{"id":"https://openalex.org/W2885571647","doi":null,"title":"Role of the PTEN phosphatase in regulating T cell function","display_name":"Role of the PTEN phosphatase in regulating T cell function","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2885571647","mag":"2885571647"},"language":"en","primary_location":{"id":"pmh:oai:collectionscanada.gc.ca:OOAMICUS.26189787","doi":null,"is_oa":false,"landing_page_url":"http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58822.pdf","pdf_url":"http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58822.pdf","source":{"id":"https://openalex.org/S4306402307","display_name":"Library and Archives Canada (Government of Canada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802286613","host_organization_name":"Government of Canada","host_organization_lineage":["https://openalex.org/I2802286613"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Electronic thesis or dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/f4a5e53f-f547-4477-aaf0-5b6e53d67743/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067054887","display_name":"Karen Andrea Berg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Karen Andrea Berg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5067054887"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/t-cell-receptor-signaling","display_name":"T cell receptor signaling","score":0.9620000123977661},{"id":"https://openalex.org/keywords/cd28-costimulation","display_name":"CD28 costimulation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8870000243186951},{"id":"https://openalex.org/keywords/thymocytes","display_name":"thymocytes","score":0.8270000219345093},{"id":"https://openalex.org/keywords/nucleolin","display_name":"nucleolin","score":0.7820000052452087},{"id":"https://openalex.org/keywords/moesin","display_name":"moesin","score":0.921999990940094},{"id":"https://openalex.org/keywords/set-protein","display_name":"SET protein","score":0.375}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.9481720924377441},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.6040709614753723},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.5892180800437927},{"id":"https://openalex.org/C2994604686","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell function","level":3,"score":0.4765130281448364},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43849003314971924},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4326365888118744},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4206632971763611},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41957178711891174},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32749730348587036},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19086536765098572},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.15032178163528442},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.1402251422405243},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.07546591758728027}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:collectionscanada.gc.ca:OOAMICUS.26189787","doi":null,"is_oa":false,"landing_page_url":"http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58822.pdf","pdf_url":"http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58822.pdf","source":{"id":"https://openalex.org/S4306402307","display_name":"Library and Archives Canada (Government of Canada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802286613","host_organization_name":"Government of Canada","host_organization_lineage":["https://openalex.org/I2802286613"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Electronic thesis or dissertation"},{"id":"pmh:oai:utoronto.scholaris.ca:1807/15454","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/15454","pdf_url":"https://utoronto.scholaris.ca/bitstreams/f4a5e53f-f547-4477-aaf0-5b6e53d67743/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2885571647","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/15454/1/MQ58822.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/15454","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/15454","pdf_url":"https://utoronto.scholaris.ca/bitstreams/f4a5e53f-f547-4477-aaf0-5b6e53d67743/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2885571647.pdf","grobid_xml":"https://content.openalex.org/works/W2885571647.