{"id":"https://openalex.org/W2885826746","doi":"https://doi.org/10.1158/1538-7445.am2018-3710","title":"Abstract 3710: Nanoparticle-mediated concomitant radiation dose amplification and PARP inhibition in lung cancer","display_name":"Abstract 3710: Nanoparticle-mediated concomitant radiation dose amplification and PARP inhibition in lung cancer","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2885826746","doi":"https://doi.org/10.1158/1538-7445.am2018-3710","mag":"2885826746"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2018-3710","doi":"https://doi.org/10.1158/1538-7445.am2018-3710","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-3710","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058211411","display_name":"Ana G. Vazquez-Pagan","orcid":"https://orcid.org/0000-0001-9984-7129","observed_orcids":["https://orcid.org/0000-0001-9984-7129"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana G. Vazquez-Pagan","raw_affiliation_strings":["1Northeastern University, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Northeastern University, Boston, MA;","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033547791","display_name":"Paige Baldwin","orcid":"https://orcid.org/0000-0002-0146-7177","observed_orcids":["https://orcid.org/0000-0002-0146-7177"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paige Baldwin","raw_affiliation_strings":["1Northeastern University, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Northeastern University, Boston, MA;","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049250000","display_name":"Ravina M. Ashtaputre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravina M. Ashtaputre","raw_affiliation_strings":["2Dana-Farber Cancer Institute, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Dana-Farber Cancer Institute, Boston, MA;","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034298071","display_name":"Sijumon Kunjachan","orcid":"https://orcid.org/0000-0002-5359-9219","observed_orcids":["https://orcid.org/0000-0002-5359-9219"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sijumon Kunjachan","raw_affiliation_strings":["3Brigham and Women's Hospital, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Brigham and Women's Hospital, Boston, MA;","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101987852","display_name":"Srinivas Sridhar","orcid":"https://orcid.org/0000-0003-1605-0734","observed_orcids":["https://orcid.org/0000-0003-1605-0734"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srinivas Sridhar","raw_affiliation_strings":["1Northeastern University, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Northeastern University, Boston, MA;","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069291161","display_name":"Rajiv Kumar","orcid":"https://orcid.org/0000-0002-2559-674X","observed_orcids":["https://orcid.org/0000-0002-2559-674X"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajiv Kumar","raw_affiliation_strings":["1Northeastern University, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Northeastern University, Boston, MA;","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101950331","display_name":"Ross I. Berbeco","orcid":"https://orcid.org/0000-0002-9076-4535","observed_orcids":["https://orcid.org/0000-0002-9076-4535"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ross Berbeco","raw_affiliation_strings":["4Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":"13_Supplement","first_page":"3710","last_page":"3710"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gold-nanoparticles","display_name":"gold nanoparticles","score":0.9959999918937683},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.8849999904632568},{"id":"https://openalex.org/keywords/parp-inhibition","display_name":"PARP inhibition","score":0.9470000267028809},{"id":"https://openalex.org/keywords/talazoparib","display_name":"talazoparib","score":0.9629999995231628},{"id":"https://openalex.org/keywords/liposomal-drug-delivery","display_name":"liposomal drug