{"id":"https://openalex.org/W2884594524","doi":"https://doi.org/10.1055/s-0038-1653267","title":"Thromboxane-Synthetase Inhibitors Could Be \u201cLarge Spectrum\u201d Anti-Aggregating Agents","display_name":"Thromboxane-Synthetase Inhibitors Could Be \u201cLarge Spectrum\u201d Anti-Aggregating Agents","publication_year":1981,"publication_date":"1981-01-01","ids":{"openalex":"https://openalex.org/W2884594524","doi":"https://doi.org/10.1055/s-0038-1653267","mag":"2884594524"},"language":"en","primary_location":{"id":"doi:10.1055/s-0038-1653267","doi":"https://doi.org/10.1055/s-0038-1653267","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0038-1653267","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0038-1653267.pdf","source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0038-1653267.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050655967","display_name":"Claude Bonne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C Bonne","raw_affiliation_strings":["Centre de Recherche sur les Maladies de la R\u00e9tine, Inserm Fra 45, Paris"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche sur les Maladies de la R\u00e9tine, Inserm Fra 45, Paris","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":null,"display_name":"B Martin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B Martin","raw_affiliation_strings":["Centre de Recherche sur les Maladies de la R\u00e9tine, Inserm Fra 45, Paris"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche sur les Maladies de la R\u00e9tine, Inserm Fra 45, Paris","institution_ids":["https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I154526488"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.57021792,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.43869999051094055,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.43869999051094055,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.2939000129699707,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.13230000436306,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thromboxane-synthase-inhibitor","display_name":"thromboxane synthetase inhibitor","score":0.9589999914169312},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.6909999847412109},{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.7080000042915344},{"id":"https://openalex.org/keywords/thromboxane-b2","display_name":"thromboxane B2","score":0.8029999732971191},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9390000104904175},{"id":"https://openalex.org/keywords/6-keto-pgf1alpha","display_name":"6-keto-PGF1 alpha","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cyclooxygenase-inhibitors","display_name":"cyclooxygenase inhibitors","score":0.7590000033378601},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.8949999809265137},{"id":"https://openalex.org/keywords/arachidonic-acid-metabolism","display_name":"arachidonic acid metabolism","score":0.8730000257492065},{"id":"https://openalex.org/keywords/platelet-rich-plasma","display_name":"platelet-rich plasma","score":0.75}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7547197937965393},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.7286574244499207},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5463292598724365},{"id":"https://openalex.org/C176685330","wikidata":"https://www.wikidata.org/wiki/Q857638","display_name":"Radioimmunoassay","level":2,"score":0.5140167474746704},{"id":"https://openalex.org/C2781024287","wikidata":"https://www.wikidata.org/wiki/Q774909","display_name":"Thromboxane A2","level":3,"score":0.4969528019428253},{"id":"https://openalex.org/C2776785769","wikidata":"https://www.wikidata.org/wiki/Q412212","display_name":"Thromboxane","level":3,"score":0.43321675062179565},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3885156512260437},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37896960973739624},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3219072222709656},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2221996784210205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11092725396156311},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0752059817314148}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0038-1653267","doi":"https://doi.org/10.1055/s-0038-1653267","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0038-1653267","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0038-1653267.pdf","source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1055/s-0038-1653267","doi":"https://doi.org/10.1055/s-0038-1653267","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0038-1653267","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0038-1653267.pdf","source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"proceedings-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2884594524.pdf","grobid_xml":"https://content.openalex.org/works/W2884594524.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1984265477","https://openalex.org/W2883388892","https://openalex.org/W2097129768","https://openalex.org/W1978074008","https://openalex.org/W2945018151","https://openalex.org/W2408747893","https://openalex.org/W1984930783","https://openalex.org/W2252430178","https://openalex.org/W2415942834","https://openalex.org/W2521390206"],"abstract_inverted_index":{"\u201cLarge":[0],"spectrum\u201danti-aggregating":[1],"activity":[2],"could":[3,19,33,209],"be":[4],"only":[5,20],"achieved":[6],"by":[7,119],"agents":[8],"which":[9],"increased":[10,190],"the":[11,22,35,44,55,75,83,104,122,154,157,160,176,197,203],"c":[12,85,111,193],"AMP":[13,86,194],"content":[14],"of":[15,27,46,57,70,77,108,124,156,178,192,199],"platelets.":[16,89],"Cyclo-oxygenase":[17],"inhibitors":[18,32],"block":[21],"Thromboxane":[23],"(Tx)-":[24],"dependent":[25],"pathway":[26],"platelet":[28,100],"aggregation.":[29],"Conversely,":[30],"Tx-synthetase":[31],"deviate":[34],"endoperoxides":[36],"metabolism":[37],"to":[38,135,170],"anti-aggregating":[39,78],"prostaglandins":[40],"in":[41,43,88,103,142,153,167,175,196],"particular":[42],"presence":[45,105,123,155,177,198],"vascular":[47],"tissues.":[48],"In":[49,121,138],"this":[50],"study":[51],"we":[52],"have":[53],"investigated":[54],"effect":[56],"CBS634":[58],"(1-(3-hydroxy-":[59],"1":[60,151],"-":[61],"octenyl)-imidazole":[62],"nicotinic":[63],"ester,":[64],"dichlorhydra-":[65],"teD,":[66],"a":[67,207,211],"potent":[68],"inhibitor":[69,201],"T\u00d7A2":[71],"synthesis,":[72],"both":[73],"on":[74,82],"production":[76,141],"prosta-":[79],"glandins":[80],"and":[81,115,148],"simultaneous":[84],"synthesis":[87],"Rat":[90],"aorta":[91],"fragments":[92],"pretreated":[93],"with":[94,98,183],"aspirin":[95],"were":[96,117],"incubated":[97],"rat":[99],"rich":[101],"plasma":[102],"or":[106],"absence":[107],"tested":[109],"compound,":[110],"AMP,":[112],"T\u00d7B2,":[113],"PGE2":[114],"6-keto-PGFF1\u03b1":[116],"determined":[118],"radioimmunoassays.":[120],"CBS63U":[125],"(50\u03bcM),":[126],"T\u00d7B2":[127],"formation":[128],"was":[129,144],"reduced":[130],"from":[131],"17":[132],"\u00b1":[133,146,150],"2":[134],"0.2":[136],"ng/ml/min.":[137],"parallel,":[139],"PGE":[140],"controls":[143],"1.4":[145],"0.6":[147],"8":[149],"ng/ml/min":[152],"drug.":[158],"On":[159],"other":[161],"hand,":[162],"6-keto-PGF1\u03b1":[163],"formation,":[164],"very":[165],"low":[166],"controls,":[168],"rose":[169],"4":[171],"\u00b11.2":[172],"ng/mV":[173],"min":[174],"CBS63U.":[179],"Radiochemical":[180],"assays":[181],"performed":[182],"c14C)-arachidonate":[184],"confirmed":[185],"that":[186,205],"metabolic":[187],"deviation.":[188],"The":[189],"level":[191],"formed":[195],"T\u00d7A2-synthetase":[200],"supports":[202],"hypothesis":[204],"such":[206],"drug":[208],"present":[210],"\u201clarge":[212],"spectrum\u201dantiaggregating":[213],"activity.":[214]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2018-08-03T00:00:00"}