{"id":"https://openalex.org/W2886166995","doi":"https://doi.org/10.1016/j.neuropharm.2018.08.004","title":"Pathophysiology and treatment of cerebral edema in traumatic brain injury","display_name":"Pathophysiology and treatment of cerebral edema in traumatic brain injury","publication_year":2018,"publication_date":"2018-08-04","ids":{"openalex":"https://openalex.org/W2886166995","doi":"https://doi.org/10.1016/j.neuropharm.2018.08.004","mag":"2886166995","pmid":"https://pubmed.ncbi.nlm.nih.gov/30086289","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6309515"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuropharm.2018.08.004","doi":"https://doi.org/10.1016/j.neuropharm.2018.08.004","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuropharm.2018.08.004","pdf_url":null,"source":{"id":"https://openalex.org/S160566677","display_name":"Neuropharmacology","issn_l":"0028-3908","issn":["0028-3908","1873-7064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropharmacology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.neuropharm.2018.08.004","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046351589","display_name":"Ruchira Menka Jha","orcid":"https://orcid.org/0000-0002-3047-7649","observed_orcids":["https://orcid.org/0000-0002-3047-7649"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruchira M. Jha","raw_affiliation_strings":["Department of Critical Care Medicine, And Safar Center for Resuscitation Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States; Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States; Department of Neurosurgery, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States; Clinical and Translational Science Institute, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States","Clinical and Translational Science Institute, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States","Department of Critical Care Medicine, And Safar Center for Resuscitation Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States","Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States","Department of Neurosurgery, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States"],"raw_orcid":"https://orcid.org/0000-0002-3047-7649","affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, And Safar Center for Resuscitation Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States; Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States; Department of Neurosurgery, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States; Clinical and Translational Science Institute, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Clinical and Translational Science Institute, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Critical Care Medicine, And Safar Center for Resuscitation Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Neurosurgery, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080778824","display_name":"Patrick Michael Kochanek","orcid":"https://orcid.org/0000-0002-2627-913X","observed_orcids":["https://orcid.org/0000-0002-2627-913X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick M. Kochanek","raw_affiliation_strings":["Department of Critical Care Medicine, And Safar Center for Resuscitation Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States; Clinical and Translational Science Institute, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States; Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA, United States","Clinical and Translational Science Institute, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States","Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA, United States","Department of Critical Care Medicine, And Safar Center for Resuscitation Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, And Safar Center for Resuscitation Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States; Clinical and Translational Science Institute, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States; Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Clinical and Translational Science Institute, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Critical Care Medicine, And Safar Center for Resuscitation Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073844022","display_name":"J. Marc Simard","orcid":"https://orcid.org/0000-0002-5373-1988","observed_orcids":["https://orcid.org/0000-0002-5373-1988","https://orcid.org/0000-0003-1161-3729"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. Marc Simard","raw_affiliation_strings":["Department of Neurosurgery, School of Medicine, University of Maryland, Baltimore, MD, United States; Department of Pathology, School of Medicine, University of Maryland, Baltimore, MD, United States; Department of Physiology, School of Medicine, University of Maryland, Baltimore, MD, United States. Electronic address: msimard@som.umaryland.edu","Department of Neurosurgery, School of Medicine, University of Maryland, Baltimore, MD, United States","Department of Pathology, School