{"id":"https://openalex.org/W2885122913","doi":"https://doi.org/10.1158/1538-7445.am2018-4931","title":"Abstract 4931: Enhanced oral bioavailability of 3,3'-diindolylmethane administered in a self-microemulsifying drug delivery system (SMEDDS)","display_name":"Abstract 4931: Enhanced oral bioavailability of 3,3'-diindolylmethane administered in a self-microemulsifying drug delivery system (SMEDDS)","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2885122913","doi":"https://doi.org/10.1158/1538-7445.am2018-4931","mag":"2885122913"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2018-4931","doi":"https://doi.org/10.1158/1538-7445.am2018-4931","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-4931","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004551947","display_name":"William D. Johnson","orcid":"https://orcid.org/0000-0002-3823-4094","observed_orcids":["https://orcid.org/0000-0002-3823-4094"]},"institutions":[{"id":"https://openalex.org/I1310264347","display_name":"IIT Research Institute","ror":"https://ror.org/057jp7h82","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1310264347"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William D. Johnson","raw_affiliation_strings":["1IIT Research Institute, Chicago, IL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1IIT Research Institute, Chicago, IL;","institution_ids":["https://openalex.org/I1310264347"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021438494","display_name":"Miguel Muzzio","orcid":"https://orcid.org/0000-0002-1287-7294","observed_orcids":["https://orcid.org/0000-0002-1287-7294"]},"institutions":[{"id":"https://openalex.org/I1310264347","display_name":"IIT Research Institute","ror":"https://ror.org/057jp7h82","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1310264347"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miguel Muzzio","raw_affiliation_strings":["1IIT Research Institute, Chicago, IL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1IIT Research Institute, Chicago, IL;","institution_ids":["https://openalex.org/I1310264347"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101491683","display_name":"Thomas L. Horn","orcid":"https://orcid.org/0000-0003-2380-1903","observed_orcids":["https://orcid.org/0000-0003-2380-1903"]},"institutions":[{"id":"https://openalex.org/I1310264347","display_name":"IIT Research Institute","ror":"https://ror.org/057jp7h82","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1310264347"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas L. Horn","raw_affiliation_strings":["1IIT Research Institute, Chicago, IL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1IIT Research Institute, Chicago, IL;","institution_ids":["https://openalex.org/I1310264347"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058884720","display_name":"Michael A. Zeligs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael A. Zeligs","raw_affiliation_strings":["2BioResponse, LLC, Boulder, CO;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2BioResponse, LLC, Boulder, CO;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091094247","display_name":"Elizabeth R. Glaze","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth R. Glaze","raw_affiliation_strings":["3National Cancer Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012424500","display_name":"David L. McCormick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1310264347","display_name":"IIT Research Institute","ror":"https://ror.org/057jp7h82","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1310264347"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L. McCormick","raw_affiliation_strings":["1IIT Research Institute, Chicago, IL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1IIT Research Institute, Chicago, IL;","institution_ids":["https://openalex.org/I1310264347"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":"13_Supplement","first_page":"4931","last_page":"4931"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10411","display_name":"Proteins in Food Systems","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/3-3-diindolylmethane","display_name":"3,3'-diindolylmethane","score":0.972000002861023},{"id":"https://openalex.org/keywords/self-microemulsifying-drug-delivery-system","display_name":"self-microemulsifying drug delivery system","score":0.9850000143051147},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.6639999747276306},{"id":"https://openalex.org/keywords/microencapsulation","display_name":"microencapsulation","score":0.5910000205039978},{"id":"https://openalex.org/keywords/lipid-based-drug-delivery-systems","display_name":"lipid-based drug delivery","score":0.6909999847412109},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.8379999995231628},{"id":"https://openalex.org/keywords/indole-derivatives","display_name":"indole derivatives","score":0.47099998593330383},{"id":"https://openalex.org/keywords/bioavailability-enhancement","display_name":"bioavailability enhancement","score":0.5479999780654907},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.5070000290870667},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.5400000214576721},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.48899999260902405},{"id":"https://openalex.org/keywords/lipophilic-drug-solubility","display_name":"lipophilic drug