{"id":"https://openalex.org/W2885517792","doi":"https://doi.org/10.1158/1538-7445.am2018-1452","title":"Abstract 1452: The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ","display_name":"Abstract 1452: The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2885517792","doi":"https://doi.org/10.1158/1538-7445.am2018-1452","mag":"2885517792"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2018-1452","doi":"https://doi.org/10.1158/1538-7445.am2018-1452","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-1452","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031420382","display_name":"Deanna N. Edwards","orcid":"https://orcid.org/0000-0001-5481-5879","observed_orcids":["https://orcid.org/0000-0001-5481-5879"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deanna N. Edwards","raw_affiliation_strings":["1Vanderbilt University Medical Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Vanderbilt University Medical Center, Nashville, TN;","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036235661","display_name":"Verra M. Ngwa","orcid":"https://orcid.org/0000-0002-8878-4350","observed_orcids":["https://orcid.org/0000-0002-8878-4350"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Verra M. Ngwa","raw_affiliation_strings":["2Vanderbilt University, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Vanderbilt University, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100388419","display_name":"Shan Wang","orcid":"https://orcid.org/0000-0001-8292-5717","observed_orcids":["https://orcid.org/0000-0001-8292-5717","https://orcid.org/0000-0001-9901-1719"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shan Wang","raw_affiliation_strings":["1Vanderbilt University Medical Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Vanderbilt University Medical Center, Nashville, TN;","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040799512","display_name":"Eileen F. Shiuan","orcid":"https://orcid.org/0000-0002-3202-4010","observed_orcids":["https://orcid.org/0000-0002-3202-4010"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eileen Shiuan","raw_affiliation_strings":["2Vanderbilt University, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Vanderbilt University, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004009810","display_name":"Dana M. Brantley\u2010Sieders","orcid":"https://orcid.org/0000-0002-2751-6547","observed_orcids":["https://orcid.org/0000-0002-2751-6547","https://orcid.org/0000-0001-9873-6339"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dana Brantley-Sieders","raw_affiliation_strings":["1Vanderbilt University Medical Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Vanderbilt University Medical Center, Nashville, TN;","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Laura Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Kim","raw_affiliation_strings":["2Vanderbilt University, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Vanderbilt University, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012331045","display_name":"Albert B. Reynolds","orcid":"https://orcid.org/0000-0002-4514-0491","observed_orcids":["https://orcid.org/0000-0002-4514-0491"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Albert B. Reynolds","raw_affiliation_strings":["2Vanderbilt University, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Vanderbilt University, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020742692","display_name":"Jin Chen","orcid":"https://orcid.org/0000-0002-5557-2079","observed_orcids":["https://orcid.org/0000-0002-5557-2079"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin Chen","raw_affiliation_strings":["1Vanderbilt University Medical Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Vanderbilt University Medical Center, Nashville, TN;","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":"13_Supplement","first_page":"1452","last_page":"1452"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.7860999703407288,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.7860999703407288,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.14650000631809235,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epha2","display_name":"EphA2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/yap","display_name":"YAP","score":0.8379999995231628},{"id":"https://openalex.org/keywords/taz","display_name":"TAZ","score":1.0},{"id":"https://openalex.org/keywords/glutamine-metabolism","display_name":"glutamine metabolism","score":0.8460000157356262},{"id":"https://openalex.org/keywords/glutaminolysis","display_name":"glutaminolysis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9789999723434448},{"id":"https://openalex.org/keywords/slc1a5","display_name":"SLC1A5","score":0.8289999961853027},{"id":"https://openalex.org/keywords/glutaminase","display_name":"glutaminase","score":0.7519999742507935},{"id":"https://openalex.org/keywords/gls","display_name":"GLS","score":0.8299999833106995},{"id":"https://openalex.org/keywords/rho-rock-signaling-pathway","display_name":"Rho/ROCK signaling","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cancer-metabolic-reprogramming","display_name":"tumor metabolic reprogramming","score":0.6579999923706055},{"id":"https://openalex.org/keywords/glutamine-addiction","display_name":"glutamine addiction","score":0.8009999990463257},{"id":"https://openalex.org/keywords/glutamine-transporter","display_name":"glutamine