{"id":"https://openalex.org/W2885510049","doi":"https://doi.org/10.1002/ajoc.201800426","title":"Direct Synthesis of 2\u2010Acyl Acridines Using Aldimines and Anthranils: Evaluation of Cytotoxicity and Anti\u2010Inflammatory Activity","display_name":"Direct Synthesis of 2\u2010Acyl Acridines Using Aldimines and Anthranils: Evaluation of Cytotoxicity and Anti\u2010Inflammatory Activity","publication_year":2018,"publication_date":"2018-08-13","ids":{"openalex":"https://openalex.org/W2885510049","doi":"https://doi.org/10.1002/ajoc.201800426","mag":"2885510049"},"language":"en","primary_location":{"id":"doi:10.1002/ajoc.201800426","doi":"https://doi.org/10.1002/ajoc.201800426","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ajoc.201800426","pdf_url":null,"source":{"id":"https://openalex.org/S2491942749","display_name":"Asian Journal of Organic Chemistry","issn_l":"2193-5807","issn":["2193-5807","2193-5815"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Journal of Organic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043377947","display_name":"Saegun Kim","orcid":"https://orcid.org/0009-0002-2838-9014","observed_orcids":["https://orcid.org/0009-0002-2838-9014","https://orcid.org/0000-0002-9998-9853"]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Saegun Kim","raw_affiliation_strings":["School of Pharmacy, Sungkyunkwan University, Suwon, 16419 Republic of Korea","These authors contributed equally"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Sungkyunkwan University, Suwon, 16419 Republic of Korea","institution_ids":["https://openalex.org/I848706"]},{"raw_affiliation_string":"These authors contributed equally","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103259076","display_name":"Amit B. Kundu","orcid":"https://orcid.org/0000-0003-1004-2741","observed_orcids":["https://orcid.org/0000-0003-1004-2741"]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Amit Kundu","raw_affiliation_strings":["School of Pharmacy, Sungkyunkwan University, Suwon, 16419 Republic of Korea","These authors contributed equally"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Sungkyunkwan University, Suwon, 16419 Republic of Korea","institution_ids":["https://openalex.org/I848706"]},{"raw_affiliation_string":"These authors contributed equally","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041988749","display_name":"Rina Chun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Rina Chun","raw_affiliation_strings":["School of Pharmacy, Sungkyunkwan University, Suwon, 16419 Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Sungkyunkwan University, Suwon, 16419 Republic of Korea","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101670115","display_name":"Sang Hoon Han","orcid":"https://orcid.org/0000-0002-8311-0293","observed_orcids":["https://orcid.org/0000-0002-8311-0293","https://orcid.org/0000-0002-2016-354X"]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang Hoon Han","raw_affiliation_strings":["School of Pharmacy, Sungkyunkwan University, Suwon, 16419 Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Sungkyunkwan University, Suwon, 16419 Republic of Korea","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101791797","display_name":"Ashok Kumar Pandey","orcid":"https://orcid.org/0000-0001-7597-7500","observed_orcids":["https://orcid.org/0000-0001-7597-7500"]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ashok Kumar Pandey","raw_affiliation_strings":["School of Pharmacy, Sungkyunkwan University, Suwon, 16419 Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Sungkyunkwan University, Suwon, 16419 Republic of Korea","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043194783","display_name":"Sungin Yoo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sungin Yoo","raw_affiliation_strings":["School of Pharmacy, Sungkyunkwan University, Suwon, 16419 Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Sungkyunkwan University, Suwon, 16419 Republic of Korea","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100722734","display_name":"Junghyun Park","orcid":"https://orcid.org/0000-0002-6263-2244","observed_orcids":["https://orcid.org/0000-0002-6263-2244"]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Junghyun Park","raw_affiliation_strings":["School of Pharmacy, Sungkyunkwan University, Suwon, 16419 Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Sungkyunkwan University, Suwon, 16419 Republic of Korea","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052433739","display_name":"Hyung Sik