{"id":"https://openalex.org/W2886450405","doi":"https://doi.org/10.1158/1538-7445.am2018-3376","title":"Abstract 3376: Early onset of chromosomal instability in breast preneoplasia detected by single-cell genomics","display_name":"Abstract 3376: Early onset of chromosomal instability in breast preneoplasia detected by single-cell genomics","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2886450405","doi":"https://doi.org/10.1158/1538-7445.am2018-3376","mag":"2886450405"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2018-3376","doi":"https://doi.org/10.1158/1538-7445.am2018-3376","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-3376","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060739449","display_name":"Katerina D. Fagan\u2010Solis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katerina Fagan-Solis","raw_affiliation_strings":["1The University of North Carolina at Chapel Hill, Chapel Hill, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of North Carolina at Chapel Hill, Chapel Hill, NC;","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088441683","display_name":"Dennis A. Simpson","orcid":"https://orcid.org/0000-0001-5332-8243","observed_orcids":["https://orcid.org/0000-0001-5332-8243"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis A. Simpson","raw_affiliation_strings":["1The University of North Carolina at Chapel Hill, Chapel Hill, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of North Carolina at Chapel Hill, Chapel Hill, NC;","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023182871","display_name":"Luciano Gast\u00f3n Martelotto","orcid":"https://orcid.org/0000-0002-9625-1183","observed_orcids":["https://orcid.org/0000-0002-9625-1183"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luciano Martelotto","raw_affiliation_strings":["2Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077235697","display_name":"Jorge Sergio Reis-Filho","orcid":"https://orcid.org/0000-0003-2969-3173","observed_orcids":["https://orcid.org/0000-0003-2969-3173"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge S. Reis-Filho","raw_affiliation_strings":["2Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013956193","display_name":"John H.J. Petrini","orcid":"https://orcid.org/0000-0001-5102-5679","observed_orcids":["https://orcid.org/0000-0001-5102-5679"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John H. Petrini","raw_affiliation_strings":["2Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112864074","display_name":"Gaorav P. Gupta","orcid":"https://orcid.org/0000-0001-9177-552X","observed_orcids":["https://orcid.org/0000-0001-9177-552X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gaorav P. Gupta","raw_affiliation_strings":["1The University of North Carolina at Chapel Hill, Chapel Hill, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of North Carolina at Chapel Hill, Chapel Hill, NC;","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":"13_Supplement","first_page":"3376","last_page":"3376"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.4018999934196472,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.4018999934196472,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.38449999690055847,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.07680000364780426,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":0.9990000128746033},{"id":"https://openalex.org/keywords/her2-neu","display_name":"HER2/neu","score":0.8109999895095825},{"id":"https://openalex.org/keywords/mre11","display_name":"MRE11","score":0.8899999856948853},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9309999942779541},{"id":"https://openalex.org/keywords/mammary-epithelial-cells","display_name":"mammary epithelial cells","score":0.8519999980926514},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.8109999895095825},{"id":"https://openalex.org/keywords/chromosome-breakpoints","display_name":"chromosomal breakpoints","score":0.8100000023841858},{"id":"https://openalex.org/keywords/r-loops","display_name":"R-loops","score":0.8939999938011169},{"id":"https://openalex.org/keywords/genomic-deletions","display_name":"genomic deletions","score":0.6079999804496765},{"id":"https://openalex.org/keywords/premalignant-breast-lesions","display_name":"premalignant breast lesions","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.8758836984634399},{"id":"https://openalex.org/C140752955","wikidata":"https://www.wikidata.org/wiki/Q1087752","display_name":"Chromosome