{"id":"https://openalex.org/W2884957232","doi":null,"title":"Staphylococcus aureus bacteremia in a secondary level Spanish hospital: clinical implications of high vancomycin MIC.","display_name":"Staphylococcus aureus bacteremia in a secondary level Spanish hospital: clinical implications of high vancomycin MIC.","publication_year":2018,"publication_date":"2018-08-01","ids":{"openalex":"https://openalex.org/W2884957232","mag":"2884957232","pmid":"https://pubmed.ncbi.nlm.nih.gov/30014681","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6172687"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6172687","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6172687/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6172687/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rev Esp Quimioter","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6172687/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050225835","display_name":"Gabriela Abelenda-Alonso","orcid":"https://orcid.org/0000-0001-8158-9934","observed_orcids":["https://orcid.org/0000-0001-8158-9934"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Abelenda Alonso","raw_affiliation_strings":["Gabriela Abelenda Alonso, Servicio de Medicina Interna, Avda Orellana s/n 28911 Legan\u00e9s, Madrid, Spain. gabi.abelenda.alonso@gmail.com","Gabriela Abelenda Alonso, Servicio de Medicina Interna, Avda Orellana s/n 28911 Legan\u00e9s, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gabriela Abelenda Alonso, Servicio de Medicina Interna, Avda Orellana s/n 28911 Legan\u00e9s, Madrid, Spain. gabi.abelenda.alonso@gmail.com","institution_ids":[]},{"raw_affiliation_string":"Gabriela Abelenda Alonso, Servicio de Medicina Interna, Avda Orellana s/n 28911 Legan\u00e9s, Madrid, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066338964","display_name":"Mar\u00eda Dolores Corbacho-Loarte","orcid":"https://orcid.org/0000-0002-1674-6304","observed_orcids":["https://orcid.org/0000-0002-1674-6304"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M D Corbacho Loarte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071042869","display_name":"N\u00fa\u00f1ez Ramos R","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R N\u00fa\u00f1ez Ramos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044966358","display_name":"M Cervero Jim\u00e9nez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Cervero Jim\u00e9nez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5001736510","display_name":"J J Jusdado Ruiz-Capillas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J J Jusdado Ruiz-Capillas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3817,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.58372255,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"31","issue":"4","first_page":"353","last_page":"362"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11551","display_name":"Infective Endocarditis Diagnosis and Management","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcus-aureus-bacteremia","display_name":"Staphylococcus aureus bacteremia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vancomycin-mic","display_name":"vancomycin MIC","score":0.9179999828338623},{"id":"https://openalex.org/keywords/persistent-bacteremia","display_name":"persistent bacteremia","score":0.781000018119812},{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.9879999756813049},{"id":"https://openalex.org/keywords/methicillin-susceptible-staphylococcus-aureus","display_name":"methicillin-susceptible Staphylococcus aureus","score":0.9800000190734863},{"id":"https://openalex.org/keywords/central-venous-catheters","display_name":"central venous catheters","score":0.8389999866485596},{"id":"https://openalex.org/keywords/catheter-related-bloodstream-infection","display_name":"catheter-related bloodstream infection","score":0.7789999842643738},{"id":"https://openalex.org/keywords/30-day-mortality","display_name":"30-day mortality","score":0.8619999885559082},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.32600000500679016}],"concepts":[{"id":"https://openalex.org/C2779443120","wikidata":"https://www.wikidata.org/wiki/Q650912","display_name":"Bacteremia","level":3,"score":0.872796893119812},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.8352470397949219},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8155808448791504},{"id":"https://openalex.org/C2778446481","wikidata":"https://www.wikidata.org/wiki/Q190404","display_name":"Central venous catheter","level":3,"score":0.6497186422348022},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.6196632385253906},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5121495723724365},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.43852710723876953},{"id":"https://openalex.org/C2781267111","wikidata":"https://www.wikidata.org/wiki/Q652297","display_name":"Catheter","level":2,"score":0.39873313903808594},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33540254831314087},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.2655520439147949},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.2573205232620239},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.07331988215446472},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06600525975227356},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013030","descriptor_name":"Spain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D020713","descriptor_name":"Vancomycin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055499","descriptor_name":"Catheter-Related Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D055499","descriptor_name":"Catheter-Related Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D055624","descriptor_name":"Methicillin-Resistant