{"id":"https://openalex.org/W2885059404","doi":"https://doi.org/10.1158/1538-7445.am2018-lb-117","title":"Abstract LB-117: Role of ectoenzymes CD39 and CD73 in the immune response to multiple myeloma","display_name":"Abstract LB-117: Role of ectoenzymes CD39 and CD73 in the immune response to multiple myeloma","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2885059404","doi":"https://doi.org/10.1158/1538-7445.am2018-lb-117","mag":"2885059404"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2018-lb-117","doi":"https://doi.org/10.1158/1538-7445.am2018-lb-117","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-lb-117","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101852866","display_name":"Rui Yang","orcid":"https://orcid.org/0000-0001-7679-9646","observed_orcids":["https://orcid.org/0000-0001-7679-9646"]},"institutions":[{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Rui Yang","raw_affiliation_strings":["1NTNU, Trondheim, Norway;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NTNU, Trondheim, Norway;","institution_ids":["https://openalex.org/I204778367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025462579","display_name":"Samah Elsaadi","orcid":"https://orcid.org/0000-0002-5554-0771","observed_orcids":["https://orcid.org/0000-0002-5554-0771"]},"institutions":[{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Samah Elsaadi","raw_affiliation_strings":["1NTNU, Trondheim, Norway;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NTNU, Trondheim, Norway;","institution_ids":["https://openalex.org/I204778367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055459709","display_name":"Kristine Misund","orcid":"https://orcid.org/0000-0002-8742-7028","observed_orcids":["https://orcid.org/0000-0002-8742-7028"]},"institutions":[{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Kristine Misund","raw_affiliation_strings":["1NTNU, Trondheim, Norway;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NTNU, Trondheim, Norway;","institution_ids":["https://openalex.org/I204778367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028599338","display_name":"Geir Slupphaug","orcid":"https://orcid.org/0000-0002-7498-3500","observed_orcids":["https://orcid.org/0000-0002-7498-3500"]},"institutions":[{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Geir Slupphaug","raw_affiliation_strings":["1NTNU, Trondheim, Norway;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NTNU, Trondheim, Norway;","institution_ids":["https://openalex.org/I204778367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003658156","display_name":"Eline Menu","orcid":"https://orcid.org/0000-0002-0805-6581","observed_orcids":["https://orcid.org/0000-0002-0805-6581"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Eline Menu","raw_affiliation_strings":["2Vrije University, Brussels, Belgium;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Vrije University, Brussels, Belgium;","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040979655","display_name":"Carl M. Hay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carl Hay","raw_affiliation_strings":["3MedImmune, Gaithersburg MD, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3MedImmune, Gaithersburg MD, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065136133","display_name":"Zac Cooper","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zac Cooper","raw_affiliation_strings":["3MedImmune, Gaithersburg MD, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3MedImmune, Gaithersburg MD, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014026887","display_name":"Karin Vanderkerken","orcid":"https://orcid.org/0000-0002-2137-7179","observed_orcids":["https://orcid.org/0000-0002-2137-7179"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Karin Vanderkerken","raw_affiliation_strings":["2Vrije University, Brussels, Belgium;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Vrije University, Brussels, Belgium;","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009564890","display_name":"Magne B\u00f8rset","orcid":"https://orcid.org/0000-0001-5179-2835","observed_orcids":["https://orcid.org/0000-0001-5179-2835"]},"institutions":[{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Magne