{"id":"https://openalex.org/W2885304558","doi":"https://doi.org/10.1186/s12934-018-0968-x","title":"High-throughput optimization of medium components and culture conditions for the efficient production of a lipopeptide pseudofactin by Pseudomonas fluorescens BD5","display_name":"High-throughput optimization of medium components and culture conditions for the efficient production of a lipopeptide pseudofactin by Pseudomonas fluorescens BD5","publication_year":2018,"publication_date":"2018-08-04","ids":{"openalex":"https://openalex.org/W2885304558","doi":"https://doi.org/10.1186/s12934-018-0968-x","mag":"2885304558","pmid":"https://pubmed.ncbi.nlm.nih.gov/30077177","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6076405"},"language":"en","primary_location":{"id":"doi:10.1186/s12934-018-0968-x","doi":"https://doi.org/10.1186/s12934-018-0968-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12934-018-0968-x","pdf_url":"https://microbialcellfactories.biomedcentral.com/track/pdf/10.1186/s12934-018-0968-x","source":{"id":"https://openalex.org/S171368329","display_name":"Microbial Cell Factories","issn_l":"1475-2859","issn":["1475-2859"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Cell Factories","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://microbialcellfactories.biomedcentral.com/track/pdf/10.1186/s12934-018-0968-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030908856","display_name":"Piotr Biniarz","orcid":"https://orcid.org/0000-0001-6368-8218","observed_orcids":["https://orcid.org/0000-0001-6368-8218"]},"institutions":[{"id":"https://openalex.org/I219388962","display_name":"University of Wroc\u0142aw","ror":"https://ror.org/00yae6e25","country_code":"PL","type":"education","lineage":["https://openalex.org/I219388962"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Piotr Biniarz","raw_affiliation_strings":["Department of Biotransformation, Faculty of Biotechnology, University of Wroclaw, Joliot-Curie 14a, 50-383, Wroclaw, Poland","University of Wroclaw (Poland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotransformation, Faculty of Biotechnology, University of Wroclaw, Joliot-Curie 14a, 50-383, Wroclaw, Poland","institution_ids":["https://openalex.org/I219388962"]},{"raw_affiliation_string":"University of Wroclaw (Poland)","institution_ids":["https://openalex.org/I219388962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089592491","display_name":"Fran\u00e7ois Coutte","orcid":"https://orcid.org/0000-0002-5233-1181","observed_orcids":["https://orcid.org/0000-0002-5233-1181"]},"institutions":[{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I4210091574","display_name":"Institut Charles Viollette","ror":"https://ror.org/0018c4h73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2279609970","https://openalex.org/I2802487185","https://openalex.org/I4210091574","https://openalex.org/I4210116330","https://openalex.org/I44563897"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"funder","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Coutte","raw_affiliation_strings":["Univ. Lille, INRA, ISA, Univ. Artois, Univ. Littoral C\u00f4te d'Opale, EA 7394-ICV Institut Charles Viollette, 59000, Lille, France","INRA - Institut National de la Recherche Agronomique (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Lille, INRA, ISA, Univ. Artois, Univ. Littoral C\u00f4te d'Opale, EA 7394-ICV Institut Charles Viollette, 59000, Lille, France","institution_ids":["https://openalex.org/I2279609970","https://openalex.org/I4210091574","https://openalex.org/I4387154544"]},{"raw_affiliation_string":"INRA - Institut National de la Recherche Agronomique (France)","institution_ids":["https://openalex.org/I4387154544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036490846","display_name":"Fr\u00e9d\u00e9rique Gancel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I4210091574","display_name":"Institut Charles Viollette","ror":"https://ror.org/0018c4h73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2279609970","https://openalex.org/I2802487185","https://openalex.org/I4210091574","https://openalex.org/I4210116330","https://openalex.org/I44563897"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"funder","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9rique Gancel","raw_affiliation_strings":["Univ. Lille, INRA, ISA, Univ. Artois, Univ. Littoral C\u00f4te d'Opale, EA 7394-ICV Institut Charles Viollette, 59000, Lille, France","INRA - Institut National de la Recherche Agronomique (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Lille, INRA, ISA, Univ. Artois, Univ. Littoral C\u00f4te d'Opale, EA 7394-ICV Institut Charles Viollette, 59000, Lille, France","institution_ids":["https://openalex.org/I2279609970","https://openalex.org/I4210091574","https://openalex.org/I4387154544"]},{"raw_affiliation_string":"INRA - Institut National de la Recherche Agronomique (France)","institution_ids":["https://openalex.org/I4387154544"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050735077","display_name":"Marcin \u0141ukaszewicz","orcid":"https://orcid.org/0000-0002-1453-8376","observed_orcids":["https://orcid.org/0000-0002-1453-8376"]},"institutions":[{"id":"https://openalex.org/I219388962","display_name":"University of Wroc\u0142aw","ror":"https://ror.org/00yae6e25","country_code":"PL","type":"education","lineage":["https://openalex.org/I219388962"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Marcin \u0141ukaszewicz","raw_affiliation_strings":["Department of Biotransformation, Faculty of Biotechnology, University of Wroclaw, Joliot-Curie 14a, 50-383, Wroclaw, Poland. marcin.lukaszewicz@uwr.edu.pl","University of Wroclaw (Poland)"],"raw_orcid":"https://orcid.org/0000-0002-1453-8376","affiliations":[{"raw_affiliation_string":"Department of Biotransformation, Faculty of Biotechnology, University of Wroclaw, Joliot-Curie 14a, 50-383, Wroclaw, Poland. marcin.lukaszewicz@uwr.edu.pl","institution_ids":["https://openalex.org/I219388962"]},{"raw_affiliation_string":"University of Wroclaw (Poland)","institution_ids":["https://openalex.org/I219388962"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5050735077"],"corresponding_institution_ids":["https://openalex.org/I219388962"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":{"value":3590,"currency":"USD","value_usd":3590},"fwci":1.8877,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.84664459,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"17","issue":"1","first_page":"121","last_page":"121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10324","display_name":"Microbial bioremediation and biosurfactants","score":0.7788000106811523,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10324","display_name":"Microbial bioremediation and biosurfactants","score":0.7788000106811523,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.15279999375343323,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipopeptides","display_name":"lipopeptides","score":0.8960000276565552},{"id":"https://openalex.org/keywords/biosurfactants","display_name":"biosurfactants","score":0.9879999756813049},{"id":"https://openalex.org/keywords/pseudomonas-fluorescens","display_name":"Pseudomonas fluorescens","score":0.9359999895095825},{"id":"https://openalex.org/keywords/culture-medium-optimization","display_name":"culture medium optimization","score":0.8790000081062317},{"id":"https://openalex.org/keywords/plackett-burman-design","display_name":"Plackett-Burman design","score":0.8009999990463257},{"id":"https://openalex.org/keywords/central-composite-design","display_name":"central composite design","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glycerol-supplementation","display_name":"glycerol supplementation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/amino-acid-supplementation","display_name":"amino acid supplementation","score":0.8360000252723694},{"id":"https://openalex.org/keywords/leucine","display_name":"leucine","score":0.902999997138977},{"id":"https://openalex.org/keywords/valine","display_name":"valine","score":0.996999979019165},{"id":"https://openalex.org/keywords/tryptone","display_name":"tryptone","score":0.8370000123977661},{"id":"https://openalex.org/keywords/aeration","display_name":"aeration","score":0.9240000247955322},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6679999828338623},{"id":"https://openalex.org/keywords/emulsification","display_name":"emulsification","score":0.5889999866485596},{"id":"https://openalex.org/keywords/foaming-activity","display_name":"foaming activity","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C2776835041","wikidata":"https://www.wikidata.org/wiki/Q135292","display_name":"Pseudomonas fluorescens","level":3,"score":0.8572524785995483},{"id":"https://openalex.org/C2777425210","wikidata":"https://www.wikidata.org/wiki/Q2903964","display_name":"Lipopeptide","level":3,"score":0.8350591659545898},{"id":"https://openalex.org/C2777573094","wikidata":"https://www.wikidata.org/wiki/Q483752","display_name":"Valine","level":3,"score":0.6046854853630066},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5247067213058472},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.425568163394928},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38855504989624023},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3487127125263214},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.33668217062950134},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.32185912132263184},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31537574529647827},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D011551","descriptor_name":"Pseudomonas fluorescens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013501","descriptor_name":"Surface-Active Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055666","descriptor_name":"Lipopeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1186/s12934-018-0968-x","doi":"https://doi.org/10.1186/s12934-018-0968-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12934-018-0968-x","pdf_url":"https://microbialcellfactories.biomedcentral.com/track/pdf/10.1186/s12934-018-0968-x","source":{"id":"https://openalex.org/S171368329","display_name":"Microbial