{"id":"https://openalex.org/W2885571663","doi":"https://doi.org/10.1049/iet-nbt.2018.5135","title":"Biogenic synthesis of biopolymer\u2010based Ag\u2013Au bimetallic nanoparticle constructs and their anti\u2010proliferative assessment","display_name":"Biogenic synthesis of biopolymer\u2010based Ag\u2013Au bimetallic nanoparticle constructs and their anti\u2010proliferative assessment","publication_year":2018,"publication_date":"2018-07-30","ids":{"openalex":"https://openalex.org/W2885571663","doi":"https://doi.org/10.1049/iet-nbt.2018.5135","mag":"2885571663","pmid":"https://pubmed.ncbi.nlm.nih.gov/30964012","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8675961"},"language":"en","primary_location":{"id":"doi:10.1049/iet-nbt.2018.5135","doi":"https://doi.org/10.1049/iet-nbt.2018.5135","is_oa":true,"landing_page_url":"https://doi.org/10.1049/iet-nbt.2018.5135","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1049/iet-nbt.2018.5135","source":{"id":"https://openalex.org/S97987397","display_name":"IET Nanobiotechnology","issn_l":"1751-8741","issn":["1751-8741","1751-875X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311714","host_organization_name":"Institution of Engineering and Technology","host_organization_lineage":["https://openalex.org/P4310311714"],"host_organization_lineage_names":["Institution of Engineering and Technology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IET Nanobiotechnology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1049/iet-nbt.2018.5135","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050453900","display_name":"Kalaignana Selvi Subbiah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8975392","display_name":"Osmania University","ror":"https://ror.org/030sjb889","country_code":"IN","type":"education","lineage":["https://openalex.org/I8975392"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kalaignana Selvi Subbiah","raw_affiliation_strings":["Department of Biochemistry, University College of Science, Osmania University, Hyderabad, 500 007 Telangana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University College of Science, Osmania University, Hyderabad, 500 007 Telangana, India","institution_ids":["https://openalex.org/I8975392"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055920760","display_name":"Sashidhar Rao Beedu","orcid":"https://orcid.org/0000-0001-9289-0394","observed_orcids":["https://orcid.org/0000-0001-9289-0394"]},"institutions":[{"id":"https://openalex.org/I8975392","display_name":"Osmania University","ror":"https://ror.org/030sjb889","country_code":"IN","type":"education","lineage":["https://openalex.org/I8975392"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sashidhar Rao Beedu","raw_affiliation_strings":["Department of Biochemistry, University College of Science, Osmania University, Hyderabad, 500 007 Telangana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University College of Science, Osmania University, Hyderabad, 500 007 Telangana, India","institution_ids":["https://openalex.org/I8975392"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5055920760"],"corresponding_institution_ids":["https://openalex.org/I8975392"],"apc_list":{"value":2610,"currency":"USD","value_usd":2610},"apc_paid":null,"fwci":0.5244,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.5385826,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"12","issue":"8","first_page":"1047","last_page":"1055"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10131","display_name":"Gold and Silver Nanoparticles Synthesis and Applications","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12416","display_name":"Polymer Nanocomposite Synthesis and Irradiation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/au-ag-bimetallic-nanoparticles","display_name":"Au-Ag bimetallic nanoparticles","score":0.953000009059906},{"id":"https://openalex.org/keywords/gum-kondagogu","display_name":"gum kondagogu","score":0.9950000047683716},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.8799999952316284},{"id":"https://openalex.org/keywords/b16f10-melanoma-cells","display_name":"B16F10 melanoma cells","score":0.9580000042915344},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.7950000166893005},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9860000014305115},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pparalpha","display_name":"PPAR\u03b1","score":0.6909999847412109},{"id":"https://openalex.org/keywords/ppardelta","display_name":"PPAR\u03b4","score":0.9980000257492065},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.8700000047683716},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.75},{"id":"https://openalex.org/keywords/green-synthesis","display_name":"green