{"id":"https://openalex.org/W2885641715","doi":"https://doi.org/10.1128/jvi.00939-18","title":"Functional Study of the C-Terminal Part of the Hepatitis C Virus E1 Ectodomain","display_name":"Functional Study of the C-Terminal Part of the Hepatitis C Virus E1 Ectodomain","publication_year":2018,"publication_date":"2018-07-31","ids":{"openalex":"https://openalex.org/W2885641715","doi":"https://doi.org/10.1128/jvi.00939-18","mag":"2885641715","pmid":"https://pubmed.ncbi.nlm.nih.gov/30068644","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6158422"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.00939-18","doi":"https://doi.org/10.1128/jvi.00939-18","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.00939-18","pdf_url":"https://jvi.asm.org/content/jvi/92/20/e00939-18.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jvi.asm.org/content/jvi/92/20/e00939-18.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054912001","display_name":"Rehab I. Moustafa","orcid":"https://orcid.org/0000-0002-8277-8304","observed_orcids":["https://orcid.org/0000-0002-8277-8304"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210098529","display_name":"Center for Infection and Immunity of Lille","ror":"https://ror.org/00dyt5s15","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210096427","https://openalex.org/I4210098529"]},{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG","FR"],"is_corresponding":false,"raw_author_name":"Rehab I. Moustafa","raw_affiliation_strings":["Department of Microbial Biotechnology, Genetic Engineering and Biotechnology Division, National Research Centre, Dokki, Cairo, Egypt","University Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019\u2013UMR 8204\u2013CIIL/Centre d'Infection et d'Immunit\u00e9 de Lille, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbial Biotechnology, Genetic Engineering and Biotechnology Division, National Research Centre, Dokki, Cairo, Egypt","institution_ids":["https://openalex.org/I4210131959"]},{"raw_affiliation_string":"University Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019\u2013UMR 8204\u2013CIIL/Centre d'Infection et d'Immunit\u00e9 de Lille, Lille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210098529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089714647","display_name":"Juliano G. Haddad","orcid":"https://orcid.org/0000-0001-5035-0162","observed_orcids":["https://orcid.org/0000-0001-5035-0162"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I160368002","display_name":"Lebanese University","ror":"https://ror.org/05x6qnc69","country_code":"LB","type":"education","lineage":["https://openalex.org/I160368002"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210098529","display_name":"Center for Infection and Immunity of Lille","ror":"https://ror.org/00dyt5s15","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210096427","https://openalex.org/I4210098529"]}],"countries":["FR","LB"],"is_corresponding":false,"raw_author_name":"Juliano G. Haddad","raw_affiliation_strings":["Laboratoire Microbiologie Sant\u00e9 et Environnement, Ecole Doctorale en Sciences et Technologie, Facult\u00e9 de Sant\u00e9 Publique, Universit\u00e9 Libanaise, Tripoli, Liban","University Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019\u2013UMR 8204\u2013CIIL/Centre d'Infection et d'Immunit\u00e9 de Lille, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Microbiologie Sant\u00e9 et Environnement, Ecole Doctorale en Sciences et Technologie, Facult\u00e9 de Sant\u00e9 Publique, Universit\u00e9 Libanaise, Tripoli, Liban","institution_ids":["https://openalex.org/I160368002"]},{"raw_affiliation_string":"University Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019\u2013UMR 8204\u2013CIIL/Centre d'Infection et d'Immunit\u00e9 de Lille, Lille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210098529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083753314","display_name":"Lydia Linna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210098529","display_name":"Center for Infection and Immunity of Lille","ror":"https://ror.org/00dyt5s15","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210096427","https://openalex.org/I4210098529"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lydia Linna","raw_affiliation_strings":["University Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019\u2013UMR 8204\u2013CIIL/Centre d'Infection et d'Immunit\u00e9 de Lille, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019\u2013UMR 8204\u2013CIIL/Centre d'Infection et d'Immunit\u00e9 de Lille, Lille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210098529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000954504","display_name":"Xavier Hanoulle","orcid":"https://orcid.org/0000-0002-3755-2680","observed_orcids":["https://orcid.org/0000-0002-3755-2680"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I4210118174","display_name":"Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle","ror":"https://ror.org/02g6y2720","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2279609970","https://openalex.org/I4210096427","https://openalex.org/I4210118174"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Xavier Hanoulle","raw_affiliation_strings":["University of Lille, CNRS, UMR 8576, Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Lille, CNRS, UMR 8576, Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle, Lille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2279609970","https://openalex.org/I4210118174"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110101265","display_name":"V\u00e9ronique