{"id":"https://openalex.org/W2885537101","doi":"https://doi.org/10.1073/pnas.1802576115","title":"Regulatory element in fibrin triggers tension-activated transition from catch to slip bonds","display_name":"Regulatory element in fibrin triggers tension-activated transition from catch to slip bonds","publication_year":2018,"publication_date":"2018-08-07","ids":{"openalex":"https://openalex.org/W2885537101","doi":"https://doi.org/10.1073/pnas.1802576115","mag":"2885537101","pmid":"https://pubmed.ncbi.nlm.nih.gov/30087181","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6112739"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1802576115","doi":"https://doi.org/10.1073/pnas.1802576115","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1802576115","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6112739","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007009397","display_name":"\u041b\u0438\u0442\u0432\u0438\u043d\u043e\u0432 \u0420\u0443\u0441\u0442\u0435\u043c \u0418\u0433\u043e\u0440\u0435\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0003-0643-1496","observed_orcids":["https://orcid.org/0000-0003-0643-1496"]},"institutions":[{"id":"https://openalex.org/I21203515","display_name":"Kazan Federal University","ror":"https://ror.org/05256ym39","country_code":"RU","type":"education","lineage":["https://openalex.org/I21203515"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["RU","US"],"is_corresponding":false,"raw_author_name":"Rustem I. Litvinov","raw_affiliation_strings":["Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104;","Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan 420008, Russian Federation;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan 420008, Russian Federation;","institution_ids":["https://openalex.org/I21203515"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Olga Kononova","orcid":"https://orcid.org/0000-0001-9267-312X","observed_orcids":["https://orcid.org/0000-0001-9267-312X"]},"institutions":[{"id":"https://openalex.org/I133738476","display_name":"University of Massachusetts Lowell","ror":"https://ror.org/03hamhx47","country_code":"US","type":"education","lineage":["https://openalex.org/I133738476"]},{"id":"https://openalex.org/I153845743","display_name":"Moscow Institute of Physics and Technology","ror":"https://ror.org/00v0z9322","country_code":"RU","type":"education","lineage":["https://openalex.org/I153845743"]}],"countries":["RU","US"],"is_corresponding":false,"raw_author_name":"Olga Kononova","raw_affiliation_strings":["Department of Chemistry, University of Massachusetts Lowell, Lowell, MA 01854;","Laboratory of Computer and Mathematical Modeling of Biological Systems, Moscow Institute of Physics and Technology, Moscow Region 141700, Russian Federation;"],"raw_orcid":"https://orcid.org/0000-0001-9267-312X","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Massachusetts Lowell, Lowell, MA 01854;","institution_ids":["https://openalex.org/I133738476"]},{"raw_affiliation_string":"Laboratory of Computer and Mathematical Modeling of Biological Systems, Moscow Institute of Physics and Technology, Moscow Region 141700, Russian Federation;","institution_ids":["https://openalex.org/I153845743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083809468","display_name":"Artem Andreyevich Zhmurov","orcid":"https://orcid.org/0000-0002-4414-8352","observed_orcids":["https://orcid.org/0000-0002-4414-8352"]},"institutions":[{"id":"https://openalex.org/I153845743","display_name":"Moscow Institute of Physics and Technology","ror":"https://ror.org/00v0z9322","country_code":"RU","type":"education","lineage":["https://openalex.org/I153845743"]},{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Artem Zhmurov","raw_affiliation_strings":["Laboratory of Computer and Mathematical Modeling of Biological Systems, Moscow Institute of Physics and Technology, Moscow Region 141700, Russian Federation;","Laboratory of Mathematical Modeling in Medicine, Sechenov University, Moscow 119991, Russian Federation;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Computer and Mathematical Modeling of Biological Systems, Moscow Institute of Physics and Technology, Moscow Region 141700, Russian Federation;","institution_ids":["https://openalex.org/I153845743"]},{"raw_affiliation_string":"Laboratory of Mathematical Modeling in Medicine, Sechenov University, Moscow 119991, Russian Federation;","institution_ids":["https://openalex.org/I17877952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113740075","display_name":"Kenneth A. Marx","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133738476","display_name":"University of Massachusetts Lowell","ror":"https://ror.org/03hamhx47","country_code":"US","type":"education","lineage":["https://openalex.org/I133738476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth A. Marx","raw_affiliation_strings":["Department of Chemistry, University of Massachusetts Lowell, Lowell, MA 01854;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Massachusetts Lowell, Lowell, MA 01854;","institution_ids":["https://openalex.org/I133738476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027517667","display_name":"Valeri Abulevich Barsegov","orcid":"https://orcid.org/0000-0003-1994-3917","observed_orcids":["https://orcid.org/0000-0003-1994-3917"]},"institutions":[{"id":"https://openalex.org/I133738476","display_name":"University of Massachusetts