synthesis","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C2778636629","wikidata":"https://www.wikidata.org/wiki/Q422649","display_name":"Biopolymer","level":3,"score":0.705834150314331},{"id":"https://openalex.org/C43411465","wikidata":"https://www.wikidata.org/wiki/Q2997621","display_name":"Bimetallic strip","level":3,"score":0.6569353342056274},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.6407475471496582},{"id":"https://openalex.org/C146088050","wikidata":"https://www.wikidata.org/wiki/Q744818","display_name":"Transmission electron microscopy","level":2,"score":0.6152113080024719},{"id":"https://openalex.org/C160892712","wikidata":"https://www.wikidata.org/wiki/Q901559","display_name":"Fourier transform infrared spectroscopy","level":2,"score":0.6150045394897461},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.5697904825210571},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5562816262245178},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5453616380691528},{"id":"https://openalex.org/C2779178360","wikidata":"https://www.wikidata.org/wiki/Q902045","display_name":"Confocal microscopy","level":2,"score":0.4948553442955017},{"id":"https://openalex.org/C26771246","wikidata":"https://www.wikidata.org/wiki/Q321095","display_name":"Scanning electron microscope","level":2,"score":0.46592235565185547},{"id":"https://openalex.org/C26926545","wikidata":"https://www.wikidata.org/wiki/Q1939992","display_name":"Nanobiotechnology","level":3,"score":0.4286192059516907},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.4113357663154602},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3815532624721527},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.35240504145622253},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.34150785207748413},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.3158653974533081},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2957770824432373},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.27741122245788574},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19619238376617432},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.19308212399482727},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.14007171988487244},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10728985071182251},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.09172973036766052},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006046","descriptor_name":"Gold","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006046","descriptor_name":"Gold","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006046","descriptor_name":"Gold","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012834","descriptor_name":"Silver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012834","descriptor_name":"Silver","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012834","descriptor_name":"Silver","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053768","descriptor_name":"Metal Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055772","descriptor_name":"Green Chemistry Technology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1049/iet-nbt.2018.5135","doi":"https://doi.org/10.1049/iet-nbt.2018.5135","is_oa":true,"landing_page_url":"https://doi.org/10.1049/iet-nbt.2018.5135","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1049/iet-nbt.2018.5135","source":{"id":"https://openalex.org/S97987397","display_name":"IET Nanobiotechnology","issn_l":"1751-8741","issn":["1751-8741","1751-875X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311714","host_organization_name":"Institution of Engineering and Technology","host_organization_lineage":["https://openalex.org/P4310311714"],"host_organization_lineage_names":["Institution of Engineering and Technology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IET Nanobiotechnology","raw_type":"journal-article"},{"id":"pmid:30964012","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30964012","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IET nanobiotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8675961","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8675961/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IET