delivery","score":0.8799999952316284},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9269999861717224},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.5770000219345093},{"id":"https://openalex.org/keywords/single-strand-breaks","display_name":"single-strand breaks","score":0.7559999823570251},{"id":"https://openalex.org/keywords/base-excision-repair","display_name":"base excision repair","score":0.9950000047683716},{"id":"https://openalex.org/keywords/nanoparticle-toxicity","display_name":"nanoparticle toxicity","score":0.6480000019073486},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6660000085830688},{"id":"https://openalex.org/keywords/clonogenic-survival","display_name":"clonogenic survival","score":0.7170000076293945},{"id":"https://openalex.org/keywords/pegylation","display_name":"PEGylation","score":0.6869999766349792},{"id":"https://openalex.org/keywords/nanoparticle-synthesis","display_name":"nanoparticle synthesis","score":0.4580000042915344},{"id":"https://openalex.org/keywords/calu-6-cells","display_name":"Calu-6 cells","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.71852707862854},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.541151225566864},{"id":"https://openalex.org/C2779138821","wikidata":"https://www.wikidata.org/wiki/Q7118227","display_name":"PARP inhibitor","level":5,"score":0.5328389406204224},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.49081119894981384},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4893166720867157},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4570574462413788},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4310323894023895},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4291134774684906},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36398395895957947},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36298906803131104},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.32697075605392456},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.28215527534484863},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.18365448713302612},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.17669200897216797},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1723083257675171},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.17014804482460022},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12226393818855286}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2018-3710","doi":"https://doi.org/10.1158/1538-7445.am2018-3710","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-3710","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4242823469","https://openalex.org/W4311356946","https://openalex.org/W2804862738","https://openalex.org/W2946008392","https://openalex.org/W4205343374","https://openalex.org/W2904602261","https://openalex.org/W1608011409","https://openalex.org/W2805636413","https://openalex.org/W4210781932","https://openalex.org/W7033508092"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"More":[2],"than":[3],"50%":[4],"of":[5,29,38,42,92,99,105,130,142,166,184,234,243,261,276,301,367,394,450],"cancer":[6,46,176,446],"patients":[7],"receive":[8],"radiation":[9,23,43,191,226,320,390,438],"therapy":[10,44,343,386,391],"at":[11,258,318,333],"some":[12],"point":[13],"during":[14,72],"their":[15],"care.":[16],"Gold":[17],"nanoparticles":[18],"(GNPs)":[19],"can":[20],"amplify":[21],"the":[22,27,39,89,95,106,135,164,167,313,323,341,365,402,451],"dose":[24,439],"by":[25,61,115,401],"facilitating":[26],"ejection":[28],"low-energy":[30],"photoelectrons,":[31],"resulting":[32],"in":[33,45,78,172,292,344,360,387,392,444],"increased":[34],"DNA":[35,55,373],"damage.":[36],"One":[37],"main":[40],"challenges":[41],"is":[47,399],"to":[48,87,162],"sustain":[49],"this":[50],"damage":[51],"for":[52,231,269,312,454],"longer":[53],"durations.":[54],"single-strand":[56],"breaks":[57],"(SSBs)":[58],"are":[59,353],"repaired":[60],"base":[62],"excision":[63],"repair,":[64],"which":[65,207],"utilizes":[66],"Poly(ADP-ribose)":[67],"polymerase":[68],"(PARP).":[69],"PARP":[70,107,442],"inhibition":[71,443],"radiotherapy":[73],"provides":[74],"an":[75,379],"attractive":[76],"alternative":[77],"maximizing":[79],"treatment":[80,186,393],"outcomes.":[81],"Here,":[82],"we":[83],"explore":[84],"a":[85,102,137,240,247,259,274,307,345,371,383],"strategy":[86],"combine":[88],"radiosensitizing":[90,368],"effect":[91,311],"GNPs":[93,112,143,168,212,271,327,369],"with":[94,211,221,246,281,298,370,389],"DNA-repair":[96],"inhibiting":[97,334],"ability":[98],"NanoTalazoparib":[100],"(nTLZ),":[101],"liposomal":[103,128],"formulation":[104,129],"inhibitor,":[108,376],"talazoparib":[109],"(TLZ).":[110],"Methods:":[111],"were":[113,159,208,296],"synthesized":[114,133],"reducing":[116],"AuCl4":[117],"using":[118,124,134,149,169,187,194,203,350],"Tetrakis(hydroxymethyl)phosphonium":[119],"chloride":[120],"and":[121,144,152,190,217,222,413,415,441],"further":[122],"PEGylating":[123],"heterobifunctional":[125],"PEGs.":[126],"A":[127],"TLZ":[131,214,257,284,325],"was":[132,146,192,200,253,329],"Nanoassemblr,":[136],"microfluidics-based":[138],"device.":[139],"Physicochemical":[140],"characterization":[141],"nTLZ":[145,189,218,251,286,316],"carried":[147,160,201],"out":[148,161,202],"TEM,":[150],"DLS":[151],"release":[153],"kinetics":[154],"studies.":[155],"In":[156,337],"vitro":[157,361],"studies":[158],"assess":[163],"toxicity":[165,268],"MTT":[170,264],"assay":[171,199,265],"non-small":[173],"cell":[174,178],"lung":[175,395,445],"(NSCLC)":[177],"line":[179],"Calu-6.":[180],"The":[181,225,303,358],"therapeutic":[182],"efficacy":[183],"combination":[185,317,328,342,366,385],"GNPs,":[188,283],"done":[193],"clonogenic":[195],"survival":[196,304],"assays.":[197],"Clonogenic":[198],"Calu":[204,351],"6":[205,352],"cells,":[206],"sequentially":[209],"treated":[210,272,280],"(1mg/mL),":[213],"(0.5":[215,219],"uM)":[216,220],"without":[223],"radiation.":[224,302],"doses":[227,300],"varied":[228],"from":[229],"0-10Gy":[230],"each":[232],"set":[233],"treatments.":[235],"Results:":[236],"PEGylated":[237,270],"GNP's":[238],"showed":[239,266,306],"hydrodynamic":[241],"diameter":[242],"~10-12":[244],"nm":[245,255],"spherical":[248],"morphology":[249],"whereas":[250],"size":[252],"70":[254],"encapsulating":[256],"concentration":[260,275],"~200":[262],"ug/ml.":[263],"no":[267],"upto":[273],"3.0":[277],"mg/mL.":[278],"Cells":[279],"either":[282],"or":[285],"did":[287],"not":[288,330],"show":[289],"significant":[290],"reduction":[291],"colony":[293,335],"formation,":[294],"but":[295],"reduced":[297],"increasing":[299],"plots":[305],"highly":[308],"additive":[309],"antiproliferative":[310],"GNP":[314],"+":[315,326],"all":[319],"doses,":[321],"while":[322],"free":[324],"as":[331,382],"effective":[332],"formation.":[336],"vivo":[338],"experiments":[339],"assessing":[340],"subcutaneous":[346],"xenograft":[347],"mice":[348],"model":[349],"currently":[354],"under":[355],"way.":[356],"Conclusions:":[357],"preliminary":[359],"results":[362],"indicate":[363],"that":[364],"potent":[372],"repair":[374],"enzyme":[375],"TLZ,":[377],"has":[378],"immense":[380],"potential":[381],"complimentary":[384],"conjunction":[388],"cancer.":[396],"This":[397],"work":[398],"supported":[400],"CaNCURE":[403],"program":[404],"(grant":[405],"#1CA174650-02),":[406],"American":[407,452],"Lung":[408],"Association,":[409],"Dana-Farber":[410],"Cancer":[411,455,468],"Institute":[412],"Brigham":[414],"Women's":[416],"Hospital.":[417],"Citation":[418],"Format:":[419],"Ana":[420],"G.":[421],"Vazquez-Pagan,":[422],"Paige":[423],"Baldwin,":[424],"Ravina":[425],"M.":[426],"Ashtaputre,":[427],"Sijumon":[428],"Kunjachan,":[429],"Srinivas":[430],"Sridhar,":[431],"Rajiv":[432],"Kumar,":[433],"Ross":[434],"Berbeco.":[435],"Nanoparticle-mediated":[436],"concomitant":[437],"amplification":[440],"[abstract].":[447],"In:":[448],"Proceedings":[449],"Association":[453],"Research":[456],"Annual":[457],"Meeting":[458],"2018;":[459],"2018":[460],"Apr":[461],"14-18;":[462],"Chicago,":[463],"IL.":[464],"Philadelphia":[465],"(PA):":[466],"AACR;":[467],"Res":[469],"2018;78(13":[470],"Suppl):Abstract":[471],"nr":[472],"3710.":[473]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2018-08-22T00:00:00"}