Lowell","ror":"https://ror.org/03hamhx47","country_code":"US","type":"education","lineage":["https://openalex.org/I133738476"]},{"id":"https://openalex.org/I153845743","display_name":"Moscow Institute of Physics and Technology","ror":"https://ror.org/00v0z9322","country_code":"RU","type":"education","lineage":["https://openalex.org/I153845743"]}],"countries":["RU","US"],"is_corresponding":false,"raw_author_name":"Valeri Barsegov","raw_affiliation_strings":["Department of Chemistry, University of Massachusetts Lowell, Lowell, MA 01854;","Laboratory of Computer and Mathematical Modeling of Biological Systems, Moscow Institute of Physics and Technology, Moscow Region 141700, Russian Federation;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Massachusetts Lowell, Lowell, MA 01854;","institution_ids":["https://openalex.org/I133738476"]},{"raw_affiliation_string":"Laboratory of Computer and Mathematical Modeling of Biological Systems, Moscow Institute of Physics and Technology, Moscow Region 141700, Russian Federation;","institution_ids":["https://openalex.org/I153845743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036725653","display_name":"Dave Thirumalai","orcid":"https://orcid.org/0000-0003-1801-5924","observed_orcids":["https://orcid.org/0000-0003-1801-5924"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Thirumalai","raw_affiliation_strings":["Department of Chemistry, University of Texas at Austin, Austin, TX 78712"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Texas at Austin, Austin, TX 78712","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089911552","display_name":"John W. Weisel","orcid":"https://orcid.org/0000-0002-9628-257X","observed_orcids":["https://orcid.org/0000-0002-9628-257X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John W. Weisel","raw_affiliation_strings":["Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4131,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.89409627,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"115","issue":"34","first_page":"8575","last_page":"8580"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibrin","display_name":"fibrin","score":0.9660000205039978},{"id":"https://openalex.org/keywords/catch-bonds","display_name":"catch bonds","score":0.8399999737739563},{"id":"https://openalex.org/keywords/slip-bonds","display_name":"slip bonds","score":0.9980000257492065},{"id":"https://openalex.org/keywords/single-molecule-force-spectroscopy","display_name":"single-molecule force spectroscopy","score":0.6800000071525574},{"id":"https://openalex.org/keywords/calcium-binding-sites","display_name":"calcium binding sites","score":0.5440000295639038},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.5180000066757202},{"id":"https://openalex.org/keywords/fibrin-polymers","display_name":"fibrin polymers","score":0.5600000023841858},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.7020000219345093},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/hydrodynamic-shear","display_name":"hydrodynamic shear","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.5525949001312256},{"id":"https://openalex.org/C195268267","wikidata":"https://www.wikidata.org/wiki/Q1928883","display_name":"Slip (aerodynamics)","level":2,"score":0.5502394437789917},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5190178155899048},{"id":"https://openalex.org/C159096172","wikidata":"https://www.wikidata.org/wiki/Q2914535","display_name":"Bond strength","level":4,"score":0.43740689754486084},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3625984191894531},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.34535861015319824},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3081815242767334},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.1426076591014862},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C68928338","wikidata":"https://www.wikidata.org/wiki/Q131790","display_name":"Adhesive","level":3,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C2779227376","wikidata":"https://www.wikidata.org/wiki/Q6505497","display_name":"Layer (electronics)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005337","descriptor_name":"Fibrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005337","descriptor_name":"Fibrin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.1802576115","doi":"https://doi.org/10.1073/pnas.1802576115","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1802576115","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5364614","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6112739","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6112739","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6112739","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:30087181","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30087181","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5364614","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6112739","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1058396818","display_name":null,"funder_award_id":"14\u201004\u201032066","funder_id":"https://openalex.org/F4320321079","funder_display_name":"Russian Foundation for Basic Research"},{"id":"https://openalex.org/G2285663300","display_name":"Multiscale modeling and empirical study of a mechanism limiting blood clot growth","funder_award_id":"U01HL116330","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3795205675","display_name":null,"funder_award_id":"15-01-06721","funder_id":"https://openalex.org/F4320321079","funder_display_name":"Russian