{"id":"https://openalex.org/W2885945321","doi":"https://doi.org/10.1038/s41467-018-05627-1","title":"Apparent bias toward long gene misregulation in MeCP2 syndromes disappears after controlling for baseline variations","display_name":"Apparent bias toward long gene misregulation in MeCP2 syndromes disappears after controlling for baseline variations","publication_year":2018,"publication_date":"2018-08-07","ids":{"openalex":"https://openalex.org/W2885945321","doi":"https://doi.org/10.1038/s41467-018-05627-1","mag":"2885945321","pmid":"https://pubmed.ncbi.nlm.nih.gov/30104565","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6089998"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-018-05627-1","doi":"https://doi.org/10.1038/s41467-018-05627-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-018-05627-1","pdf_url":"https://www.nature.com/articles/s41467-018-05627-1.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-018-05627-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010468072","display_name":"Ayush T. Raman","orcid":"https://orcid.org/0000-0003-2872-2307","observed_orcids":["https://orcid.org/0000-0003-2872-2307"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayush T. Raman","raw_affiliation_strings":["Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX, 77030, USA","Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA","Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, USA","Jan and Dan Duncan Neurological Research Institute at Texas Children\u2019s Hospital, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I4210147586"]},{"raw_affiliation_string":"Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Jan and Dan Duncan Neurological Research Institute at Texas Children\u2019s Hospital, Houston, USA","institution_ids":["https://openalex.org/I4210147586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000410806","display_name":"Amy E. Pohodich","orcid":"https://orcid.org/0000-0002-1802-7995","observed_orcids":["https://orcid.org/0000-0002-1802-7995"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy E. Pohodich","raw_affiliation_strings":["Department of Neuroscience, Baylor College of Medicine, Houston, TX, 77030, USA","Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA","Department of Neuroscience, Baylor College of Medicine, Houston, USA","Jan and Dan Duncan Neurological Research Institute at Texas Children\u2019s Hospital, Houston, USA"],"raw_orcid":"https://orcid.org/0000-0002-1802-7995","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Baylor College of Medicine, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I4210147586"]},{"raw_affiliation_string":"Department of Neuroscience, Baylor College of Medicine, Houston, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Jan and Dan Duncan Neurological Research Institute at Texas Children\u2019s Hospital, Houston, USA","institution_ids":["https://openalex.org/I4210147586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016453515","display_name":"Ying\u2010Wooi Wan","orcid":"https://orcid.org/0000-0002-4354-7482","observed_orcids":["https://orcid.org/0000-0002-4354-7482"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying-Wooi Wan","raw_affiliation_strings":["Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA","Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA","Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, USA","Jan and Dan Duncan Neurological Research Institute at Texas Children\u2019s Hospital, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I4210147586"]},{"raw_affiliation_string":"Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Jan and Dan Duncan Neurological Research Institute at Texas Children\u2019s Hospital, Houston, USA","institution_ids":["https://openalex.org/I4210147586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000384375","display_name":"Hari Krishna Yalamanchili","orcid":"https://orcid.org/0000-0001-9892-3054","observed_orcids":["https://orcid.org/0000-0001-9892-3054"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hari Krishna Yalamanchili","raw_affiliation_strings":["Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA","Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA","Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, USA","Jan and Dan Duncan Neurological Research Institute at Texas Children\u2019s Hospital, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I4210147586"]},{"raw_affiliation_string":"Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Jan and Dan Duncan Neurological Research Institute at Texas Children\u2019s Hospital, Houston, USA","institution_ids":["https://openalex.org/I4210147586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008667539","display_name":"William E. Lowry","orcid":"https://orcid.org/0000-0003-2932-2276","observed_orcids":["https://orcid.org/0000-0003-2932-2276"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E. Lowry","raw_affiliation_strings":["Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, 90095, USA","Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020701219","display_name":"Huda Yahya Zoghbi","orcid":"https://orcid.org/0000-0002-0700-3349","observed_orcids":["https://orcid.org/0000-0002-0700-3349"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Huda Y. Zoghbi","raw_affiliation_strings":["Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA. hzoghbi@bcm.edu","Department of Neuroscience, Baylor College of Medicine, Houston, TX, 77030, USA. hzoghbi@bcm.edu","Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX, 77030, USA. hzoghbi@bcm.edu","Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA. hzoghbi@bcm.edu","Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, USA","Department of Neuroscience, Baylor College of Medicine, Houston, USA","Howard Hughes Medical Institute, Baylor College of Medicine, Houston, USA","Jan and Dan Duncan Neurological Research Institute at Texas Children\u2019s Hospital, Houston, USA"],"raw_orcid":"https://orcid.org/0000-0002-0700-3349","affiliations":[{"raw_affiliation_string":"Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA. hzoghbi@bcm.edu","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Neuroscience, Baylor College of