Staphylococcus aureus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063728","descriptor_name":"Secondary Care Centers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:6172687","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6172687/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6172687/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rev Esp Quimioter","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:5118495","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6172687","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:30014681","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30014681","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia","raw_type":"Journal Article"},{"id":"mag:2884957232","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30014681","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6172687","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6172687/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6172687/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rev Esp Quimioter","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2884957232.pdf","grobid_xml":"https://content.openalex.org/works/W2884957232.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1480576861","https://openalex.org/W1841453375","https://openalex.org/W1878404532","https://openalex.org/W1955538980","https://openalex.org/W1977802041","https://openalex.org/W1984408381","https://openalex.org/W2005964189","https://openalex.org/W2017937043","https://openalex.org/W2024945939","https://openalex.org/W2028918855","https://openalex.org/W2032411240","https://openalex.org/W2044368480","https://openalex.org/W2104009211","https://openalex.org/W2105851160","https://openalex.org/W2114585210","https://openalex.org/W2115806935","https://openalex.org/W2116331284","https://openalex.org/W2118897654","https://openalex.org/W2119583581","https://openalex.org/W2126915534","https://openalex.org/W2134186143","https://openalex.org/W2140777443","https://openalex.org/W2143848418","https://openalex.org/W2149023722","https://openalex.org/W2157419230","https://openalex.org/W2160244430","https://openalex.org/W2163392158","https://openalex.org/W2166146713","https://openalex.org/W2604841717","https://openalex.org/W2615594254","https://openalex.org/W2615701584"],"related_works":["https://openalex.org/W2760119935","https://openalex.org/W2026106048","https://openalex.org/W2056906333","https://openalex.org/W2564442729","https://openalex.org/W3119968837","https://openalex.org/W2103081763","https://openalex.org/W7097437618","https://openalex.org/W2143848418","https://openalex.org/W2062845481","https://openalex.org/W1997967615"],"abstract_inverted_index":{"OBJECTIVE:":[0],"One":[1],"of":[2,15,25,42,71,79,98,110,139,234,237],"the":[3,12,31,39,61,99],"most":[4,116],"controversial":[5],"issues":[6],"in":[7,19,38,164,174,227],"recent":[8],"years":[9],"has":[10,37],"been":[11],"clinical":[13,32,229],"significance":[14,163],"high":[16,215],"vancomycin":[17,80,143,149,216,222],"MIC":[18,81,144,150,217,223],"Staphylococcus":[20],"aureus":[21,167,177,239],"bacteremia.":[22],"The":[23,89,115,137],"aim":[24],"this":[26,35,161],"study":[27,50],"was":[28,82,92,119,135,151,185,210],"to":[29,245],"elucidate":[30],"implication":[33],"that":[34],"parameter":[36],"staphylococcal":[40],"bacteremia":[41,156,184],"a":[43,102,111,142,232],"second":[44],"level":[45],"hospital.":[46],"METHODS:":[47],"Retrospective":[48],"descriptive":[49],"between":[51,214],"January":[52],"2014":[53],"and":[54,96,202,218],"September":[55],"2016":[56],"with":[57,154,189],"138":[58],"records":[59],"from":[60],"blood":[62],"culture":[63],"Severo":[64],"Ochoa":[65],"University":[66],"Hospital":[67],"registry.":[68],"A":[69,106],"total":[70],"98":[72],"cases":[73],"were":[74,108,125],"finally":[75],"analized.":[76],"Microbiological":[77],"analysis":[78],"performed":[83],"using":[84],"micro":[85],"dilution":[86],"technique.":[87],"RESULTS:":[88],"mean":[90],"age":[91],"71.4":[93],"\u00b1":[94],"12.45":[95],"63.26%":[97],"patients":[100],"had":[101,141],"Charlson":[103],"index":[104],"\u22656.":[105],"30.61%":[107],"carriers":[109,192],"venous":[112,120],"central":[113,121],"catheter.":[114],"frequent":[117],"source":[118,198],"catheter":[122,191,197],"(26.53%).":[123],"There":[124,209],"14.24%":[126],"metastatic":[127,203],"events.":[128],"Global":[129],"mortality":[130],"rate":[131],"at":[132],"30":[133],"days":[134],"25.51%.":[136],"43.87%":[138],"strains":[140],"\u2265":[145],"2":[146],"mg/L.":[147],"High":[148,221],"significantly":[152,187],"associated":[153],"persistent":[155],"(OR":[157,193,199,205],"3.12":[158],"[1.13-8.93]),":[159],"maintaining":[160],"statistical":[162],"methicillin-resistant":[165],"S.":[166,176,238],"(MRSA)":[168],"group":[169,179],"(p":[170,180],"=0.001)":[171],"but":[172],"no":[173,211],"methicillin-susceptible":[175],"(MSSA)":[178],"=":[181],"0.13).":[182],"Persistent":[183],"also":[186],"related":[188],"permanent":[190],"4.18":[194],"[1.38-12.61]),":[195],"peripheric":[196],"5.18":[200],"[1.13-8.93])":[201],"complications":[204],"3.82":[206],"[1.03-":[207],"12.81]).":[208],"significant":[212],"association":[213],"mortality.":[219],"CONCLUSIONS:":[220],"may":[224],"be":[225],"useful":[226],"daily":[228],"practice":[230],"as":[231],"marker":[233],"poor":[235],"clearance":[236],"bacteremia,":[240],"specially":[241],"when":[242],"is":[243],"due":[244],"MRSA":[246],"strains.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2018-08-03T00:00:00"}