{"id":"https://openalex.org/W2886476219","doi":"https://doi.org/10.1021/acs.jpclett.8b01696","title":"Nanoparticle-Engendered Rupture of Lipid Membranes","display_name":"Nanoparticle-Engendered Rupture of Lipid Membranes","publication_year":2018,"publication_date":"2018-08-07","ids":{"openalex":"https://openalex.org/W2886476219","doi":"https://doi.org/10.1021/acs.jpclett.8b01696","mag":"2886476219","pmid":"https://pubmed.ncbi.nlm.nih.gov/30085675"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jpclett.8b01696","doi":"https://doi.org/10.1021/acs.jpclett.8b01696","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jpclett.8b01696","pdf_url":null,"source":{"id":"https://openalex.org/S123480357","display_name":"The Journal of Physical Chemistry Letters","issn_l":"1948-7185","issn":["1948-7185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083077202","display_name":"Sean Burgess","orcid":"https://orcid.org/0000-0001-8209-9662","observed_orcids":["https://orcid.org/0000-0001-8209-9662"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean Burgess","raw_affiliation_strings":["Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, 98 Brett Road, Piscataway, New Jersey 08854, United States"],"raw_orcid":"https://orcid.org/0000-0001-8209-9662","affiliations":[{"raw_affiliation_string":"Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, 98 Brett Road, Piscataway, New Jersey 08854, United States","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102763984","display_name":"Aleksey Vishnyakov","orcid":"https://orcid.org/0000-0002-1621-3858","observed_orcids":["https://orcid.org/0000-0002-1621-3858"]},"institutions":[{"id":"https://openalex.org/I125989756","display_name":"Skolkovo Institute of Science and Technology","ror":"https://ror.org/03f9nc143","country_code":"RU","type":"education","lineage":["https://openalex.org/I125989756"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Aleksey Vishnyakov","raw_affiliation_strings":["Skolkovo Institute of Science and Technology, Nobel st. 1, 121205 Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0002-1621-3858","affiliations":[{"raw_affiliation_string":"Skolkovo Institute of Science and Technology, Nobel st. 1, 121205 Moscow, Russia","institution_ids":["https://openalex.org/I125989756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089975298","display_name":"Christopher Tsovko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Tsovko","raw_affiliation_strings":["Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, 98 Brett Road, Piscataway, New Jersey 08854, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, 98 Brett Road, Piscataway, New Jersey 08854, United States","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013313042","display_name":"Alexander V. Neimark","orcid":"https://orcid.org/0000-0002-3443-0389","observed_orcids":["https://orcid.org/0000-0002-3443-0389"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alexander V. Neimark","raw_affiliation_strings":["Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, 98 Brett Road, Piscataway, New Jersey 08854, United States"],"raw_orcid":"https://orcid.org/0000-0002-3443-0389","affiliations":[{"raw_affiliation_string":"Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, 98 Brett Road, Piscataway, New Jersey 08854, United States","institution_ids":["https://openalex.org/I102322142"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013313042"],"corresponding_institution_ids":["https://openalex.org/I102322142"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.7998,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.69520072,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"9","issue":"17","first_page":"4872","last_page":"4877"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10721","display_name":"Surfactants and Colloidal Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rupture-of-membranes","display_name":"membrane rupture","score":0.7940000295639038},{"id":"https://openalex.org/keywords/lipid-membranes","display_name":"lipid membranes","score":0.5920000076293945},{"id":"https://openalex.org/keywords/distributed-model-predictive-control","display_name":"distributed model predictive control","score":0.6980000138282776},{"id":"https://openalex.org/keywords/hydrophobic-nanoparticles","display_name":"hydrophobic nanoparticles","score":0.8889999985694885},{"id":"https://openalex.org/keywords/membrane-tension","display_name":"membrane tension","score":0.7789999842643738},{"id":"https://openalex.org/keywords/hole-formation","display_name":"hole formation","score":0.6159999966621399},{"id":"https://openalex.org/keywords/homogeneous-nucleation","display_name":"homogeneous nucleation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/heterogeneous-nucleation","display_name":"heterogeneous nucleation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/contact-angle","display_name":"contact angle","score":0.7429999709129333},{"id":"https://openalex.org/keywords/nanoparticle-size-dependence","display_name":"nanoparticle size dependence","score":0.9150000214576721},{"id":"https://openalex.org/keywords/membrane-stability","display_name":"membrane stability","score":0.7210000157356262},{"id":"https://openalex.org/keywords/nanoparticle-encapsulation","display_name":"nanoparticle encapsulation","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C61048295","wikidata":"https://www.wikidata.org/wiki/Q909022","display_name":"Nucleation","level":2,"score":0.9103960990905762},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.8191032409667969},{"id":"https://openalex.org/C45594756","wikidata":"https://www.wikidata.org/wiki/Q5282784","display_name":"Dissipative particle dynamics","level":3,"score":0.7673404812812805},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.6771142482757568},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.6616684198379517},{"id":"https://openalex.org/C8892853","wikidata":"https://www.wikidata.org/wiki/Q170749","display_name":"Surface