{"id":"https://openalex.org/W2885969448","doi":"https://doi.org/10.1158/1538-7445.am2018-2234","title":"Abstract 2234: Dietary-AGE ingestion during puberty modifies the breast microenvironment to alter mammary gland development: Linking diet, development and breast cancer risk","display_name":"Abstract 2234: Dietary-AGE ingestion during puberty modifies the breast microenvironment to alter mammary gland development: Linking diet, development and breast cancer risk","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2885969448","doi":"https://doi.org/10.1158/1538-7445.am2018-2234","mag":"2885969448"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2018-2234","doi":"https://doi.org/10.1158/1538-7445.am2018-2234","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-2234","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058224663","display_name":"Jaime F. Randise","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaime F. Randise","raw_affiliation_strings":["1Medical University of South Carolina, Charleston, SC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Medical University of South Carolina, Charleston, SC;","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019584943","display_name":"Bradley A. Krisanits","orcid":"https://orcid.org/0000-0001-8259-118X","observed_orcids":["https://orcid.org/0000-0001-8259-118X"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradley A. Krisanits","raw_affiliation_strings":["1Medical University of South Carolina, Charleston, SC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Medical University of South Carolina, Charleston, SC;","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029824637","display_name":"Lourdes M. Nogueira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lourdes M. Nogueira","raw_affiliation_strings":["1Medical University of South Carolina, Charleston, SC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Medical University of South Carolina, Charleston, SC;","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019011382","display_name":"Kristi L. Helke","orcid":"https://orcid.org/0000-0001-9746-0764","observed_orcids":["https://orcid.org/0000-0001-9746-0764"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristi L. Helke","raw_affiliation_strings":["1Medical University of South Carolina, Charleston, SC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Medical University of South Carolina, Charleston, SC;","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046560196","display_name":"Taaliah Campbell","orcid":"https://orcid.org/0000-0002-0131-1770","observed_orcids":["https://orcid.org/0000-0002-0131-1770"]},"institutions":[{"id":"https://openalex.org/I16892885","display_name":"Claflin University","ror":"https://ror.org/052rx6v10","country_code":"US","type":"education","lineage":["https://openalex.org/I16892885"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taaliah Campbell","raw_affiliation_strings":["2Claflin University, Orangeburg, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Claflin University, Orangeburg, SC","institution_ids":["https://openalex.org/I16892885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086296004","display_name":"Victoria J. Findlay","orcid":"https://orcid.org/0000-0002-9994-6319","observed_orcids":["https://orcid.org/0000-0002-9994-6319"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria J. Findlay","raw_affiliation_strings":["1Medical University of South Carolina, Charleston, SC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Medical University of South Carolina, Charleston, SC;","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030420068","display_name":"David P. Turner","orcid":"https://orcid.org/0000-0003-3667-8844","observed_orcids":["https://orcid.org/0000-0003-3667-8844"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David P. Turner","raw_affiliation_strings":["1Medical University of South Carolina, Charleston, SC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Medical University of South Carolina, Charleston, SC;","institution_ids":["https://openalex.org/I153297377"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":"13_Supplement","first_page":"2234","last_page":"2234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.9789999723434448},{"id":"https://openalex.org/keywords/dietary-age-intake","display_name":"dietary