of Medicine, University of Maryland, Baltimore, MD, United States","Department of Physiology, School of Medicine, University of Maryland, Baltimore, MD, United States"],"raw_orcid":"https://orcid.org/0000-0002-5373-1988","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, School of Medicine, University of Maryland, Baltimore, MD, United States; Department of Pathology, School of Medicine, University of Maryland, Baltimore, MD, United States; Department of Physiology, School of Medicine, University of Maryland, Baltimore, MD, United States. Electronic address: msimard@som.umaryland.edu","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Department of Neurosurgery, School of Medicine, University of Maryland, Baltimore, MD, United States","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Department of Pathology, School of Medicine, University of Maryland, Baltimore, MD, United States","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Department of Physiology, School of Medicine, University of Maryland, Baltimore, MD, United States","institution_ids":["https://openalex.org/I126744593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073844022"],"corresponding_institution_ids":["https://openalex.org/I126744593"],"apc_list":{"value":4300,"currency":"USD","value_usd":4300},"apc_paid":{"value":4300,"currency":"USD","value_usd":4300},"fwci":5.1075,"has_fulltext":false,"cited_by_count":501,"citation_normalized_percentile":{"value":0.98137149,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"145","issue":"Pt B","first_page":"230","last_page":"246"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-edema","display_name":"cerebral edema","score":0.9980000257492065},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":1.0},{"id":"https://openalex.org/keywords/intracranial-hypertension","display_name":"intracranial hypertension","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pathophysiology","display_name":"pathophysiology","score":0.8479999899864197},{"id":"https://openalex.org/keywords/vasogenic-edema","display_name":"vasogenic edema","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cytotoxic-edema","display_name":"cytotoxic edema","score":0.9810000061988831},{"id":"https://openalex.org/keywords/blood-brain-barrier-disruption","display_name":"blood-brain barrier disruption","score":0.9980000257492065},{"id":"https://openalex.org/keywords/secondary-injury","display_name":"secondary injury","score":0.7490000128746033},{"id":"https://openalex.org/keywords/neurocritical-care","display_name":"neurocritical care","score":0.8629999756813049},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.6909999847412109},{"id":"https://openalex.org/keywords/molecular-therapeutic-targets","display_name":"molecular therapeutic targets","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.8158184289932251},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7124863862991333},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6606578826904297},{"id":"https://openalex.org/C3019162651","wikidata":"https://www.wikidata.org/wiki/Q979168","display_name":"Brain edema","level":2,"score":0.6311565637588501},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.5968999266624451},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5867066979408264},{"id":"https://openalex.org/C2779493303","wikidata":"https://www.wikidata.org/wiki/Q979168","display_name":"Cerebral edema","level":2,"score":0.5203439593315125},{"id":"https://openalex.org/C165455791","wikidata":"https://www.wikidata.org/wiki/Q7002299","display_name":"Neurointensive care","level":2,"score":0.47059547901153564},{"id":"https://openalex.org/C2780954326","wikidata":"https://www.wikidata.org/wiki/Q1416096","display_name":"Intracranial pressure","level":2,"score":0.455305278301239},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4491010010242462},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.4339004158973694},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3500556945800781},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2202509045600891},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.18314874172210693},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.1732558310031891},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.15672045946121216},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000070642","descriptor_name":"Brain Injuries, Traumatic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000070642","descriptor_name":"Brain Injuries, Traumatic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000070642","descriptor_name":"Brain Injuries, Traumatic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001929","descriptor_name":"Brain Edema","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001929","descriptor_name":"Brain Edema","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001929","descriptor_name":"Brain