B\u00f8rset","raw_affiliation_strings":["1NTNU, Trondheim, Norway;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NTNU, Trondheim, Norway;","institution_ids":["https://openalex.org/I204778367"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082769169","display_name":"Anne\u2010Marit Sponaas","orcid":"https://orcid.org/0000-0002-0860-8446","observed_orcids":["https://orcid.org/0000-0002-0860-8446"]},"institutions":[{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Anne Marit Sponaas","raw_affiliation_strings":["1NTNU, Trondheim, Norway;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NTNU, Trondheim, Norway;","institution_ids":["https://openalex.org/I204778367"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":"13_Supplement","first_page":"LB","last_page":"117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.949999988079071},{"id":"https://openalex.org/keywords/cd39","display_name":"CD39","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cd73","display_name":"CD73","score":1.0},{"id":"https://openalex.org/keywords/ectoenzymes","display_name":"ectoenzymes","score":0.8050000071525574},{"id":"https://openalex.org/keywords/adenosine","display_name":"adenosine","score":0.9599999785423279},{"id":"https://openalex.org/keywords/tumor-immunosuppression","display_name":"tumor immunosuppression","score":0.7279999852180481},{"id":"https://openalex.org/keywords/bone-marrow-microenvironment","display_name":"bone marrow microenvironment","score":0.8690000176429749},{"id":"https://openalex.org/keywords/adenosine-a2a-receptor","display_name":"adenosine A2A receptor","score":0.656000018119812},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.7099999785423279},{"id":"https://openalex.org/keywords/zm241385","display_name":"ZM241385","score":0.9200000166893005},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.5},{"id":"https://openalex.org/keywords/adenosine-pathway","display_name":"adenosine pathway","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.808948278427124},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.7316139936447144},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6784012317657471},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.6340075135231018},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.6217261552810669},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5443309545516968},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5016708374023438},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.47120994329452515},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.46076133847236633},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4582615792751312},{"id":"https://openalex.org/C2776885095","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immunosurveillance","level":3,"score":0.4573293626308441},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3699968457221985},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36424142122268677},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.333188533782959},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29210662841796875},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2669675052165985},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.17117533087730408}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2018-lb-117","doi":"https://doi.org/10.1158/1538-7445.am2018-lb-117","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-lb-117","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2981130493","https://openalex.org/W3213137172","https://openalex.org/W3024703728","https://openalex.org/W4310161267","https://openalex.org/W4362524727","https://openalex.org/W4282971942","https://openalex.org/W4221093336","https://openalex.org/W4394615084","https://openalex.org/W4389219626","https://openalex.org/W2795064496"],"abstract_inverted_index":{"Abstract":[0],"Multiple":[1],"Myeloma":[2],"is":[3,29,35,77],"a":[4,330],"cancer":[5,49,96],"of":[6,48,66,71,80,115,128,206,235,307,333,339,364,398,413],"the":[7,11,16,25,46,67,78,83,113,118,131,165,175,233,260,265,270,281,296,305,323,340,352,404,414],"plasma":[8,134],"cells":[9,153,163,171,179,199,209