{"id":"https://openalex.org/W2884955754","doi":"https://doi.org/10.1158/0008-5472.can-18-0644","title":"Targeting USP7 Identifies a Metastasis-Competent State within Bone Marrow\u2013Resident Melanoma CTCs","display_name":"Targeting USP7 Identifies a Metastasis-Competent State within Bone Marrow\u2013Resident Melanoma CTCs","publication_year":2018,"publication_date":"2018-07-19","ids":{"openalex":"https://openalex.org/W2884955754","doi":"https://doi.org/10.1158/0008-5472.can-18-0644","mag":"2884955754","pmid":"https://pubmed.ncbi.nlm.nih.gov/30026332","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6139068"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-18-0644","doi":"https://doi.org/10.1158/0008-5472.can-18-0644","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-18-0644","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6139068","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066206649","display_name":"Monika Vishnoi","orcid":"https://orcid.org/0000-0002-3934-7285","observed_orcids":["https://orcid.org/0000-0002-3934-7285"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monika Vishnoi","raw_affiliation_strings":["1Biomarker Research Program Center, Houston Methodist Research Institute, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Biomarker Research Program Center, Houston Methodist Research Institute, Houston, Texas","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075913956","display_name":"Debasish Boral","orcid":"https://orcid.org/0000-0001-9505-9811","observed_orcids":["https://orcid.org/0000-0001-9505-9811"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debasish Boral","raw_affiliation_strings":["1Biomarker Research Program Center, Houston Methodist Research Institute, Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0001-9505-9811","affiliations":[{"raw_affiliation_string":"1Biomarker Research Program Center, Houston Methodist Research Institute, Houston, Texas","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Haowen Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haowen Liu","raw_affiliation_strings":["1Biomarker Research Program Center, Houston Methodist Research Institute, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Biomarker Research Program Center, Houston Methodist Research Institute, Houston, Texas","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060292009","display_name":"Marc L. Sprouse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc L. Sprouse","raw_affiliation_strings":["1Biomarker Research Program Center, Houston Methodist Research Institute, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Biomarker Research Program Center, Houston Methodist Research Institute, Houston, Texas","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112030221","display_name":"Wei Hsian Yin","orcid":"https://orcid.org/0009-0000-1866-7071","observed_orcids":["https://orcid.org/0009-0000-1866-7071","https://orcid.org/0000-0002-8457-8306"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Yin","raw_affiliation_strings":["1Biomarker Research Program Center, Houston Methodist Research Institute, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Biomarker Research Program Center, Houston Methodist Research Institute, Houston, Texas","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082230833","display_name":"Debalina Goswami-Sewell","orcid":"https://orcid.org/0000-0002-1803-6875","observed_orcids":["https://orcid.org/0000-0002-1803-6875"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debalina Goswami-Sewell","raw_affiliation_strings":["1Biomarker Research Program Center, Houston Methodist Research Institute, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Biomarker Research Program Center, Houston Methodist Research Institute, Houston, Texas","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067831105","display_name":"Michael T. Tetzlaff","orcid":"https://orcid.org/0000-0001-7899-4138","observed_orcids":["https://orcid.org/0000-0001-7899-4138"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael T. Tetzlaff","raw_affiliation_strings":["2Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048327749","display_name":"Michael A. Davies","orcid":"https://orcid.org/0000-0002-0977-0912","observed_orcids":["https://orcid.org/0000-0002-0977-0912"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Davies","raw_affiliation_strings":["2Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0002-0977-0912","affiliations":[{"raw_affiliation_string":"2Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019203117","display_name":"Isabella C. Glitza Oliva","orcid":"https://orcid.org/0000-0002-4530-7765","observed_orcids":["https://orcid.org/0000-0002-4530-7765"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isabella