transporter","score":0.40700000524520874},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C2778160063","wikidata":"https://www.wikidata.org/wiki/Q1532402","display_name":"Glutaminolysis","level":4,"score":0.733646810054779},{"id":"https://openalex.org/C109549099","wikidata":"https://www.wikidata.org/wiki/Q24773687","display_name":"Glutaminase","level":4,"score":0.7263948917388916},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6420730948448181},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.570677638053894},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.5599636435508728},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5238085985183716},{"id":"https://openalex.org/C150582083","wikidata":"https://www.wikidata.org/wiki/Q18250395","display_name":"EPH receptor A2","level":4,"score":0.47867685556411743},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4484352469444275},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4347218871116638},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.38455730676651},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.302599161863327},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23264062404632568},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09116548299789429},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2018-1452","doi":"https://doi.org/10.1158/1538-7445.am2018-1452","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-1452","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4238428669","https://openalex.org/W2771792762","https://openalex.org/W2259934843","https://openalex.org/W2800085901","https://openalex.org/W2888319851","https://openalex.org/W2807792304","https://openalex.org/W2168636113","https://openalex.org/W4401076441","https://openalex.org/W2486939364","https://openalex.org/W1587484222"],"abstract_inverted_index":{"Abstract":[0],"Malignant":[1],"tumors":[2,266],"reprogram":[3],"cellular":[4],"metabolism":[5,41,71,264],"to":[6,30,68,210],"support":[7],"cancer":[8,25,168,206,229],"cell":[9],"proliferation":[10],"and":[11,34,60,74,90,92,130,141,150,156,178,186,197,230,273],"survival.":[12],"Although":[13,188],"most":[14],"cancers":[15],"depend":[16],"on":[17],"a":[18,65,216],"high":[19,189],"rate":[20],"of":[21,77,82,88,96,101,122,128,147,176,184,220,278],"aerobic":[22],"glycolysis,":[23],"many":[24],"cells":[26,73,207],"also":[27,202],"display":[28],"addiction":[29],"glutamine.":[31],"Glutamine":[32],"transporters":[33],"glutaminase":[35,211],"activity":[36],"are":[37],"critical":[38],"for":[39,282],"glutamine":[40,70,139,263],"in":[42,64,72,161,226,234,265],"tumor":[43],"cells.":[44],"We":[45],"found":[46],"that":[47,134,137,175,183],"the":[48,54,85,94,102,106,120,269,279],"receptor":[49,258],"tyrosine":[50,259],"kinase":[51,107,260],"EphA2":[52,83,170,192,261],"activated":[53],"TEAD":[55,153],"family":[56],"transcriptional":[57,270],"coactivators":[58,271],"YAP":[59,89,115,177,272],"TAZ":[61,91,117,274],"(YAP/TAZ),":[62],"likely":[63],"ligand-independent":[66],"manner,":[67],"promote":[69,138],"mouse":[75],"models":[76],"HER2-positive":[78,204,227],"breast":[79,167,205,228],"cancer.":[80],"Overexpression":[81],"induced":[84],"nuclear":[86,112],"accumulation":[87],"increased":[93],"expression":[95,127,171,190],"YAP/TAZ":[97,111,224],"target":[98],"genes.":[99],"Inhibition":[100],"GTPase":[103],"Rho":[104],"or":[105,116,191],"ROCK":[108],"abolished":[109],"EphA2-dependent":[110,163],"localization.":[113],"Silencing":[114],"substantially":[118],"reduced":[119],"amount":[121],"intracellular":[123],"glutamate":[124],"through":[125,223],"decreased":[126],"SLC1A5":[129,149],"GLS,":[131],"respectively,":[132],"genes":[133],"encode":[135],"proteins":[136],"uptake":[140],"metabolism.":[142],"The":[143,213,257],"regulatory":[144],"DNA":[145],"elements":[146],"both":[148],"GLS":[151,185],"contain":[152],"binding":[154],"sites":[155],"were":[157],"bound":[158],"by":[159,267],"TEAD4":[160],"an":[162],"manner.":[164],"In":[165],"patient":[166,199],"tissues,":[169],"positively":[172],"correlated":[173],"with":[174],"TAZ,":[179],"as":[180,182],"well":[181],"SLC1A5.":[187],"predicted":[193],"enhanced":[194],"metastatic":[195],"potential":[196],"poor":[198],"survival,":[200],"it":[201],"rendered":[203],"more":[208],"sensitive":[209],"inhibition.":[212],"findings":[214],"define":[215],"previously":[217],"unknown":[218],"mechanism":[219],"EphA2-mediated":[221],"glutaminolysis":[222],"activation":[225],"identify":[231],"therapeutic":[232],"targets":[233],"patients.":[235],"Citation":[236],"Format:":[237],"Deanna":[238],"N.":[239],"Edwards,":[240],"Verra":[241],"M.":[242],"Ngwa,":[243],"Shan":[244],"Wang,":[245],"Eileen":[246],"Shiuan,":[247],"Dana":[248],"Brantley-Sieders,":[249],"Laura":[250],"Kim,":[251],"Albert":[252],"B.":[253],"Reynolds,":[254],"Jin":[255],"Chen.":[256],"promotes":[262],"activating":[268],"[abstract].":[275],"In:":[276],"Proceedings":[277],"American":[280],"Association":[281],"Cancer":[283,296],"Research":[284],"Annual":[285],"Meeting":[286],"2018;":[287],"2018":[288],"Apr":[289],"14-18;":[290],"Chicago,":[291],"IL.":[292],"Philadelphia":[293],"(PA):":[294],"AACR;":[295],"Res":[297],"2018;78(13":[298],"Suppl):Abstract":[299],"nr":[300],"1452.":[301]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2018-08-22T00:00:00"}
