{"id":"https://openalex.org/W2885056324","doi":"https://doi.org/10.1158/1538-7445.am2018-2537","title":"Abstract 2537: Regulation of LMO2 oncogene expression in high-risk B-cell acute lymphoblastic leukemia","display_name":"Abstract 2537: Regulation of LMO2 oncogene expression in high-risk B-cell acute lymphoblastic leukemia","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2885056324","doi":"https://doi.org/10.1158/1538-7445.am2018-2537","mag":"2885056324"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2018-2537","doi":"https://doi.org/10.1158/1538-7445.am2018-2537","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-2537","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012215574","display_name":"Yali Ding","orcid":"https://orcid.org/0009-0005-3629-1908","observed_orcids":["https://orcid.org/0009-0005-3629-1908"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yali Ding","raw_affiliation_strings":["1Pennsylvania State University College of Medicine, Hershey, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pennsylvania State University College of Medicine, Hershey, PA;","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036090467","display_name":"Jonathon Lee Payne","orcid":"https://orcid.org/0000-0001-7891-2921","observed_orcids":["https://orcid.org/0000-0001-7891-2921"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathon L. Payne","raw_affiliation_strings":["2Loma Linda University School of Medicine, Loma Linda, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Loma Linda University School of Medicine, Loma Linda, CA","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030722163","display_name":"Shriya Kane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shriya Kane","raw_affiliation_strings":["1Pennsylvania State University College of Medicine, Hershey, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pennsylvania State University College of Medicine, Hershey, PA;","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089030665","display_name":"Elanora Dovat","orcid":"https://orcid.org/0000-0001-9022-5358","observed_orcids":["https://orcid.org/0000-0001-9022-5358"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elanora Dovat","raw_affiliation_strings":["1Pennsylvania State University College of Medicine, Hershey, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pennsylvania State University College of Medicine, Hershey, PA;","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110626497","display_name":"Mario Soliman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mario Soliman","raw_affiliation_strings":["1Pennsylvania State University College of Medicine, Hershey, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pennsylvania State University College of Medicine, Hershey, PA;","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077299625","display_name":"Chunhua Song","orcid":"https://orcid.org/0000-0002-4081-2543","observed_orcids":["https://orcid.org/0000-0002-4081-2543"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chunhua Song","raw_affiliation_strings":["1Pennsylvania State University College of Medicine, Hershey, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pennsylvania State University College of Medicine, Hershey, PA;","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072518893","display_name":"Sinisa Dovat","orcid":"https://orcid.org/0000-0003-3906-6165","observed_orcids":["https://orcid.org/0000-0003-3906-6165"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sinisa Dovat","raw_affiliation_strings":["1Pennsylvania State University College of Medicine, Hershey, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pennsylvania State University College of Medicine, Hershey, PA;","institution_ids":["https://openalex.org/I130769515"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":"13_Supplement","first_page":"2537","last_page":"2537"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-cell-acute-lymphoblastic-leukemia","display_name":"B-cell acute lymphoblastic leukemia","score":0.9419999718666077},{"id":"https://openalex.org/keywords/ikaros","display_name":"Ikaros","score":0.8320000171661377},{"id":"https://openalex.org/keywords/ikzf1","display_name":"IKZF1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.7839999794960022},{"id":"https://openalex.org/keywords/casein-kinase-2","display_name":"casein kinase 2","score":0.8489999771118164},{"id":"https://openalex.org/keywords/ck2-inhibitors","display_name":"CK2 inhibitors","score":0.8270000219345093},{"id":"https://openalex.org/keywords/cx-4945","display_name":"CX-4945","score":0.9819999933242798},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7020000219345093},{"id":"https://openalex.org/keywords/chromatin-binding","display_name":"chromatin