solubility","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.9313211441040039},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7614459991455078},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7013019323348999},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6552985310554504},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5996268391609192},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.5613916516304016},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5293346643447876},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.506773054599762},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.4955817461013794},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.42925459146499634},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34583741426467896},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.06064695119857788},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.05858370661735535},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2018-4931","doi":"https://doi.org/10.1158/1538-7445.am2018-4931","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-4931","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2043810138","https://openalex.org/W4282978097","https://openalex.org/W2462943904","https://openalex.org/W2042591945","https://openalex.org/W4391431154","https://openalex.org/W2164690076","https://openalex.org/W1620184170","https://openalex.org/W2599692244","https://openalex.org/W1967939998","https://openalex.org/W1999748605"],"abstract_inverted_index":{"Abstract":[0],"3,3'-diindolylmethane":[1,450],"(DIM)":[2],"is":[3,32,49],"a":[4,65,123,134,141,148,158,174,453],"stable,":[5],"water-insoluble":[6],"indole":[7],"that":[8,24,335,375],"demonstrates":[9],"chemopreventive":[10,395],"activity":[11,46],"in":[12,37,40,43,86,115,122,264,270,283,296,310,318,353,367,452],"several":[13],"preclinical":[14],"models":[15],"for":[16,245,326,336,419,466],"human":[17],"cancer.":[18],"Although":[19],"clinical":[20],"data":[21,373],"have":[22],"shown":[23],"the":[25,42,70,90,107,116,222,265,271,275,286,324,327,337,356,387,394,407,415,424,463],"safety":[26],"profile":[27],"of":[28,47,73,110,139,151,161,166,178,185,189,192,239,259,291,330,362,380,391,397,409,417,449,462],"absorption-enhanced,":[29],"microencapsulated":[30,142,300,322,338,370],"DIM":[31,48,111,143,152,168,246,260,281,294,308,316,331,339,351,365,381,398,418],"consistent":[33],"with":[34,76,299,321],"its":[35,113,230],"use":[36,408],"cancer":[38,420],"chemoprevention":[39],"humans,":[41],"vivo":[44],"biological":[45],"limited":[50,402],"by":[51,120,173,248,385,403],"poor":[52,77,404],"solubility":[53,94],"and":[54,95,112,187,203,212,229,236,243,250,345,377],"very":[55],"low":[56],"oral":[57,78,108,136,257,405,447],"bioavailability.":[58,79],"Self-Microemulsifying":[59],"Drug":[60],"Delivery":[61],"Systems":[62],"(SMEDDS)":[63,458],"provide":[64,181],"novel":[66],"approach":[67],"to":[68,104,180,400],"improving":[69],"systemic":[71,97],"delivery":[72,456],"lipophilic":[74],"agents":[75],"Lipid-based":[80],"SMEDDS":[81,125,149,266,287,328,357,389,410],"formulations":[82],"form":[83],"oil-in-water":[84],"microemulsions":[85,91],"aqueous":[87],"gastric":[88],"fluid;":[89],"increase":[92,414],"drug":[93,455],"improve":[96],"absorption.":[98],"The":[99,256],"present":[100],"study":[101],"was":[102,170,218,227,232,261,332],"performed":[103],"determine":[105],"if":[106],"bioavailability":[109,258,448],"levels":[114,282,295,309,317,352,366,379],"prostate":[117,231,240,350,364,378],"are":[118],"increased":[119,384],"administration":[121,165],"DIM-specific":[124],"formulation.":[126,340],"Fifteen":[127],"male":[128],"CD":[129],"rats":[130,194,284,297,312,319,354,368],"per":[131,195],"group":[132,196],"received":[133,157],"single":[135],"(gavage)":[137],"dose":[138,160,177],"either":[140],"formulation":[144,150,169,268,288,329,358,390,411],"(BR-DIM\u00ae,":[145],"BioResponse)":[146],"or":[147],"(BR-9001,":[153],"BioResponse).":[154],"Both":[155],"groups":[156],"DIM-equivalent":[159],"30":[162],"mg/kg.":[163],"Gavage":[164],"each":[167,216,225],"immediately":[171],"followed":[172],"second":[175,223],"gavage":[176],"saline":[179],"uniform":[182],"intragastric":[183],"emulsification":[184],"BR-9001":[186,267,388],"suspension":[188],"BR-DIM.":[190,301,371],"Cohorts":[191],"three":[193],"were":[197,241,254,289,359],"bled":[198,219],"at":[199,204,274,342],"time":[200],"0":[201],"(pre-dose)":[202],"0.25,":[205],"0.5,":[206],"0.75,":[207],"1.0,":[208],"2.0,":[209],"4.0,":[210],"8.0,":[211],"24":[213],"hours":[214,304,347],"post-dosing;":[215],"rat":[217,226],"twice.":[220],"After":[221],"bleed,":[224],"euthanized":[228],"collected.":[233],"Plasma":[234],"samples":[235,238],"weighed":[237],"extracted":[242],"analyzed":[244],"content":[247],"LC-MS/MS,":[249],"plasma":[251,280,293,307,315,376],"pharmacokinetics":[252],"parameters":[253],"calculated.":[255],"substantially":[262],"greater":[263],"than":[269],"BR-DIM":[272],"formulation:":[273],"Tmax":[276],"(30":[277],"min),":[278],"mean":[279,292,349,363],"receiving":[285,355,369],">400%":[290],"dosed":[298],"For":[302],"four":[303],"after":[305],"dosing,":[306],"SMEDDS-treated":[311],"remained":[313],"above":[314],"treated":[320],"DIM;":[323],"AUC":[325],"approximately":[333,360],"twice":[334],"Similarly,":[341],"2,":[343],"4,":[344],"6":[346],"post-dosing,":[348],"200%":[361],"These":[372],"demonstrate":[374],"can":[382],"be":[383,401],"using":[386],"DIM.":[392],"Because":[393],"efficacy":[396,416],"appears":[399],"bioavailability,":[406],"technology":[412],"may":[413],"chemoprevention.":[421],"[HHSN261201500024I":[422],"from":[423],"NCI,":[425],"DHHS.]":[426],"Citation":[427],"Format:":[428],"William":[429],"D.":[430],"Johnson,":[431],"Miguel":[432],"Muzzio,":[433],"Thomas":[434],"L.":[435,444],"Horn,":[436],"Michael":[437],"A.":[438],"Zeligs,":[439],"Elizabeth":[440],"R.":[441],"Glaze,":[442],"David":[443],"McCormick.":[445],"Enhanced":[446],"administered":[451],"self-microemulsifying":[454],"system":[457],"[abstract].":[459],"In:":[460],"Proceedings":[461],"American":[464],"Association":[465],"Cancer":[467,480],"Research":[468],"Annual":[469],"Meeting":[470],"2018;":[471],"2018":[472],"Apr":[473],"14-18;":[474],"Chicago,":[475],"IL.":[476],"Philadelphia":[477],"(PA):":[478],"AACR;":[479],"Res":[481],"2018;78(13":[482],"Suppl):Abstract":[483],"nr":[484],"4931.":[485]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2018-08-22T00:00:00"}