{"id":"https://openalex.org/W2884965254","doi":"https://doi.org/10.4103/0973-1482.187369","title":"Combination therapy with azacitidine, etoposide, and cytarabine in the treatment of elderly acute myeloid leukemia patients: A single center experience","display_name":"Combination therapy with azacitidine, etoposide, and cytarabine in the treatment of elderly acute myeloid leukemia patients: A single center experience","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2884965254","doi":"https://doi.org/10.4103/0973-1482.187369","mag":"2884965254","pmid":"https://pubmed.ncbi.nlm.nih.gov/30197357"},"language":"en","primary_location":{"id":"doi:10.4103/0973-1482.187369","doi":"https://doi.org/10.4103/0973-1482.187369","is_oa":true,"landing_page_url":"https://doi.org/10.4103/0973-1482.187369","pdf_url":null,"source":{"id":"https://openalex.org/S53738828","display_name":"Journal of Cancer Research and Therapeutics","issn_l":"1998-4138","issn":["1998-4138","0973-1482"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer Research and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.4103/0973-1482.187369","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061031275","display_name":"Birg\u00fcl \u00d6ne\u00e7","orcid":"https://orcid.org/0000-0003-2824-1044","observed_orcids":["https://orcid.org/0000-0003-2824-1044"]},"institutions":[{"id":"https://openalex.org/I4210138303","display_name":"D\u0131\u015fkap\u0131 Y\u0131ld\u0131r\u0131m Beyaz\u0131t E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/04bghze60","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210138303"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Birgul Onec","raw_affiliation_strings":["Department of Hematology, Ankara Diskapi Y\u0131ld\u0131r\u0131m Beyazit Training and Research Hospital, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Ankara Diskapi Y\u0131ld\u0131r\u0131m Beyazit Training and Research Hospital, Ankara, Turkey","institution_ids":["https://openalex.org/I4210138303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082932422","display_name":"Harika Okutan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138303","display_name":"D\u0131\u015fkap\u0131 Y\u0131ld\u0131r\u0131m Beyaz\u0131t E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/04bghze60","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210138303"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Harika Okutan","raw_affiliation_strings":["Department of Hematology, Ankara Diskapi Y\u0131ld\u0131r\u0131m Beyazit Training and Research Hospital, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Ankara Diskapi Y\u0131ld\u0131r\u0131m Beyazit Training and Research Hospital, Ankara, Turkey","institution_ids":["https://openalex.org/I4210138303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076943240","display_name":"Murat Albayrak","orcid":"https://orcid.org/0000-0003-4025-741X","observed_orcids":["https://orcid.org/0000-0003-4025-741X","https://orcid.org/0000-0003-2375-1117"]},"institutions":[{"id":"https://openalex.org/I4210138303","display_name":"D\u0131\u015fkap\u0131 Y\u0131ld\u0131r\u0131m Beyaz\u0131t E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/04bghze60","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210138303"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Murat Albayrak","raw_affiliation_strings":["Department of Hematology, Ankara Diskapi Y\u0131ld\u0131r\u0131m Beyazit Training and Research Hospital, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Ankara Diskapi Y\u0131ld\u0131r\u0131m Beyazit Training and Research Hospital, Ankara, Turkey","institution_ids":["https://openalex.org/I4210138303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037329732","display_name":"Esra Sar\u0131bacak Can","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138303","display_name":"D\u0131\u015fkap\u0131 Y\u0131ld\u0131r\u0131m Beyaz\u0131t E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/04bghze60","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210138303"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Esra Saribacak Can","raw_affiliation_strings":["Department of Hematology, Ankara Diskapi Y\u0131ld\u0131r\u0131m Beyazit Training and Research Hospital, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Ankara Diskapi Y\u0131ld\u0131r\u0131m Beyazit Training and Research Hospital, Ankara, Turkey","institution_ids":["https://openalex.org/I4210138303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017381930","display_name":"Vedat Aslan","orcid":"https://orcid.org/0000-0002-5415-5812","observed_orcids":["https://orcid.org/0000-0002-5415-5812"]},"institutions":[{"id":"https://openalex.org/I4210138303","display_name":"D\u0131\u015fkap\u0131 Y\u0131ld\u0131r\u0131m Beyaz\u0131t E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/04bghze60","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210138303"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Vedat Aslan","raw_affiliation_strings":["Department of Hematology, Ankara Diskapi Y\u0131ld\u0131r\u0131m Beyazit Training and Research Hospital, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Ankara Diskapi Y\u0131ld\u0131r\u0131m Beyazit Training and Research Hospital, Ankara, Turkey","institution_ids":["https://openalex.org/I4210138303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071091527","display_name":"Ba\u015fak \u00dcnver