Medicine, Houston, TX, 77030, USA. hzoghbi@bcm.edu","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX, 77030, USA. hzoghbi@bcm.edu","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I181547552"]},{"raw_affiliation_string":"Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA. hzoghbi@bcm.edu","institution_ids":["https://openalex.org/I4210147586"]},{"raw_affiliation_string":"Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Neuroscience, Baylor College of Medicine, Houston, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Baylor College of Medicine, Houston, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I181547552"]},{"raw_affiliation_string":"Jan and Dan Duncan Neurological Research Institute at Texas Children\u2019s Hospital, Houston, USA","institution_ids":["https://openalex.org/I4210147586"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004947640","display_name":"Zhandong Liu","orcid":"https://orcid.org/0000-0002-7608-0831","observed_orcids":["https://orcid.org/0000-0002-7608-0831","https://orcid.org/0000-0002-5310-8272"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhandong Liu","raw_affiliation_strings":["Department of Pediatrics, Section of Neurology, Baylor College of Medicine, Houston, TX, USA. zhandong.liu@bcm.edu","Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX, 77030, USA. zhandong.liu@bcm.edu","Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA. zhandong.liu@bcm.edu","Department of Pediatrics, Section of Neurology, Baylor College of Medicine, Houston, USA","Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, USA","Jan and Dan Duncan Neurological Research Institute at Texas Children\u2019s Hospital, Houston, USA"],"raw_orcid":"https://orcid.org/0000-0002-7608-0831","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Section of Neurology, Baylor College of Medicine, Houston, TX, USA. zhandong.liu@bcm.edu","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX, 77030, USA. zhandong.liu@bcm.edu","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX, 77030, USA. zhandong.liu@bcm.edu","institution_ids":["https://openalex.org/I4210147586"]},{"raw_affiliation_string":"Department of Pediatrics, Section of Neurology, Baylor College of Medicine, Houston, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Jan and Dan Duncan Neurological Research Institute at Texas Children\u2019s Hospital, Houston, USA","institution_ids":["https://openalex.org/I4210147586"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5004947640","https://openalex.org/A5020701219"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I181547552","https://openalex.org/I4210147586"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":4.14,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.94901961,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"3225","last_page":"3225"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mecp2","display_name":"MeCP2","score":0.9390000104904175},{"id":"https://openalex.org/keywords/rett-syndrome","display_name":"Rett syndrome","score":0.9509999752044678},{"id":"https://openalex.org/keywords/baseline-variability","display_name":"baseline variability","score":0.8130000233650208},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7170000076293945},{"id":"https://openalex.org/keywords/pcr-bias","display_name":"PCR bias","score":0.7329999804496765},{"id":"https://openalex.org/keywords/nanostring","display_name":"NanoString","score":0.8289999961853027},{"id":"https://openalex.org/keywords/topoisomerase-inhibition","display_name":"topoisomerase inhibition","score":0.9739999771118164}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6333664059638977},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5791363716125488},{"id":"https://openalex.org/C2778863441","wikidata":"https://www.wikidata.org/wiki/Q18028997","display_name":"MECP2","level":4,"score":0.5759732723236084},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4758062958717346},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.46970173716545105},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.43531277775764465},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.36946237087249756},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3466326594352722}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013577","descriptor_name":"Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015138","descriptor_name":"RNA, Nuclear","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015518","descriptor_name":"Rett Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015982","descriptor_name":"Bias","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019772","descriptor_name":"Topotecan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020029","descriptor_name":"Base Pairing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051783","descriptor_name":"Methyl-CpG-Binding Protein 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1038/s41467-018-05627-1","doi":"https://doi.org/10.1038/s41467-018-05627-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-018-05627-1","pdf_url":"https://www.nature.com/articles/s41467-018-05627-1.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.1101/240705","doi":"https://doi.org/10.1101/240705","is_oa":true,"landing_page_url":"https://doi.org/10.1101/240705","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2018/01/05/240705.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:5039076","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6089998","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6089998","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6089998","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:30104565","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30104565","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05627-1","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-018-05627-1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:558d10a20c1240ebb849e9756a465fe5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/558d10a20c1240ebb849e9756a465fe5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:ead5dd8d10b247b2a8ea1d25c2b71dd6","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ead5dd8d10b247b2a8ea1d25c2b71dd6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-018-05627-1","doi":"https://doi.org/10.1038/s41467-018-05627-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-018-05627-1","pdf_url":"https://www.nature.com/articles/s41467-018-05627-1.