{"id":"https://openalex.org/W2884887484","doi":"https://doi.org/10.1007/s00277-018-3451-1","title":"A comparison of qPCR and ddPCR used for quantification of the JAK2 V617F allele burden in Ph negative MPNs","display_name":"A comparison of qPCR and ddPCR used for quantification of the JAK2 V617F allele burden in Ph negative MPNs","publication_year":2018,"publication_date":"2018-07-28","ids":{"openalex":"https://openalex.org/W2884887484","doi":"https://doi.org/10.1007/s00277-018-3451-1","mag":"2884887484","pmid":"https://pubmed.ncbi.nlm.nih.gov/30056580","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6208664"},"language":"en","primary_location":{"id":"doi:10.1007/s00277-018-3451-1","doi":"https://doi.org/10.1007/s00277-018-3451-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00277-018-3451-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00277-018-3451-1.pdf","source":{"id":"https://openalex.org/S163204731","display_name":"Annals of Hematology","issn_l":"0939-5555","issn":["0939-5555","1432-0584"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Hematology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00277-018-3451-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091424959","display_name":"Dorota Link-Lenczowska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166853","display_name":"Szpital Uniwersytecki w Krakowie","ror":"https://ror.org/05vgmh969","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210166853"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Dorota Link-Lenczowska","raw_affiliation_strings":["Department of Hematology Diagnostics, The University Hospital, Krak\u00f3w, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology Diagnostics, The University Hospital, Krak\u00f3w, Poland","institution_ids":["https://openalex.org/I4210166853"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075557171","display_name":"Niels Pallisgaard","orcid":"https://orcid.org/0000-0002-0749-0810","observed_orcids":["https://orcid.org/0000-0002-0749-0810"]},"institutions":[{"id":"https://openalex.org/I4210087803","display_name":"Zealand University Hospital","ror":"https://ror.org/00363z010","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799668677","https://openalex.org/I2802567020","https://openalex.org/I4210087803"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Niels Pallisgaard","raw_affiliation_strings":["Department of Pathology, Zealand University Hospital, Roskilde, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Zealand University Hospital, Roskilde, Denmark","institution_ids":["https://openalex.org/I4210087803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087535069","display_name":"Sabrina Cordua","orcid":"https://orcid.org/0000-0002-0585-7957","observed_orcids":["https://orcid.org/0000-0002-0585-7957"]},"institutions":[{"id":"https://openalex.org/I2799546111","display_name":"Roskilde Sygehus","ror":"https://ror.org/00t2n7611","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799546111"]},{"id":"https://openalex.org/I4210087803","display_name":"Zealand University Hospital","ror":"https://ror.org/00363z010","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799668677","https://openalex.org/I2802567020","https://openalex.org/I4210087803"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Sabrina Cordua","raw_affiliation_strings":["Department of Hematology, Zealand University Hospital, Roskilde, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Zealand University Hospital, Roskilde, Denmark","institution_ids":["https://openalex.org/I2799546111","https://openalex.org/I4210087803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079195304","display_name":"Magdalena Zawada","orcid":"https://orcid.org/0000-0001-9105-1767","observed_orcids":["https://orcid.org/0000-0001-9105-1767"]},"institutions":[{"id":"https://openalex.org/I4210166853","display_name":"Szpital Uniwersytecki w Krakowie","ror":"https://ror.org/05vgmh969","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210166853"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Magdalena Zawada","raw_affiliation_strings":["Department of Hematology Diagnostics, The University Hospital, Krak\u00f3w, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology Diagnostics, The University Hospital, Krak\u00f3w, Poland","institution_ids":["https://openalex.org/I4210166853"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014922552","display_name":"Sylwia