Descamps","orcid":"https://orcid.org/0009-0001-0310-4150","observed_orcids":["https://orcid.org/0009-0001-0310-4150"]},"institutions":[{"id":"https://openalex.org/I4210096553","display_name":"Centre Hospitalier Universitaire Amiens-Picardie","ror":"https://ror.org/010567a58","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210096553"]},{"id":"https://openalex.org/I4401200328","display_name":"Agents infectieux, r\u00e9sistance et chimioth\u00e9rapie","ror":"https://ror.org/04mywez65","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4401200328","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4647051","display_name":"Universit\u00e9 de Picardie Jules Verne","ror":"https://ror.org/01gyxrk03","country_code":"FR","type":"education","lineage":["https://openalex.org/I4647051"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"V\u00e9ronique Descamps","raw_affiliation_strings":["Equipe AGIR EA4294, Laboratoire de Virologie du Centre Hospitalier Universitaire d'Amiens, Universit\u00e9 de Picardie Jules Verne, Amiens, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Equipe AGIR EA4294, Laboratoire de Virologie du Centre Hospitalier Universitaire d'Amiens, Universit\u00e9 de Picardie Jules Verne, Amiens, France","institution_ids":["https://openalex.org/I4210096553","https://openalex.org/I4401200328","https://openalex.org/I4647051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077984792","display_name":"Ahmed Atef Mesalam","orcid":"https://orcid.org/0000-0003-4605-2976","observed_orcids":["https://orcid.org/0000-0003-4605-2976"]},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]},{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["BE","EG"],"is_corresponding":false,"raw_author_name":"Ahmed Atef Mesalam","raw_affiliation_strings":["Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium","Department of Therapeutic Chemistry, National Research Centre, Dokki, Cairo, Egypt","Research Group Immune- and Bio-markers for Infection, Centre of Excellence for Advanced Sciences, National Research Centre, Dokki, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium","institution_ids":["https://openalex.org/I32597200"]},{"raw_affiliation_string":"Department of Therapeutic Chemistry, National Research Centre, Dokki, Cairo, Egypt","institution_ids":["https://openalex.org/I4210131959"]},{"raw_affiliation_string":"Research Group Immune- and Bio-markers for Infection, Centre of Excellence for Advanced Sciences, National Research Centre, Dokki, Cairo, Egypt","institution_ids":["https://openalex.org/I4210131959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013323616","display_name":"Thomas F. Baumert","orcid":"https://orcid.org/0000-0002-8864-2168","observed_orcids":["https://orcid.org/0000-0002-8864-2168"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210145324","display_name":"H\u00f4pitaux Universitaires de Strasbourg","ror":"https://ror.org/04bckew43","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210145324"]},{"id":"https://openalex.org/I4387153412","display_name":"Institute for Translational Medicine and Liver Disease","ror":"https://ror.org/00jvqbw52","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4387153412","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thomas F. Baumert","raw_affiliation_strings":["INSERM, U1110, University of Strasbourg, P\u00f4le H\u00e9pato-digestif-H\u00f4pitaux Universitaires de Strasbourg, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, U1110, University of Strasbourg, P\u00f4le H\u00e9pato-digestif-H\u00f4pitaux Universitaires de Strasbourg, Strasbourg, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210145324","https://openalex.org/I4387153412","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108385085","display_name":"Gilles Duverlie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096553","display_name":"Centre Hospitalier Universitaire Amiens-Picardie","ror":"https://ror.org/010567a58","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210096553"]},{"id":"https://openalex.org/I4401200328","display_name":"Agents infectieux, r\u00e9sistance et chimioth\u00e9rapie","ror":"https://ror.org/04mywez65","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4401200328","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4647051","display_name":"Universit\u00e9 de Picardie Jules Verne","ror":"https://ror.org/01gyxrk03","country_code":"FR","type":"education","lineage":["https://openalex.org/I4647051"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gilles Duverlie","raw_affiliation_strings":["Equipe AGIR EA4294, Laboratoire de Virologie du Centre Hospitalier Universitaire d'Amiens, Universit\u00e9 de Picardie Jules Verne, Amiens, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Equipe AGIR EA4294, Laboratoire de Virologie du Centre Hospitalier Universitaire d'Amiens, Universit\u00e9 de Picardie Jules Verne, Amiens, France","institution_ids":["https://openalex.org/I4210096553","https://openalex.org/I4401200328","https://openalex.org/I4647051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055758010","display_name":"Philip Meuleman","orcid":"https://orcid.org/0000-0001-6821-234X","observed_orcids":["https://orcid.org/0000-0001-6821-234X"]},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Philip Meuleman","raw_affiliation_strings":["Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087727909","display_name":"Jean Dubuisson","orcid":"https://orcid.org/0000-0003-1626-7693","observed_orcids":["https://orcid.org/0000-0003-1626-7693"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210098529","display_name":"Center