133],"(SOX2),":[123],"nestin,":[124,178],"doublecortin":[125],"(DCX),":[126],"nuclear":[128],"factor":[129,132],"erythroid":[130],"2-related":[131],"(Nrf2)":[134],"levels":[135,156,198],"within":[136,216],"hippocampus.":[138,159,201],"In":[139],"addition,":[140],"significantly":[142],"increased":[143],"p21":[144,193],"positive":[145,194],"cell":[146],"number":[147],"subgranular":[150],"zone":[151],"(SGZ)":[152],"malondialdehyde":[154],"(MDA)":[155],"Administration":[160],"both":[162],"prevention":[167],"was":[170],"able":[171],"prevent":[173],"decreases":[174,191],"Notch1":[176],"SOX2,":[177],"DCX,":[179],"Nrf2":[181],"also":[188],"led":[189],"cells":[195],"MDA":[197],"These":[202],"findings":[203],"exhibit":[204],"has":[207],"ability":[209],"counteract":[211],"down-regulation":[213],"hippocampus":[218],"deficits":[221],"via":[225],"increasing":[230],"neuroprotective":[231],"properties.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-08-22T00:00:00"}
