{"id":"https://openalex.org/W2884902118","doi":"https://doi.org/10.5505/tjtes.2018.68473","title":"The Therapeutic Effects of Thalidomide and Etanercept on Septic Rats Exposed to Lipopolysaccharide","display_name":"The Therapeutic Effects of Thalidomide and Etanercept on Septic Rats Exposed to Lipopolysaccharide","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2884902118","doi":"https://doi.org/10.5505/tjtes.2018.68473","mag":"2884902118","pmid":"https://pubmed.ncbi.nlm.nih.gov/30892678"},"language":"en","primary_location":{"id":"doi:10.5505/tjtes.2018.68473","doi":"https://doi.org/10.5505/tjtes.2018.68473","is_oa":true,"landing_page_url":"https://doi.org/10.5505/tjtes.2018.68473","pdf_url":"https://doi.org/10.5505/tjtes.2018.68473","source":{"id":"https://openalex.org/S2754011711","display_name":"Turkish Journal of Trauma and Emergency Surgery","issn_l":"1300-6738","issn":["1300-6738","1306-696X","1307-7945"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","poland-40","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4324032569","host_organization_name":"Turkish Association of Trauma and Emergency Surgery","host_organization_lineage":["https://openalex.org/P4324032569"],"host_organization_lineage_names":["Turkish Association of Trauma and Emergency Surgery"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Trauma and Emergency Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.5505/tjtes.2018.68473","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039672518","display_name":"Nevin \u0130lhan","orcid":"https://orcid.org/0000-0002-0208-8929","observed_orcids":["https://orcid.org/0000-0002-0208-8929","https://orcid.org/0000-0001-9997-0418"]},"institutions":[{"id":"https://openalex.org/I143396566","display_name":"F\u0131rat University","ror":"https://ror.org/05teb7b63","country_code":"TR","type":"education","lineage":["https://openalex.org/I143396566"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Nevin \u0130lhan","raw_affiliation_strings":["Department of Medical Biochemistry, Firat University Faculty of Medicine, Elaz\u0131\u011f-Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry, Firat University Faculty of Medicine, Elaz\u0131\u011f-Turkey","institution_ids":["https://openalex.org/I143396566"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039672518"],"corresponding_institution_ids":["https://openalex.org/I143396566"],"apc_list":null,"apc_paid":null,"fwci":0.8133,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.72335788,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"25","issue":"2","first_page":"99","last_page":"104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thalidomide","display_name":"thalidomide","score":0.9760000109672546},{"id":"https://openalex.org/keywords/etanercept","display_name":"etanercept","score":1.0},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9490000009536743},{"id":"https://openalex.org/keywords/endotoxemia","display_name":"endotoxemia","score":0.8040000200271606},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7910000085830688},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8960000276565552},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9789999723434448},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9440000057220459},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.9679999947547913},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9150000214576721},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9409999847412109},{"id":"https://openalex.org/keywords/total-oxidant-status","display_name":"total oxidant status","score":0.8930000066757202},{"id":"https://openalex.org/keywords/liver-tissue","display_name":"liver tissue","score":0.5619999766349792},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C2779609412","wikidata":"https://www.wikidata.org/wiki/Q203174","display_name":"Thalidomide","level":3,"score":0.6976996660232544},{"id":"https://openalex.org/C2777226972","wikidata":"https://www.wikidata.org/wiki/Q415343","display_name":"Etanercept","level":3,"score":0.6945337653160095},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.679280698299408},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6479681134223938},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.6344243288040161},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6273549795150757},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.5410096049308777},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5310611724853516},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4453592300415039},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3598308563232422},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3477592468261719},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068800","descriptor_name":"Etanercept","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013792","descriptor_name":"Thalidomide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.5505/tjtes.2018.68473","doi":"https://doi.org/10.5505/tjtes.2018.68473","is_oa":true,"landing_page_url":"https://doi.org/10.5505/tjtes.2018.68473","pdf_url":"https://doi.org/10.5505/tjtes.2018.68473","source":{"id":"https://openalex.org/S2754011711","display_name":"Turkish Journal of Trauma and Emergency Surgery","issn_l":"1300-6738","issn":["1300-6738","1306-696X","1307-7945"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","poland-40","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4324032569","host_organization_name":"Turkish Association of Trauma and Emergency Surgery","host_organization_lineage":["https://openalex.org/P4324032569"],"host_organization_lineage_names":["Turkish Association of Trauma and Emergency Surgery"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Trauma and Emergency Surgery","raw_type":"journal-article"},{"id":"pmid:30892678","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30892678","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES","raw_type":"Journal