Cell Factories","issn_l":"1475-2859","issn":["1475-2859"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Cell Factories","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5028810","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6076405","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6076405","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6076405","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microb Cell Fact","raw_type":"Text"},{"id":"pmid:30077177","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30077177","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial cell factories","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-02626261v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.inrae.fr/hal-02626261","pdf_url":"https://hal.inrae.fr/hal-02626261v1/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Microbial Cell Factories, 2018, 17, pp.1-18. ⟨10.1186/s12934-018-0968-x⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-03886670v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.univ-lille.fr/hal-03886670","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Microbial Cell Factories, 2018, 17 (1), pp.121. ⟨10.1186/s12934-018-0968-x⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:8bbad1dd29614c009273a4ca6064db24","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8bbad1dd29614c009273a4ca6064db24","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Microbial Cell Factories, Vol 17, Iss 1, Pp 1-18 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12934-018-0968-x","doi":"https://doi.org/10.1186/s12934-018-0968-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12934-018-0968-x","pdf_url":"https://microbialcellfactories.biomedcentral.com/track/pdf/10.1186/s12934-018-0968-x","source":{"id":"https://openalex.org/S171368329","display_name":"Microbial Cell Factories","issn_l":"1475-2859","issn":["1475-2859"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Cell Factories","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1888088267","display_name":null,"funder_award_id":"2014-2020\u2019","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G1953887145","display_name":null,"funder_award_id":"2014\u20102020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2415866787","display_name":null,"funder_award_id":"ANR-11-EQPX-0037","funder_id":"https://openalex.org/F4320326227","funder_display_name":"R\u00e9gion Hauts-de-France"},{"id":"https://openalex.org/G241839593","display_name":null,"funder_award_id":"2016/20/T/NZ1/00536","funder_id":"https://openalex.org/F4320322511","funder_display_name":"Narodowe Centrum Nauki"},{"id":"https://openalex.org/G3133105334","display_name":null,"funder_award_id":"2016/21/N/NZ1/02829","funder_id":"https://openalex.org/F4320322511","funder_display_name":"Narodowe Centrum Nauki"},{"id":"https://openalex.org/G4205382568","display_name":null,"funder_award_id":"ANR-11-EQPX-0037","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G5311873022","display_name":"Plateforme int\u00e9gREe AppLiqu\u00e9e au criblage haut d\u00e9bit de CATalyseurs pour les bioraffineries","funder_award_id":"ANR-11-EQPX-0037","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G7972033715","display_name":null,"funder_award_id":"ANR-11-EQPX-0037","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320316137","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320322511","display_name":"Narodowe Centrum Nauki","ror":"https://ror.org/03ha2q922"},{"id":"https://openalex.org/F4320322650","display_name":"Narodowym Centrum Nauki","ror":"https://ror.org/03ha2q922"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"},{"id":"https://openalex.org/F4320326227","display_name":"R\u00e9gion Hauts-de-France","ror":null},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320335327","display_name":"Krajowy Naukowy Osrodek Wiodacy","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2885304558.pdf","grobid_xml":"https://content.openalex.org/works/W2885304558.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1531654029","https://openalex.org/W1581154118","https://openalex.org/W1763493835","https://openalex.org/W1844865274","https://openalex.org/W1846335002","https://openalex.org/W1856219842","https://openalex.org/W1893791156","https://openalex.org/W1975747950","https://openalex.org/W1978609583","https://openalex.org/W1978662438","https://openalex.org/W1979463199","https://openalex.org/W1982890083","https://openalex.org/W1985064640","https://openalex.org/W1994402826","https://openalex.org/W1997109383","https://openalex.org/W1998835867","https://openalex.org/W1999890035","https://openalex.org/W2004411008","https://openalex.org/W2011700260","https://openalex.org/W2017422800","https://openalex.org/W2021045389","https://openalex.org/W2024949703","https://openalex.org/W2045919907","https://