C. Glitza Oliva","raw_affiliation_strings":["2Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0002-4530-7765","affiliations":[{"raw_affiliation_string":"2Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":null,"display_name":"Dario Marchetti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dario Marchetti","raw_affiliation_strings":["1Biomarker Research Program Center, Houston Methodist Research Institute, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Biomarker Research Program Center, Houston Methodist Research Institute, Houston, Texas","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"],"apc_list":null,"apc_paid":null,"fwci":1.9286,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.90122465,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"78","issue":"18","first_page":"5349","last_page":"5362"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.017999999225139618,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8410000205039978},{"id":"https://openalex.org/keywords/circulating-tumor-cells","display_name":"circulating tumor cells","score":0.953000009059906},{"id":"https://openalex.org/keywords/usp7","display_name":"USP7","score":0.7699999809265137},{"id":"https://openalex.org/keywords/deubiquitinase","display_name":"deubiquitinase","score":0.7570000290870667},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.9049999713897705},{"id":"https://openalex.org/keywords/metastatic-latency","display_name":"metastatic latency","score":0.8100000023841858},{"id":"https://openalex.org/keywords/micrometastasis","display_name":"micrometastases","score":0.9380000233650208},{"id":"https://openalex.org/keywords/bone-marrow-homing","display_name":"bone marrow homing","score":0.5659999847412109},{"id":"https://openalex.org/keywords/usp7-inhibitors","display_name":"USP7 inhibitors","score":0.7739999890327454},{"id":"https://openalex.org/keywords/melanoma-recurrence","display_name":"melanoma recurrence","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.7261766791343689},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.7213156819343567},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.660366415977478},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6179357767105103},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5981984734535217},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5672749280929565},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4921371340751648},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3204556703567505},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21003606915473938}],"mesh":[{"descriptor_ui":"D000076084","descriptor_name":"Ubiquitin-Specific Peptidase 7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009360","descriptor_name":"Neoplastic Cells, Circulating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.can-18-0644","doi":"https://doi.org/10.1158/0008-5472.can-18-0644","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-18-0644","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:30026332","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30026332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6139068","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6139068","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6139068","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6139068","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2729628047","display_name":"Mechanisms of melanoma brain metastasis by CTCs isolated from patients' blood and CSF","funder_award_id":"R01CA216991","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6337227970","display_name":"Functional characterization of brain-colonizing breast cancer CTC subsets","funder_award_id":"R01CA193213","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8458495048","display_name":"Heparanase Mechanisms in Brain-metastatic Breast Cancer","funder_award_id":"R01CA160335","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G904125514","display_name":"MOLECULAR DETERMINANTS OF BRAIN-METASTATIC MELANOMA","funder_award_id":"R01CA086832","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320316483","display_name":"Menarini Silicon