{"id":"https://openalex.org/W2884615338","doi":"https://doi.org/10.2147/ott.s164711","title":"LINC00888 promoted tumorigenicity of melanoma via miR-126/CRK signaling axis","display_name":"LINC00888 promoted tumorigenicity of melanoma via miR-126/CRK signaling axis","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2884615338","doi":"https://doi.org/10.2147/ott.s164711","mag":"2884615338","pmid":"https://pubmed.ncbi.nlm.nih.gov/30104884","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6074824"},"language":"en","primary_location":{"id":"doi:10.2147/ott.s164711","doi":"https://doi.org/10.2147/ott.s164711","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ott.s164711","pdf_url":"https://www.dovepress.com/getfile.php?fileID=43397","source":{"id":"https://openalex.org/S120324992","display_name":"OncoTargets and Therapy","issn_l":"1178-6930","issn":["1178-6930"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoTargets and Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=43397","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101743459","display_name":"Wei Lu","orcid":"https://orcid.org/0000-0003-1658-1703","observed_orcids":["https://orcid.org/0000-0003-1658-1703"]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Lu","raw_affiliation_strings":["Department of Dermatology, People's Hospital of Hangzhou Medical College, Hangzhou 310006, China","Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210008, China, daniluo2005@163.com","Department of Dermatology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China","Department of Dermatology,","Department of Dermatology, The First affiliated hospital of nanjing Medical University, nanjing 210008, china;","People's hospital of hangzhou Medical college, hangzhou 310006, china;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, People's Hospital of Hangzhou Medical College, Hangzhou 310006, China","institution_ids":["https://openalex.org/I4210165441"]},{"raw_affiliation_string":"Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210008, China, daniluo2005@163.com","institution_ids":["https://openalex.org/I4210152119"]},{"raw_affiliation_string":"Department of Dermatology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China","institution_ids":["https://openalex.org/I4210131061"]},{"raw_affiliation_string":"Department of Dermatology,","institution_ids":[]},{"raw_affiliation_string":"Department of Dermatology, The First affiliated hospital of nanjing Medical University, nanjing 210008, china;","institution_ids":["https://openalex.org/I4210152119"]},{"raw_affiliation_string":"People's hospital of hangzhou Medical college, hangzhou 310006, china;","institution_ids":["https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053343957","display_name":"Xiaohua Tao","orcid":"https://orcid.org/0009-0007-0229-7126","observed_orcids":["https://orcid.org/0009-0007-0229-7126","https://orcid.org/0000-0003-3527-2914"]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohua Tao","raw_affiliation_strings":["Department of Dermatology, People's Hospital of Hangzhou Medical College, Hangzhou 310006, China","Department of Dermatology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China","Department of Dermatology,","People's hospital of hangzhou Medical college, hangzhou 310006, china;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, People's Hospital of Hangzhou Medical College, Hangzhou 310006, China","institution_ids":["https://openalex.org/I4210165441"]},{"raw_affiliation_string":"Department of Dermatology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China","institution_ids":["https://openalex.org/I4210131061"]},{"raw_affiliation_string":"Department of Dermatology,","institution_ids":[]},{"raw_affiliation_string":"People's hospital of hangzhou Medical college, hangzhou 310006, china;","institution_ids":["https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100744613","display_name":"Yibin Fan","orcid":"https://orcid.org/0000-0003-4201-8498","observed_orcids":["https://orcid.org/0000-0003-4201-8498"]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yibin Fan","raw_affiliation_strings":["Department of Dermatology, People's Hospital of Hangzhou Medical College, Hangzhou 310006, China","Department of Dermatology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China","Department of Dermatology,","People's hospital of hangzhou Medical college, hangzhou 310006, china;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, People's Hospital of Hangzhou Medical College, Hangzhou 310006, China","institution_ids":["https://openalex.org/I4210165441"]},{"raw_affiliation_string":"Department of Dermatology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China","institution_ids":["https://openalex.org/I4210131061"]},{"raw_affiliation_string":"Department of Dermatology,","institution_ids":[]},{"raw_affiliation_string":"People's hospital of hangzhou Medical college, hangzhou 310006, china;","institution_ids":["https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021026358","display_name":"Yi