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W69869516","https://openalex.org/W1484278528","https://openalex.org/W1489145507","https://openalex.org/W1521412534","https://openalex.org/W1581287839","https://openalex.org/W1592624601","https://openalex.org/W1631908837","https://openalex.org/W1672865967","https://openalex.org/W1726025741","https://openalex.org/W1806127905","https://openalex.org/W1877572689","https://openalex.org/W1954313480","https://openalex.org/W1964359053","https://openalex.org/W1972239225","https://openalex.org/W1979147887","https://openalex.org/W1983199685","https://openalex.org/W1985334285","https://openalex.org/W1985551609","https://openalex.org/W1988594478","https://openalex.org/W1992104313","https://openalex.org/W1997468256","https://openalex.org/W1999125576","https://openalex.org/W2004356154","https://openalex.org/W2006796385","https://openalex.org/W2008065206","https://openalex.org/W2009335336","https://openalex.org/W2013355944","https://openalex.org/W2013685285","https://openalex.org/W2014761974","https://openalex.org/W2019017173","https://openalex.org/W2024923170","https://openalex.org/W2026559965","https://openalex.org/W2028847269","https://openalex.org/W2030720692","https://openalex.org/W2035147500","https://openalex.org/W2047826668","https://openalex.org/W2050039768","https://openalex.org/W2057599008","https://openalex.org/W2057723407","https://openalex.org/W2058138221","https://openalex.org/W2058733098","https://openalex.org/W2059199407","https://openalex.org/W2064242629","https://openalex.org/W2065279599","https://openalex.org/W2068345721","https://openalex.org/W2068427129","https://openalex.org/W2070942270","https://openalex.org/W2076262819","https://openalex.org/W2081868968","https://openalex.org/W2092354039","https://openalex.org/W2092395106","https://openalex.org/W2093628776","https://openalex.org/W2094068658","https://openalex.org/W2094126922","https://openalex.org/W2097767970","https://openalex.org/W2098386399","https://openalex.org/W2102369096","https://openalex.org/W2103002807","https://openalex.org/W2113190292","https://openalex.org/W2119433488","https://openalex.org/W2119683782","https://openalex.org/W2124432707","https://openalex.org/W2129558898","https://openalex.org/W2137407985","https://openalex.org/W2145936343","https://openalex.org/W2146854995","https://openalex.org/W2150233389","https://openalex.org/W2150769903","https://openalex.org/W2152988906","https://openalex.org/W2155737059","https://openalex.org/W2156216950","https://openalex.org/W2157189324","https://openalex.org/W2157191335","https://openalex.org/W2160700807","https://openalex.org/W2160953520","https://openalex.org/W2161810908"],"related_works":["https://openalex.org/W2405711333","https://openalex.org/W2911859072","https://openalex.org/W2519988782","https://openalex.org/W2673816731","https://openalex.org/W7097146850","https://openalex.org/W7028828385","https://openalex.org/W2626523888","https://openalex.org/W1672865967","https://openalex.org/W3002284515","https://openalex.org/W2045958434"],"abstract_inverted_index":{"While":[0],"an":[1],"important":[2],"role":[3,168,187],"for":[4,54],"the":[5,9,25,60,68,116,129,154,162,190,201],"PTEN":[6,29,65,106,119,183,206],"phosphatase":[7],"in":[8,108,151,169,188],"modulation":[10],"of":[11,19,62,78,92,105,128,192,205],"TCR":[12,32,193,213],"signaling":[13,164],"is":[14,22,178],"suggested":[15],"by":[16,180],"many":[17],"lines":[18],"evidence,":[20],"little":[21],"known":[23],"about":[24],"biochemical":[26],"mechanisms":[27],"whereby":[28,210],"impacts":[30],"on":[31],"function.":[33],"To":[34],"address":[35],"this":[36,176],"issue,":[37],"affinity":[38],"chromatography":[39],"and":[40,47,75,85,99,115,133,144,174],"mass":[41],"spectrometry":[42],"were":[43],"used":[44],"to":[45,59,120,126,147,195],"isolate":[46],"identify":[48],"T":[49,109,130,171],"cell":[50,110,131,172],"proteins":[51],"representing":[52],"binding-partners":[53],"PTEN.":[55],"This":[56],"approach":[57],"led":[58],"identification":[61],"seven":[63],"potential":[64],"ligands":[66],"including":[67],"SET,":[69],"PHAPI2b,":[70],"PHAPI,":[71],"tubulin":[72],"beta-1,":[73],"eta":[74],"theta":[76],"subunits":[77],"chaperonin":[79],"containing":[80],"T-complex":[81],"protein":[82],"1,":[83],"nucleolin":[84],"moesin":[86],"proteins,":[87],"with":[88],"apparent":[89],"molecular":[90],"weights":[91],"23,":[93],"28,":[94],"30,":[95],"50,":[96],"55,":[97],"67":[98,100],"kDa,":[101],"respectively.":[102],"An":[103],"analysis":[104],"roles":[107],"activation":[111,173],"was":[112,138,145],"also":[113,139],"undertaken":[114],"results":[117,159,199],"revealed":[118],"be":[121,148],"inducibly":[122],"tyrosine":[123,156],"phosphorylated":[124],"consequent":[125],"cross-linking":[127],"antigen":[132],"CD28":[134],"receptors.":[135],"AKT":[136,196],"phosphorylation":[137],"observed":[140],"following":[141],"TCR/CD28":[142],"costimulation":[143],"found":[146],"relatively":[149],"increased":[150],"thymocytes":[152],"lacking":[153],"SHP-1":[155,211],"phosphatase.":[157],"These":[158],"suggest":[160],"that":[161,175,203],"PI3K/AKT":[163],"cascade":[165],"plays":[166,184],"a":[167,185,208],"TCR-elicited":[170],"pathway":[177],"regulated":[179],"SHP-1.":[181],"As":[182],"critical":[186],"downregulation":[189],"coupling":[191],"engagement":[194],"phosphorylation/activation,":[197],"these":[198],"raise":[200],"possibility":[202],"dephosphorylation":[204],"represents":[207],"mechanism":[209],"inhibits":[212],"signaling.":[214]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2018-08-22T00:00:00"}