{"id":"https://openalex.org/W2886475686","doi":"https://doi.org/10.1038/s41385-018-0047-y","title":"High-dimensional immune phenotyping and transcriptional analyses reveal robust recovery of viable human immune and epithelial cells from frozen gastrointestinal tissue","display_name":"High-dimensional immune phenotyping and transcriptional analyses reveal robust recovery of viable human immune and epithelial cells from frozen gastrointestinal tissue","publication_year":2018,"publication_date":"2018-08-15","ids":{"openalex":"https://openalex.org/W2886475686","doi":"https://doi.org/10.1038/s41385-018-0047-y","mag":"2886475686","pmid":"https://pubmed.ncbi.nlm.nih.gov/30111863","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6512331"},"language":"en","primary_location":{"id":"doi:10.1038/s41385-018-0047-y","doi":"https://doi.org/10.1038/s41385-018-0047-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41385-018-0047-y","pdf_url":"https://www.nature.com/articles/s41385-018-0047-y.pdf","source":{"id":"https://openalex.org/S68384121","display_name":"Mucosal Immunology","issn_l":"1933-0219","issn":["1933-0219","1935-3456"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mucosal Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nature.com/articles/s41385-018-0047-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054972029","display_name":"Liza Konnikova","orcid":"https://orcid.org/0000-0003-4804-5497","observed_orcids":["https://orcid.org/0000-0003-4804-5497"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liza Konnikova","raw_affiliation_strings":["Department of Pediatrics and Newborn Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA","Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, 02115, USA","Harvard Medical School, Boston, MA, 02115, USA","Department of Pediatrics and Newborn Medicine, Brigham and Women's Hospital, 02115, Boston, MA, USA","Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, 02115, Boston, MA, USA","Harvard Medical School, 02115, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Newborn Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Pediatrics and Newborn Medicine, Brigham and Women's Hospital, 02115, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, 02115, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Harvard Medical School, 02115, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102881435","display_name":"Gilles Boschetti","orcid":"https://orcid.org/0000-0003-4039-7607","observed_orcids":["https://orcid.org/0000-0003-4039-7607"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gilles Boschetti","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA","Icahn School of Medicine at Mount Sinai, 10029, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, 10029, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020454256","display_name":"Adeeb H Rahman","orcid":"https://orcid.org/0000-0002-8620-3161","observed_orcids":["https://orcid.org/0000-0002-8620-3161"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adeeb Rahman","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA","Icahn School of Medicine at Mount Sinai, 10029, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, 10029, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036786028","display_name":"Vanessa Mitsialis","orcid":"https://orcid.org/0000-0002-1186-3616","observed_orcids":["https://orcid.org/0000-0002-1186-3616"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vanessa Mitsialis","raw_affiliation_strings":["Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA, 02115, USA","Division of Gastroenterology, Brigham and Women's Hospital, 02115, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Division of Gastroenterology, Brigham and Women's Hospital, 02115, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081050229","display_name":"James D. Lord","orcid":"https://orcid.org/0000-0001-8961-3660","observed_orcids":["https://orcid.org/0000-0001-8961-3660"]},"institutions":[{"id":"https://openalex.org/I4391012615","display_name":"Benaroya Research Institute","ror":"https://ror.org/04j9rp686","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802797007","https://openalex.org/I4210118434","https://openalex.org/I4391012615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Lord","raw_affiliation_strings":["Benaroya Research Institute, Seattle, WA, 98101, USA","Benaroya Research Institute, 98101, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Benaroya Research Institute, Seattle, WA, 98101, USA","institution_ids":["https://openalex.org/I4391012615"]},{"raw_affiliation_string":"Benaroya Research Institute, 98101, Seattle, WA, USA","institution_ids":["https://openalex.org/I4391012615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014463483","display_name":"Camilla A. Richmond","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Camilla Richmond","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, 02115, USA","Harvard Medical School, Boston, MA, 02115, USA","Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, 02115, Boston, MA, USA","Harvard Medical School, 02115, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, 02115, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Harvard Medical School, 02115, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037517168","display_name":"Vesselin