{"id":"https://openalex.org/W2885588086","doi":"https://doi.org/10.1111/ajt.15057","title":"Polygenic risk score as a determinant of risk of non-melanoma skin cancer in a European-descent renal transplant cohort","display_name":"Polygenic risk score as a determinant of risk of non-melanoma skin cancer in a European-descent renal transplant cohort","publication_year":2018,"publication_date":"2018-08-07","ids":{"openalex":"https://openalex.org/W2885588086","doi":"https://doi.org/10.1111/ajt.15057","mag":"2885588086","pmid":"https://pubmed.ncbi.nlm.nih.gov/30085400","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6367067"},"language":"en","primary_location":{"id":"doi:10.1111/ajt.15057","doi":"https://doi.org/10.1111/ajt.15057","is_oa":true,"landing_page_url":"https://doi.org/10.1111/ajt.15057","pdf_url":null,"source":{"id":"https://openalex.org/S182625382","display_name":"American Journal of Transplantation","issn_l":"1600-6135","issn":["1600-6135","1600-6143"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1111/ajt.15057","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078519943","display_name":"Caragh P. Stapleton","orcid":"https://orcid.org/0000-0002-5354-7822","observed_orcids":["https://orcid.org/0000-0002-5354-7822"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Caragh P. Stapleton","raw_affiliation_strings":["Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012471874","display_name":"Kelly A. Birdwell","orcid":"https://orcid.org/0000-0002-7996-3947","observed_orcids":["https://orcid.org/0000-0002-7996-3947"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly A. Birdwell","raw_affiliation_strings":["Department of Medicine, Vanderbilt University Medical Centre, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University Medical Centre, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067092840","display_name":"Amy Jayne McKnight","orcid":"https://orcid.org/0000-0002-7482-709X","observed_orcids":["https://orcid.org/0000-0002-7482-709X"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Amy Jayne McKnight","raw_affiliation_strings":["Centre for Public Health, Queen's University of Belfast, Belfast, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Public Health, Queen's University of Belfast, Belfast, UK","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090093329","display_name":"Alexander Peter Maxwell","orcid":"https://orcid.org/0000-0002-6110-7253","observed_orcids":["https://orcid.org/0000-0002-6110-7253"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alexander P. Maxwell","raw_affiliation_strings":["Centre for Public Health, Queen's University of Belfast, Belfast, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Public Health, Queen's University of Belfast, Belfast, UK","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042828582","display_name":"Patrick Barry Mark","orcid":"https://orcid.org/0000-0003-3387-2123","observed_orcids":["https://orcid.org/0000-0003-3387-2123"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Patrick B. Mark","raw_affiliation_strings":["Institute of Cardiovascular and Medical Sciences, BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cardiovascular and Medical Sciences, BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056996198","display_name":"M. Lee Sanders","orcid":"https://orcid.org/0000-0002-5968-9899","observed_orcids":["https://orcid.org/0000-0002-5968-9899"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I2802216851","display_name":"University of Iowa Hospitals and Clinics","ror":"https://ror.org/04g2swc55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I2802216851","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Lee Sanders","raw_affiliation_strings":["Hospitals and Clinics, University of Iowa, Iowa City, IA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospitals and Clinics, University of Iowa, Iowa City, IA, USA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I2802216851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014864385","display_name":"Fiona A. Chapman","orcid":"https://orcid.org/0000-0002-9774-1643","observed_orcids":["https://orcid.org/0000-0002-9774-1643"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Fiona A. Chapman","raw_affiliation_strings":["Institute of Cardiovascular and Medical Sciences, BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cardiovascular and Medical Sciences, BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020949943","display_name":"Jessica van Setten","orcid":"https://orcid.org/0000-0002-4934-7510","observed_orcids":["https://orcid.org/0000-0002-4934-7510"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jessica van Setten","raw_affiliation_strings":["Department of Cardiology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071093993","display_name":"Paul J. Phelan","orcid":"https://orcid.org/0000-0003-2549-5049","observed_orcids":["https://orcid.org/0000-0003-2549-5049"]},"institutions":[{"id":"https://openalex.org/I1324252669","display_name":"NHS Lothian","ror":"https://ror.org/03q82t418","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669"]},{"id":"https://openalex.org/I2802789809","display_name":"Edinburgh Royal Infirmary","ror":"https://ror.org/009bsy196","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802789809"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul J. Phelan","raw_affiliation_strings":["Department of Nephrology, Royal Infirmary of Edinburgh, NHS Lothian, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Royal Infirmary of Edinburgh, NHS Lothian, UK","institution_ids":["https://openalex.org/I1324252669","https://openalex.org/I2802789809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013058473","display_name":"Claire Kennedy","orcid":"https://orcid.org/0000-0001-7277-2171","observed_orcids":["https://orcid.org/0000-0001-7277-2171"]},"institutions":[{"id":"https://openalex.org/I2801846703","display_name":"Beaumont Hospital","ror":"https://ror.org/043mzjj67","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2801846703"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Claire Kennedy","raw_affiliation_strings":["Department of Nephrology, Beaumont Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Beaumont Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I2801846703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071642919","display_name":"Alan G. Jardine","orcid":"https://orcid.org/0000-0001-5815-9370","observed_orcids":["https://orcid.org/0000-0001-5815-9370"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alan Jardine","raw_affiliation_strings":["Institute of Cardiovascular and Medical Sciences, BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cardiovascular and Medical Sciences, BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079152480","display_name":"Jamie P. Traynor","orcid":"https://orcid.org/0000-0002-4339-0366","observed_orcids":["https://orcid.org/0000-0002-4339-0366"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jamie P. Traynor","raw_affiliation_strings":["Institute of Cardiovascular and Medical Sciences, BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cardiovascular and Medical Sciences, BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058430815","display_name":"Brendan J. Keating","orcid":"https://orcid.org/0000-0002-3320-3723","observed_orcids":["https://orcid.org/0000-0002-3320-3723"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brendan Keating","raw_affiliation_strings":["Department of Surgery, Penn Transplant Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Penn Transplant Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077564795","display_name":"Peter J. Conlon","orcid":"https://orcid.org/0000-0001-6772-9531","observed_orcids":["https://orcid.org/0000-0001-6772-9531"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]},{"id":"https://openalex.org/I2801846703","display_name":"Beaumont Hospital","ror":"https://ror.org/043mzjj67","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2801846703"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Peter J. Conlon","raw_affiliation_strings":["Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland","Department of Nephrology, Beaumont Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]},{"raw_affiliation_string":"Department of Nephrology, Beaumont Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I2801846703"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042026444","display_name":"Gianpiero L. Cavalleri","orcid":"https://orcid.org/0000-0002-9802-0506","observed_orcids":["https://orcid.org/0000-0002-9802-0506"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Gianpiero L. Cavalleri","raw_affiliation_strings":["Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5042026444","https://openalex.org/A5077564795"],"corresponding_institution_ids":["https://openalex.org/I142762351","https://openalex.org/I2801846703"],"apc_list":{"value":4300,"currency":"USD","value_usd":4300},"apc_paid":{"value":4300,"currency":"USD","value_usd":4300},"fwci":3.118,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.91829685,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"19","issue":"3","first_page":"801","last_page":"810"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polygenic-risk-score","display_name":"polygenic risk score","score":0.9819999933242798},{"id":"https://openalex.org/keywords/non-melanoma-skin-cancer","display_name":"non-melanoma skin cancer","score":1.0},{"id":"https://openalex.org/keywords/kidney-transplant-recipients","display_name":"kidney transplant recipients","score":0.9480000138282776},{"id":"https://openalex.org/keywords/basal-cell-carcinoma","display_name":"basal cell carcinoma","score":0.9559999704360962},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.5590000152587891},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.8450000286102295},{"id":"https://openalex.org/keywords/european-ancestry","display_name":"European ancestry","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8965980410575867},{"id":"https://openalex.org/C2777789703","wikidata":"https://www.wikidata.org/wiki/Q192102","display_name":"Skin cancer","level":3,"score":0.8181381821632385},{"id":"https://openalex.org/C2778804307","wikidata":"https://www.wikidata.org/wiki/Q809758","display_name":"Basal cell