for Infection and Immunity of Lille","ror":"https://ror.org/00dyt5s15","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210096427","https://openalex.org/I4210098529"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean Dubuisson","raw_affiliation_strings":["University Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019\u2013UMR 8204\u2013CIIL/Centre d'Infection et d'Immunit\u00e9 de Lille, Lille, France"],"raw_orcid":"https://orcid.org/0000-0003-1626-7693","affiliations":[{"raw_affiliation_string":"University Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019\u2013UMR 8204\u2013CIIL/Centre d'Infection et d'Immunit\u00e9 de Lille, Lille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210098529"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017628978","display_name":"Muriel Lavie","orcid":"https://orcid.org/0000-0003-3308-811X","observed_orcids":["https://orcid.org/0000-0003-3308-811X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210098529","display_name":"Center for Infection and Immunity of Lille","ror":"https://ror.org/00dyt5s15","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210096427","https://openalex.org/I4210098529"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Muriel Lavie","raw_affiliation_strings":["University Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019\u2013UMR 8204\u2013CIIL/Centre d'Infection et d'Immunit\u00e9 de Lille, Lille, France"],"raw_orcid":"https://orcid.org/0000-0003-3308-811X","affiliations":[{"raw_affiliation_string":"University Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019\u2013UMR 8204\u2013CIIL/Centre d'Infection et d'Immunit\u00e9 de Lille, Lille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210098529"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":16,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.469,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.65463313,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"92","issue":"20","first_page":"e00939","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10494","display_name":"Plant Virus Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.996999979019165},{"id":"https://openalex.org/keywords/e1-envelope-protein","display_name":"E1 envelope protein","score":0.8700000047683716},{"id":"https://openalex.org/keywords/fusion-peptide","display_name":"fusion peptide","score":0.8690000176429749},{"id":"https://openalex.org/keywords/alpha-helix","display_name":"alpha-helix","score":0.7080000042915344},{"id":"https://openalex.org/keywords/virus-entry","display_name":"viral entry","score":0.8569999933242798},{"id":"https://openalex.org/keywords/virus-infectivity","display_name":"viral infectivity","score":0.6660000085830688},{"id":"https://openalex.org/keywords/hcv-receptor","display_name":"HCV receptor","score":0.75},{"id":"https://openalex.org/keywords/virus-assembly","display_name":"viral assembly","score":0.609000027179718},{"id":"https://openalex.org/keywords/viral-morphogenesis","display_name":"viral morphogenesis","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C1009742","wikidata":"https://www.wikidata.org/wiki/Q5333998","display_name":"Ectodomain","level":3,"score":0.9788357019424438},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8955094814300537},{"id":"https://openalex.org/C106358424","wikidata":"https://www.wikidata.org/wiki/Q1662346","display_name":"Infectivity","level":3,"score":0.8447136878967285},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.7188016772270203},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.701076865196228},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6361222267150879},{"id":"https://openalex.org/C103038307","wikidata":"https://www.wikidata.org/wiki/Q6556360","display_name":"Lipid bilayer fusion","level":3,"score":0.5462004542350769},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.4739682376384735},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42186814546585083},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37729954719543457},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3637503981590271},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.3496420383453369}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019065","descriptor_name":"Virus Assembly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053586","descriptor_name":"Virus Internalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1128/jvi.00939-18","doi":"https://doi.org/10.1128/jvi.00939-18","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.00939-18","pdf_url":"https://jvi.asm.org/content/jvi/92/20/e00939-18.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5412771","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6158422","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6158422","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6158422","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:30068644","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30068644","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-02112519v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-02112519","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Virology, 2018, 92 (20), pp.e00939-18. &#x27E8;10.1128/JVI.00939-18&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:archive.ugent.be:8576096","doi":null,"is_oa":false,"landing_page_url":"https://biblio.ugent.be/publication/8576096","pdf_url":null,"source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1098-5514","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:lilloa.univ-lille.fr:20.500.12210/28780","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.12210/28780","pdf_url":null,"source":{"id":"https://openalex.org/S4306402203","display_name":"LillOA (Universit\u00e9 de Lille (University Of Lille))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210123514","host_organization_name":"Centre d'\u00c9tudes en Civilisations, Langues et Lettres \u00c9trang\u00e8res","host_organization_lineage":["https://openalex.org/I4210123514"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1128/jvi.00939-18","doi":"https://doi.org/10.1128/jvi.00939-18","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.00939-18","pdf_url":"https://jvi.asm.org/content/jvi/92/20/e00939-18.