Article"},{"id":"pmh:oai:openaccess.firat.edu.tr:11508/52843","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11508/52843","pdf_url":null,"source":{"id":"https://openalex.org/S4377196733","display_name":"DSpace - FIRAT (F\u0131rat University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143396566","host_organization_name":"F\u0131rat University","host_organization_lineage":["https://openalex.org/I143396566"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.5505/tjtes.2018.68473","doi":"https://doi.org/10.5505/tjtes.2018.68473","is_oa":true,"landing_page_url":"https://doi.org/10.5505/tjtes.2018.68473","pdf_url":"https://doi.org/10.5505/tjtes.2018.68473","source":{"id":"https://openalex.org/S2754011711","display_name":"Turkish Journal of Trauma and Emergency Surgery","issn_l":"1300-6738","issn":["1300-6738","1306-696X","1307-7945"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","poland-40","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4324032569","host_organization_name":"Turkish Association of Trauma and Emergency Surgery","host_organization_lineage":["https://openalex.org/P4324032569"],"host_organization_lineage_names":["Turkish Association of Trauma and Emergency Surgery"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Trauma and Emergency Surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2884902118.pdf","grobid_xml":"https://content.openalex.org/works/W2884902118.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1503795283","https://openalex.org/W1775749144","https://openalex.org/W1946087945","https://openalex.org/W1974947860","https://openalex.org/W1976590837","https://openalex.org/W1987704186","https://openalex.org/W1992507257","https://openalex.org/W2005914282","https://openalex.org/W2011859994","https://openalex.org/W2024898666","https://openalex.org/W2035262960","https://openalex.org/W2035355922","https://openalex.org/W2041243667","https://openalex.org/W2051153504","https://openalex.org/W2052165300","https://openalex.org/W2055437345","https://openalex.org/W2056790168","https://openalex.org/W2061918839","https://openalex.org/W2065290731","https://openalex.org/W2084267233","https://openalex.org/W2087068114","https://openalex.org/W2101192701","https://openalex.org/W2104010066","https://openalex.org/W2120242825","https://openalex.org/W2124816784","https://openalex.org/W2134911483","https://openalex.org/W2142506176","https://openalex.org/W2151033853","https://openalex.org/W2159758267","https://openalex.org/W2163832808","https://openalex.org/W2462006984","https://openalex.org/W2539838201","https://openalex.org/W2572187401","https://openalex.org/W4321509157"],"related_works":["https://openalex.org/W2616254069","https://openalex.org/W2993165540","https://openalex.org/W6990276069","https://openalex.org/W3017963093","https://openalex.org/W2026826416","https://openalex.org/W2131741011","https://openalex.org/W2068284801","https://openalex.org/W4322761968","https://openalex.org/W1988428759","https://openalex.org/W4393091735"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,41,152],"aim":[2],"of":[3,12,52,68,154,160,173,197,225],"this":[4],"study":[5],"was":[6,44],"to":[7,86,203,219],"evaluate":[8],"the":[9,59,87,145,150,158,185,221],"therapeutic":[10,88,166,210],"effects":[11,224],"thalidomide":[13,169,214],"and":[14,39,79,102,114,118,141,163,170,191,200,215],"etanercept":[15,80,216],"on":[16],"lipopolysaccharide":[17],"(LPS)-induced":[18],"sepsis":[19],"in":[20,144,180,184],"a":[21,46,64,165,181],"rat":[22],"model.":[23],"METHODS:":[24],"Thirty":[25],"male":[26],"Wistar":[27],"Albino":[28],"rats":[29,60],"were":[30,61,83,108,123],"divided":[31],"into":[32],"5":[33],"groups:":[34],"Control,":[35],"LPS,":[36],"LPS+Thalidomide,":[37],"LPS+Etanercept,":[38],"LPS+Thalidomide+Etanercept.":[40],"control":[42],"group":[43],"given":[45],"1":[47],"mL":[48],"intraperitoneal":[49],"(i.p.)":[50],"injection":[51],"0.9%":[53],"saline":[54],"solution.":[55],"For":[56],"endotoxic":[57],"treatment,":[58],"injected":[62],"with":[63,149,176,208],"single":[65],"i.p.":[66,85],"dose":[67],"LPS":[69],"(Escherichia":[70],"coli":[71],"0111:":[72],"B4":[73],"(5":[74],"mg/kg).":[75],"Thalidomide":[76],"(0.5":[77],"mg/kg)":[78,82],"(1":[81],"administered":[84],"groups.":[89],"Hepatic":[90],"tissue":[91,135,156],"tumor":[92],"necrosis":[93],"factor-\u03b1":[94],"(TNF-\u03b1),":[95],"interleukin-6":[96],"(IL-6),":[97],"intercellular":[98],"adhesion":[99],"molecule-1":[100],"(ICAM-1)":[101],"platelet-derived":[103],"growth":[104],"factor":[105],"(PDGF)":[106],"levels":[107,117,143,205],"determined":[109],"by":[110],"enzyme-linked":[111],"immunosorbent":[112],"assay":[113],"malondialdehyde":[115],"(MDA)":[116],"total":[119],"oxidant":[120,201],"status":[121,202],"(TOS)":[122],"measured":[124],"using":[125],"appropriate":[126],"methods.":[127],"RESULTS:":[128],"In":[129],"vivo":[130],"results":[131],"exhibited":[132],"elevated":[133],"liver":[134,155],"TNF-\u03b1,":[136],"IL-6,":[137],"ICAM-1,":[138],"PDGF,":[139],"MDA,":[140],"TOS":[142],"LPS-treated":[146],"animals":[147,175],"compared":[148],"controls.":[151],"analysis":[153],"supported":[157],"findings":[159],"biochemical":[161],"alterations":[162],"indicated":[164],"role":[167],"for":[168],"etanercept.":[171],"Treatment":[172],"septic":[174],"these":[177],"agents":[178,211],"resulted":[179],"remarkable":[182],"decrease":[183],"selected":[186,209],"proinflammatory":[187],"cytokines,":[188],"angiogenic":[189],"factors,":[190],"reactive":[192],"oxygen":[193],"parameters.":[194],"CONCLUSION:":[195],"Restoration":[196],"cytokine":[198],"balance":[199],"normal":[204],"following":[206],"treatment":[207],"suggests":[212],"that":[213],"can":[217],"help":[218],"avoid":[220],"potentially":[222],"devastating":[223],"sepsis.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-08-03T00:00:00"}