Czekalska","orcid":"https://orcid.org/0009-0007-3736-7577","observed_orcids":["https://orcid.org/0009-0007-3736-7577"]},"institutions":[{"id":"https://openalex.org/I4210166853","display_name":"Szpital Uniwersytecki w Krakowie","ror":"https://ror.org/05vgmh969","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210166853"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Sylwia Czekalska","raw_affiliation_strings":["Department of Hematology Diagnostics, The University Hospital, Krak\u00f3w, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology Diagnostics, The University Hospital, Krak\u00f3w, Poland","institution_ids":["https://openalex.org/I4210166853"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021184599","display_name":"Dorota Krochmalczyk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Dorota Krochmalczyk","raw_affiliation_strings":["Chair of Hematology, Jagiellonian University Medical College, Kopernika 17, 31-501, Krakow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Hematology, Jagiellonian University Medical College, Kopernika 17, 31-501, Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004764706","display_name":"Zuzanna Kandu\u0142a","orcid":"https://orcid.org/0000-0003-3734-271X","observed_orcids":["https://orcid.org/0000-0003-3734-271X"]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Zuzanna Kandu\u0142a","raw_affiliation_strings":["Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Poznan, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Poznan, Poland","institution_ids":["https://openalex.org/I120230055"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029712912","display_name":"Tomasz Sacha","orcid":"https://orcid.org/0000-0002-7207-6595","observed_orcids":["https://orcid.org/0000-0002-7207-6595"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Tomasz Sacha","raw_affiliation_strings":["Chair of Hematology, Jagiellonian University Medical College, Kopernika 17, 31-501, Krakow, Poland. sachatom@gmail.com","Chair of Hematology, Jagiellonian University Medical College, Kopernika 17, 31-501, Krakow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Hematology, Jagiellonian University Medical College, Kopernika 17, 31-501, Krakow, Poland. sachatom@gmail.com","institution_ids":["https://openalex.org/I126596746"]},{"raw_affiliation_string":"Chair of Hematology, Jagiellonian University Medical College, Kopernika 17, 31-501, Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5029712912"],"corresponding_institution_ids":["https://openalex.org/I126596746"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":{"value":4590,"currency":"USD","value_usd":4590},"fwci":4.4497,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.9589491,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"97","issue":"12","first_page":"2299","last_page":"2308"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/jak2-v617f-mutation","display_name":"JAK2 V617F mutation","score":0.9850000143051147},{"id":"https://openalex.org/keywords/philadelphia-chromosome-negative-myeloproliferative-neoplasms","display_name":"Philadelphia-negative myeloproliferative neoplasms","score":0.9789999723434448},{"id":"https://openalex.org/keywords/droplet-digital-pcr","display_name":"droplet digital PCR","score":0.9580000042915344},{"id":"https://openalex.org/keywords/real-time-pcr","display_name":"real-time PCR","score":0.7689999938011169},{"id":"https://openalex.org/keywords/ruxolitinib","display_name":"ruxolitinib","score":0.9610000252723694},{"id":"https://openalex.org/keywords/minimal-residual-disease-monitoring","display_name":"minimal residual disease monitoring","score":0.9190000295639038},{"id":"https://openalex.org/keywords/jak-inhibitor-therapy","display_name":"JAK inhibitor therapy","score":0.7300000190734863},{"id":"https://openalex.org/keywords/detection-limit","display_name":"detection limit","score":0.8149999976158142},{"id":"https://openalex.org/keywords/diagnostic-sensitivity","display_name":"diagnostic sensitivity","score":0.4090000092983246}],"concepts":[{"id":"https://openalex.org/C2776112149","wikidata":"https://www.wikidata.org/wiki/Q7383611","display_name":"Ruxolitinib","level":4,"score":0.6656917929649353},{"id":"https://openalex.org/C2909272587","wikidata":"https://www.wikidata.org/wiki/Q14914514","display_name":"JAK2 