Nanobiotechnol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1049/iet-nbt.2018.5135","doi":"https://doi.org/10.1049/iet-nbt.2018.5135","is_oa":true,"landing_page_url":"https://doi.org/10.1049/iet-nbt.2018.5135","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1049/iet-nbt.2018.5135","source":{"id":"https://openalex.org/S97987397","display_name":"IET Nanobiotechnology","issn_l":"1751-8741","issn":["1751-8741","1751-875X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311714","host_organization_name":"Institution of Engineering and Technology","host_organization_lineage":["https://openalex.org/P4310311714"],"host_organization_lineage_names":["Institution of Engineering and Technology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IET Nanobiotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2885571663.pdf"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W583146321","https://openalex.org/W1503790445","https://openalex.org/W1810522911","https://openalex.org/W1963920922","https://openalex.org/W1972500802","https://openalex.org/W1983412916","https://openalex.org/W1984657728","https://openalex.org/W1995468808","https://openalex.org/W1996045694","https://openalex.org/W1997118025","https://openalex.org/W1997774370","https://openalex.org/W2014290035","https://openalex.org/W2023193204","https://openalex.org/W2033069724","https://openalex.org/W2034694747","https://openalex.org/W2035220807","https://openalex.org/W2039509144","https://openalex.org/W2040114377","https://openalex.org/W2044863505","https://openalex.org/W2048725087","https://openalex.org/W2048816568","https://openalex.org/W2059346226","https://openalex.org/W2078093237","https://openalex.org/W2081555916","https://openalex.org/W2082622864","https://openalex.org/W2085143181","https://openalex.org/W2088354065","https://openalex.org/W2120791835","https://openalex.org/W2122322099","https://openalex.org/W2122848464","https://openalex.org/W2146084342","https://openalex.org/W2152738055","https://openalex.org/W2158395637","https://openalex.org/W2180909531","https://openalex.org/W2189153162","https://openalex.org/W2327578322","https://openalex.org/W2328049393","https://openalex.org/W2328631282","https://openalex.org/W2329396160","https://openalex.org/W2335358834","https://openalex.org/W2534592945","https://openalex.org/W2584619924","https://openalex.org/W2734369225"],"related_works":["https://openalex.org/W2734369225","https://openalex.org/W2774206129","https://openalex.org/W4401361389","https://openalex.org/W3088222898","https://openalex.org/W4220800227","https://openalex.org/W4402341009","https://openalex.org/W4402334103","https://openalex.org/W4292702184","https://openalex.org/W2001228802","https://openalex.org/W3131638535"],"abstract_inverted_index":{"This":[0],"study":[1],"reports":[2],"an":[3],"eco\u2010friendly\u2010based":[4],"method":[5],"for":[6],"the":[7,117,121],"preparation":[8],"of":[9,30,58,66,90,104,120],"biopolymer":[10],"Ag\u2013Au":[11],"nanoparticles":[12],"(NPs)":[13],"by":[14,35,71],"using":[15],"gum":[16],"kondagogu":[17],"(GK;":[18],"Cochlospermum":[19],"gossypium":[20],"),":[21],"as":[22],"both":[23],"reducing":[24],"and":[25,49,78,99,102,106],"protecting":[26],"agent.":[27],"The":[28,54,63],"formation":[29],"GK\u2010(Ag\u2013Au)":[31,55,114],"NPs":[32,56,115],"was":[33,69],"confirmed":[34],"UV\u2010absorption,":[36],"fourier":[37],"transformed":[38],"infrared":[39],"(FTIR),":[40],"atomic":[41],"force":[42],"microscopy":[43],"(AFM),":[44],"scanning":[45],"electron":[46,51],"microscope":[47,52],"(SEM)":[48],"transmission":[50],"(TEM).":[53],"were":[57],"1\u201312":[59],"nm":[60],"in":[61,109],"size.":[62],"anti\u2010proliferative":[64,118],"activity":[65],"nanoparticle":[67],"constructs":[68],"assessed":[70],"MTT":[72],"assay,":[73],"confocal":[74],"microscopy,":[75],"flow":[76],"cytometry":[77],"quantitative":[79],"real\u2010time":[80],"polymerase":[81],"chain":[82],"reaction":[83],"(PCR)":[84],"techniques.":[85],"Expression":[86],"studies":[87],"revealed":[88],"up\u2010regulation":[89],"p53,":[91],"caspase\u20103,":[92],"caspase\u20109,":[93],"peroxisome":[94],"proliferator\u2010activated":[95],"receptors":[96],"(PPAR)":[97],"PPARa":[98],"PPARb,":[100],"genes":[101],"down\u2010regulation":[103],"Bcl\u20102":[105],"Bcl\u2010x(K)":[107],"genes,":[108],"B16F10":[110],"cells":[111],"treated":[112],"with":[113],"confirming":[116],"properties":[119],"nanoparticles.":[122]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2018-08-22T00:00:00"}