{"id":"https://openalex.org/W2885412941","doi":"https://doi.org/10.1158/1538-7445.am2018-sy22-02","title":"Abstract SY22-02: Metabolic vulnerability of PTEN mutant cancer","display_name":"Abstract SY22-02: Metabolic vulnerability of PTEN mutant cancer","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2885412941","doi":"https://doi.org/10.1158/1538-7445.am2018-sy22-02","mag":"2885412941"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2018-sy22-02","doi":"https://doi.org/10.1158/1538-7445.am2018-sy22-02","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-sy22-02","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082690187","display_name":"Ramon E. Parsons","orcid":"https://orcid.org/0000-0002-6656-3514","observed_orcids":["https://orcid.org/0000-0002-6656-3514"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ramon E. Parsons","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5082690187"],"corresponding_institution_ids":["https://openalex.org/I98704320"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":"13_Supplement","first_page":"SY22","last_page":"02"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.5458999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.5458999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.3456999957561493,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.039799999445676804,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.75},{"id":"https://openalex.org/keywords/metabolic-vulnerability","display_name":"metabolic vulnerability","score":0.8859999775886536},{"id":"https://openalex.org/keywords/de-novo-pyrimidine-synthesis","display_name":"de novo pyrimidine biosynthesis","score":0.8759999871253967},{"id":"https://openalex.org/keywords/dhodh-inhibition","display_name":"DHODH inhibition","score":0.8610000014305115},{"id":"https://openalex.org/keywords/atr-signaling","display_name":"ATR signaling","score":0.7350000143051147},{"id":"https://openalex.org/keywords/topbp1","display_name":"TopBP1","score":0.8519999980926514},{"id":"https://openalex.org/keywords/chk1","display_name":"Chk1","score":0.9819999933242798},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.7720000147819519},{"id":"https://openalex.org/keywords/uridine","display_name":"uridine","score":0.7590000033378601},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.7710000276565552},{"id":"https://openalex.org/keywords/chromosome-breakage","display_name":"chromosome breakage","score":0.5329999923706055},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.9216856956481934},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.578336775302887},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5373967885971069},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4968552887439728},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.48688021302223206},{"id":"https://openalex.org/C186000732","wikidata":"https://www.wikidata.org/wiki/Q6881914","display_name":"Mitotic catastrophe","level":4,"score":0.4830087423324585},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.4453691244125366},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4351648688316345},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.27156326174736023},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21575337648391724},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.1869640052318573}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2018-sy22-02","doi":"https://doi.org/10.1158/1538-7445.am2018-sy22-02","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-sy22-02","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2590621600","https://openalex.org/W3004950633","https://openalex.org/W3126203997","https://openalex.org/W4400299317","https://openalex.org/W2531713070","https://openalex.org/W3033644676","https://openalex.org/W2949911367","https://openalex.org/W2080595478","https://openalex.org/W2322234107","https://openalex.org/W4296379008"],"abstract_inverted_index":{"Abstract":[0],"Signaling":[1],"pathways":[2,15,48],"that":[3,49,83,114,147,156,167,192],"act":[4],"as":[5],"drivers":[6],"of":[7,27,45,54,57,71,78,92,100,110,131,140,144,151,171,182,188,210,240,256,268,275],"cancer":[8,271],"cell":[9,24,124,205,213],"growth":[10],"and":[11,32,37,75,123,176,179,190,204,237],"proliferation":[12],"activate":[13],"metabolic":[14,47],"required":[16,22],"to":[17,34,40,117,129,149,160,208,218,222,242,254],"generate":[18],"the":[19,46,60,138,141,145,199,233,276],"building":[20],"blocks":[21],"for":[23,279],"doubling.":[25],"Loss":[26],"PTEN":[28,58,66,111,152,183,216,226,250,269],"activates":[29],"PI3K,":[30],"AKT":[31,197],"mTOR":[33],"stimulate":[35],"glucose":[36],"glutamine":[38],"flux":[39,239],"allow":[41],"DNA":[42,73,105,202,245],"replication.":[43],"One":[44],"is":[50,59],"activated":[51,172],"after":[52],"deletion":[53],"both":[55],"alleles":[56],"de":[61,93,257],"novo":[62,94,258],"pyrimidine":[63,95,259],"synthesis":[64,96],"pathway.":[65],"null":[67,112,153,184],"cells":[68,113,154,185,200,229,252],"show":[69],"evidence":[70],"increased":[72,104,238],"replication":[74,81,108,165,247],"low":[76],"levels":[77],"damage":[79,106,203],"at":[80,107,164,246],"forks":[82,109,166,248],"can":[84],"be":[85,194,219],"rescued":[86,134,198],"by":[87,196],"providing":[88],"supplementary":[89],"uridine.":[90],"Interruption":[91],"with":[97,135,186],"an":[98],"inhibitor":[99],"dihydroorotate":[101],"dehydrogenase":[102],"(DHODH)":[103],"ultimately":[115],"led":[116,148],"chromosome":[118],"breaks":[119],"detected":[120],"in":[121],"mitosis":[122],"death.":[125],"This":[126],"cellular":[127],"vulnerability":[128,150,267],"inhibition":[130,209,224],"DHODH":[132,223],"was":[133,158,168],"uridine,":[136],"demonstrating":[137],"specificity":[139],"effect.":[142],"Exploration":[143],"mechanism":[146],"demonstrated":[155],"it":[157],"due":[159,207],"defective":[161],"ATR":[162,235],"signaling":[163,236],"a":[169],"consequence":[170],"AKT,":[173],"which":[174],"phosphorylate":[175],"attenuate":[177],"TOPBP1":[178,189],"CHK1.":[180],"Complementation":[181],"mutants":[187],"CHK1":[191],"cannot":[193],"phosphorylated":[195],"from":[201],"death":[206],"DHODH.":[211],"Tumor":[212],"lines":[214],"lacking":[215],"tended":[217],"more":[220],"sensitive":[221],"than":[225],"wild":[227],"type":[228],"were.":[230],"In":[231],"conclusion,":[232],"attenuated":[234],"nucleotides":[241],"newly":[243],"synthesized":[244],"makes":[249],"mutant":[251,270],"vulnerable":[253],"disruption":[255],"synthesis.":[260],"Citation":[261],"Format:":[262],"Ramon":[263],"E.":[264],"Parsons.":[265],"Metabolic":[266],"[abstract].":[272],"In:":[273],"Proceedings":[274],"American":[277],"Association":[278],"Cancer":[280,293],"Research":[281],"Annual":[282],"Meeting":[283],"2018;":[284],"2018":[285],"Apr":[286],"14-18;":[287],"Chicago,":[288],"IL.":[289],"Philadelphia":[290],"(PA):":[291],"AACR;":[292],"Res":[294],"2018;78(13":[295],"Suppl):Abstract":[296],"nr":[297],"SY22-02.":[298]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2018-08-22T00:00:00"}