V617F","level":4,"score":0.6145679354667664},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6043631434440613},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5942891240119934},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5896644592285156},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.48804154992103577},{"id":"https://openalex.org/C48126324","wikidata":"https://www.wikidata.org/wiki/Q5276136","display_name":"Digital polymerase chain reaction","level":4,"score":0.4864180088043213},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.48628342151641846},{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.4505133032798767},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4422953724861145},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.4111808240413666},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.3454029858112335},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25603246688842773},{"id":"https://openalex.org/C2780076729","wikidata":"https://www.wikidata.org/wiki/Q1752571","display_name":"Myelofibrosis","level":3,"score":0.24572822451591492},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20293790102005005},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20008772611618042},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.12103772163391113},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069283","descriptor_name":"Rituximab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010677","descriptor_name":"Philadelphia Chromosome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1007/s00277-018-3451-1","doi":"https://doi.org/10.1007/s00277-018-3451-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00277-018-3451-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00277-018-3451-1.pdf","source":{"id":"https://openalex.org/S163204731","display_name":"Annals of Hematology","issn_l":"0939-5555","issn":["0939-5555","1432-0584"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Hematology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5167059","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6208664","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6208664","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6208664","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ann Hematol","raw_type":"Text"},{"id":"pmid:30056580","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30056580","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of hematology","raw_type":"Clinical Trial"},{"id":"pmh:oai:ruj.uj.edu.pl:item/143673","doi":null,"is_oa":true,"landing_page_url":"https://ruj.uj.edu.pl/xmlui/handle/item/143673","pdf_url":"http://ruj.uj.edu.pl/bitstreams/b2394d20-52d5-4f1a-adca-9a4062d77264/download","source":{"id":"https://openalex.org/S4306400316","display_name":"Homo Politicus (Academy of Humanities and Economics in Lodz)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"artyku\u0142 w czasopi\u015bmie"},{"id":"pmh:oai:ruj.uj.edu.pl:item/111770","doi":null,"is_oa":false,"landing_page_url":"https://ruj.uj.edu.pl/xmlui/handle/item/111770","pdf_url":null,"source":{"id":"https://openalex.org/S4306400316","display_name":"Homo Politicus (Academy of Humanities and Economics in Lodz)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"artyku\u0142 w czasopi\u015bmie"},{"id":"pmh:oai:ruj.uj.edu.pl:item/121802","doi":null,"is_oa":true,"landing_page_url":"https://ruj.uj.edu.pl/xmlui/handle/item/121802","pdf_url":null,"source":{"id":"https://openalex.org/S4306401249","display_name":"Jagiellonian University Repository (Jagiellonian University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126596746","host_organization_name":"Jagiellonian University","host_organization_lineage":["https://openalex.org/I126596746"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:ruj.uj.edu.pl:item/97607","doi":null,"is_oa":true,"landing_page_url":"https://ruj.uj.edu.pl/xmlui/handle/item/97607","pdf_url":null,"source":{"id":"https://openalex.org/S4306400316","display_name":"Homo Politicus (Academy of Humanities and Economics in Lodz)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"artyku\u0142 w czasopi\u015bmie"}],"best_oa_location":{"id":"doi:10.1007/s00277-018-3451-1","doi":"https://doi.org/10.1007/s00277-018-3451-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00277-018-3451-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00277-018-3451-1.pdf","source":{"id":"https://openalex.org/S163204731","display_name":"Annals of Hematology","issn_l":"0939-5555","issn":["0939-5555","1432-0584"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Hematology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2884887484.pdf","grobid_xml":"https://content.openalex.org/works/W2884887484.