{"id":"https://openalex.org/W2884793253","doi":"https://doi.org/10.1194/jlr.m085647","title":"NT-PGC-1\u03b1 deficiency decreases mitochondrial FA oxidation in brown adipose tissue and alters substrate utilization in vivo","display_name":"NT-PGC-1\u03b1 deficiency decreases mitochondrial FA oxidation in brown adipose tissue and alters substrate utilization in vivo","publication_year":2018,"publication_date":"2018-07-20","ids":{"openalex":"https://openalex.org/W2884793253","doi":"https://doi.org/10.1194/jlr.m085647","mag":"2884793253","pmid":"https://pubmed.ncbi.nlm.nih.gov/30026188","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6121938"},"language":"en","primary_location":{"id":"doi:10.1194/jlr.m085647","doi":"https://doi.org/10.1194/jlr.m085647","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.m085647","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1194/jlr.m085647","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100462758","display_name":"Ji-Hyun Kim","orcid":"https://orcid.org/0000-0001-8232-2932","observed_orcids":["https://orcid.org/0000-0001-8232-2932"]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jihyun Kim","raw_affiliation_strings":["Laboratory of Gene Regulation and Metabolism, Pennington Biomedical Research Center, Baton Rouge, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Gene Regulation and Metabolism, Pennington Biomedical Research Center, Baton Rouge, LA","institution_ids":["https://openalex.org/I103990859"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041881822","display_name":"Min Sung Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Sung Park","raw_affiliation_strings":["Laboratory of Gene Regulation and Metabolism, Pennington Biomedical Research Center, Baton Rouge, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Gene Regulation and Metabolism, Pennington Biomedical Research Center, Baton Rouge, LA","institution_ids":["https://openalex.org/I103990859"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006155318","display_name":"Kyoung\u2010Soo Ha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyoungsoo Ha","raw_affiliation_strings":["Laboratory of Gene Regulation and Metabolism, Pennington Biomedical Research Center, Baton Rouge, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Gene Regulation and Metabolism, Pennington Biomedical Research Center, Baton Rouge, LA","institution_ids":["https://openalex.org/I103990859"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034560646","display_name":"Chulhong Park","orcid":"https://orcid.org/0000-0003-3589-9864","observed_orcids":["https://orcid.org/0000-0003-3589-9864"]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chulhong Park","raw_affiliation_strings":["Laboratory of Gene Regulation and Metabolism, Pennington Biomedical Research Center, Baton Rouge, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Gene Regulation and Metabolism, Pennington Biomedical Research Center, Baton Rouge, LA","institution_ids":["https://openalex.org/I103990859"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101665507","display_name":"Jisu Lee","orcid":"https://orcid.org/0000-0002-3327-1945","observed_orcids":["https://orcid.org/0000-0002-3327-1945"]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jisu Lee","raw_affiliation_strings":["Laboratory of Gene Regulation and Metabolism, Pennington Biomedical Research Center, Baton Rouge, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Gene Regulation and Metabolism, Pennington Biomedical Research Center, Baton Rouge, LA","institution_ids":["https://openalex.org/I103990859"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008448236","display_name":"Randall L. Mynatt","orcid":"https://orcid.org/0000-0003-4399-0019","observed_orcids":["https://orcid.org/0000-0003-4399-0019"]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randall L. Mynatt","raw_affiliation_strings":["Transgenic Core, Pennington Biomedical Research Center, Baton Rouge, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transgenic Core, Pennington Biomedical Research Center, Baton Rouge, LA","institution_ids":["https://openalex.org/I103990859"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018633179","display_name":"Ji Suk Chang","orcid":"https://orcid.org/0000-0002-0706-1960","observed_orcids":["https://orcid.org/0000-0002-0706-1960"]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ji Suk Chang","raw_affiliation_strings":["Laboratory of Gene Regulation and Metabolism, Pennington Biomedical Research Center, Baton Rouge, LA. Electronic address: jisuk.chang@pbrc.edu","Laboratory of Gene Regulation and Metabolism, Pennington Biomedical Research Center, Baton Rouge, LA"],"raw_orcid":"https://orcid.org/0000-0002-0706-1960","affiliations":[{"raw_affiliation_string":"Laboratory of Gene Regulation and Metabolism, Pennington Biomedical Research Center, Baton Rouge, LA. Electronic address: jisuk.chang@pbrc.edu","institution_ids":["https://openalex.org/I103990859"]},{"raw_affiliation_string":"Laboratory of Gene Regulation and Metabolism, Pennington Biomedical Research Center, Baton Rouge, LA","institution_ids":["https://openalex.org/I103990859"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018633179"],"corresponding_institution_ids":["https://openalex.org/I103990859"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.6727,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.66076205,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"59","issue":"9","first_page":"1660","last_page":"1670"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pgc-1alpha","display_name":"PGC-1\u03b1","score":0.8939999938011169},{"id":"https://openalex.org/keywords/brown-adipose-tissue","display_name":"brown adipose tissue","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mitochondrial-fatty-acid-oxidation","display_name":"mitochondrial fatty acid oxidation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/thermogenesis","display_name":"thermogenesis","score":0.7900000214576721},{"id":"https://openalex.org/keywords/thermoneutrality","display_name":"thermoneutrality","score":0.8859999775886536},{"id":"https://openalex.org/keywords/substrate-utilization","display_name":"substrate utilization","score":0.6570000052452087},{"id":"https://openalex.org/keywords/glucose-utilization","display_name":"glucose utilization","score":0.777999997138977},{"id":"https://openalex.org/keywords/lipid-droplets","display_name":"lipid droplets","score":0.890999972820282},{"id":"https://openalex.org/keywords/cold-exposure","display_name":"cold exposure","score":0.6100000143051147},{"id":"https://openalex.org/keywords/beta3-adrenergic-receptor","display_name":"beta3-adrenergic receptor","score":0.8820000290870667},{"id":"https://openalex.org/keywords/knockout-mice","display_name":"knockout mice","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C151279926","wikidata":"https://www.wikidata.org/wiki/Q965695","display_name":"Thermogenesis","level":3,"score":0.8786303997039795},{"id":"https://openalex.org/C2780642333","wikidata":"https://www.wikidata.org/wiki/Q901269","display_name":"Brown adipose tissue","level":3,"score":0.8340421915054321},{"id":"https://openalex.org/C77445288","wikidata":"https://www.wikidata.org/wiki/Q637488","display_name":"Coactivator","level":4,"score":0.7841501235961914},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7145439982414246},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6563154458999634},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6381126046180725},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4490740895271301},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4341529607772827},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.35076597332954407},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24808847904205322},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15904882550239563},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14880704879760742},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0531078577041626},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000071248","descriptor_name":"Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D000071248","descriptor_name":"Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071248","descriptor_name":"Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002001","descriptor_name":"Adipose Tissue, Brown","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D002001","descriptor_name":"Adipose Tissue, Brown","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008066","descriptor_name":"Lipolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022722","descriptor_name":"Thermogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1194/jlr.m085647","doi":"https://doi.org/10.1194/jlr.m085647","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.m085647","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5675589","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6121938","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30026188","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30026188","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of lipid research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6121938","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6121938/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Lipid Res","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:10e836d918fa42b9a31f69951e7e66ff","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/10e836d918fa42b9a31f69951e7e66ff","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Lipid Research, Vol 59, Iss 9, Pp 1660-1670 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1194/jlr.m085647","doi":"https://doi.org/10.1194/jlr.m085647","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.m085647","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3919482367","display_name":"The