T. Tomov","orcid":"https://orcid.org/0000-0003-4006-1230","observed_orcids":["https://orcid.org/0000-0003-4006-1230"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vesselin T. Tomov","raw_affiliation_strings":["Department of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA","Department of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, 19104, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, 19104, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081349730","display_name":"Will Gordon","orcid":"https://orcid.org/0000-0001-9455-321X","observed_orcids":["https://orcid.org/0000-0001-9455-321X"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Will Gordon","raw_affiliation_strings":["Pfizer, Cambridge, MA, 02139, USA","Pfizer, 02139, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer, Cambridge, MA, 02139, USA","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Pfizer, 02139, Cambridge, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056750016","display_name":"Scott A. Jelinsky","orcid":"https://orcid.org/0000-0002-5114-0236","observed_orcids":["https://orcid.org/0000-0002-5114-0236"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Jelinsky","raw_affiliation_strings":["Pfizer, Cambridge, MA, 02139, USA","Pfizer, 02139, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer, Cambridge, MA, 02139, USA","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Pfizer, 02139, Cambridge, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010010256","display_name":"James B. Canavan","orcid":"https://orcid.org/0000-0003-0701-8396","observed_orcids":["https://orcid.org/0000-0003-0701-8396"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Canavan","raw_affiliation_strings":["Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA, 02115, USA","Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, 02115, USA","Harvard Medical School, Boston, MA, 02115, USA","Division of Gastroenterology, Brigham and Women's Hospital, 02115, Boston, MA, USA","Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, 02115, Boston, MA, USA","Harvard Medical School, 02115, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of Gastroenterology, Brigham and Women's Hospital, 02115, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, 02115, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Harvard Medical School, 02115, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082729431","display_name":"Andrew Scott Liss","orcid":"https://orcid.org/0000-0002-4040-9172","observed_orcids":["https://orcid.org/0000-0002-4040-9172"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Liss","raw_affiliation_strings":["Department of Pathology, Boston Children's Hospital, Boston, MA, 02115, USA","Department of Pathology, Boston Children's Hospital, 02115, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Boston Children's Hospital, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Department of Pathology, Boston Children's Hospital, 02115, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032143866","display_name":"Sarah M. Wall","orcid":"https://orcid.org/0000-0002-4357-0690","observed_orcids":["https://orcid.org/0000-0002-4357-0690"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Wall","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, 02115, USA","Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, 02115, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, 02115, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042693721","display_name":"Michael Field","orcid":"https://orcid.org/0000-0002-4003-0568","observed_orcids":["https://orcid.org/0000-0002-4003-0568"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Field","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, 02115, USA","Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, 02115, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, 02115, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011416685","display_name":"Fanny Zhou","orcid":"https://orcid.org/0000-0001-8260-6775","observed_orcids":["https://orcid.org/0000-0001-8260-6775"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fanny Zhou","raw_affiliation_strings":["Department of Pathology, Boston Children's Hospital, Boston, MA, 02115, USA","Department of Pathology, Boston Children's Hospital, 02115, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Boston Children's Hospital, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Department of Pathology, Boston Children's Hospital, 02115, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037472475","display_name":"Jeffery D. Goldsmith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffery D. Goldsmith","raw_affiliation_strings":["Department of Pathology, Boston Children's Hospital, Boston, MA, 02115, USA","Harvard Medical School, Boston, MA, 02115, USA","Department of Pathology, Boston Children's Hospital, 02115, Boston, MA, USA","Harvard Medical School, 02115, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Boston Children's Hospital, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Pathology, Boston Children's Hospital, 02115, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Harvard Medical School, 02115, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066241193","display_name":"Meenakshi Bewtra","orcid":"https://orcid.org/0000-0002-6489-7043","observed_orcids":["https://orcid.org/0000-0002-6489-7043"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meenakshi