carcinoma","level":3,"score":0.6829609870910645},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6029404401779175},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5766902565956116},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5392393469810486},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.503900945186615},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5020201206207275},{"id":"https://openalex.org/C2778439243","wikidata":"https://www.wikidata.org/wiki/Q7157043","display_name":"Pazopanib","level":4,"score":0.469255656003952},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4494011402130127},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.40501201152801514},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32874661684036255},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.15047836303710938},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.14954614639282227},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09075891971588135},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0797414481639862},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.05991089344024658},{"id":"https://openalex.org/C2779490328","wikidata":"https://www.wikidata.org/wiki/Q417542","display_name":"Sunitinib","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002280","descriptor_name":"Basal Cell Carcinoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002280","descriptor_name":"Basal Cell Carcinoma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002280","descriptor_name":"Basal Cell Carcinoma","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066027","descriptor_name":"Transplant Recipients","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1111/ajt.15057","doi":"https://doi.org/10.1111/ajt.15057","is_oa":true,"landing_page_url":"https://doi.org/10.1111/ajt.15057","pdf_url":null,"source":{"id":"https://openalex.org/S182625382","display_name":"American Journal of Transplantation","issn_l":"1600-6135","issn":["1600-6135","1600-6143"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Transplantation","raw_type":"journal-article"},{"id":"pmid:30085400","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30085400","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.gla.ac.uk:166591","doi":null,"is_oa":true,"landing_page_url":"http://eprints.gla.ac.uk/166591/7/166591.pdf","pdf_url":"http://eprints.gla.ac.uk/166591/7/166591.pdf","source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/I4405259220","host_organization_name":"Institut Agama Islam Negeri Langsa","host_organization_lineage":["https://openalex.org/I4405259220"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Articles"},{"id":"pmh:oai:pure.qub.ac.uk/portal:openaire/f96e2fbc-2466-41a4-bd48-f650c922d660","doi":null,"is_oa":true,"landing_page_url":"https://pure.qub.ac.uk/en/publications/f96e2fbc-2466-41a4-bd48-f650c922d660","pdf_url":"https://pureadmin.qub.ac.uk/ws/files/156053481/Polygenic_risk_score_as_a_determinant_of_risk_of_non_melanoma_skin_cancer_in_a_European_descent_renal_transplant_cohort.pdf","source":{"id":"https://openalex.org/S4306402319","display_name":"Research Portal (Queen's University Belfast)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126231945","host_organization_name":"Queen's University Belfast","host_organization_lineage":["https://openalex.org/I126231945"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:5989068","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6367067","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6367067","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6367067","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Am J Transplant","raw_type":"Text"},{"id":"pmh:oai:dspace.library.uu.nl:1874/394254","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/394254","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:figshare.com:article/20306349","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Polygenic_risk_score_as_a_determinant_of_risk_of_non-melanoma_skin_cancer_in_a_European-descent_renal_transplant_cohort/20306349","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/394254","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/394254","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Transplantation, 19(3), 801. Blackwell Publishing Asia Pty Ltd","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1111/ajt.15057","doi":"https://doi.org/10.1111/ajt.15057","is_oa":true,"landing_page_url":"https://doi.org/10.1111/ajt.15057","pdf_url":null,"source":{"id":"https://openalex.org/S182625382","display_name":"American Journal of Transplantation","issn_l":"1600-6135","issn":["1600-6135","1600-6143"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Transplantation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1356607191","display_name":"Discovery of an integrated risk profile for chronic kidney disease and development of a clinical biomarker panel for personalising medicine","funder_award_id":"15/IA/3152","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"},{"id":"https://openalex.org/G2311296441","display_name":null,"funder_award_id":"EPSPG2015","funder_id":"https://openalex.org/F4320321056","funder_display_name":"Irish Research Council"},{"id":"https://openalex.org/G3115710350","display_name":"Pharmacogenomics of Tacrolimus and New Onset Diabetes After Kidney Transplant","funder_award_id":"K23GM100183","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3177098586","display_name":null,"funder_award_id":"STL/3714/07","funder_id":"https://openalex.org/F4320320853","funder_display_name":"Public