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2808203159","display_name":"Identification of host factors involved in Hepatitis C Virus assembly and characterization of their potential role in vivo","funder_award_id":"ANR-13-IFEC-0002","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320321833","display_name":"Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales","ror":"https://ror.org/01kv58h76"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2885641715.pdf","grobid_xml":"https://content.openalex.org/works/W2885641715.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W2156982","https://openalex.org/W58511937","https://openalex.org/W832466652","https://openalex.org/W1607071191","https://openalex.org/W1635062911","https://openalex.org/W1947712816","https://openalex.org/W1963825210","https://openalex.org/W1964179400","https://openalex.org/W1969699638","https://openalex.org/W1971311328","https://openalex.org/W1982370923","https://openalex.org/W1988761191","https://openalex.org/W1991809658","https://openalex.org/W1995278959","https://openalex.org/W2002451924","https://openalex.org/W2003579943","https://openalex.org/W2010133215","https://openalex.org/W2022687771","https://openalex.org/W2030094974","https://openalex.org/W2030371794","https://openalex.org/W2043080047","https://openalex.org/W2045875941","https://openalex.org/W2046254711","https://openalex.org/W2051108527","https://openalex.org/W2054730058","https://openalex.org/W2059125177","https://openalex.org/W2061343285","https://openalex.org/W2064778609","https://openalex.org/W2069597046","https://openalex.org/W2078591526","https://openalex.org/W2086853864","https://openalex.org/W2087583050","https://openalex.org/W2087870820","https://openalex.org/W2090562889","https://openalex.org/W2091001172","https://openalex.org/W2096675564","https://openalex.org/W2102253058","https://openalex.org/W2105291849","https://openalex.org/W2108463852","https://openalex.org/W2110842901","https://openalex.org/W2111170944","https://openalex.org/W2116753660","https://openalex.org/W2118422968","https://openalex.org/W2127444976","https://openalex.org/W2133036275","https://openalex.org/W2134747025","https://openalex.org/W2141406123","https://openalex.org/W2145943989","https://openalex.org/W2147126871","https://openalex.org/W2154115492","https://openalex.org/W2158819883","https://openalex.org/W2161890443","https://openalex.org/W2172176008","https://openalex.org/W2341508496","https://openalex.org/W2574179652","https://openalex.org/W2585398696","https://openalex.org/W2586988783","https://openalex.org/W2620240072","https://openalex.org/W2767967441","https://openalex.org/W2768461977","https://openalex.org/W2780150340","https://openalex.org/W2998642600","https://openalex.org/W3108410359"],"related_works":["https://openalex.org/W2148466686","https://openalex.org/W2574179652","https://openalex.org/W2038454674","https://openalex.org/W2586988783","https://openalex.org/W2061343285","https://openalex.org/W2805710053","https://openalex.org/W2154115492","https://openalex.org/W2142582216","https://openalex.org/W4281393433","https://openalex.org/W2129729109"],"abstract_inverted_index":{"HCV":[0,95,120],"is":[1],"a":[2,132,142],"major":[3],"public":[4],"health":[5],"problem":[6],"worldwide.":[7],"The":[8],"virion":[9],"harbors":[10],"two":[11],"envelope":[12],"proteins,":[13],"E1":[14,37,59,102],"and":[15,51,122],"E2,":[16],"which":[17,61],"are":[18],"involved":[19],"at":[20],"different":[21],"steps":[22],"of":[23,36,46,57,77,101,106,134,144],"the":[24,34,44,47,52,58,75,81,90,99,104,107,115,127],"viral":[25],"life":[26],"cycle.":[27],"Whereas":[28,112],"E2":[29],"has":[30],"been":[31,63],"extensively":[32],"characterized,":[33],"function":[35,45],"remains":[38],"poorly":[39],"defined.":[40],"We":[41,72],"characterized":[42],"here":[43],"putative":[48,116],"fusion":[49,117],"peptide":[50,118],"region":[53,129,146],"containing":[54],"\u03b1":[55],"helices":[56],"ectodomain,":[60],"had":[62],"previously":[64],"suggested":[65],"to":[66,131],"be":[67],"important":[68],"for":[69,80],"virus":[70,82,108,148],"entry.":[71,149],"could":[73],"confirm":[74],"importance":[76],"these":[78],"regions":[79],"infectivity.":[83],"Interestingly,":[84],"we":[85],"found":[86],"several":[87,94,124],"residues":[88],"modulating":[89],"virus's":[91],"dependence":[92],"on":[93,139],"receptors,":[96],"thus":[97],"highlighting":[98],"role":[100,143],"in":[103,114,126,147],"interaction":[105],"with":[109,136],"cellular":[110],"receptors.":[111],"mutations":[113,125],"affected":[119],"infectivity":[121,135],"morphogenesis,":[123],"\u03b12-helix":[128],"led":[130],"loss":[133],"no":[137],"effect":[138],"assembly,":[140],"indicating":[141],"this":[145]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-08-22T00:00:00"}