instability","level":4,"score":0.7081843614578247},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6778254508972168},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.6709237098693848},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6191645860671997},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5079599022865295},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4832625985145569},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41804665327072144},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39629244804382324},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37019050121307373},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.23245644569396973},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.20664912462234497},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.19877856969833374},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.12635350227355957}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2018-3376","doi":"https://doi.org/10.1158/1538-7445.am2018-3376","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-3376","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2483540076","https://openalex.org/W2013338142","https://openalex.org/W4403757624","https://openalex.org/W7100758989","https://openalex.org/W2139578605","https://openalex.org/W2111024091","https://openalex.org/W2627071825","https://openalex.org/W6991404271","https://openalex.org/W4255757219","https://openalex.org/W4417043193"],"abstract_inverted_index":{"Abstract":[0],"Chromosomal":[1],"rearrangements":[2],"and":[3,45,62,96,207],"copy":[4,204],"number":[5,151,205],"aberrations":[6,206],"are":[7,27,120],"a":[8,46,77,98,130],"major":[9],"mechanism":[10],"for":[11,58,133,193,290],"driver":[12],"gene":[13,134],"alterations":[14],"in":[15,37,76,107,114,123,138,234,276],"breast":[16,25,74,181,224,235,251,277],"cancer.":[17],"However,":[18],"the":[19,59,70,124,139,150,157,186,200,209,229,246,287],"origins":[20,230],"of":[21,64,72,101,126,141,152,188,202,212,223,231,248,273,286],"chromosomal":[22,105,118,153,173,232,274],"instability":[23,106,174,196,233,275],"during":[24,179],"tumorigenesis":[26],"poorly":[28],"understood.":[29],"We":[30],"have":[31,83],"recently":[32],"shown":[33],"that":[34,163,172,237],"oncogene":[35,102],"expression":[36,103],"normal":[38],"mammary":[39,89],"epithelial":[40,90],"cells":[41,91],"induces":[42],"replication":[43],"stress":[44],"DNA":[47],"damage":[48],"response":[49],"(DDR).":[50],"The":[51],"double-strand":[52],"break":[53],"sensor":[54],"Mre11":[55,65,145,189],"is":[56,66,111,164,175],"required":[57,192],"oncogene-induced":[60,142,194],"DDR,":[61],"suppression":[63],"sufficient":[67],"to":[68,87,161,220,242],"promote":[69],"development":[71],"Her2/Neu-driven":[73],"cancer":[75,236],"transgenic":[78],"mouse":[79,94],"model.":[80],"Here":[81],"we":[82],"applied":[84,219],"single-cell":[85,217,281],"genomics":[86,218,282],"primary":[88],"from":[92],"this":[93],"model":[95],"demonstrate":[97],"profound":[99],"effect":[100],"on":[104],"preneoplastic":[108],"cells,":[109],"which":[110],"further":[112],"augmented":[113],"Mre11-mutant":[115],"cells.":[116],"Her2/Neu-induced":[117],"breakpoints":[119,154],"highly":[121],"enriched":[122],"vicinity":[125],"large":[127],"genes,":[128],"suggesting":[129],"possible":[131],"role":[132],"transcription":[135],"and/or":[136],"R-loops":[137],"origin":[140],"genomic":[143,158,195],"fragility.":[144],"hypomorphism":[146],"does":[147],"not":[148,191],"affect":[149],"but":[155,197],"alters":[156,199],"aberration":[159],"signature":[160],"one":[162],"over-represented":[165],"by":[166,280],"larger-size":[167],"deletions.":[168],"These":[169],"findings":[170],"indicate":[171],"an":[176],"early":[177],"event":[178],"Her2/Neu-initiated":[180],"neoplasia.":[182],"Furthermore,":[183],"DDR":[184],"perturbation\u2014in":[185],"form":[187],"hypomorphism\u2014is":[190],"rather":[198],"pattern":[201],"observed":[203],"promotes":[208],"proliferative":[210],"expansion":[211],"genomically":[213],"unstable":[214],"clones.":[215],"Thus,":[216],"murine":[221],"models":[222],"preneoplasia":[225,278],"reveals":[226],"insights":[227],"into":[228],"may":[238],"inform":[239],"novel":[240],"strategies":[241],"prognosticate":[243],"or":[244],"prevent":[245],"progression":[247],"high-risk":[249],"premalignant":[250],"lesions.":[252],"Citation":[253],"Format:":[254],"Katerina":[255],"Fagan-Solis,":[256],"Dennis":[257],"A.":[258],"Simpson,":[259],"Luciano":[260],"Martelotto,":[261],"Jorge":[262],"S.":[263],"Reis-Filho,":[264],"John":[265],"H.":[266],"Petrini,":[267],"Gaorav":[268],"P.":[269],"Gupta.":[270],"Early":[271],"onset":[272],"detected":[279],"[abstract].":[283],"In:":[284],"Proceedings":[285],"American":[288],"Association":[289],"Cancer":[291,304],"Research":[292],"Annual":[293],"Meeting":[294],"2018;":[295],"2018":[296],"Apr":[297],"14-18;":[298],"Chicago,":[299],"IL.":[300],"Philadelphia":[301],"(PA):":[302],"AACR;":[303],"Res":[305],"2018;78(13":[306],"Suppl):Abstract":[307],"nr":[308],"3376.":[309]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2018-08-22T00:00:00"}