{"id":"https://openalex.org/W2885900475","doi":"https://doi.org/10.1158/1538-7445.am2018-2356","title":"Abstract 2356: Prioritizing cancer gene drivers defined in large-scale cancer genome analyses using the SBCDDB","display_name":"Abstract 2356: Prioritizing cancer gene drivers defined in large-scale cancer genome analyses using the SBCDDB","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2885900475","doi":"https://doi.org/10.1158/1538-7445.am2018-2356","mag":"2885900475"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2018-2356","doi":"https://doi.org/10.1158/1538-7445.am2018-2356","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-2356","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026835151","display_name":"Justin Y. Newberg","orcid":"https://orcid.org/0000-0002-3764-4956","observed_orcids":["https://orcid.org/0000-0002-3764-4956"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin Y. Newberg","raw_affiliation_strings":["Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000590204","display_name":"Michael B. Mann","orcid":"https://orcid.org/0000-0002-7515-6515","observed_orcids":["https://orcid.org/0000-0002-7515-6515"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael B. Mann","raw_affiliation_strings":["Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068461186","display_name":"Karen M. Mann","orcid":"https://orcid.org/0000-0002-7161-4523","observed_orcids":["https://orcid.org/0000-0002-7161-4523"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen M. Mann","raw_affiliation_strings":["Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I3019308854"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":"13_Supplement","first_page":"2356","last_page":"2356"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-driver-genes","display_name":"cancer driver genes","score":0.984000027179718},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.7689999938011169},{"id":"https://openalex.org/keywords/data-integration","display_name":"data integration","score":0.5230000019073486},{"id":"https://openalex.org/keywords/tumor-initiation-and-progression","display_name":"tumor initiation and progression","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6742270588874817},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5901650786399841},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5728576183319092},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5073902010917664},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.48824694752693176},{"id":"https://openalex.org/C107635520","wikidata":"https://www.wikidata.org/wiki/Q1967554","display_name":"Insertional mutagenesis","level":4,"score":0.4814159870147705},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4444689452648163},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.4275425970554352},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.42534857988357544},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3445354104042053},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3163589537143707},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.10832065343856812}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2018-2356","doi":"https://doi.org/10.1158/1538-7445.am2018-2356","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-2356","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2766367874","https://openalex.org/W2803935634","https://openalex.org/W3150519244","https://openalex.org/W2093831139","https://openalex.org/W2048673295","https://openalex.org/W4244095008","https://openalex.org/W4364320868","https://openalex.org/W2158134420","https://openalex.org/W2038232750","https://openalex.org/W4389655544"],"abstract_inverted_index":{"Abstract":[0],"Next-generation":[1],"sequencing":[2,87],"approaches":[3],"to":[4,52,71,97,113,152,176,247,279],"identify":[5,53,98,121,153,177],"molecular":[6,282],"signatures":[7,283],"of":[8,29,74,106,128,179,240,259,317],"cancer":[9,26,57,91,133,180,192,302,308],"have":[10,212],"uncovered":[11],"few":[12],"frequently":[13],"altered":[14,18,224],"genes,":[15,19],"many":[16],"infrequently":[17,214],"and":[20,31,43,66,99,120,135,154,160,204,235,249],"various":[21,35],"transcriptional":[22],"changes":[23],"associated":[24,183],"with":[25,84,131,184,199],"initiation/progression.":[27],"Prioritization":[28],"genetic":[30,189],"epigentic":[32],"alterations":[33],"in":[34,103,197,218,225,231,236,262,273,306],"contexts":[36],"is":[37,48,69,149,269],"therefore":[38],"important":[39,271],"for":[40,157,255,321],"biological":[41,158],"discovery":[42,93],"therapy":[44],"development.":[45,58,126],"Comparative":[46],"oncogenomics":[47,76],"a":[49,89,167,256,274],"powerful":[50,90],"approach":[51,278],"drivers":[54,102,123,229,304],"that":[55,221,284],"impact":[56],"Importantly,":[59],"data":[60,67,130,137],"integration":[61],"across":[62],"different":[63,117],"experimental":[64],"systems":[65],"types":[68,187],"imperative":[70],"the":[72,169,195,208,287,312,318],"success":[73],"these":[75],"approaches.":[77],"Sleeping":[78,170],"Beauty":[79,171],"(SB)":[80],"insertional":[81],"mutagenesis":[82],"coupled":[83],"next":[85],"generation":[86],"forms":[88],"gene":[92,303],"framework":[94],"widely":[95],"used":[96,112],"prioritize":[100,155],"candidate":[101],"mouse":[104,238],"models":[105,239],"human":[107,118,132,200,219,233],"cancers.":[108],"SB":[109,129,226],"has":[110,165],"been":[111],"model":[114],"over":[115],"20":[116],"cancers":[119],"cooperating":[122],"underlying":[124],"tumor":[125,186,263,288],"Integration":[127],"genomic":[134],"transcriptomic":[136],"from":[138,207],"The":[139],"Cancer":[140,172,228,322,335],"Genome":[141],"Atlas":[142],"(TCGA)":[143],"/":[144],"Genomic":[145],"Data":[146],"Commons":[147],"(GDC)":[148],"one":[150],"way":[151],"genes":[156,182,217],"validation":[159],"targeted":[161],"therapies.":[162],"Our":[163],"group":[164],"built":[166],"resource,":[168],"Driver":[173],"Database":[174],"(SBCDDB),":[175],"sets":[178],"driver":[181,216],"specific":[185],"or":[188],"aberrations":[190],"underling":[191],"initiation.":[193],"Using":[194],"SBCDDB,":[196],"combination":[198],"mutation,":[201],"copy-number":[202],"alteration,":[203],"mRNA-seq":[205],"datasets":[206],"Broad":[209],"Firehose,":[210],"we":[211],"prioritized":[213],"mutated":[215],"tumors":[220,234],"are":[222],"recurrently":[223],"tumors.":[227],"defined":[230,305],"both":[232],"related":[237],"cancer,":[241],"using":[242,311],"distinct":[243],"but":[244],"complimentary":[245],"methods":[246],"discover":[248],"catalog":[250],"mutations,":[251],"provide":[252],"strong":[253],"evidence":[254],"causal":[257],"role":[258],"detectable":[260],"alteration":[261],"initiation":[264],"and/or":[265],"progression.":[266],"This":[267],"work":[268],"an":[270],"step":[272],"larger,":[275],"comparative":[276],"pan-cancer":[277],"better":[280],"define":[281],"make":[285],"up":[286],"landscape.":[289],"Citation":[290],"Format:":[291],"Justin":[292],"Y.":[293],"Newberg,":[294],"Michael":[295],"B.":[296],"Mann,":[297],"Karen":[298],"M.":[299],"Mann.":[300],"Prioritizing":[301],"large-scale":[307],"genome":[309],"analyses":[310],"SBCDDB":[313],"[abstract].":[314],"In:":[315],"Proceedings":[316],"American":[319],"Association":[320],"Research":[323],"Annual":[324],"Meeting":[325],"2018;":[326],"2018":[327],"Apr":[328],"14-18;":[329],"Chicago,":[330],"IL.":[331],"Philadelphia":[332],"(PA):":[333],"AACR;":[334],"Res":[336],"2018;78(13":[337],"Suppl):Abstract":[338],"nr":[339],"2356.":[340]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2018-08-22T00:00:00"}