tension","level":2,"score":0.6076042652130127},{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.4968850910663605},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.46488308906555176},{"id":"https://openalex.org/C2778517922","wikidata":"https://www.wikidata.org/wiki/Q7140482","display_name":"Particle (ecology)","level":2,"score":0.45144718885421753},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.44078049063682556},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4240152835845947},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.41668838262557983},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.34500741958618164},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.32677707076072693},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2834543287754059},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1609140932559967},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.15006250143051147},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.09116682410240173},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0703980028629303},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D004134","descriptor_name":"Dimyristoylphosphatidylcholine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jpclett.8b01696","doi":"https://doi.org/10.1021/acs.jpclett.8b01696","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jpclett.8b01696","pdf_url":null,"source":{"id":"https://openalex.org/S123480357","display_name":"The Journal of Physical Chemistry Letters","issn_l":"1948-7185","issn":["1948-7185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:30085675","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30085675","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of physical chemistry letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G8276670645","display_name":null,"funder_award_id":"CBET-1264702","funder_id":"https://openalex.org/F4320337390","funder_display_name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320337390","display_name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems","ror":"https://ror.org/0471zv972"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W88907887","https://openalex.org/W773424392","https://openalex.org/W1185112711","https://openalex.org/W1824216747","https://openalex.org/W1847678620","https://openalex.org/W1922937991","https://openalex.org/W1976081665","https://openalex.org/W1980285981","https://openalex.org/W1981925626","https://openalex.org/W1989945146","https://openalex.org/W1993553528","https://openalex.org/W2000859922","https://openalex.org/W2001214825","https://openalex.org/W2011088564","https://openalex.org/W2023144502","https://openalex.org/W2029667189","https://openalex.org/W2032655419","https://openalex.org/W2036647717","https://openalex.org/W2043701535","https://openalex.org/W2058127226","https://openalex.org/W2067499774","https://openalex.org/W2079344858","https://openalex.org/W2088060865","https://openalex.org/W2088706830","https://openalex.org/W2092144432","https://openalex.org/W2093310284","https://openalex.org/W2099040624","https://openalex.org/W2112057811","https://openalex.org/W2117326659","https://openalex.org/W2117942196","https://openalex.org/W2138402450","https://openalex.org/W2140115060","https://openalex.org/W2140344088","https://openalex.org/W2146726980","https://openalex.org/W2148320012","https://openalex.org/W2158558808","https://openalex.org/W2319556041","https://openalex.org/W2342179512","https://openalex.org/W2412916541","https://openalex.org/W2531599276","https://openalex.org/W2552979639","https://openalex.org/W2580325886","https://openalex.org/W2595463699","https://openalex.org/W2607292593","https://openalex.org/W2738226037","https://openalex.org/W2744738409","https://openalex.org/W2754448668","https://openalex.org/W2760091598"],"related_works":["https://openalex.org/W2097024113","https://openalex.org/W2738226037","https://openalex.org/W3107963697","https://openalex.org/W2167123410","https://openalex.org/W3214407225","https://openalex.org/W2117942196","https://openalex.org/W7100184883","https://openalex.org/W2997606426","https://openalex.org/W2991221638","https://openalex.org/W2315676770"],"abstract_inverted_index":{"Tension-induced":[0],"rupture":[1,38],"of":[2,21,36,46,52,69,79,100,143],"1,2-dimyristoyl-":[3],"sn-glycero-3-phosphocholine":[4],"(DMPC)":[5],"lipid":[6],"membranes":[7,74],"with":[8,76,137],"encapsulated":[9],"hydrophobic":[10],"nanoparticles":[11],"is":[12,24,31,103],"elucidated":[13],"using":[14],"dissipative":[15],"particle":[16,95],"dynamics":[17,20],"simulations.":[18],"The":[19,98,120],"hole":[22,53],"formation":[23,54],"studied,":[25],"and":[26,59,129,147],"a":[27,40,44],"nanoparticle":[28,64],"size-dependent":[29],"relationship":[30],"established":[32],"for":[33],"the":[34,47,63,67,77,80,85,94,112,117,126,131],"probability":[35],"membrane":[37,48,132],"within":[39],"given":[41],"time":[42],"as":[43,93],"function":[45],"tension.":[49],"Two":[50],"mechanisms":[51],"are":[55],"explored:":[56],"homogeneous":[57,70],"nucleation":[58,61,71,87,102],"heterogeneous":[60,86,101],"at":[62,111],"surface.":[65],"While":[66],"kinetics":[68],"in":[72,134],"unloaded":[73],"complies":[75],"predictions":[78],"classical":[81],"Deryagin-Gutop":[82],"(DG)":[83],"theory,":[84],"causes":[88],"progressively":[89],"lower":[90],"lysis":[91],"tensions":[92],"size":[96],"increases.":[97],"thermodynamics":[99],"treated":[104],"by":[105],"introducing":[106],"an":[107],"effective":[108],"contact":[109],"angle":[110],"three-phase,":[113],"solvent-membrane-solid":[114],"boundary":[115],"into":[116],"DG":[118],"theory.":[119],"proposed":[121],"approach":[122],"helps":[123],"quantitatively":[124],"interpret":[125],"simulation":[127],"results":[128],"predict":[130],"stability":[133],"real":[135],"experiments":[136],"significantly":[138],"larger":[139],"(by":[140],"many":[141],"orders":[142],"magnitude)":[144],"observation":[145],"times":[146],"spatial":[148],"scales.":[149]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-08-22T00:00:00"}