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2711403535","display_name":null,"funder_award_id":"R01-GM120033","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3476636859","display_name":null,"funder_award_id":"5R01GM120033","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G3677904328","display_name":null,"funder_award_id":"5R01NS057819","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G5626600246","display_name":null,"funder_award_id":"5R01GM120033","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6638733536","display_name":null,"funder_award_id":"1R01AG057339","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G7868389717","display_name":"Development and Validation of a Network-guided, Multi-objective Optimization Model for Cancer Data Analysis.","funder_award_id":"RP170387","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G8612422018","display_name":"Functional Dissection of Alzheimer's Disease Networks in Drosophila: from Association to   Causal Modulators of Age-Dependent Neurodegeration","funder_award_id":"R01AG057339","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000900532","display_name":"MOLECULAR PATHOGENESIS STUDIES OF RETT SYNDROME","funder_award_id":"R01NS057819","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G952381353","display_name":"Advanced Computational Approaches for NMR Data-mining","funder_award_id":"5r01gm120033-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320306182","display_name":"March of Dimes Foundation","ror":"https://ror.org/04bd5p711"},{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320317068","display_name":"Paul G. Allen Frontiers Group","ror":null},{"id":"https://openalex.org/F4320317232","display_name":"Huffington Foundation","ror":"https://ror.org/04bcjs591"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2885945321.pdf","grobid_xml":"https://content.openalex.org/works/W2885945321.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1970707135","https://openalex.org/W1975934689","https://openalex.org/W1980577992","https://openalex.org/W1986992140","https://openalex.org/W1994102103","https://openalex.org/W2001420461","https://openalex.org/W2010305827","https://openalex.org/W2012896813","https://openalex.org/W2016365513","https://openalex.org/W2023621259","https://openalex.org/W2023879783","https://openalex.org/W2035016973","https://openalex.org/W2039276157","https://openalex.org/W2056013470","https://openalex.org/W2064397275","https://openalex.org/W2097630554","https://openalex.org/W2098809361","https://openalex.org/W2099517884","https://openalex.org/W2099879295","https://openalex.org/W2107018762","https://openalex.org/W2109008714","https://openalex.org/W2114104545","https://openalex.org/W2114504176","https://openalex.org/W2116634113","https://openalex.org/W2118258530","https://openalex.org/W2131478115","https://openalex.org/W2135061646","https://openalex.org/W2146258577","https://openalex.org/W2147140183","https://openalex.org/W2152239989","https://openalex.org/W2152668149","https://openalex.org/W2154537630","https://openalex.org/W2164808158","https://openalex.org/W2165909549","https://openalex.org/W2166288018","https://openalex.org/W2168342464","https://openalex.org/W2169456326","https://openalex.org/W2170989872","https://openalex.org/W2179438025","https://openalex.org/W2263028779","https://openalex.org/W2298660302","https://openalex.org/W2365381881","https://openalex.org/W2399950674","https://openalex.org/W2414910334","https://openalex.org/W2565629561","https://openalex.org/W2755967972","https://openalex.org/W2800616945","https://openalex.org/W4255830679"],"related_works":["https://openalex.org/W1975934689","https://openalex.org/W2752625363","https://openalex.org/W2035016973","https://openalex.org/W1986992140","https://openalex.org/W3216514024","https://openalex.org/W4234555075","https://openalex.org/W2096777785","https://openalex.org/W7067054519","https://openalex.org/W2990623560","https://openalex.org/W1628658472"],"abstract_inverted_index":{"Recent":[0],"studies":[1],"have":[2],"suggested":[3],"that":[4,59,137],"genes":[5,86],"longer":[6],"than":[7],"100":[8],"kb":[9],"are":[10,33],"more":[11],"likely":[12],"to":[13,104,107],"be":[14,105,127],"misregulated":[15],"in":[16,35,66],"neurological":[17],"diseases":[18],"associated":[19],"with":[20,87,95],"synaptic":[21],"dysfunction,":[22],"such":[23,119],"as":[24,120],"autism":[25],"and":[26,69],"Rett":[27],"syndrome.":[28],"These":[29],"length-dependent":[30,62,141],"transcriptional":[31],"changes":[32],"modest":[34],"MeCP2-mutant":[36],"samples,":[37],"but,":[38],"given":[39],"the":[40,51,60],"low":[41,88],"sensitivity":[42],"of":[43,54,140],"high-throughput":[44],"transcriptome":[45],"profiling":[46],"technology,":[47,97],"here":[48],"we":[49],"re-evaluate":[50],"statistical":[52],"significance":[53],"these":[55],"results.":[56],"We":[57,91,135],"find":[58,92],"apparent":[61],"trends":[63,144],"previously":[64],"observed":[65],"MeCP2":[67],"microarray":[68],"RNA-sequencing":[70],"datasets":[71],"disappear":[72],"after":[73,130],"estimating":[74],"baseline":[75,133,148],"variability":[76],"from":[77,149],"randomized":[78,150],"control":[79,151],"samples.":[80,152],"This":[81],"is":[82],"particularly":[83],"true":[84],"for":[85,132],"fold":[89],"changes.":[90],"no":[93],"bias":[94,102],"NanoString":[96],"so":[98],"this":[99],"long":[100,116],"gene":[101,117],"seems":[103],"particular":[106],"polymerase":[108],"chain":[109],"reaction":[110],"amplification-based":[111],"platforms.":[112],"In":[113],"contrast,":[114],"authentic":[115],"effects,":[118],"those":[121],"caused":[122],"by":[123],"topoisomerase":[124],"inhibition,":[125],"can":[126],"detected":[128],"even":[129],"adjustment":[131],"variability.":[134],"conclude":[136],"accurate":[138],"characterization":[139],"(or":[142],"other)":[143],"requires":[145],"establishing":[146],"a":[147]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-08-22T00:00:00"}