AGE intake","score":0.6710000038146973},{"id":"https://openalex.org/keywords/puberty","display_name":"puberty","score":0.8640000224113464},{"id":"https://openalex.org/keywords/mammary-gland-development","display_name":"mammary gland development","score":0.9940000176429749},{"id":"https://openalex.org/keywords/breast-microenvironment","display_name":"breast microenvironment","score":0.8190000057220459},{"id":"https://openalex.org/keywords/metabolic-memory","display_name":"metabolic memory","score":0.7580000162124634},{"id":"https://openalex.org/keywords/rage-signaling","display_name":"RAGE signaling","score":0.8410000205039978},{"id":"https://openalex.org/keywords/breast-cancer-risk","display_name":"breast cancer risk","score":0.7549999952316284},{"id":"https://openalex.org/keywords/hyperplastic-lesions","display_name":"hyperplastic lesions","score":0.8500000238418579},{"id":"https://openalex.org/keywords/ductal-branching","display_name":"ductal branching","score":0.7770000100135803},{"id":"https://openalex.org/keywords/terminal-end-buds","display_name":"terminal end buds","score":0.7570000290870667},{"id":"https://openalex.org/keywords/myoepithelial-cells","display_name":"myoepithelial cells","score":0.9509999752044678},{"id":"https://openalex.org/keywords/fvb-mice","display_name":"FVB mice","score":0.6970000267028809},{"id":"https://openalex.org/keywords/dietary-intervention","display_name":"dietary intervention","score":0.5199999809265137},{"id":"https://openalex.org/keywords/inflammation-and-oxidative-stress","display_name":"inflammation and oxidative stress","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5697852969169617},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5438604354858398},{"id":"https://openalex.org/C2778857457","wikidata":"https://www.wikidata.org/wiki/Q153641","display_name":"Rage (emotion)","level":2,"score":0.5417585372924805},{"id":"https://openalex.org/C2776880931","wikidata":"https://www.wikidata.org/wiki/Q6745783","display_name":"Breast development","level":3,"score":0.541395366191864},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5267319679260254},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.47561055421829224},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4716958999633789},{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.4249695837497711},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3889867663383484},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3677637577056885},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.16835445165634155},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.12655285000801086},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2018-2234","doi":"https://doi.org/10.1158/1538-7445.am2018-2234","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-2234","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3048670182","https://openalex.org/W4387408495","https://openalex.org/W3044596668","https://openalex.org/W2593589987","https://openalex.org/W4411288875","https://openalex.org/W3033578713","https://openalex.org/W3030381813","https://openalex.org/W3171911187","https://openalex.org/W3039899277","https://openalex.org/W4387396274"],"abstract_inverted_index":{"Abstract":[0],"Evidence":[1],"supports":[2],"the":[3,18,81,129,154,247,253,337,365,375,380,414,433],"notion":[4],"that":[5,61,303,364],"critical":[6],"events":[7,38],"during":[8,109,291,309,325,411],"mammary":[9,176,186,204,334,376,419],"development":[10,178,335,424],"permanently":[11],"alter":[12,418],"developmentally":[13],"regulated":[14],"programs":[15],"which":[16],"influence":[17],"breast":[19,23,384,415,426],"microenvironment":[20,416],"to":[21,29,42,73,128,141,153,251,295,305,317,417],"increase":[22],"cancer":[24,385,427],"risk.":[25],"This":[26],"is":[27,150],"analogous":[28,316],"metabolic":[30,37,157,318,360,372],"memory":[31],"in":[32,50,64,162,285,329],"diabetic":[33],"patients":[34],"where":[35],"early":[36],"have":[39],"been":[40],"found":[41],"be":[43],"remembered":[44],"and":[45,75,103,123,138,144,147,179,192,206,210,231,240,243,336,425],"affect":[46],"disease":[47],"severity":[48],"later":[49],