Edema","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.neuropharm.2018.08.004","doi":"https://doi.org/10.1016/j.neuropharm.2018.08.004","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuropharm.2018.08.004","pdf_url":null,"source":{"id":"https://openalex.org/S160566677","display_name":"Neuropharmacology","issn_l":"0028-3908","issn":["0028-3908","1873-7064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropharmacology","raw_type":"journal-article"},{"id":"pmid:30086289","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30086289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6309515","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6309515","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neuropharmacology","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.neuropharm.2018.08.004","doi":"https://doi.org/10.1016/j.neuropharm.2018.08.004","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuropharm.2018.08.004","pdf_url":null,"source":{"id":"https://openalex.org/S160566677","display_name":"Neuropharmacology","issn_l":"0028-3908","issn":["0028-3908","1873-7064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1970492027","display_name":"Fn14, non-canonical NF-kappaB and downstream signaling in neuropathic pain","funder_award_id":"R01NS105633","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G1980181314","display_name":null,"funder_award_id":"I01 BX001629","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G302416031","display_name":"2,3 cAMP in Traumatic Brain Injury","funder_award_id":"R01NS087978","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3619539375","display_name":"Non-canonical NF-kappaB signaling and Sur1-Trpm4 in traumatic brain injury","funder_award_id":"R01NS102589","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3706036739","display_name":null,"funder_award_id":"SCI170199","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5295068808","display_name":null,"funder_award_id":"WH81XWH-14-2-0018","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5360641798","display_name":"Astrocyte regulation of the blood-brain barrier in intracerebral hemorrhage","funder_award_id":"R01HL082517","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5872581430","display_name":"Translational assessment of sulfonylurea receptor-1 as a biomarker and therapeutic target for cerebral edema in traumatic brain injury","funder_award_id":"K23NS101036","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G878158308","display_name":null,"funder_award_id":"I01BX002889","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G8925550715","display_name":"Spinal cord injury, progressive hemorrhagic necrosis and the NC(Ca-ATP) channel","funder_award_id":"R01NS060801","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000860797","display_name":"Pediatric Neurointensive Care and Resuscitation Research","funder_award_id":"T32HD040686","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":248,"referenced_works":["https://openalex.org/W32206287","https://openalex.org/W53863878","https://openalex.org/W62510279","https://openalex.org/W154597966","https://openalex.org/W202418849","https://openalex.org/W250973550","https://openalex.org/W317392237","https://openalex.org/W583881585","https://openalex.org/W652893124","https://openalex.org/W1491555408","https://openalex.org/W1495656315","https://openalex.org/W1502176921","https://openalex.org/W1503384439","https://openalex.org/W1519585367","https://openalex.org/W1520448322","https://openalex.org/W1527749865","https://openalex.org/W1528778626","https://openalex.org/W1540258377","https://openalex.org/W1589778987","https://openalex.org/W1629254220","https://openalex.org/W1677366313","https://openalex.org/W1702507500","https://openalex.org/W1755360319","https://openalex.org/W1831020075","https://openalex.org/W1848568713","https://openalex.org/W1857364306","https://openalex.org/W1885773216","https://openalex.org/W1902460967","https://openalex.org/W1966439088","https://openalex.org/W1966961217","https://openalex.org/W1968099474","https://openalex.org/W1969937710","https://openalex.org/W1970826358","https://openalex.org/W1971931351","https://openalex.org/W1974449064","https://openalex.org/W1978531932","https://openalex.org/W1978680875","https://openalex.org/W1980654171","https://openalex.org/W1982752048","https://openalex.org/W1984587620","https://openalex.org/W1985455477","https://openalex.org/W1987770173","https://openalex.org/W1988610853","https://openalex.org/W1988963161","https://openalex.org/W1991420366","https://openalex.org/W1991694778","https://openalex.org/W1992237388","https://openalex.org/W1994041719","https://openalex.org/W1995957136","https://openalex.org/W1996347218","https://openalex.org/W1997989029","https://openalex.org/W1999377197","https://openalex.org/W1999493192","https://openalex.org/W2002491188","https://openalex.org/W2004159587","https://openalex.org/W2007701595","https://openalex.org/W2008262065","https://openalex.org/W2009662334","https://openalex.org/W2010219513","https://openalex.org/W2011398156","https://openalex.org/W2011506481","https://openalex.org/W2012727285","https://openalex.org/W2012763966","https://openalex.org/W2013937093","https://openalex.org/W2014847742","https://openalex.org/W2015427111","https://openalex.org/W2016451391","https://openalex.org/W2021163309","https://openalex.org/W2021316489","https://openalex.org/W2023250693","https://openalex.org/W2025547429","https://openalex.org/W2026652437","https://openalex.org/W2027169930","https://openalex.org/W2028460422","https://openalex.org/W2030204664","https://openalex.org/W2030688762","https://openalex.org/W2030861304","https://openalex.org/W2032753317","https://openalex.org/W2034035188","https://openalex.org/W2034998253","https://openalex.org/W2035576570","https://openalex.org/W2036385397","https://openalex.org/W2036679871","https://openalex.org/W2038917001","https://openalex.org/W2040733706","https://openalex.org/W2041119909","https://openalex.org/W2041225773","https://openalex.org/W2043291008","https://openalex.org/W2048130772","https://openalex.org/W2049939831","https://openalex.org/W2051140555","https://openalex.org/W2051355546","https://openalex.org/W2052349674","https://openalex.org/W2052468495","https://openalex.org/W2057179701","https://openalex.org/W2057229827","https://openalex.org/W2057235759","https://openalex.org/W2058267482","https://openalex.org/W2058403158","https://openalex.org/W2058778905","https://openalex.org/W2059000843","https://openalex.org/W2059467874","https://openalex.org/W2060257080","https://openalex.org/W2060701169","https://openalex.org/W2061102313","https://openalex.org/W2062473036","https://openalex.org/W2062599159","https://openalex.org/W2064839996","https://openalex.org/W2065232910","https://openalex.org/W2065551431","https://openalex.org/W2065705442","https://openalex.org/W2066450038","https://openalex.org/W2069958444","https://openalex.org/W2073923875","https://openalex.org/W2074175132","https://openalex.org/W2076461458","https://openalex.org/W2076749993","https://openalex.org/W2078442598","https://openalex.org/W2082107386","https://openalex.org/W2082870917","https://openalex.org/W2083581277","https://openalex.org/W2084962044","https://openalex.org/W2085925390","https://openalex.org/W2086474773","https://openalex.org/W2086688096","https://openalex.org/W2088134039","https://openalex.org/W2089581014","https://openalex.org/W2090188507","https://openalex.org/W2091365603","https://openalex.org/W2092814867","https://openalex.org/W2093126739","https://openalex.org/W2093569692","https://openalex.org/W2094704459","https://openalex.org/W2094785614","https://openalex.org/W2097573610","https://openalex.org/W2098678041","https://openalex.org/W2098893487","https://openalex.org/W2100590935","https://openalex.org/W2100786169","https://openalex.org/W2101551122","https://openalex.org/W2102881079","https://openalex.org/W2104412737","https://openalex.org/W2105443363","https://openalex.org/W2105507719","https://openalex.org/W2105605379","https://openalex.org/W2107377133","https://openalex.org/W2108367699","https://openalex.org/W2108794373","https://openalex.org/W2109095295","https://openalex.org/W2111848939","https://openalex.org/W2113585989","https://openalex.org/W2113870612","https://openalex.org/W2118307790","https://openalex.org/W2121432793","https://openalex.org/W2124439764","https://openalex.org/W2124713161","https://openalex.org/W2129535484","https://openalex.org/W2129783501","https://openalex.org/W2135738755","https://openalex.org/W2136830984","https://openalex.org/W2137706047","https://openalex.org/W2142918299","https://openalex.org/W2145798230","https://openalex.org/W2146459156","https://openalex.org/W2163862018","https://openalex.org/W2166505057","https://openalex.org/W2167402790","https://openalex.org/W2169454631","https://openalex.org/W2170071961","https://openalex.org/W2170559169","https://openalex.org/W2174745877","https://openalex.org/W2185108053","https://openalex.org/W2187515179","https://openalex.org/W2188765569","https://openalex.org/W2199142894","https://openalex.org/W2210114002","https://openalex.org/W2248259092","https://openalex.org/W2260645037","https://openalex.org/W2265424409","https://openalex.org/W2274185705","https://openalex.org/W2291424342","https://openalex.org/W2291566131","https://openalex.org/W2315595893","https://openalex.org/W2327324823","https://openalex.org/W2343601674","https://openalex.org/W2345284478","https://openalex.org/W2345654941","https://openalex.org/W2396062233","https://openalex.org/W2407634272","https://openalex.org/W2408432782","https://openalex.org/W2416048376","https://openalex.org/W2470682262","https://openalex.org/W2471407841","https://openalex.org/W2488581011","https://openalex.org/W2505024819","https://openalex.org/W2513406197","https://openalex.org/W2515100021","https://openalex.org/W2515168653","https://openalex.org/W2518303214","https://openalex.org/W2519065143","https://openalex.org/