Tang","orcid":"https://orcid.org/0000-0002-1738-5811","observed_orcids":["https://orcid.org/0000-0002-1738-5811"]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Tang","raw_affiliation_strings":["Department of Dermatology, People's Hospital of Hangzhou Medical College, Hangzhou 310006, China","Department of Dermatology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China","Department of Dermatology,","People's hospital of hangzhou Medical college, hangzhou 310006, china;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, People's Hospital of Hangzhou Medical College, Hangzhou 310006, China","institution_ids":["https://openalex.org/I4210165441"]},{"raw_affiliation_string":"Department of Dermatology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China","institution_ids":["https://openalex.org/I4210131061"]},{"raw_affiliation_string":"Department of Dermatology,","institution_ids":[]},{"raw_affiliation_string":"People's hospital of hangzhou Medical college, hangzhou 310006, china;","institution_ids":["https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102027894","display_name":"Xin Xu","orcid":"https://orcid.org/0000-0002-6486-0961","observed_orcids":["https://orcid.org/0000-0002-6486-0961"]},"institutions":[{"id":"https://openalex.org/I4405278572","display_name":"Zhejiang College of Sports","ror":"https://ror.org/007m7pb04","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405278572"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Xu","raw_affiliation_strings":["Department of Sport Medicine, Zhejiang College of Sports, Hangzhou 310000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sport Medicine, Zhejiang College of Sports, Hangzhou 310000, China","institution_ids":["https://openalex.org/I4405278572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064919528","display_name":"Shasha Fan","orcid":"https://orcid.org/0000-0002-8699-3634","observed_orcids":["https://orcid.org/0000-0002-8699-3634"]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shasha Fan","raw_affiliation_strings":["Department of Dermatology, People's Hospital of Hangzhou Medical College, Hangzhou 310006, China","Department of Dermatology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China","Department of Dermatology,","People's hospital of hangzhou Medical college, hangzhou 310006, china;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, People's Hospital of Hangzhou Medical College, Hangzhou 310006, China","institution_ids":["https://openalex.org/I4210165441"]},{"raw_affiliation_string":"Department of Dermatology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China","institution_ids":["https://openalex.org/I4210131061"]},{"raw_affiliation_string":"Department of Dermatology,","institution_ids":[]},{"raw_affiliation_string":"People's hospital of hangzhou Medical college, hangzhou 310006, china;","institution_ids":["https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033565599","display_name":"Youming Huang","orcid":"https://orcid.org/0000-0001-7871-1644","observed_orcids":["https://orcid.org/0000-0001-7871-1644"]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Youming Huang","raw_affiliation_strings":["Department of Dermatology, People's Hospital of Hangzhou Medical College, Hangzhou 310006, China","Department of Dermatology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China","Department of Dermatology,","People's hospital of hangzhou Medical college, hangzhou 310006, china;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, People's Hospital of Hangzhou Medical College, Hangzhou 310006, China","institution_ids":["https://openalex.org/I4210165441"]},{"raw_affiliation_string":"Department of Dermatology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China","institution_ids":["https://openalex.org/I4210131061"]},{"raw_affiliation_string":"Department of Dermatology,","institution_ids":[]},{"raw_affiliation_string":"People's hospital of hangzhou Medical college, hangzhou 310006, china;","institution_ids":["https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105003866","display_name":"Yong Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Yu","raw_affiliation_strings":["Department of Dermatology, People's Hospital of Hangzhou Medical College, Hangzhou 310006, China","Department of Dermatology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China","Department of Dermatology,","People's hospital of hangzhou Medical college, hangzhou 310006, china;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, People's Hospital of Hangzhou Medical College, Hangzhou 310006, China","institution_ids":["https://openalex.org/I4210165441"]},{"raw_affiliation_string":"Department of Dermatology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China","institution_ids":["https://openalex.org/I4210131061"]},{"raw_affiliation_string":"Department of Dermatology,","institution_ids":[]},{"raw_affiliation_string":"People's hospital of hangzhou Medical college, hangzhou 310006, china;","institution_ids":["https://openalex.org/I4210165441"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100612880","display_name":"Dan Luo","orcid":"https://orcid.org/0000-0001-6074-1298","observed_orcids":["https://orcid.org/0000-0001-6074-1298"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dan