{"id":"https://openalex.org/W2886435389","doi":"https://doi.org/10.1097/ijg.0000000000001055","title":"Intraocular Pressure Lowering Effect of Latanoprost as First-line Treatment for Glaucoma","display_name":"Intraocular Pressure Lowering Effect of Latanoprost as First-line Treatment for Glaucoma","publication_year":2018,"publication_date":"2018-08-14","ids":{"openalex":"https://openalex.org/W2886435389","doi":"https://doi.org/10.1097/ijg.0000000000001055","mag":"2886435389","pmid":"https://pubmed.ncbi.nlm.nih.gov/30113517"},"language":"en","primary_location":{"id":"doi:10.1097/ijg.0000000000001055","doi":"https://doi.org/10.1097/ijg.0000000000001055","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ijg.0000000000001055","pdf_url":null,"source":{"id":"https://openalex.org/S174695746","display_name":"Journal of Glaucoma","issn_l":"1057-0829","issn":["1057-0829","1536-481X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Glaucoma","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021666493","display_name":"Johan Aspberg","orcid":"https://orcid.org/0000-0001-9707-9509","observed_orcids":["https://orcid.org/0000-0001-9707-9509"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Johan Aspberg","raw_affiliation_strings":["Department of Clinical Sciences in Malm\u00f6, Ophthalmology, Lund University, Malm\u00f6"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences in Malm\u00f6, Ophthalmology, Lund University, Malm\u00f6","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022617905","display_name":"Anders Heijl","orcid":"https://orcid.org/0000-0001-7233-6919","observed_orcids":["https://orcid.org/0000-0001-7233-6919"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Anders Heijl","raw_affiliation_strings":["Department of Clinical Sciences in Malm\u00f6, Ophthalmology, Lund University, Malm\u00f6"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences in Malm\u00f6, Ophthalmology, Lund University, Malm\u00f6","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068216380","display_name":"Gauti J\u00f3hannesson","orcid":"https://orcid.org/0000-0003-0218-4563","observed_orcids":["https://orcid.org/0000-0003-0218-4563"]},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Gauti J\u00f3hannesson","raw_affiliation_strings":["Department of Clinical Sciences, Ophthalmology","Wallenberg Centre for Molecular Medicine, Ume\u00e5 University, Ume\u00e5, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Ophthalmology","institution_ids":[]},{"raw_affiliation_string":"Wallenberg Centre for Molecular Medicine, Ume\u00e5 University, Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015009421","display_name":"Christina Lind\u00e9n","orcid":"https://orcid.org/0000-0002-3597-4740","observed_orcids":["https://orcid.org/0000-0002-3597-4740"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christina Lind\u00e9n","raw_affiliation_strings":["Department of Clinical Sciences, Ophthalmology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Ophthalmology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022928507","display_name":"Sabina Andersson\u2010Geimer","orcid":"https://orcid.org/0000-0003-2703-7092","observed_orcids":["https://orcid.org/0000-0003-2703-7092"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Sabina Andersson-Geimer","raw_affiliation_strings":["Department of Clinical Sciences in Malm\u00f6, Ophthalmology, Lund University, Malm\u00f6"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences in Malm\u00f6, Ophthalmology, Lund University, Malm\u00f6","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042154148","display_name":"Boel Bengtsson","orcid":"https://orcid.org/0000-0002-5997-3953","observed_orcids":["https://orcid.org/0000-0002-5997-3953"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Boel Bengtsson","raw_affiliation_strings":["Department of Clinical Sciences in Malm\u00f6, Ophthalmology, Lund University, Malm\u00f6"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences in Malm\u00f6, Ophthalmology, Lund