Biosystems","ror":"https://ror.org/02q5qyt72"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W77524147","https://openalex.org/W1075451730","https://openalex.org/W1589068858","https://openalex.org/W1923075068","https://openalex.org/W1968718605","https://openalex.org/W1991981189","https://openalex.org/W1994777972","https://openalex.org/W2001823383","https://openalex.org/W2012226530","https://openalex.org/W2028092387","https://openalex.org/W2028662053","https://openalex.org/W2031821806","https://openalex.org/W2037270683","https://openalex.org/W2063725270","https://openalex.org/W2071732560","https://openalex.org/W2076471871","https://openalex.org/W2076693703","https://openalex.org/W2080833200","https://openalex.org/W2081924125","https://openalex.org/W2082015682","https://openalex.org/W2086949005","https://openalex.org/W2096926001","https://openalex.org/W2100877370","https://openalex.org/W2113302024","https://openalex.org/W2122568288","https://openalex.org/W2123453785","https://openalex.org/W2135682361","https://openalex.org/W2155358741","https://openalex.org/W2162311181","https://openalex.org/W2172034611","https://openalex.org/W2183070954","https://openalex.org/W2189531780","https://openalex.org/W2231156824","https://openalex.org/W2275678839","https://openalex.org/W2400710539","https://openalex.org/W2401291964","https://openalex.org/W2480997739","https://openalex.org/W2507916070","https://openalex.org/W2512022372","https://openalex.org/W2597394530","https://openalex.org/W2605233023","https://openalex.org/W2660354083","https://openalex.org/W2731078159","https://openalex.org/W2740569386","https://openalex.org/W2746510664","https://openalex.org/W2766320058","https://openalex.org/W2766422151","https://openalex.org/W2800104500","https://openalex.org/W2952309297"],"related_works":["https://openalex.org/W2887505726","https://openalex.org/W4235474014","https://openalex.org/W3197813906","https://openalex.org/W2906064573","https://openalex.org/W1998582960","https://openalex.org/W4233090591","https://openalex.org/W2885857693","https://openalex.org/W2791316031","https://openalex.org/W4296794736","https://openalex.org/W4409117101"],"abstract_inverted_index":{"Abstract":[0],"Systemic":[1],"metastasis":[2],"is":[3],"the":[4,11,38,58,62,83,92,172],"major":[5],"cause":[6],"of":[7,15,29,40,65,85,94,113,127,145,150,175,213,235],"death":[8],"from":[9,82],"melanoma,":[10,89],"most":[12,19],"lethal":[13],"form":[14],"skin":[16],"cancer.":[17],"Although":[18],"patients":[20,86],"with":[21,87],"melanoma":[22,48,177,214],"exhibit":[23],"a":[24,69,141,152,197,218],"substantial":[25],"gap":[26],"between":[27],"onset":[28],"primary":[30],"and":[31,55,101,109,123,162,216],"metastatic":[32,41,88,176,224],"tumors,":[33],"signaling":[34],"mechanisms":[35],"implicated":[36],"in":[37,57,106,116,158,181],"period":[39],"latency":[42],"remain":[43],"unclear.":[44],"We":[45],"hypothesized":[46],"that":[47,171,190],"circulating":[49],"tumor":[50,132,230],"cells":[51,133,231],"(CTC)":[52],"home":[53],"to":[54,71,199,202,221],"reside":[56],"bone":[59,130,159,228],"marrow":[60,160],"during":[61],"asymptomatic":[63,173],"phase":[64],"disease":[66,225],"progression.":[67],"Using":[68],"strategy":[70,198],"deplete":[72],"normal":[73],"cell":[74,80,107],"lineages":[75],"(Lin\u2212),":[76],"we":[77],"isolated":[78],"CTC-enriched":[79],"populations":[81],"blood":[84],"verified":[90],"by":[91,98,226],"presence":[93],"putative":[95],"CTCs":[96],"characterized":[97],"melanoma-specific":[99],"biomarkers":[100],"upregulated":[102],"gene":[103],"transcripts":[104],"involved":[105],"survival":[108],"prodevelopment":[110],"functions.":[111],"Implantation":[112],"Lin\u2212":[114],"population":[115],"NSG":[117],"mice":[118],"(CTC-derived":[119],"xenografts,":[120],"i.e.,":[121],"CDX),":[122],"subsequent":[124],"transcriptomic":[125],"analysis":[126],"ex":[128],"vivo":[129,182],"marrow\u2013resident":[131],"(BMRTC)":[134],"versus":[135],"CTC":[136],"identified":[137],"protein":[138],"ubiquitination":[139],"as":[140,196],"significant":[142],"regulatory":[143],"pathway":[144],"BMRTC":[146],"signaling.":[147],"Selective":[148],"inhibition":[149,234],"USP7,":[151],"key":[153],"deubiquinating":[154],"enzyme,":[155],"arrested":[156],"BMRTCs":[157],"locales":[161],"decreased":[163],"systemic":[164],"micrometastasis.":[165],"This":[166],"study":[167],"provides":[168],"first-time":[169],"evidence":[170],"progression":[174,201],"can":[178],"be":[179],"recapitulated":[180],"using":[183],"patient-isolated":[184],"CTCs.":[185],"Furthermore,":[186],"these":[187],"results":[188],"suggest":[189],"USP7":[191],"inhibitors":[192],"warrant":[193],"further":[194],"investigation":[195],"prevent":[200],"overt":[203],"clinical":[204],"metastasis.":[205],"Significance:":[206],"These":[207],"findings":[208],"provide":[209],"insights":[210],"into":[211],"mechanism":[212],"recurrence":[215],"propose":[217],"novel":[219],"approach":[220],"inhibit":[222],"systematic":[223],"targeting":[227],"marrow-resident":[229],"through":[232],"pharmacological":[233],"USP7.":[236],"Graphical":[237],"Abstract:":[238],"http://cancerres.aacrjournals.org/content/canres/78/18/5349/F1.large.jpg.":[239],"Cancer":[240],"Res;":[241],"78(18);":[242],"5349\u201362.":[243],"\u00a92018":[244],"AACR.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-08-03T00:00:00"}