Foundation for Basic Research"},{"id":"https://openalex.org/G4144338054","display_name":"Collaborative Research: Experimental and Theoretical Studies of the Biomechanics of Fibrin Polymer","funder_award_id":"1505316","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5156607902","display_name":null,"funder_award_id":"13GRNT16960013","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G6417541488","display_name":"Computational Approaches to Single Molecule Force Spectroscopy","funder_award_id":"R01GM089685","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6564763543","display_name":null,"funder_award_id":"17-71-10202","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"},{"id":"https://openalex.org/G7784273973","display_name":"Experiment-based multi-scale modeling of the tensile and compressive deformations of fibrin","funder_award_id":"R01HL135254","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320321079","display_name":"Russian Foundation for Basic Research","ror":"https://ror.org/02mh1ke95"},{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1963857259","https://openalex.org/W1966086662","https://openalex.org/W1966558481","https://openalex.org/W1967158690","https://openalex.org/W1971529415","https://openalex.org/W1977751952","https://openalex.org/W1984845371","https://openalex.org/W1985837832","https://openalex.org/W1991788752","https://openalex.org/W2002919621","https://openalex.org/W2003632920","https://openalex.org/W2004614757","https://openalex.org/W2005785099","https://openalex.org/W2011682997","https://openalex.org/W2012795074","https://openalex.org/W2022046477","https://openalex.org/W2025735516","https://openalex.org/W2028813239","https://openalex.org/W2030162988","https://openalex.org/W2052192720","https://openalex.org/W2058322086","https://openalex.org/W2058705371","https://openalex.org/W2070008310","https://openalex.org/W2071328014","https://openalex.org/W2073159733","https://openalex.org/W2090400738","https://openalex.org/W2097081828","https://openalex.org/W2105482820","https://openalex.org/W2106782261","https://openalex.org/W2122060254","https://openalex.org/W2133566253","https://openalex.org/W2142802803","https://openalex.org/W2144871740","https://openalex.org/W2155708268","https://openalex.org/W2160648230","https://openalex.org/W2285632628","https://openalex.org/W2293514414","https://openalex.org/W2500142620","https://openalex.org/W2526331410","https://openalex.org/W2572149156","https://openalex.org/W2749092846","https://openalex.org/W4242114372"],"related_works":["https://openalex.org/W2911647025","https://openalex.org/W2754651837","https://openalex.org/W2003632920","https://openalex.org/W2073159733","https://openalex.org/W2013259586","https://openalex.org/W2012795074","https://openalex.org/W2008760595","https://openalex.org/W7098524784","https://openalex.org/W3008143469","https://openalex.org/W4280526536"],"abstract_inverted_index":{"Fibrin":[0],"formation":[1,193],"and":[2,9,44,70,105,121,155],"mechanical":[3,14,167],"stability":[4],"are":[5],"essential":[6],"in":[7,102,115,142,147,202],"thrombosis":[8],"hemostasis.":[10],"To":[11,58],"reveal":[12],"how":[13],"load":[15],"impacts":[16],"fibrin,":[17],"we":[18,66],"carried":[19],"out":[20],"optical":[21],"trap-based":[22],"single-molecule":[23],"forced":[24],"unbinding":[25],"experiments.":[26],"The":[27,78,125],"strength":[28],"of":[29,63,74,118,127,130,144,169,173,176,181,194],"noncovalent":[30],"A:a":[31,75,183],"knob-hole":[32,76,131,184],"bond":[33,123,132],"stabilizing":[34],"fibrin":[35,196],"polymers":[36],"first":[37],"increases":[38],"with":[39,47],"tensile":[40],"force":[41,48,51],"(catch":[42],"bonds)":[43],"then":[45],"decreases":[46],"when":[49],"the":[50,60,86,99,103,116,148,152,166,182],"exceeds":[52],"a":[53,93,139,161],"critical":[54],"value":[55],"(slip":[56],"bonds).":[57],"provide":[59,160],"structural":[61,145],"basis":[62],"catch-slip-bond":[64],"behavior,":[65],"analyzed":[67],"crystal":[68],"structures":[69],"performed":[71],"molecular":[72],"modeling":[73],"complex.":[77],"movable":[79],"flap":[80],"(residues":[81],"\u03b3295":[82],"to":[83,107,164,188,199],"\u03b3305)":[84],"containing":[85],"weak":[87],"calcium-binding":[88],"site":[89],"\u03b32":[90],"serves":[91],"as":[92],"tension":[94],"sensor.":[95],"Flap":[96],"dissociation":[97],"from":[98],"B":[100],"domain":[101],"\u03b3-nodule":[104],"translocation":[106],"knob":[108],"'A'":[109],"triggers":[110],"hole":[111],"'a'":[112],"closure,":[113],"resulting":[114],"increase":[117],"binding":[119,149],"affinity":[120],"prolonged":[122],"lifetimes.":[124],"discovery":[126],"biphasic":[128],"kinetics":[129],"rupture":[133],"is":[134],"quantitatively":[135],"explained":[136],"by":[137],"using":[138],"theory,":[140],"formulated":[141],"terms":[143],"transitions":[146],"pocket":[150],"between":[151],"low-affinity":[153],"(slip)":[154],"high-affinity":[156],"(catch)":[157],"states.":[158],"We":[159],"general":[162],"framework":[163],"understand":[165],"response":[168],"protein":[170],"pairs":[171],"capable":[172],"tension-induced":[174],"remodeling":[175],"their":[177],"association":[178],"interface.":[179],"Strengthening":[180],"bonds":[185],"at":[186],"30-":[187],"40-pN":[189],"forces":[190],"might":[191],"favor":[192],"nascent":[195],"clots":[197],"subject":[198],"hydrodynamic":[200],"shear":[201],"vivo.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-08-22T00:00:00"}