Health Agency"},{"id":"https://openalex.org/G4432921003","display_name":null,"funder_award_id":"MC_PC_15025","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G6071898252","display_name":null,"funder_award_id":"STL/4760/13","funder_id":"https://openalex.org/F4320320853","funder_display_name":"Public Health Agency"},{"id":"https://openalex.org/G7773456091","display_name":"The Vanderbilt Institute for Clinical and Translational Research (VICTR)","funder_award_id":"UL1TR000445","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8173526563","display_name":null,"funder_award_id":"15/IA/","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"}],"funders":[{"id":"https://openalex.org/F4320320847","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38"},{"id":"https://openalex.org/F4320320853","display_name":"Public Health Agency","ror":"https://ror.org/03ek62e72"},{"id":"https://openalex.org/F4320321056","display_name":"Irish Research Council","ror":"https://ror.org/051xex213"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1507854104","https://openalex.org/W1520683642","https://openalex.org/W1972517554","https://openalex.org/W1976754559","https://openalex.org/W1983931127","https://openalex.org/W1992436001","https://openalex.org/W2004944131","https://openalex.org/W2006617902","https://openalex.org/W2026884584","https://openalex.org/W2033151532","https://openalex.org/W2067211606","https://openalex.org/W2067453004","https://openalex.org/W2080408627","https://openalex.org/W2089632286","https://openalex.org/W2098399289","https://openalex.org/W2098597355","https://openalex.org/W2098951833","https://openalex.org/W2099085143","https://openalex.org/W2102714321","https://openalex.org/W2103949162","https://openalex.org/W2104549677","https://openalex.org/W2111307685","https://openalex.org/W2116243022","https://openalex.org/W2119665774","https://openalex.org/W2121754832","https://openalex.org/W2126930838","https://openalex.org/W2129140467","https://openalex.org/W2132731072","https://openalex.org/W2139168999","https://openalex.org/W2147216920","https://openalex.org/W2147477044","https://openalex.org/W2166610199","https://openalex.org/W2321487929","https://openalex.org/W2411385633","https://openalex.org/W2463912758","https://openalex.org/W2504048115","https://openalex.org/W2511515754","https://openalex.org/W2517068497","https://openalex.org/W2529241974","https://openalex.org/W2578814677","https://openalex.org/W2598022332","https://openalex.org/W2768987398","https://openalex.org/W2785912241","https://openalex.org/W2803332630","https://openalex.org/W4231373967","https://openalex.org/W7026795824"],"related_works":["https://openalex.org/W2917227523","https://openalex.org/W3025190403","https://openalex.org/W1995424659","https://openalex.org/W2073533454","https://openalex.org/W2579330110","https://openalex.org/W3037012453","https://openalex.org/W2036583232","https://openalex.org/W4229084026","https://openalex.org/W2110342116","https://openalex.org/W2084707936"],"abstract_inverted_index":{"Renal":[0],"transplant":[1,87],"recipients":[2],"have":[3],"an":[4],"increased":[5],"risk":[6,22,40,200],"of":[7,31,96,120,123,159,179,184],"non-melanoma":[8],"skin":[9,46],"cancer":[10],"(NMSC)":[11],"compared":[12],"to":[13,44,101,161,189,196,203],"in":[14,33],"the":[15,116,155],"general":[16],"population.":[17],"Here,":[18],"we":[19],"show":[20],"polygenic":[21],"scores":[23],"(PRS)":[24],"calculated":[25,78,106],"from":[26,57],"genome-wide":[27],"association":[28],"studies":[29],"(GWAS)":[30],"NMSC":[32,102,124,163,181,190],"a":[34],"general,":[35],"nontransplant":[36,68,180],"setting,":[37],"can":[38,199],"predict":[39],"of,":[41],"and":[42,63,74,92,99,140,187],"time":[43,100,160,188],"posttransplant":[45,125,162],"cancer.":[47],"Genetic":[48],"variants,":[49],"reaching":[50],"predefined":[51],"P":[52,108,130,147,165],"-value":[53,109,148],"thresholds":[54],"were":[55,77],"chosen":[56],"published":[58],"squamous":[59],"cell":[60,65],"carcinoma":[61,66],"(SCC)":[62],"basal":[64],"(BCC)":[67],"GWAS.":[69],"Using":[70],"these":[71],"GWAS,":[72],"BCC":[73,104],"SCC":[75,144],"PRS":[76,105,145,178],"for":[79,137],"each":[80],"sample":[81],"across":[82],"three":[83],"European":[84],"ancestry":[85],"renal":[86],"cohorts":[88],"(n":[89],"=":[90,127,131,142,166,176],"889)":[91],"tested":[93],"as":[94],"predictors":[95,139],"case:control":[97,121,185],"status":[98,122,186],"posttransplant.":[103,191],"at":[107,146],"threshold":[110,149],"1":[111,150],"\u00d7":[112,151,168],"10":[113,152,169],"\u22125":[114,153],"was":[115,154],"most":[117,156],"significant":[118,157],"predictor":[119,158],"(OR":[126],"1.61;":[128],"adjusted":[129,136],".0022;":[132],"AUC":[133],"[full":[134,174],"model":[135],"clinical":[138],"PRS]":[141],"0.81).":[143],"(adjusted":[164],"9.39":[167],"\u22127":[170],";":[171],"HR=1.41,":[172],"concordance":[173],"model]":[175],"0.74).":[177],"is":[182],"predictive":[183],"These":[192],"results":[193],"are":[194],"relevant":[195],"how":[197],"genomics":[198],"stratify":[201],"patients":[202],"help":[204],"develop":[205],"personalized":[206],"treatment":[207],"regimens.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-08-22T00:00:00"}