Koluman","orcid":"https://orcid.org/0000-0003-1106-5021","observed_orcids":["https://orcid.org/0000-0003-1106-5021"]},"institutions":[{"id":"https://openalex.org/I4210138303","display_name":"D\u0131\u015fkap\u0131 Y\u0131ld\u0131r\u0131m Beyaz\u0131t E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/04bghze60","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210138303"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Basak Unver Koluman","raw_affiliation_strings":["Department of Hematology, Ankara Diskapi Y\u0131ld\u0131r\u0131m Beyazit Training and Research Hospital, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Ankara Diskapi Y\u0131ld\u0131r\u0131m Beyazit Training and Research Hospital, Ankara, Turkey","institution_ids":["https://openalex.org/I4210138303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035528835","display_name":"\u00d6zge Soyer K\u00f6semehmeto\u011flu","orcid":"https://orcid.org/0000-0002-8613-8910","observed_orcids":["https://orcid.org/0000-0002-8613-8910"]},"institutions":[{"id":"https://openalex.org/I4210138303","display_name":"D\u0131\u015fkap\u0131 Y\u0131ld\u0131r\u0131m Beyaz\u0131t E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/04bghze60","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210138303"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ozge Soyer Kosemehmetoglu","raw_affiliation_strings":["Department of Hematology, Ankara Diskapi Y\u0131ld\u0131r\u0131m Beyazit Training and Research Hospital, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Ankara Diskapi Y\u0131ld\u0131r\u0131m Beyazit Training and Research Hospital, Ankara, Turkey","institution_ids":["https://openalex.org/I4210138303"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110143395","display_name":"Aynur Albayrak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138303","display_name":"D\u0131\u015fkap\u0131 Y\u0131ld\u0131r\u0131m Beyaz\u0131t E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/04bghze60","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210138303"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Aynur Albayrak","raw_affiliation_strings":["Department of Pathology, Ankara Diskapi Y\u0131ld\u0131r\u0131m Beyazit Training and Research Hospital, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Ankara Diskapi Y\u0131ld\u0131r\u0131m Beyazit Training and Research Hospital, Ankara, Turkey","institution_ids":["https://openalex.org/I4210138303"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5061031275"],"corresponding_institution_ids":["https://openalex.org/I4210138303"],"apc_list":null,"apc_paid":null,"fwci":0.7293,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.70241472,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"14","issue":"5","first_page":"1105","last_page":"1111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.9990000128746033},{"id":"https://openalex.org/keywords/azacitidine","display_name":"azacitidine","score":0.996999979019165},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cytarabine","display_name":"cytarabine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.8840000033378601},{"id":"https://openalex.org/keywords/hypomethylating-agents","display_name":"hypomethylating agents","score":0.9599999785423279},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9620000123977661},{"id":"https://openalex.org/keywords/response-rate","display_name":"response rate","score":0.5799999833106995},{"id":"https://openalex.org/keywords/performance-status","display_name":"performance status","score":0.5590000152587891},{"id":"https://openalex.org/keywords/age","display_name":"age","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8638849854469299},{"id":"https://openalex.org/C2776239401","wikidata":"https://www.wikidata.org/wiki/Q416451","display_name":"Azacitidine","level":5,"score":0.8530073165893555},{"id":"https://openalex.org/C2778041864","wikidata":"https://www.wikidata.org/wiki/Q180983","display_name":"Cytarabine","level":3,"score":0.8277479410171509},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7264193296432495},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.7157347202301025},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.6728776693344116},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.6251000165939331},{"id":"https://openalex.org/C2776012956","wikidata":"https://www.wikidata.org/wiki/Q17125294","display_name":"Hypomethylating agent","level":5,"score":0.5157085061073303},{"id":"https://openalex.org/C2776907518","wikidata":"https://www.wikidata.org/wiki/Q1734165","display_name":"Performance status","level":3,"score":0.4209284782409668},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4159405827522278},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4145965278148651},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4129254221916199},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.408456027507782},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3603817820549011},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003561","descriptor_name":"Cytarabine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003561","descriptor_name":"Cytarabine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005853","descriptor_name":"Geriatrics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4103/0973-1482.187369","doi":"https://doi.org/10.4103/0973-1482.187369","is_oa":true,"landing_page_url":"https://doi.org/10.4103/0973-1482.187369","pdf_url":null,"source":{"id":"https://openalex.org/S53738828","display_name":"Journal