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1970553871","https://openalex.org/W1982105192","https://openalex.org/W1983780601","https://openalex.org/W1998271419","https://openalex.org/W2002302430","https://openalex.org/W2004511852","https://openalex.org/W2005582645","https://openalex.org/W2015662674","https://openalex.org/W2022159066","https://openalex.org/W2027616756","https://openalex.org/W2028803880","https://openalex.org/W2030868349","https://openalex.org/W2056777053","https://openalex.org/W2060988701","https://openalex.org/W2062654985","https://openalex.org/W2077661091","https://openalex.org/W2082724803","https://openalex.org/W2082888299","https://openalex.org/W2084050646","https://openalex.org/W2088263025","https://openalex.org/W2093290834","https://openalex.org/W2099262599","https://openalex.org/W2104201440","https://openalex.org/W2110190127","https://openalex.org/W2126816979","https://openalex.org/W2129799496","https://openalex.org/W2135367830","https://openalex.org/W2149858388","https://openalex.org/W2151027920","https://openalex.org/W2157114147","https://openalex.org/W2168420558","https://openalex.org/W2289275218","https://openalex.org/W2289879004","https://openalex.org/W2339658711","https://openalex.org/W2557168632","https://openalex.org/W2602360350","https://openalex.org/W2606092354","https://openalex.org/W2608363029","https://openalex.org/W2612571615","https://openalex.org/W2761444984","https://openalex.org/W2793344857"],"related_works":["https://openalex.org/W2289275218","https://openalex.org/W3009387282","https://openalex.org/W2104047952","https://openalex.org/W272002360","https://openalex.org/W2771971723","https://openalex.org/W4388713031","https://openalex.org/W7171299514","https://openalex.org/W1989601173","https://openalex.org/W4400965588","https://openalex.org/W4389229207"],"abstract_inverted_index":{"Philadelphia-negative":[0],"myeloproliferative":[1],"neoplasms":[2],"(MPNs)":[3],"are":[4,134],"a":[5,38,107,147],"diverse":[6],"group":[7],"of":[8,16,19,26,87,97,136,144,149,152,162,185,191,197,203,220],"diseases":[9],"whose":[10],"common":[11],"feature":[12],"is":[13,37,207],"the":[14,20,24,72,111,138,195,200,217,221,233],"presence":[15],"V617F":[17,91,140,164,222],"mutation":[18,92,141,223],"JAK2":[21,90,139,163],"gene.":[22],"In":[23,67],"era":[25],"novel":[27],"therapeutic":[28,59],"strategies":[29],"in":[30,93,167,187,232],"MPNs,":[31],"such":[32,61],"as":[33,62],"JAK-inhibitor":[34],"therapy,":[35],"there":[36],"growing":[39],"need":[40],"for":[41,57,81,128,154,158,216],"establishing":[42],"high":[43,108,125],"sensitive":[44],"quantitative":[45],"methods,":[46],"which":[47,98],"can":[48],"be":[49,214],"useful":[50],"not":[51],"only":[52],"at":[53,142,224],"diagnosis":[54,143],"but":[55],"also":[56],"monitoring":[58,86,188],"outcomes,":[60],"minimal":[63],"residual":[64],"disease":[65],"(MRD).":[66],"this":[68],"study,":[69],"we":[70],"compared":[71],"qPCR":[73,155,204,231],"and":[74,77,84,156,205,210],"ddPCR":[75,186,206,227],"methods":[76,113,176,212],"their":[78],"clinical":[79,201],"utility":[80,202],"diagnosis,":[82,225],"prognostication,":[83],"treatment":[85],"MPNs":[88],"with":[89,146,170,177],"63":[94],"MPN":[95,145],"patients":[96,168],"6":[99],"were":[100,172],"subjected":[101],"to":[102,236],"ruxolitinib":[103,171],"treatment.":[104],"We":[105],"show":[106],"conformance":[109],"between":[110],"two":[112],"(correlation":[114],"coefficient":[115],"r":[116],"=":[117],"0.998":[118],"(p":[119],"<":[120],"0.0001)).":[121],"Our":[122],"experiments":[123],"revealed":[124],"analytical":[126],"sensitivity":[127],"both":[129,175,211],"tests,":[130],"suggesting":[131],"that":[132],"they":[133],"capable":[135],"detecting":[137],"limit":[148],"detection":[150,219],"(LoD)":[151],"0.12%":[153],"0.01%":[157],"ddPCR.":[159],"The":[160,180],"alterations":[161],"allele":[165,192],"burden":[166],"treated":[169],"measured":[173],"by":[174],"equal":[178],"accuracy.":[179],"results":[181],"suggest":[182],"an":[183],"advantage":[184],"MRD":[189],"because":[190],"burdens":[193],"below":[194],"LoD":[196],"qPCR.":[198],"Overall,":[199],"very":[208],"high,":[209],"could":[213],"recommended":[215],"routine":[218],"though":[226],"will":[228],"probably":[229],"supersede":[230],"future":[234],"due":[235],"cost-effectiveness.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-08-03T00:00:00"}