short isoform of PGC-1alpha in the control of brown adipose tissue thermogenesis","funder_award_id":"R01DK104748","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6306356698","display_name":"Mentoring Obesity and Diabetes Research in Louisiana","funder_award_id":"P30GM118430","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000013714","display_name":null,"funder_award_id":"NIH8 1P30GM118430-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000905746","display_name":"Pennington/Louisiana NORC","funder_award_id":"P30DK072476","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W49027603","https://openalex.org/W1520083061","https://openalex.org/W1550000221","https://openalex.org/W1574890413","https://openalex.org/W1964739304","https://openalex.org/W1971082641","https://openalex.org/W1972836378","https://openalex.org/W1975962309","https://openalex.org/W1977339956","https://openalex.org/W1996039273","https://openalex.org/W1996840778","https://openalex.org/W1997917664","https://openalex.org/W2006148647","https://openalex.org/W2008632158","https://openalex.org/W2017839348","https://openalex.org/W2044782567","https://openalex.org/W2049869836","https://openalex.org/W2055651091","https://openalex.org/W2064694581","https://openalex.org/W2075282827","https://openalex.org/W2077132863","https://openalex.org/W2080394935","https://openalex.org/W2081567987","https://openalex.org/W2088655832","https://openalex.org/W2102921035","https://openalex.org/W2105404724","https://openalex.org/W2106956546","https://openalex.org/W2109907677","https://openalex.org/W2112520822","https://openalex.org/W2115941382","https://openalex.org/W2132358997","https://openalex.org/W2153081066","https://openalex.org/W2162919259","https://openalex.org/W2168771789","https://openalex.org/W2481037500","https://openalex.org/W2610222140","https://openalex.org/W2770114672","https://openalex.org/W4238372547","https://openalex.org/W4253244719","https://openalex.org/W4416702841","https://openalex.org/W6689234452"],"related_works":["https://openalex.org/W2481037500","https://openalex.org/W2106956546","https://openalex.org/W2804157341","https://openalex.org/W2006148647","https://openalex.org/W2610222140","https://openalex.org/W7099540567","https://openalex.org/W1996039273","https://openalex.org/W4224325088","https://openalex.org/W7099244850","https://openalex.org/W2057622186"],"abstract_inverted_index":{"Transcriptional":[0],"coactivator":[1,4],"PPAR":[2],"\u03b3":[3],"(PGC)-1\u03b1":[5],"and":[6,182,192],"its":[7],"splice":[8],"variant":[9],"N-terminal":[10],"(NT)-PGC-1\u03b1":[11],"mediate":[12],"transcriptional":[13,100],"regulation":[14],"of":[15,45,66,85,93,175,190],"brown":[16],"adipose":[17],"tissue":[18],"(BAT)":[19],"thermogenesis":[20,34,152],"in":[21,25,47,107,113,178],"response":[22,137],"to":[23,62,138,172,194],"changes":[24],"ambient":[26],"temperature.":[27],"PGC-1\u03b1":[28,191],"is":[29,39,168],"dispensable":[30],"for":[31],"cold-induced":[32],"BAT":[33,48,71,80,122,179,196],"as":[35,37,158],"long":[36],"NT-PGC-1\u03b1":[38,46,59,67,75,108,120,128,146,167,193],"present.":[40],"However,":[41],"the":[42,54,64,119,173,187],"functional":[43],"significance":[44],"has":[49],"not":[50],"been":[51],"determined.":[52],"In":[53,124,136],"present":[55],"study,":[56],"we":[57],"generated":[58],"\u2212/\u2212":[60,76,109,121,129,147],"mice":[61,77,130,148],"investigate":[63],"effect":[65],"deficiency":[68],"on":[69,134],"adaptive":[70],"thermogenesis.":[72],"At":[73],"thermoneutrality,":[74],"exhibited":[78,150],"abnormal":[79],"phenotype":[81],"with":[82,90,99,126],"increased":[83],"accumulation":[84],"large":[86],"lipid":[87],"droplets":[88],"concomitant":[89],"marked":[91],"downregulation":[92],"FA":[94],"oxidation":[95],"(FAO)-related":[96],"genes.":[97],"Consistent":[98],"changes,":[101],"mitochondrial":[102],"FAO":[103,176],"was":[104],"significantly":[105],"diminished":[106],"BAT.":[110],"This":[111],"alteration,":[112],"turn,":[114],"enhanced":[115],"glucose":[116],"utilization":[117],"within":[118],"mitochondria.":[123],"line":[125],"this,":[127],"had":[131],"higher":[132],"reliance":[133],"carbohydrates.":[135],"cold":[139],"or":[140],"\u03b2":[141],"3":[142],"-adrenergic":[143],"receptor":[144],"agonist,":[145],"transiently":[149],"lower":[151],"but":[153],"reached":[154],"similar":[155],"thermogenic":[156],"capacities":[157],"their":[159],"WT":[160],"littermates.":[161],"Collectively,":[162],"these":[163],"findings":[164],"demonstrate":[165],"that":[166],"an":[169],"important":[170],"contributor":[171],"maintenance":[174],"capacity":[177],"at":[180],"thermoneutrality":[181],"provide":[183],"deeper":[184],"insights":[185],"into":[186],"relative":[188],"contributions":[189],"temperature-regulated":[195],"remodeling.":[197]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-08-03T00:00:00"}