"life.":[51],"Advanced":[52],"glycation":[53,85],"end":[54,86],"products":[55,87],"(AGEs)":[56],"are":[57],"highly":[58],"reactive":[59],"metabolites":[60],"irreversibly":[62],"accumulate":[63],"tissues":[65],"as":[66,117],"we":[67],"age.":[68],"AGE":[69,130,136,169,234,259,271,298,306,323,348,367],"accumulation":[70,131],"can":[71],"contribute":[72,127],"pro-inflammatory":[74],"-oxidant":[76],"phenotypes":[77],"when":[78],"signaling":[79,94],"through":[80],"receptor":[82],"for":[83,436],"advanced":[84],"(RAGE).":[88],"The":[89,133,198],"pathogenic":[90],"effects":[91,254],"of":[92,135,156,175,218,332,339,345,359,382,432],"AGE-RAGE":[93],"include":[95],"tissue":[96],"degeneration,":[97],"protein":[98],"dysfunction,":[99],"aberrant":[100,193],"cell":[101,201,212],"signaling,":[102],"reduced":[104],"genetic":[105],"fidelity.":[106],"AGEs":[107],"form":[108],"normal":[110,333],"metabolism":[111],"but":[112],"critically,":[113],"lifestyle":[114,122],"factors":[115],"such":[116],"poor":[118],"diet,":[119,260,423],"a":[120,167,172,257,264,268,288,296,313,346,351,371],"sedentary":[121],"being":[124],"obese":[125],"also":[126],"pool.":[132],"permanence":[134],"adducts":[137],"their":[139],"ability":[140],"mediate":[142],"chronic":[143],"persistent":[145],"inflammatory":[146],"oxidative":[148],"stresses":[149],"particularly":[151],"compatible":[152],"concept":[155],"memory.":[158,319,361],"Our":[159],"dietary":[160],"studies":[161],"pubertal":[163,269,326],"FVB/n":[164],"mice":[165,261,286],"fed":[166,263,287],"high":[168,258,270,297,347,366],"diet":[170,266,277,290,349,353,368],"show":[171],"significant":[173,330],"dysregulation":[174],"gland":[177,377,420],"hyperplastic":[180,220,280,340,356],"lesion":[181],"formation.":[182],"We":[183,362],"observe":[184],"delayed":[185],"ductal":[187,190],"extension,":[188],"increased":[189,237,241,322],"branching":[191],"terminal":[194],"end-bud":[195],"(TEB)":[196],"morphology.":[197],"basal":[199],"myoepithelial":[200],"layer":[202],"surrounding":[203],"ducts":[205],"TEBs":[207],"was":[208,214],"irregular":[209],"epithelial":[211],"proliferation":[213],"increased.":[215],"Molecular":[216],"characterization":[217],"these":[219],"lesions":[221,274,281,341,357],"were":[222,262,282],"defined":[223],"using":[224],"DCIS":[225],"progression":[226],"markers":[227],"by":[228,256,342],"histopathological":[229],"staining":[230],"qRT-PCR.":[232],"Elevated":[233],"levels":[235],"accompanied":[236],"RAGE":[238],"expression":[239],"macrophage":[242],"fibroblast":[244],"infiltration":[245],"around":[246],"TEBs.":[248],"In":[249,320],"attempt":[250],"reverse":[252],"caused":[255],"control":[265,289,352],"after":[267],"diet.":[272,299],"Hyperplastic":[273],"persisted":[275],"despite":[276,350],"intervention.":[278],"Importantly,":[279],"not":[283],"observed":[284],"puberty,":[292],"then":[293],"switched":[294],"These":[300],"data":[301],"indicate":[302],"exposure":[304],"induced":[307],"changes":[308],"puberty":[310,412],"may":[311,369],"leave":[312,370],"long-lasting":[314],"imprint":[315,373],"conclusion,":[321],"consumption":[324],"growth":[327],"results":[328],"disruption":[331],"appearance":[338],"adulthood.":[343],"Consumption":[344],"intervention,":[354],"reveals":[355],"indicative":[358],"hypothesize":[363],"on":[374],"microenvironment,":[378],"increasing":[379],"risk":[381,428],"future":[383],"development.":[386],"Citation":[387],"Format:":[388],"Jaime":[389],"F.":[390],"Randise,":[391],"Bradley":[392],"A.":[393],"Krisanits,":[394],"Lourdes":[395],"M.":[396],"Nogueira,":[397],"Kristi":[398],"L.":[399],"Helke,":[400],"Taaliah":[401],"Campbell,":[402],"Victoria":[403],"J.":[404],"Findlay,":[405],"David":[406],"P.":[407],"Turner.":[408],"Dietary-AGE":[409],"ingestion":[410],"modifies":[413],"development:":[421],"Linking":[422],"[abstract].":[429],"In:":[430],"Proceedings":[431],"American":[434],"Association":[435],"Cancer":[437,450],"Research":[438],"Annual":[439],"Meeting":[440],"2018;":[441],"2018":[442],"Apr":[443],"14-18;":[444],"Chicago,":[445],"IL.":[446],"Philadelphia":[447],"(PA):":[448],"AACR;":[449],"Res":[451],"2018;78(13":[452],"Suppl):Abstract":[453],"nr":[454],"2234.":[455]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2018-08-22T00:00:00"}