Luo","raw_affiliation_strings":["Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210008, China, daniluo2005@163.com","Department of Dermatology, The First affiliated hospital of nanjing Medical University, nanjing 210008, china;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210008, China, daniluo2005@163.com","institution_ids":["https://openalex.org/I4210152119"]},{"raw_affiliation_string":"Department of Dermatology, The First affiliated hospital of nanjing Medical University, nanjing 210008, china;","institution_ids":["https://openalex.org/I4210152119"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100612880"],"corresponding_institution_ids":["https://openalex.org/I4210152119"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.9061,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.65902265,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"Volume 11","issue":null,"first_page":"4431","last_page":"4442"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.8560000061988831},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mir-126","display_name":"miR-126","score":0.9779999852180481},{"id":"https://openalex.org/keywords/crk","display_name":"Crk","score":0.9700000286102295},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8240000009536743},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7429999709129333},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.703000009059906},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9179999828338623},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9850000143051147},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.6570000052452087},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.3569999933242798},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6990000009536743},{"id":"https://openalex.org/keywords/mirna-sponge","display_name":"microRNA sponge","score":0.5230000019073486},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.828000009059906},{"id":"https://openalex.org/keywords/molecular-targets","display_name":"molecular targets","score":0.3050000071525574},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.671999990940094},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.34299999475479126}],"concepts":[{"id":"https://openalex.org/C133570447","wikidata":"https://www.wikidata.org/wiki/Q17909794","display_name":"Adapter molecule crk","level":4,"score":0.8619954586029053},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5263530015945435},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5100350975990295},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4197462201118469},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.394258588552475},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35655778646469116},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.312138170003891},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27507534623146057},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21231147646903992},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.167533278465271},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.12610885500907898},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10799843072891235}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.2147/ott.s164711","doi":"https://doi.org/10.2147/ott.s164711","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ott.s164711","pdf_url":"https://www.dovepress.com/getfile.php?fileID=43397","source":{"id":"https://openalex.org/S120324992","display_name":"OncoTargets and Therapy","issn_l":"1178-6930","issn":["1178-6930"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoTargets and Therapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5036134","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6074824","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30104884","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30104884","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoTargets and therapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6074824","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6074824/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Onco Targets Ther","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f65f49465480429ea4557b1ccc6c3210","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f65f49465480429ea4557b1ccc6c3210","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"OncoTargets and Therapy, Vol Volume 11, Pp 4431-4442 (2018)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/39588","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/linc00888-promoted-tumorigenicity-of-melanoma-via-mir-126crk-signaling-peer-reviewed-article-OTT","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/ott.s164711","doi":"https://doi.org/10.2147/ott.s164711","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ott.s164711","pdf_url":"https://www.dovepress.com/getfile.php?fileID=43397","source":{"id":"https://openalex.org/S120324992","display_name":"OncoTargets and Therapy","issn_l":"1178-6930","issn":["1178-6930"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoTargets and Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309432","display_name":"F. Hoffmann-La Roche","ror":"https://ror.org/00by1q217"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2884615338.pdf","grobid_xml":"https://content.openalex.org/works/W2884615338.