Kim","orcid":"https://orcid.org/0000-0001-7657-3970","observed_orcids":["https://orcid.org/0000-0001-7657-3970"]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hyung Sik Kim","raw_affiliation_strings":["School of Pharmacy, Sungkyunkwan University, Suwon, 16419 Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Sungkyunkwan University, Suwon, 16419 Republic of Korea","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015158338","display_name":"Jin\u2010Mo Ku","orcid":"https://orcid.org/0000-0003-0218-810X","observed_orcids":["https://orcid.org/0000-0003-0218-810X"]},"institutions":[{"id":"https://openalex.org/I4405260488","display_name":"Gyeonggido Business and Science Accelerator","ror":"https://ror.org/03tpec229","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405260488"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jin\u2010Mo Ku","raw_affiliation_strings":["Biocenter Gyeonggido Business & Science Accelerator (GBSA) Suwon 16229 Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biocenter Gyeonggido Business & Science Accelerator (GBSA) Suwon 16229 Republic of Korea","institution_ids":["https://openalex.org/I4405260488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052727983","display_name":"In Su Kim","orcid":"https://orcid.org/0000-0002-2665-9431","observed_orcids":["https://orcid.org/0000-0002-2665-9431"]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"In Su Kim","raw_affiliation_strings":["School of Pharmacy, Sungkyunkwan University, Suwon, 16419 Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-2665-9431","affiliations":[{"raw_affiliation_string":"School of Pharmacy, Sungkyunkwan University, Suwon, 16419 Republic of Korea","institution_ids":["https://openalex.org/I848706"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015158338","https://openalex.org/A5052433739","https://openalex.org/A5052727983"],"corresponding_institution_ids":["https://openalex.org/I4405260488","https://openalex.org/I848706"],"apc_list":{"value":4030,"currency":"USD","value_usd":4030},"apc_paid":null,"fwci":0.9798,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.68655384,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"7","issue":"10","first_page":"2069","last_page":"2075"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10354","display_name":"Catalytic C\u2013H Functionalization Methods","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10354","display_name":"Catalytic C\u2013H Functionalization Methods","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12251","display_name":"Synthesis and Catalytic Reactions","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rhodium-iii-catalysis","display_name":"rhodium(III) catalysis","score":0.8149999976158142},{"id":"https://openalex.org/keywords/c-h-amination","display_name":"C\u2013H amination","score":0.9490000009536743},{"id":"https://openalex.org/keywords/aldimines","display_name":"aldimines","score":0.9710000157356262},{"id":"https://openalex.org/keywords/anthranils","display_name":"anthranils","score":0.9160000085830688},{"id":"https://openalex.org/keywords/intramolecular-cyclization","display_name":"intramolecular cyclization","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8700000047683716},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9120000004768372},{"id":"https://openalex.org/keywords/renal-carcinoma-cells","display_name":"renal carcinoma cells","score":0.796999990940094},{"id":"https://openalex.org/keywords/breast-cancer-cells","display_name":"breast cancer cells","score":0.9679999947547913},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8880000114440918},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9279999732971191},{"id":"https://openalex.org/keywords/raw-264-7-macrophages","display_name":"RAW 264.7 macrophages","score":0.9449999928474426},{"id":"https://openalex.org/keywords/doxorubicin-comparison","display_name":"doxorubicin comparison","score":0.7110000252723694},{"id":"https://openalex.org/keywords/dexamethasone-comparison","display_name":"dexamethasone comparison","score":0.9700000286102295}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9231956601142883},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.7142198085784912},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6436257362365723},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.604986846446991},{"id":"https://openalex.org/C67524406","wikidata":"https://www.wikidata.org/wiki/Q408057","display_name":"Aldimine","level":3,"score":0.5968846082687378},{"id":"https://openalex.org/C75079739","wikidata":"https://www.wikidata.org/wiki/Q1571801","display_name":"Intramolecular