Bewtra","raw_affiliation_strings":["Department of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA","Department of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, 19104, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, 19104, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061357351","display_name":"David T. Breault","orcid":"https://orcid.org/0000-0002-0402-4857","observed_orcids":["https://orcid.org/0000-0002-0402-4857"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T. Breault","raw_affiliation_strings":["Division of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA","Harvard Medical School, Boston, MA, 02115, USA","Harvard Stem Cell Institute, Cambridge, MA, 02138, USA","Division of Endocrinology, Boston Children's Hospital, 02115, Boston, MA, USA","Harvard Medical School, 02115, Boston, MA, USA","Harvard Stem Cell Institute, 02138, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Cambridge, MA, 02138, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]},{"raw_affiliation_string":"Division of Endocrinology, Boston Children's Hospital, 02115, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Harvard Medical School, 02115, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, 02138, Cambridge, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070354041","display_name":"Miriam M\u00e9rad","orcid":"https://orcid.org/0000-0002-4481-7827","observed_orcids":["https://orcid.org/0000-0002-4481-7827"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miriam Merad","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA","Icahn School of Medicine at Mount Sinai, 10029, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, 10029, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052060864","display_name":"Scott B. Snapper","orcid":"https://orcid.org/0000-0003-0267-4247","observed_orcids":["https://orcid.org/0000-0003-0267-4247"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Scott B. Snapper","raw_affiliation_strings":["Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA, 02115, USA. scott.snapper@childrens.harvard.edu","Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, 02115, USA. scott.snapper@childrens.harvard.edu","Harvard Medical School, Boston, MA, 02115, USA. scott.snapper@childrens.harvard.edu","Division of Gastroenterology, Brigham and Women's Hospital, 02115, Boston, MA, USA","Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, 02115, Boston, MA, USA","Harvard Medical School, 02115, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA, 02115, USA. scott.snapper@childrens.harvard.edu","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, 02115, USA. scott.snapper@childrens.harvard.edu","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, 02115, USA. scott.snapper@childrens.harvard.edu","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of Gastroenterology, Brigham and Women's Hospital, 02115, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, 02115, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Harvard Medical School, 02115, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5052060864"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1288882113","https://openalex.org/I136199984"],"apc_list":{"value":4370,"currency":"USD","value_usd":4370},"apc_paid":null,"fwci":1.7642,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.84035625,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"11","issue":"6","first_page":"1684","last_page":"1693"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.35499998927116394,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.35499998927116394,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.20170000195503235,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.17710000276565552,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cryopreservation","display_name":"cryopreservation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/gastrointestinal-tissue","display_name":"gastrointestinal tissue","score":0.8960000276565552},{"id":"https://openalex.org/keywords/mucosal-immune-cells","display_name":"mucosal immune cells","score":0.9210000038146973},{"id":"https://openalex.org/keywords/epithelial-cells","display_name":"epithelial cells","score":0.9139999747276306},{"id":"https://openalex.org/keywords/immunophenotyping","display_name":"immunophenotyping","score":0.7310000061988831},{"id":"https://openalex.org/keywords/transcriptional-analysis","display_name":"transcriptional analysis","score":0.8320000171661377},{"id":"https://openalex.org/keywords/tissue-storage","display_name":"tissue storage","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.835178017616272},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6702658534049988},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.553839921951294},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49046704173088074},{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.44118109345436096},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015925","descriptor_name":"Cryopreservation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41385-018-0047-y","doi":"https://doi.org/10.1038/s41385-018-0047-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41385-018-0047-y","pdf_url":"https://www.nature.com/articles/s41385-018-0047-y.pdf","source":{"id":"https://openalex.org/S68384121","display_name":"Mucosal