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1564613369","https://openalex.org/W1869433628","https://openalex.org/W1881338771","https://openalex.org/W1978967539","https://openalex.org/W1981078952","https://openalex.org/W2008947745","https://openalex.org/W2018621577","https://openalex.org/W2029919331","https://openalex.org/W2032768171","https://openalex.org/W2036672958","https://openalex.org/W2037907723","https://openalex.org/W2049381344","https://openalex.org/W2059569578","https://openalex.org/W2087616533","https://openalex.org/W2117001122","https://openalex.org/W2117977572","https://openalex.org/W2134792081","https://openalex.org/W2134807618","https://openalex.org/W2150556769","https://openalex.org/W2163294226","https://openalex.org/W2315983151","https://openalex.org/W2366484523","https://openalex.org/W2514183797","https://openalex.org/W2530338988","https://openalex.org/W2589218376","https://openalex.org/W2746626197","https://openalex.org/W2760989328","https://openalex.org/W2761015390","https://openalex.org/W2767142469","https://openalex.org/W7057746781"],"related_works":["https://openalex.org/W3134905336","https://openalex.org/W2889344839","https://openalex.org/W4385898109","https://openalex.org/W3084025043","https://openalex.org/W3108983026","https://openalex.org/W2944725310","https://openalex.org/W3031230382","https://openalex.org/W4389340082","https://openalex.org/W4322748216","https://openalex.org/W4220831830"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Melanoma":[1],"is":[2],"an":[3,269],"aggressive":[4],"skin":[5],"cancer.":[6],"Understanding":[7],"the":[8,38,49,71,74,80,89,94,100,113,121,177,188,210,219,231,238,243,249,254,277],"underlying":[9],"mechanisms":[10],"for":[11,301],"melanomagenesis":[12],"and":[13,17,56,70,79,97,106,117,182,207,280,288],"identification":[14],"of":[15,51,77,91,124,158,170,173,184,190,212,221,240,251,282],"novel":[16],"effective":[18],"melanoma":[19,64,101,141,153,185,272,283],"treatment":[20],"strategies":[21],"are":[22,28],"urgently":[23],"necessary.":[24],"The":[25,148],"long-noncoding":[26,264],"RNAs":[27],"considered":[29],"as":[30,268],"new":[31],"essential":[32],"players":[33],"during":[34],"cancer":[35],"development,":[36],"including":[37],"melanoma.":[39,303],"MATERIALS":[40],"AND":[41],"METHODS:":[42],"In":[43],"this":[44],"study,":[45],"we":[46,87,196],"first":[47],"determined":[48],"expression":[50,75,137,157,169,206,211,220,233],"LINC00888":[52,78,92,125,136,159,174,191,205,252,266],"in":[53,99,140,152,165,223,235,257,271],"tumor":[54,130,255],"tissues":[55,59],"adjacent":[57,145],"normal":[58,146],"from":[60],"28":[61],"patients":[62,154],"with":[63,144,155,167,237],"using":[65,112,129],"quantitative":[66],"polymerase":[67],"chain":[68],"reaction,":[69],"correlation":[72],"between":[73],"level":[76,234],"survival":[81,151],"months":[82],"was":[83,126,138,160,201],"also":[84,127,275],"examined.":[85],"Next,":[86],"investigated":[88],"effect":[90],"on":[93],"proliferation,":[95,178],"apoptosis,":[96,179],"invasion":[98,183,281],"cells.":[102],"Moreover,":[103],"LINC00888-specific":[104],"miRNA":[105],"target":[107,300],"gene":[108],"were":[109],"further":[110,208,246],"confirmed":[111],"dual-luciferase":[114],"reporter":[115],"assay":[116],"Western":[118],"blotting.":[119],"Last,":[120,242],"tumorigenesis":[122],"role":[123],"explored":[128],"xenografts":[131],"mouse":[132],"model.":[133],"RESULTS:":[134],"Elevated":[135],"found":[139],"specimens":[142],"compared":[143],"tissues.":[147],"4-year":[149],"overall":[150],"high":[156],"substantially":[161],"shorter":[162],"than":[163],"that":[164,198,248,263],"those":[166],"low":[168],"LINC00888.":[171,241],"Knockdown":[172],"significantly":[175],"inhibited":[176],"epithelial-mesenchymal":[180],"transition,":[181],"cells,":[186,225],"while":[187,226],"overexpression":[189,239,250],"exerted":[192],"opposite":[193],"effect.":[194],"Furthermore,":[195],"revealed":[197],"microRNA-126":[199],"(miR-126)":[200],"able":[202],"to":[203],"regulate":[204],"influence":[209],"CRK.":[213],"Consistently,":[214],"miR-126":[215,227],"inhibitor":[216],"could":[217,229,295],"rescue":[218],"CRK":[222,232],"LINC00888-downregulated":[224],"mimics":[228],"reduce":[230],"cells":[236],"animal":[244],"experiment":[245],"demonstrated":[247],"enhanced":[253],"development":[256],"vivo.":[258],"CONCLUSION:":[259],"Our":[260],"data":[261],"showed":[262],"RNA":[265],"functioned":[267],"oncogene":[270],"tumorigenesis,":[273],"it":[274],"regulated":[276],"cellular":[278],"proliferation":[279],"via":[284,290],"miR126/CRK":[285],"signaling":[286,292],"pathway":[287],"metastasis":[289],"miR-126/CRK":[291],"axis,":[293],"which":[294],"be":[296],"a":[297],"promising":[298],"molecular":[299],"treating":[302]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-08-03T00:00:00"}