,213,226,239],"in":[10,24,74,82,117,130,164,174,232,280,290,318,329,343,403],"bone":[12,84,132,166,176],"marrow.":[13,167],"Despite":[14],"from":[15,135,154,237,300],"fact":[17,253],"that":[18,223,254,264,359],"new":[19,40,92],"drugs":[20],"have":[21,293],"increased":[22,126],"survival":[23],"past":[26],"decade,":[27],"it":[28],"still":[30],"an":[31,90],"incurable":[32],"cancer.":[33],"It":[34],"therefore":[36],"important":[37,104],"to":[38,45,60,109,121,184,189,202,217,310,325,407],"develop":[39],"drugs.":[41],"Tumor":[42],"immunosurveillance":[43],"contributes":[44],"control":[47],"growth,":[50],"but":[51],"there":[52],"many":[53],"different":[54],"escape":[55],"mechanisms":[56,70],"utilized":[57],"by":[58,146,191,259,269],"tumour":[59],"evade":[61],"anti-tumour":[62],"immune":[63,72,119,405],"responses.":[64],"One":[65],"largely":[68],"unexplored":[69],"suppression":[73,266],"multiple":[75,122,334,344,408],"myeloma":[76,136,147,152,193,208,345,409],"role":[79,114],"adenosine":[81,116,129,278,312,341],"marrow":[85,133],"microenvironment,":[86],"which":[87],"now":[88],"represents":[89],"attractive":[91],"therapeutic":[93],"target":[94],"for":[95,105,417],"therapy.":[97],"2":[98],"ectoenzymes,":[99],"CD39":[100,142,274,365,400],"and":[101,150,161,196,210,302,314,371,401],"CD73":[102,156,173,297,402],"are":[103,303],"converting":[106],"extracellular":[107,215],"ATP":[108,186,216],"adenosine.":[110,185,203,219],"When":[111],"investigating":[112],"response":[120,406],"myeloma,":[123],"we":[124,221,357],"found":[125,158,222,346,358],"concentration":[127],"patients":[137,360],"compared":[138],"with":[139,228,361],"healthy":[140],"controls.":[141],"(ENTPD1)":[143],"was":[144,157,187,257,267],"expressed":[145,172],"cell":[148,194,247,288,316],"lines":[149],"on":[151,159],"patients.":[155],"leukocytes":[160],"stromal":[162,198,212],"Although":[168],"very":[169],"few":[170],"marrow,":[177],"these":[178],"could":[180],"clearly":[181],"convert":[182],"AMP":[183,190,201],"converted":[188,200],"CD39+":[192,207],"lines,":[195],"CD73+":[197,211],"Importantly,":[204],"co-culture":[205,282],"catalyzed":[214],"immunosuppressive":[218],"Indeed,":[220],"CD3":[224],"T":[225,246,287,315],"stimulated":[227],"anti":[229],"CD3/CD28":[230],"beads":[231],"presence":[234],"supernatants":[236],"co-cultured":[238],"did":[240],"not":[241],"proliferate":[242],"as":[243,245,284,286,320,322],"well":[244,285,321],"culture":[248],"without":[249],"this":[250,255,308],"supernatant.":[251],"The":[252,273,336],"proliferation":[256,289,317],"inhibited":[258,277],"ZM241385":[261],"inhibitor,":[262],"suggested":[263],"mediated":[268],"A2AR":[271],"receptor.":[272],"inhibitor":[275],"POM1":[276],"generation":[279],"system":[283],"vitro.":[291],"We":[292],"recently":[294],"obtained":[295],"antibody":[298,309],"MEDI199447":[299],"MedImmune":[301],"testing":[304],"ability":[306,324],"prevent":[311],"production":[313],"vitro,":[319],"reduce":[326],"tumor":[327],"growth":[328],"mouse":[331],"model":[332],"myeloma.":[335],"clinical":[337],"importance":[338],"pathway":[342],"when":[347],"analyzing":[348],"patient":[349],"data.":[350],"Using":[351],"publicly":[353],"available":[354],"coMMpass":[355],"database,":[356],"high":[362],"expression":[363],"had":[366],"significantly":[367],"reduced":[368],"progression":[369],"free":[370],"overall":[372],"survival.":[373],"Citation":[374],"Format:":[375],"Rui":[376],"Yang,":[377],"Samah":[378],"Elsaadi,":[379],"Kristine":[380],"Misund,":[381],"Geir":[382],"Slupphaug,":[383],"Eline":[384],"Menu,":[385],"Carl":[386],"Hay,":[387],"Zac":[388],"Cooper,":[389],"Karin":[390],"Vanderkerken,":[391],"Magne":[392],"B\u00f8rset,":[393],"Anne":[394],"Marit":[395],"Sponaas.":[396],"Role":[397],"ectoenzymes":[399],"[abstract].":[410],"In:":[411],"Proceedings":[412],"American":[415],"Association":[416],"Cancer":[418,431],"Research":[419],"Annual":[420],"Meeting":[421],"2018;":[422],"2018":[423],"Apr":[424],"14-18;":[425],"Chicago,":[426],"IL.":[427],"Philadelphia":[428],"(PA):":[429],"AACR;":[430],"Res":[432],"2018;78(13":[433],"Suppl):Abstract":[434],"nr":[435],"LB-117.":[436]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-08-22T00:00:00"}