Immunology","issn_l":"1933-0219","issn":["1933-0219","1935-3456"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mucosal Immunology","raw_type":"journal-article"},{"id":"pmid:30111863","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30111863","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mucosal immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6512331","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6512331","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mucosal Immunol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41385-018-0047-y","doi":"https://doi.org/10.1038/s41385-018-0047-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41385-018-0047-y","pdf_url":"https://www.nature.com/articles/s41385-018-0047-y.pdf","source":{"id":"https://openalex.org/S68384121","display_name":"Mucosal Immunology","issn_l":"1933-0219","issn":["1933-0219","1935-3456"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mucosal Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1707775733","display_name":"Characterization of Telomerase Expressing Intestinal Stem Cells","funder_award_id":"R01DK084056","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G332990701","display_name":null,"funder_award_id":"P30HD18655","funder_id":"https://openalex.org/F4320332591","funder_display_name":"Intellectual and Developmental Disabilities Research Center"},{"id":"https://openalex.org/G3827883186","display_name":"Employing novel humanized murine strains to develop hematopoietic stem cell gene therapeutic approaches for very early-onset inflammatory bowel disease due to IL10-receptor deficiency.","funder_award_id":"R56AI125766","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4679260162","display_name":null,"funder_award_id":"HDDC P30DK034854","funder_id":"https://openalex.org/F4320332591","funder_display_name":"Intellectual and Developmental Disabilities Research Center"},{"id":"https://openalex.org/G4957318891","display_name":null,"funder_award_id":"422348","funder_id":"https://openalex.org/F4320312926","funder_display_name":"Crohn's and Colitis Foundation"},{"id":"https://openalex.org/G5566193345","display_name":"Regulation of Dormant Intestinal Stem Cells","funder_award_id":"K08DK106562","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5857948765","display_name":null,"funder_award_id":"P30DK034854","funder_id":"https://openalex.org/F4320334528","funder_display_name":"Harvard Digestive Diseases Center, Harvard University"},{"id":"https://openalex.org/G7981559554","display_name":"Novel tools to maximize profiling of tissue and antigen specific immune dysregulation in allergy and inflammatory bowel disesase","funder_award_id":"U24AI118644","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8596008389","display_name":"Intellectual and Developmental Disablities Research Center","funder_award_id":"P30HD018655","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G8880645619","display_name":"Alimentary Tract Lipid and Disease","funder_award_id":"T32DK007533","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000865716","display_name":"Type III interferon Control of Mucosal Immunity","funder_award_id":"R01DK115217","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000886307","display_name":"Integrated Epithelial and Muscosal Biology","funder_award_id":"P30DK034854","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306301","display_name":"Crohn's and Colitis Foundation of America","ror":"https://ror.org/05f2xbq60"},{"id":"https://openalex.org/F4320309446","display_name":"Leona M. and Harry B. Helmsley Charitable Trust","ror":"https://ror.org/011x6n313"},{"id":"https://openalex.org/F4320312926","display_name":"Crohn's and Colitis Foundation","ror":"https://ror.org/05f2xbq60"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332591","display_name":"Intellectual and Developmental Disabilities Research Center","ror":"https://ror.org/02pttbw34"},{"id":"https://openalex.org/F4320334528","display_name":"Harvard Digestive Diseases Center, Harvard University","ror":null},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2886475686.pdf","grobid_xml":"https://content.openalex.org/works/W2886475686.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W111805191","https://openalex.org/W1077031352","https://openalex.org/W1631320694","https://openalex.org/W1982729887","https://openalex.org/W2015671099","https://openalex.org/W2016322906","https://openalex.org/W2024626836","https://openalex.org/W2025780730","https://openalex.org/W2027289497","https://openalex.org/W2027445302","https://openalex.org/W2092819032","https://openalex.org/W2133567825","https://openalex.org/W2137526110","https://openalex.org/W2146512944","https://openalex.org/W2151150534","https://openalex.org/W2222859485","https://openalex.org/W2335639107","https://openalex.org/W2394799259","https://openalex.org/W2402558483","https://openalex.org/W2556269208","https://openalex.org/W2583464358","https://openalex.org/W2953209396"],"related_works":["https://openalex.org/W2787536509","https://openalex.org/W2950956622","https://openalex.org/W4229054479","https://openalex.org/W2065947008","https://openalex.org/W2944151044","https://openalex.org/W3133800387","https://openalex.org/W7223065169","https://openalex.org/W3035000186","https://openalex.org/W2953209396","https://openalex.org/W77823720"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2018-08-22T00:00:00"}