W2522738478","https://openalex.org/W2524401450","https://openalex.org/W2531213638","https://openalex.org/W2551862508","https://openalex.org/W2560014610","https://openalex.org/W2560632301","https://openalex.org/W2560761116","https://openalex.org/W2566082815","https://openalex.org/W2586518645","https://openalex.org/W2586825713","https://openalex.org/W2593901040","https://openalex.org/W2599018512","https://openalex.org/W2602372940","https://openalex.org/W2620694208","https://openalex.org/W2728433254","https://openalex.org/W2735633271","https://openalex.org/W2754554955","https://openalex.org/W2755565529","https://openalex.org/W2766658121","https://openalex.org/W2767554822","https://openalex.org/W2769774984","https://openalex.org/W2770703860","https://openalex.org/W2772676629","https://openalex.org/W2775117242","https://openalex.org/W2780280812","https://openalex.org/W2784122958","https://openalex.org/W2790955930","https://openalex.org/W2791204453","https://openalex.org/W2791644790","https://openalex.org/W2795592077","https://openalex.org/W2796526042","https://openalex.org/W2800902718","https://openalex.org/W2800928691","https://openalex.org/W2802800934","https://openalex.org/W2805218717","https://openalex.org/W2887702453","https://openalex.org/W2965285562","https://openalex.org/W2981192711","https://openalex.org/W4256057982","https://openalex.org/W4290436329","https://openalex.org/W6609561553","https://openalex.org/W6660866472","https://openalex.org/W6678683470","https://openalex.org/W6715896265","https://openalex.org/W6730543547","https://openalex.org/W6747391179","https://openalex.org/W6799491555","https://openalex.org/W6841398368"],"related_works":["https://openalex.org/W7092366527","https://openalex.org/W4312296717","https://openalex.org/W2519065143","https://openalex.org/W3009159149","https://openalex.org/W4289886023","https://openalex.org/W2899711308","https://openalex.org/W4250770600","https://openalex.org/W2068462003","https://openalex.org/W2950619069","https://openalex.org/W1932478442"],"abstract_inverted_index":{"Cerebral":[0],"edema":[1],"(CE)":[2],"and":[3,33,60,68,160,190],"resultant":[4,69],"intracranial":[5,70],"hypertension":[6],"are":[7,131,158,162,174],"associated":[8],"with":[9,30,37,86,114,140],"unfavorable":[10],"prognosis":[11],"in":[12,26,48,197],"traumatic":[13],"brain":[14],"injury":[15,64],"(TBI).":[16],"CE":[17,67,144,173,194],"is":[18,58,95,145,209],"a":[19,76,87,96,185,201],"leading":[20],"cause":[21],"of":[22,28,35,45,54,66,79,90,98,137,149,154,188,200,211],"in-hospital":[23],"mortality,":[24],"occurring":[25],">60%":[27],"patients":[29],"mass":[31,46],"lesions,":[32],"\u223c15%":[34],"those":[36],"normal":[38],"initial":[39],"computed":[40],"tomography":[41],"scans.":[42],"After":[43],"treatment":[44],"lesions":[47],"severe":[49],"TBI,":[50],"an":[51,134],"important":[52],"focus":[53],"acute":[55],"neurocritical":[56],"care":[57],"evaluating":[59],"managing":[61],"the":[62,115,147,152,198,212],"secondary":[63],"process":[65],"hypertension.":[71],"This":[72,207],"review":[73],"focuses":[74],"on":[75,177],"contemporary":[77],"understanding":[78],"various":[80],"pathophysiologic":[81,178],"pathways":[82,130,139],"contributing":[83,127],"to":[84,102,128,143,183],"CE,":[85,103],"subsequent":[88],"description":[89],"potential":[91],"targeted":[92],"therapies.":[93],"There":[94],"discussion":[97,136],"identified":[99],"cellular/cytotoxic":[100],"contributors":[101,157],"as":[104,106],"well":[105],"mechanisms":[107],"that":[108,117],"influence":[109],"blood-brain-barrier":[110],"(BBB)":[111],"disruption/vasogenic":[112],"edema,":[113],"caveat":[116],"this":[118,150],"distinction":[119],"may":[120],"be":[121],"somewhat":[122],"artificial":[123],"since":[124],"molecular":[125,169],"processes":[126],"these":[129],"interrelated.":[132],"While":[133],"exhaustive":[135],"all":[138],"putative":[141],"contributions":[142],"beyond":[146],"scope":[148],"review,":[151],"roles":[153],"some":[155],"key":[156],"highlighted,":[159],"references":[161],"provided":[163],"for":[164,171,218],"further":[165],"details.":[166],"Potential":[167],"future":[168,191],"targets":[170],"treating":[172],"presented":[175],"based":[176],"mechanisms.":[179],"We":[180],"thus":[181],"aim":[182],"provide":[184],"translational":[186],"synopsis":[187],"present":[189],"strategies":[192],"targeting":[193],"after":[195],"TBI":[196],"context":[199],"paradigm":[202],"shift":[203],"towards":[204],"precision":[205],"medicine.":[206],"article":[208],"part":[210],"Special":[213],"Issue":[214],"entitled":[215],"\"Novel":[216],"Treatments":[217],"Traumatic":[219],"Brain":[220],"Injury\".":[221]},"counts_by_year":[{"year":2026,"cited_by_count":72},{"year":2025,"cited_by_count":83},{"year":2024,"cited_by_count":84},{"year":2023,"cited_by_count":69},{"year":2022,"cited_by_count":60},{"year":2021,"cited_by_count":72},{"year":2020,"cited_by_count":45},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-08-22T00:00:00"}