{"id":"https://openalex.org/W2885941582","doi":"https://doi.org/10.31069/japsr.v1i01.13058","title":"ANTICONVULSANT ACTIVITY OF ISONICOTINIC ACID HYDRAZONE DERIVATIVES USING MES, scPTZ AND ROTOROD NEUROTOXICITY MODELS","display_name":"ANTICONVULSANT ACTIVITY OF ISONICOTINIC ACID HYDRAZONE DERIVATIVES USING MES, scPTZ AND ROTOROD NEUROTOXICITY MODELS","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2885941582","doi":"https://doi.org/10.31069/japsr.v1i01.13058","mag":"2885941582"},"language":"en","primary_location":{"id":"doi:10.31069/japsr.v1i01.13058","doi":"https://doi.org/10.31069/japsr.v1i01.13058","is_oa":true,"landing_page_url":"https://doi.org/10.31069/japsr.v1i01.13058","pdf_url":null,"source":{"id":"https://openalex.org/S4210229562","display_name":"Journal of Applied Pharmaceutical Sciences and Research","issn_l":"2581-5520","issn":["2581-5520"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Pharmaceutical Sciences and Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.31069/japsr.v1i01.13058","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045944191","display_name":"Reema Sinha","orcid":"https://orcid.org/0000-0001-7837-4385","observed_orcids":["https://orcid.org/0000-0001-7837-4385"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sinha R","raw_affiliation_strings":["RamEesh Institute of Vocationa & Technical Education, Greater Noida, Uttar Pradesh-201310"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RamEesh Institute of Vocationa & Technical Education, Greater Noida, Uttar Pradesh-201310","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097839367","display_name":"Singh UVS","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Singh UVS","raw_affiliation_strings":["M.C. Saxena College of Pharmacy, Lucknow"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.C. Saxena College of Pharmacy, Lucknow","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110412981","display_name":"Khosa Rl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Khosa RL","raw_affiliation_strings":["School of Pharmacy, Bharat Institute of Technology, Meerut, Uttar Pradesh-250103"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Bharat Institute of Technology, Meerut, Uttar Pradesh-250103","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"Jain J","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jain J","raw_affiliation_strings":["RamEesh Institute of Vocationa & Technical Education, Greater Noida, Uttar Pradesh-201310"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RamEesh Institute of Vocationa & Technical Education, Greater Noida, Uttar Pradesh-201310","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.11118144,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"16","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.03290000185370445,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anticonvulsant-activity","display_name":"anticonvulsant activity","score":0.9959999918937683},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.8169999718666077},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.7490000128746033},{"id":"https://openalex.org/keywords/rotarod-test","display_name":"rotarod test","score":0.6320000290870667},{"id":"https://openalex.org/keywords/halogen-substituent-effects","display_name":"halogen substituent effects","score":0.7080000042915344},{"id":"https://openalex.org/keywords/antiepileptic-drug-development","display_name":"antiepileptic drug development","score":0.6010000109672546},{"id":"https://openalex.org/keywords/hydrazone-synthesis","display_name":"hydrazone synthesis","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.8555507063865662},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8501704335212708},{"id":"https://openalex.org/C2775998212","wikidata":"https://www.wikidata.org/wiki/Q419637","display_name":"Hydrazide","level":2,"score":0.7298057079315186},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.6293579936027527},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.597686767578125},{"id":"https://openalex.org/C2777854368","wikidata":"https://www.wikidata.org/wiki/Q410465","display_name":"Isonicotinic