University, Malm\u00f6","institution_ids":["https://openalex.org/I187531555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5021666493","https://openalex.org/A5022617905","https://openalex.org/A5022928507","https://openalex.org/A5042154148"],"corresponding_institution_ids":["https://openalex.org/I187531555"],"apc_list":null,"apc_paid":null,"fwci":0.7345,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.70093212,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"27","issue":"11","first_page":"976","last_page":"980"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/latanoprost","display_name":"latanoprost","score":1.0},{"id":"https://openalex.org/keywords/intraocular-pressure-reduction","display_name":"intraocular pressure reduction","score":0.8349999785423279},{"id":"https://openalex.org/keywords/open-angle-glaucoma","display_name":"open-angle glaucoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/pseudoexfoliation-glaucoma","display_name":"pseudoexfoliation glaucoma","score":0.9700000286102295},{"id":"https://openalex.org/keywords/treatment-naive-patients","display_name":"treatment-naive patients","score":0.6919999718666077},{"id":"https://openalex.org/keywords/prostamide","display_name":"prostamide","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C2776740260","wikidata":"https://www.wikidata.org/wiki/Q634959","display_name":"Latanoprost","level":3,"score":0.9755280017852783},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.8960781097412109},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8674625158309937},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.8625267148017883},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.7798624038696289},{"id":"https://openalex.org/C2991803831","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Open angle glaucoma","level":3,"score":0.6161397099494934},{"id":"https://openalex.org/C2776521421","wikidata":"https://www.wikidata.org/wiki/Q9294051","display_name":"Ocular hypertension","level":3,"score":0.4679863452911377}],"mesh":[{"descriptor_ui":"D000077338","descriptor_name":"Latanoprost","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000077338","descriptor_name":"Latanoprost","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005902","descriptor_name":"Glaucoma, Open-Angle","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011461","descriptor_name":"Prostaglandins F, Synthetic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014065","descriptor_name":"Tonometry, Ocular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017889","descriptor_name":"Exfoliation Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/ijg.0000000000001055","doi":"https://doi.org/10.1097/ijg.0000000000001055","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ijg.0000000000001055","pdf_url":null,"source":{"id":"https://openalex.org/S174695746","display_name":"Journal of Glaucoma","issn_l":"1057-0829","issn":["1057-0829","1536-481X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Glaucoma","raw_type":"journal-article"},{"id":"pmid:30113517","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30113517","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of glaucoma","raw_type":"Journal Article"},{"id":"pmh:oai:lup.lub.lu.se:6361a7d1-b22e-4592-bc02-48ea812240e8","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/6361a7d1-b22e-4592-bc02-48ea812240e8","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1057-0829","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W93725138","https://openalex.org/W1490909919","https://openalex.org/W1556122751","https://openalex.org/W1563367972","https://openalex.org/W1798854394","https://openalex.org/W1810830878","https://openalex.org/W1967197378","https://openalex.org/W1974689966","https://openalex.org/W1975161644","https://openalex.org/W1977653161","https://openalex.org/W1978372306","https://openalex.org/W1981684730","https://openalex.org/W1995338802","https://openalex.org/W1996539435","https://openalex.org/W2003916074","https://openalex.org/W2004167709","https://openalex.org/W2008057268","https://openalex.org/W2013186162","https://openalex.org/W2015927231","https://openalex.org/W2019431885","https://openalex.org/W2021727285","https://openalex.org/W2022247556","https://