of Cancer Research and Therapeutics","issn_l":"1998-4138","issn":["1998-4138","0973-1482"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer Research and Therapeutics","raw_type":"journal-article"},{"id":"pmid:30197357","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30197357","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cancer research and therapeutics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4103/0973-1482.187369","doi":"https://doi.org/10.4103/0973-1482.187369","is_oa":true,"landing_page_url":"https://doi.org/10.4103/0973-1482.187369","pdf_url":null,"source":{"id":"https://openalex.org/S53738828","display_name":"Journal of Cancer Research and Therapeutics","issn_l":"1998-4138","issn":["1998-4138","0973-1482"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer Research and Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W46662938","https://openalex.org/W1645524462","https://openalex.org/W1849389269","https://openalex.org/W1909698311","https://openalex.org/W1965658643","https://openalex.org/W1976889521","https://openalex.org/W1987178328","https://openalex.org/W1988758777","https://openalex.org/W1998475390","https://openalex.org/W2039238951","https://openalex.org/W2044942890","https://openalex.org/W2057809753","https://openalex.org/W2062968550","https://openalex.org/W2063607020","https://openalex.org/W2065464763","https://openalex.org/W2067654005","https://openalex.org/W2068296418","https://openalex.org/W2068556430","https://openalex.org/W2070012795","https://openalex.org/W2080584244","https://openalex.org/W2081391009","https://openalex.org/W2081576971","https://openalex.org/W2103043828","https://openalex.org/W2106658124","https://openalex.org/W2109065151","https://openalex.org/W2116858301","https://openalex.org/W2117954942","https://openalex.org/W2147083172","https://openalex.org/W2157287007","https://openalex.org/W2185856844"],"related_works":["https://openalex.org/W3138542065","https://openalex.org/W2134069813","https://openalex.org/W4247193509","https://openalex.org/W4405054989","https://openalex.org/W4390456707","https://openalex.org/W2602892784","https://openalex.org/W2588896151","https://openalex.org/W2953921000","https://openalex.org/W1974117002","https://openalex.org/W2067934287"],"abstract_inverted_index":{"AIMS:":[0],"The":[1,186],"prognosis":[2],"of":[3,48,69,223,259],"acute":[4],"myeloid":[5],"leukemia":[6],"(AML)":[7],"in":[8,34,50,58,124],"elderly":[9,264],"patients":[10,210],"is":[11],"worse":[12],"due":[13],"to":[14,29,90,256],"age":[15,192,213],"and":[16,46,55,67,78,128,181,193,214,227,232],"comorbidities.":[17],"Lately,":[18],"monotherapy":[19,182],"with":[20,52,126,191,211,225,250],"hypomethylating":[21],"agents":[22],"like":[23],"azacitidine":[24],"(Aza)":[25],"has":[26],"been":[27],"used":[28],"prolong":[30,233],"overall":[31,154],"survival":[32,234],"(OS)":[33],"AML":[35,73,265],"patients.":[36,266],"Herein,":[37],"we":[38],"present":[39],"a":[40],"retrospective":[41],"study":[42],"investigating":[43,247],"treatment":[44,261],"responses":[45],"OS":[47,165,187],"Aza":[49,116,123,144,224,248],"combination":[51,125,149,180,221],"etoposide":[53],"(Eto)":[54],"cytarabine":[56],"(ARA-C)":[57],"elderly.":[59],"MATERIALS":[60],"AND":[61],"METHODS:":[62],"In":[63],"this":[64,236],"study,":[65],"therapies":[66,102],"outcomes":[68],"37":[70],"newly":[71],"diagnosed":[72],"patients,":[74],">60":[75],"years":[76],"old,":[77],"ineligible":[79],"for":[80,205,209,235,263],"intensive":[81],"chemotherapy":[82],"were":[83,87],"investigated":[84],"retrospectively.":[85],"Patients":[86],"grouped":[88],"according":[89],"the":[91,177,197,257],"treatments":[92],"they":[93],"received":[94],"as":[95,103],"follows":[96],"-":[97],"Group":[98,114,121,167],"1:":[99],"low-dose":[100,105],"conventional":[101],"hydroxyurea,":[104],"ARA-C,":[106,134],"or":[107],"best":[108],"supportive":[109],"care":[110],"(n":[111,118],"=":[112,119,136,158],"11);":[113],"2:":[115],"alone":[117],"6);":[120],"3:":[122],"Eto":[127,132,146,226],"ARA-C":[129,148,228],"(Aza":[130],"+":[131,133,145,147],"n":[135],"20).":[137],"RESULTS:":[138],"It":[139],"was":[140,183,188,199],"found":[141],"that":[142,220,243],"an":[143],"therapy":[150,222],"had":[151,162],"significantly":[152,163],"better":[153,164,215],"response":[155,230],"rates":[156],"(P":[157],"0.002).":[159],"Combination":[160],"group":[161],"than":[166],"1":[168,172],"(8":[169],"months":[170],"vs.":[171],"month,":[173],"P":[174],"<":[175],"0.001),":[176],"difference":[178,198],"between":[179],"not":[184],"significant.":[185],"also":[189],"associated":[190],"performance":[194],"status,":[195],"but":[196],"still":[200],"statistically":[201],"significant":[202],"after":[203],"adjustment":[204],"these":[206],"factors,":[207],"especially":[208],"younger":[212],"performance.":[216],"CONCLUSIONS:":[217],"We":[218,241],"concluded":[219],"increases":[229],"rates,":[231],"poor":[237],"prognosed":[238],"patient":[239],"group.":[240],"believe":[242],"larger":[244],"controlled":[245],"studies":[246],"combinations":[249],"other":[251],"antileukemic":[252],"drugs":[253],"will":[254],"contribute":[255],"development":[258],"tolerable":[260],"protocols":[262]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2018-08-03T00:00:00"}