acid","level":3,"score":0.574849545955658},{"id":"https://openalex.org/C2780349576","wikidata":"https://www.wikidata.org/wiki/Q416007","display_name":"Hydrazone","level":2,"score":0.5048114061355591},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4193602204322815},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.3918551802635193},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.36966967582702637},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.21965399384498596},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.12873753905296326},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07100185751914978},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.31069/japsr.v1i01.13058","doi":"https://doi.org/10.31069/japsr.v1i01.13058","is_oa":true,"landing_page_url":"https://doi.org/10.31069/japsr.v1i01.13058","pdf_url":null,"source":{"id":"https://openalex.org/S4210229562","display_name":"Journal of Applied Pharmaceutical Sciences and Research","issn_l":"2581-5520","issn":["2581-5520"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Pharmaceutical Sciences and Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.31069/japsr.v1i01.13058","doi":"https://doi.org/10.31069/japsr.v1i01.13058","is_oa":true,"landing_page_url":"https://doi.org/10.31069/japsr.v1i01.13058","pdf_url":null,"source":{"id":"https://openalex.org/S4210229562","display_name":"Journal of Applied Pharmaceutical Sciences and Research","issn_l":"2581-5520","issn":["2581-5520"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Pharmaceutical Sciences and Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2181847512","https://openalex.org/W2024595278","https://openalex.org/W2740998176","https://openalex.org/W1985320052","https://openalex.org/W2120904939","https://openalex.org/W3157723887","https://openalex.org/W2031675296","https://openalex.org/W2151868233","https://openalex.org/W2953123395","https://openalex.org/W2070383718"],"abstract_inverted_index":{"Epilepsy":[0],"is":[1,42],"a":[2,43],"chronic":[3],"neurological":[4],"disorder,":[5],"involving":[6],"group":[7],"of":[8,18,31,45,58,62,96,235],"nerve":[9],"cells,":[10],"or":[11],"neurons,":[12],"in":[13,92,179],"the":[14,26],"brain.":[15],"Many":[16],"classes":[17],"antiepilepticdrugs":[19],"are":[20,33],"being":[21],"prescribed":[22],"and":[23,39,53,69,75,112,124,133,146,151,156,160,167,204],"used":[24],"by":[25,81,102],"stake":[27],"holders":[28],"but":[29],"most":[30],"them":[32],"associated":[34],"with":[35,49,86,232],"serious":[36],"side":[37,51],"effects":[38,52],"toxicity.":[40,54,220],"There":[41],"strongneed":[44],"new":[46,224],"antiepileptic":[47],"molecules":[48,225],"less":[50,233],"Objective:":[55],"A":[56],"series":[57],"aryl":[59],"acid":[60,64,84],"hydrazones":[61],"Isonicotinic":[63,83],"hydrazide(RINH1":[65],"-RINH14)":[66,79],"were":[67,100,117,226],"synthesized":[68,98,115,186,223],"evaluated":[70],"for":[71,119],"Anticonvulsant":[72,180],"activity.":[73,181],"Material":[74],"Method:":[76],"Compounds":[77,165],"(RINH1":[78],"weresynthesized":[80],"refluxing":[82],"hydrazide":[85],"different":[87],"substituted":[88,90],"benzaldehydes/":[89],"acetophenones":[91],"absolute":[93],"ethanol.Melting":[94],"points":[95],"all":[97,185],"compounds":[99,116,154],"monitored":[101],"open":[103],"glass-capillary":[104],"tube":[105],"method":[106],"on":[107],"Digital":[108],"Melting":[109],"point":[110],"apparatus":[111],"areuncorrected.":[113],"The":[114,222],"tested":[118],"anticonvulsant":[120],"potential":[121],"using":[122],"MES":[123,171],"scPTZ":[125,183],"whereas":[126],"neurotoxicity":[127],"was":[128],"determinedusing":[129],"Rotarod":[130],"model.":[131],"Result":[132],"Discussion:":[134],"At":[135],"100mg/kg":[136],"compound":[137,213],"RINH10":[138,157,168,217],"have":[139,176,218],"shown":[140,219],"29%":[141],"protection":[142,163,195],"at":[143,196,201],"both":[144],"0.5hr":[145],"4.0":[147,205],"time":[148],"interval.At":[149],"300mg/kg":[150],"0.5":[152,202],"hr,":[153],"RINH4":[155,166],"showed":[158],"100%":[159],"50":[161],"%":[162],"respectively.":[164],"havebetter":[169],"anti":[170],"activity":[172,231],"proving":[173],"that":[174],"halogens":[175],"prominent":[177],"contribution":[178],"In":[182],"screen,":[184],"Acidhydrazone":[187],"(RINH1-":[188],"RINH14":[189],")":[190],"did":[191],"not":[192],"show":[193],"any":[194],"30,":[197],"100,300":[198],"mg/kg":[199],",":[200,216],"hr":[203,206],"duration":[207],".In":[208],"rotorod":[209],"test":[210],"i.e":[211],"neurotoxicityscreen,":[212],"RINH5,":[214],"RINH6":[215],"Conclusion:":[221],"proved":[227],"to":[228],"be":[229],"havinganticonvulsant":[230],"signs":[234],"neurotoxicity.":[236]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-08-22T00:00:00"}