openalex.org/W2049393964","https://openalex.org/W2051330990","https://openalex.org/W2056959588","https://openalex.org/W2064336821","https://openalex.org/W2065728777","https://openalex.org/W2073431842","https://openalex.org/W2074887819","https://openalex.org/W2078064123","https://openalex.org/W2086338959","https://openalex.org/W2088464751","https://openalex.org/W2090154954","https://openalex.org/W2092237875","https://openalex.org/W2096178424","https://openalex.org/W2110832756","https://openalex.org/W2126101664","https://openalex.org/W2126184950","https://openalex.org/W2130812432","https://openalex.org/W2134878666","https://openalex.org/W2146402498","https://openalex.org/W2148310323","https://openalex.org/W2162522694","https://openalex.org/W2166501045","https://openalex.org/W2168999294","https://openalex.org/W2253092623","https://openalex.org/W2337765461","https://openalex.org/W2468042444","https://openalex.org/W2473045471","https://openalex.org/W2475326573","https://openalex.org/W2515422683","https://openalex.org/W2604915145","https://openalex.org/W2606965854","https://openalex.org/W2620480471","https://openalex.org/W2642679254","https://openalex.org/W2744022891","https://openalex.org/W2767176835","https://openalex.org/W4231461371","https://openalex.org/W4387952076"],"related_works":["https://openalex.org/W6902369118","https://openalex.org/W2049393964","https://openalex.org/W3110452324","https://openalex.org/W2793802885","https://openalex.org/W2600806472","https://openalex.org/W6981076094","https://openalex.org/W4247222144","https://openalex.org/W2208534853","https://openalex.org/W2889620338","https://openalex.org/W4377043009"],"abstract_inverted_index":{"Lipopeptides":[0],"are":[1,15,32,51,164,248],"a":[2,63,108,198],"promising":[3],"group":[4],"of":[5,8,24,40,49,105,122,200,228,243,261,265,275,302],"surface-active":[6],"compounds":[7],"microbial":[9],"origin":[10],"(biosurfactants).":[11],"These":[12],"diverse":[13],"molecules":[14,39],"produced":[16,65,201,283],"mainly":[17,52,170],"by":[18,66],"Bacillus":[19],"and":[20,28,37,56,79,84,91,100,125,154,181,237,253,277,299],"Pseudomonas":[21,67],"strains.":[22],"Because":[23],"their":[25,53,254,278],"attractive":[26],"physiochemical":[27],"biological":[29,300],"properties,":[30],"biosurfactants":[31,50,276],"considered":[33],"to":[34,147,206,271,292],"be":[35,290],"\u201cgreen":[36],"versatile":[38],"the":[41,195,226,262,272,294,297],"future\u201d.":[42],"The":[43],"main":[44],"obstacles":[45],"in":[46,107,138,197,204,259],"widespread":[47,279],"use":[48],"low":[54],"yields":[55,256],"high":[57,171,189,255],"production":[58,104,130,137,252,263,274],"costs.":[59],"Pseudofactin":[60],"(PF)":[61],"is":[62],"lipopeptide":[64,251,285],"fluorescens":[68,133],"BD5.":[69,134],"Recently,":[70],"we":[71,117,159,282],"identified":[72,160],"two":[73,229],"analogues,":[74],"PF1":[75,221],"(C":[76,81,234,239],"16":[77,82],"-Val)":[78,236],"PF2":[80,87,215],"-Leu),":[83],"reported":[85,225],"that":[86,163,247,288],"has":[88],"good":[89],"emulsification":[90],"foaming":[92],"activities,":[93],"as":[94,96,186,188],"well":[95,187],"antibacterial,":[97],"antifungal,":[98],"anticancer,":[99],"antiadhesive":[101],"properties.":[102],"Reported":[103],"PF":[106,129,141,168,202,231],"mineral":[109],"salt":[110],"medium":[111,124],"was":[112],"approximately":[113],"10":[114],"mg/L.":[115,151],"Here,":[116],"report":[118],"successful":[119],"high-throughput":[120],"optimization":[121],"culture":[123,190,245],"conditions":[126],"for":[127,166,250],"efficient":[128,167],"using":[131],"P.":[132],"Compared":[135],"with":[136,175,208],"minimal":[139],"medium,":[140],"yield":[142],"increased":[143],"almost":[144],"120-fold,":[145],"up":[146],"1187":[148],"\u00b1":[149],"13.0":[150],"Using":[152],"Plackett\u2013Burman":[153],"central":[155],"composite":[156],"design":[157],"methodologies":[158],"critical":[161,244],"factors":[162],"important":[165,249],"production,":[169,216],"glycerol":[172],"concentration,":[173],"supplementation":[174,207],"amino":[176,210],"acids":[177],"(leucine":[178],"or":[179],"valine)":[180],"complex":[182],"additives":[183],"(e.g.":[184],"tryptone),":[185],"aeration.":[191],"We":[192,223],"also":[193,224],"detected":[194],"shift":[196],"ratio":[199],"analogues":[203,287],"response":[205],"different":[209],"acids.":[211],"Leucine":[212],"strongly":[213],"induces":[214],"while":[217],"valine":[218],"addition":[219],"supports":[220],"production.":[222],"identification":[227],"new":[230,284],"analogues:":[232],"PF3":[233],"18":[235,240],"PF4":[238],"-Leu).":[241],"Identification":[242],"parameters":[246],"can":[257,289],"result":[258],"reduction":[260],"costs":[264],"these":[266],"molecules.":[267],"This":[268],"may":[269],"lead":[270],"industrial-scale":[273],"use.":[280],"Moreover,":[281],"pure":[286],"used":[291],"investigate":[293],"relationship":[295],"between":[296],"structure":[298],"activity":[301],"lipopeptides.":[303]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-08-22T00:00:00"}