openalex.org/W2026430850","https://openalex.org/W2031866719","https://openalex.org/W2040322156","https://openalex.org/W2046193987","https://openalex.org/W2052495147","https://openalex.org/W2054125819","https://openalex.org/W2054732313","https://openalex.org/W2060032838","https://openalex.org/W2064116153","https://openalex.org/W2065137480","https://openalex.org/W2067868996","https://openalex.org/W2068213488","https://openalex.org/W2070012048","https://openalex.org/W2076260416","https://openalex.org/W2081647886","https://openalex.org/W2091423352","https://openalex.org/W2093081766","https://openalex.org/W2097872314","https://openalex.org/W2105749464","https://openalex.org/W2108979184","https://openalex.org/W2114271694","https://openalex.org/W2114445036","https://openalex.org/W2116493905","https://openalex.org/W2130206051","https://openalex.org/W2131063971","https://openalex.org/W2144015336","https://openalex.org/W2147093603","https://openalex.org/W2150119670","https://openalex.org/W2158689141","https://openalex.org/W2162927994","https://openalex.org/W2169721886","https://openalex.org/W2320976765","https://openalex.org/W2889420129"],"related_works":["https://openalex.org/W2024562545","https://openalex.org/W2083598624","https://openalex.org/W2108979184","https://openalex.org/W2409686889","https://openalex.org/W1976659381","https://openalex.org/W2413452396","https://openalex.org/W2081226371","https://openalex.org/W7216839502","https://openalex.org/W2092753875","https://openalex.org/W3156913892"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1,51,82,100,124,227],"purpose":[2],"of":[3,16,29,32,43,60,186,201,214,259],"this":[4,204],"study":[5],"was":[6,62,71,86,127,190,229],"to":[7,78,107,117,209,231],"assess":[8],"the":[9,30,137,199,207,211,232,257],"intraocular":[10],"pressure":[11,84],"(IOP)":[12],"-":[13],"reducing":[14],"effect":[15,126,185,213,228],"latanoprost":[17,215,260],"in":[18,102,131,192,222,250],"treatment-na\u00efve":[19],"patients":[20,37],"with":[21,26,40,49,91,133,152,194],"newly":[22,223],"detected":[23,224],"open-angle":[24,44],"glaucoma":[25,45,225],"no":[27,160],"restriction":[28],"level":[31],"untreated":[33,66,135,148,153,173,219,233,246],"IOP.":[34,149],"METHODS:":[35],"Eighty-six":[36],"(105":[38],"eyes)":[39],"a":[41,262],"diagnosis":[42],"received":[46],"IOP-lowering":[47,184],"therapy":[48,264],"latanoprost.":[50],"IOP":[52,67,103,154,169,220,234,247],"reduction":[53,85,101,138,170],"1":[54,96,112],"and":[55,97,114,242],"3":[56,98,122],"months":[57],"after":[58,111,121],"initiation":[59],"treatment":[61,216],"recorded.":[63],"RESULTS:":[64],"Mean":[65],"for":[68,265],"all":[69,218,236],"eyes":[70,132,193],"26.2":[72],"mm":[73,80,88,109,119,142,145,175,188,240],"Hg":[74,89,110,120,143,146,189,241],"(ranging":[75],"from":[76,105,115],"10":[77],"51":[79],"Hg).":[81],"mean":[83],"7.9":[87],"(28%),":[90],"equivalent":[92],"average":[93],"levels":[94,221,237],"at":[95,172,217,235,244],"months.":[99,123],"ranged":[104],"-2.3":[106],"25.3":[108],"month,":[113],"-1.3":[116],"33.3":[118],"pressure-lowering":[125],"considerably":[128],"more":[129],"pronounced":[130],"higher":[134,147,245],"IOP;":[136],"increased":[139],"by":[140],"0.55":[141],"per":[144],"Four":[150],"eyes,":[151],"within":[155],"statistically":[156],"normal":[157],"limits,":[158],"had":[159],"or":[161],"negative":[162],"IOP-reduction.":[163],"A":[164],"regression":[165,178],"model":[166],"predicted":[167],"that":[168,181],"ended":[171],"IOP\u226416":[174],"Hg.":[176],"Multiple":[177],"analysis":[179],"showed":[180],"an":[182],"additional":[183],"1.28":[187],"achieved":[191],"pseudoexfoliation":[195],"glaucoma.":[196,266],"CONCLUSIONS:":[197],"To":[198],"best":[200],"our":[202],"knowledge,":[203],"paper":[205],"is":[206],"first":[208],"report":[210],"IOP-reducing":[212],"patients.":[226],"proportional":[230],"above":[238],"16":[239],"better":[243],"levels,":[248],"also":[249],"relative":[251],"terms.":[252],"Our":[253],"results":[254],"further":[255],"confirm":[256],"indication":[258],"as":[261],"first-line":[263]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-08-22T00:00:00"}