force","level":2,"score":0.5259920954704285},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4852764308452606},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.41327527165412903},{"id":"https://openalex.org/C2779703632","wikidata":"https://www.wikidata.org/wiki/Q581996","display_name":"Anti-inflammatory","level":2,"score":0.4124014377593994},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29821088910102844},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.25561630725860596},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.1240130066871643},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.06643718481063843},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/ajoc.201800426","doi":"https://doi.org/10.1002/ajoc.201800426","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ajoc.201800426","pdf_url":null,"source":{"id":"https://openalex.org/S2491942749","display_name":"Asian Journal of Organic Chemistry","issn_l":"2193-5807","issn":["2193-5807","2193-5815"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Journal of Organic Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1652153701","https://openalex.org/W1813333825","https://openalex.org/W1849819493","https://openalex.org/W1949559959","https://openalex.org/W1964616795","https://openalex.org/W1983356092","https://openalex.org/W1998763573","https://openalex.org/W2001124223","https://openalex.org/W2029987088","https://openalex.org/W2039124321","https://openalex.org/W2050640183","https://openalex.org/W2060650434","https://openalex.org/W2069483854","https://openalex.org/W2071069876","https://openalex.org/W2078831149","https://openalex.org/W2109689528","https://openalex.org/W2126201149","https://openalex.org/W2139376946","https://openalex.org/W2139474242","https://openalex.org/W2204286420","https://openalex.org/W2311483858","https://openalex.org/W2322705312","https://openalex.org/W2323997881","https://openalex.org/W2342398302","https://openalex.org/W2417851625","https://openalex.org/W2418991601","https://openalex.org/W2558057658","https://openalex.org/W2569012662","https://openalex.org/W2581496864","https://openalex.org/W2594684291","https://openalex.org/W2607420241","https://openalex.org/W2615835201","https://openalex.org/W2743907213","https://openalex.org/W2776260466","https://openalex.org/W2807816850","https://openalex.org/W2952838883","https://openalex.org/W2952897157"],"related_works":["https://openalex.org/W2654096432","https://openalex.org/W2743893443","https://openalex.org/W2607420241","https://openalex.org/W2950400183","https://openalex.org/W2172682163","https://openalex.org/W2411359198","https://openalex.org/W7018958030","https://openalex.org/W2058946848","https://openalex.org/W2396051665","https://openalex.org/W2035825571"],"abstract_inverted_index":{"Abstract":[0],"Rhodium":[1],"(III)\u2010catalyzed":[2],"C\u2212H":[3],"aminations":[4],"of":[5,21,73,132],"aldimines":[6],"with":[7,99],"anthranils":[8],"followed":[9],"by":[10],"intramolecular":[11],"cyclization":[12],"are":[13,25,123],"described.":[14],"These":[15],"transformations":[16],"facilitate":[17],"the":[18,63,133],"efficient":[19],"generation":[20],"2\u2010acyl":[22,37],"acridines,":[23],"which":[24,68],"important":[26],"motifs":[27],"found":[28,117],"in":[29,91],"bioactive":[30],"natural":[31],"products":[32],"and":[33,51,53,77,112],"pharmaceuticals.":[34],"All":[35],"synthesized":[36],"acridines":[38],"were":[39,87,116],"first":[40],"screened":[41],"for":[42,89],"cytotoxic":[43,66],"activity":[44,94],"against":[45,75],"human":[46,54],"renal":[47],"carcinoma":[48,56],"cells":[49,57],"(CAKI\u20101":[50],"786\u2010O)":[52],"breast":[55],"(MCF\u20107).":[58],"Compound":[59],"3":[60,108,110,113],"z":[61],"showed":[62],"most":[64],"potent":[65,85,129],"activity,":[67],"is":[69],"stronger":[70],"than":[71,130],"that":[72,83,122,131],"doxorubicin":[74],"CAKI\u20101":[76],"786\u2010O":[78],"cells.":[79,103],"In":[80],"addition,":[81],"compounds":[82,105],"exhibited":[84],"cytotoxicities":[86],"selected":[88],"further":[90],"vitro":[92],"anti\u2010inflammatory":[93,134],"testing":[95],"using":[96],"interleukin\u20106":[97],"(IL\u20106)":[98],"lipopolysaccharide":[100],"(LPS)\u2010induced":[101],"RAW264.7":[102],"Notably,":[104],"(3":[106],"k,":[107],"n,":[109],"s":[111],"x\u20133":[114],"z)":[115],"to":[118,126],"exhibit":[119],"inhibitory":[120],"activities":[121],"about":[124],"two\u2010":[125],"three\u2010times":[127],"more":[128],"drug":[135],"dexamethasone.":[136]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2018-08-22T00:00:00"}