binding","score":0.5239999890327454},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.4519999921321869},{"id":"https://openalex.org/keywords/enhancers","display_name":"enhancers","score":0.3059999942779541}],"concepts":[{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.7822035551071167},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6370746493339539},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6076979637145996},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5585689544677734},{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.5361077785491943},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.46192237734794617},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.4556477665901184},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42755427956581116},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.4248567819595337},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.32090383768081665},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2505863308906555},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.15952709317207336},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14440786838531494}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2018-2537","doi":"https://doi.org/10.1158/1538-7445.am2018-2537","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-2537","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2979786504","https://openalex.org/W2739634082","https://openalex.org/W4389019172","https://openalex.org/W2885540765","https://openalex.org/W2341394478","https://openalex.org/W2483032490","https://openalex.org/W2741359029","https://openalex.org/W2741742254","https://openalex.org/W2550848110","https://openalex.org/W3009682980"],"abstract_inverted_index":{"Abstract":[0],"LIM":[1],"domain":[2],"only":[3],"protein":[4],"2":[5],"(LMO2)":[6],"is":[7,11,42,51,60,192],"an":[8],"oncogene":[9,308,356],"that":[10,24,36,140,179,250,274,296],"overexpressed":[12],"in":[13,28,40,80,86,120,124,149,168,173,185,190,228,287,309,323,358],"a":[14,46,90,222,254,314],"subset":[15],"of":[16,38,64,69,97,118,147,160,171,183,209,219,231,234,253,257,270,305,317,320,326,331,354,367],"B-cell":[17,360],"acute":[18,361],"lymphoblastic":[19,362],"leukemia":[20,363],"(B-ALL).":[21],"The":[22,67],"mechanisms":[23],"regulate":[25,300],"LMO2":[26,39,99,105,122,137,144,172,184,245,267,283,289,307,327,355],"expression":[27,159,230,304,328,357],"B-ALL":[29,41,83,125,150,174,191,249,272],"are":[30],"still":[31],"unknown.":[32],"Here,":[33],"we":[34,201],"show":[35],"transcription":[37,123,170,182,301],"regulated":[43,194],"by":[44,53,109,195],"Ikaros,":[45],"tumor":[47,333],"suppressor":[48,334],"protein,":[49],"which":[50],"encoded":[52],"the":[54,75,95,98,104,116,136,244,258,266,282,306,368],"IKZF1":[55,259,276],"gene,":[56,260],"and":[57,85,128,216,285,298,302],"whose":[58],"deletion":[59,252],"associated":[61,155,238],"with":[62,74,135,156,165,214,221,239],"development":[63],"high-risk":[65,248,324,359],"B-ALL.":[66,186,310],"use":[68],"global":[70],"chromatin":[71,111],"immunoprecipitation":[72,112],"coupled":[73],"next-generation":[76],"sequencing":[77],"(ChIP-seq)":[78],"studies":[79],"primary":[81,271],"human":[82],"cells":[84,273],"cell":[87],"lines":[88],"revealed":[89],"strong":[91],"Ikaros":[92,101,119,141,148,163,180,241,261,279,297],"occupancy":[93,242],"at":[94,243],"promoter":[96,106,138,284],"gene.":[100],"binding":[102,280],"to":[103,265,281],"was":[107,154,236],"confirmed":[108],"quantitative":[110],"(qChIP).":[113],"We":[114],"tested":[115,202],"role":[117],"regulating":[121],"using":[126],"gain-of-function":[127],"loss-of-function":[129],"experiments.":[130],"A":[131],"luciferase":[132],"reporter":[133],"assay":[134],"showed":[139],"directly":[142],"represses":[143,181],"transcription.":[145],"Overexpression":[146],"via":[151,329],"retroviral":[152],"transduction":[153],"strongly":[157],"reduced":[158,229,288],"LMO2.":[161,210,232],"Furthermore,":[162],"knock-down":[164],"shRNA,":[166,215],"resulted":[167,227],"increased":[169,240],"cells.":[175],"These":[176],"results":[177,286,312],"suggest":[178],"Since":[187],"Ikaros'":[188,332],"function":[189],"negatively":[193],"pro-oncogenic":[196],"Casein":[197],"Kinase":[198],"II":[199],"(CK2),":[200],"whether":[203],"CK2":[204,220,224,235,299,321],"inhibition":[205,213,218],"affects":[206],"Ikaros-mediated":[207],"repression":[208],"Both":[211],"molecular":[212],"pharmacological":[217],"specific":[223],"inhibitor,":[225],"CX-4945,":[226],"Inhibition":[233],"also":[237],"promoter.":[246,268],"In":[247,291],"have":[251,275],"single":[255],"copy":[256],"does":[262],"not":[263],"bind":[264],"Treatment":[269],"haploinsufficiency":[277],"restores":[278],"expression.":[290],"conclusion,":[292],"our":[293],"data":[294],"demonstrate":[295],"overall":[303],"Our":[311],"identify":[313],"novel":[315],"mechanism":[316],"therapeutic":[318],"action":[319],"inhibitors":[322],"B-ALL\u2014repression":[325],"restoration":[330],"function.":[335],"Citation":[336],"Format:":[337],"Yali":[338],"Ding,":[339],"Jonathon":[340],"L.":[341],"Payne,":[342],"Shriya":[343],"Kane,":[344],"Elanora":[345],"Dovat,":[346],"Mario":[347],"Soliman,":[348],"Chunhua":[349],"Song,":[350],"Sinisa":[351],"Dovat.":[352],"Regulation":[353],"[abstract].":[364],"In:":[365],"Proceedings":[366],"American":[369],"Association":[370],"for":[371],"Cancer":[372,385],"Research":[373],"Annual":[374],"Meeting":[375],"2018;":[376],"2018":[377],"Apr":[378],"14-18;":[379],"Chicago,":[380],"IL.":[381],"Philadelphia":[382],"(PA):":[383],"AACR;":[384],"Res":[386],"2018;78(13":[387],"Suppl):Abstract":[388],"nr":[389],"2537.":[390]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2018-08-22T00:00:00"}