{"id":"https://openalex.org/W2884580975","doi":"https://doi.org/10.1002/adhm.201800341","title":"Prevention of Type 1 Diabetes with Acetalated Dextran Microparticles Containing Rapamycin and Pancreatic Peptide P31","display_name":"Prevention of Type 1 Diabetes with Acetalated Dextran Microparticles Containing Rapamycin and Pancreatic Peptide P31","publication_year":2018,"publication_date":"2018-07-26","ids":{"openalex":"https://openalex.org/W2884580975","doi":"https://doi.org/10.1002/adhm.201800341","mag":"2884580975","pmid":"https://pubmed.ncbi.nlm.nih.gov/30051618"},"language":"en","primary_location":{"id":"doi:10.1002/adhm.201800341","doi":"https://doi.org/10.1002/adhm.201800341","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adhm.201800341","pdf_url":null,"source":{"id":"https://openalex.org/S2500736452","display_name":"Advanced Healthcare Materials","issn_l":"2192-2640","issn":["2192-2640","2192-2659"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Healthcare Materials","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033980210","display_name":"Naihan Chen","orcid":"https://orcid.org/0000-0002-7145-0776","observed_orcids":["https://orcid.org/0000-0002-7145-0776","https://orcid.org/0009-0002-8763-8930"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naihan Chen","raw_affiliation_strings":["Division of Pharmacoengineering and Molecular Pharmaceutics Eshelman School of Pharmacy The University of North Carolina at Chapel Hill  Chapel Hill NC 27599 USA","Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599 USA"],"raw_orcid":"https://orcid.org/0000-0002-7145-0776","affiliations":[{"raw_affiliation_string":"Division of Pharmacoengineering and Molecular Pharmaceutics Eshelman School of Pharmacy The University of North Carolina at Chapel Hill  Chapel Hill NC 27599 USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599 USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059183680","display_name":"Charles J. Kroger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles J. Kroger","raw_affiliation_strings":["Department of Microbiology and Immunology School of Medicine The University of North Carolina at Chapel Hill  Chapel Hill NC 27599 USA","Department of Microbiology and Immunology, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology School of Medicine The University of North Carolina at Chapel Hill  Chapel Hill NC 27599 USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599 USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015143701","display_name":"Roland Tisch","orcid":"https://orcid.org/0000-0001-7751-7241","observed_orcids":["https://orcid.org/0000-0001-7751-7241"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roland M. Tisch","raw_affiliation_strings":["Department of Microbiology and Immunology School of Medicine The University of North Carolina at Chapel Hill  Chapel Hill NC 27599 USA","Department of Microbiology and Immunology, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology School of Medicine The University of North Carolina at Chapel Hill  Chapel Hill NC 27599 USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599 USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013153851","display_name":"Eric M. Bachelder","orcid":"https://orcid.org/0000-0002-8572-888X","observed_orcids":["https://orcid.org/0000-0002-8572-888X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric M. Bachelder","raw_affiliation_strings":["Division of Pharmacoengineering and Molecular Pharmaceutics Eshelman School of Pharmacy The University of North Carolina at Chapel Hill  Chapel Hill NC 27599 USA","Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacoengineering and Molecular Pharmaceutics Eshelman School of Pharmacy The University of North Carolina at Chapel Hill  Chapel Hill NC 27599 USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599 USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079566195","display_name":"Kristy M. Ainslie","orcid":"https://orcid.org/0000-0002-1820-8382","observed_orcids":["https://orcid.org/0000-0002-1820-8382"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kristy M. Ainslie","raw_affiliation_strings":["Division of Pharmacoengineering and Molecular Pharmaceutics Eshelman School of Pharmacy The University of North Carolina at Chapel Hill  Chapel Hill NC 27599 USA","Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacoengineering and Molecular Pharmaceutics Eshelman School of Pharmacy The University of North Carolina at Chapel Hill  Chapel Hill NC 27599 USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599 USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5079566195"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":1.5251,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.82384292,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"18","first_page":"e1800341","last_page":"e1800341"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes-prevention","display_name":"type 1 diabetes prevention","score":0.9829999804496765},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/antigen-specific-immunotherapy","display_name":"antigen-specific immunotherapy","score":0.9589999914169312},{"id":"https://openalex.org/keywords/self-tolerance","display_name":"self-tolerance","score":0.5540000200271606},{"id":"https://openalex.org/keywords/cd4-t-cell-tolerance","display_name":"CD4+ T cell tolerance","score":0.8059999942779541},{"id":"https://openalex.org/keywords/foxp3-regulatory-t-cells","display_name":"Foxp3+ regulatory T cells","score":0.8090000152587891},{"id":"https://openalex.org/keywords/dendritic-cell-maturation","display_name":"dendritic cell maturation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/pd-1-expression","display_name":"PD-1 expression","score":0.8080000281333923},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.777999997138977},{"id":"https://openalex.org/keywords/islet-autoimmunity","display_name":"islet autoimmunity","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.73844313621521},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.580488383769989},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5165578126907349},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5159597992897034},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.463443785905838},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.42699044942855835},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35082942247390747},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3263836205005646},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.32373517751693726},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.14099043607711792}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003911","descriptor_name":"Dextrans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003911","descriptor_name":"Dextrans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003911","descriptor_name":"Dextrans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003911","descriptor_name":"Dextrans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010191","descriptor_name":"Pancreatic Polypeptide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010191","descriptor_name":"Pancreatic Polypeptide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010191","descriptor_name":"Pancreatic Polypeptide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010191","descriptor_name":"Pancreatic Polypeptide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010191","descriptor_name":"Pancreatic Polypeptide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010191","descriptor_name":"Pancreatic Polypeptide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010191","descriptor_name":"Pancreatic Polypeptide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010191","descriptor_name":"Pancreatic Polypeptide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/adhm.201800341","doi":"https://doi.org/10.1002/adhm.201800341","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adhm.201800341","pdf_url":null,"source":{"id":"https://openalex.org/S2500736452","display_name":"Advanced Healthcare Materials","issn_l":"2192-2640","issn":["2192-2640","2192-2659"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Healthcare Materials","raw_type":"journal-article"},{"id":"pmid:30051618","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30051618","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced healthcare materials","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8100000023841858,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7563968767","display_name":null,"funder_award_id":"R21 NS072813","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8330768690","display_name":null,"funder_award_id":"1\u2010SRA\u20102015\u201012\u2010Q\u2010R","funder_id":"https://openalex.org/F4320310699","funder_display_name":"Juvenile Diabetes Research Foundation United Kingdom"},{"id":"https://openalex.org/G9000913976","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016086","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G958207224","display_name":null,"funder_award_id":"P30-CA016086","funder_id":"https://openalex.org/F4320337594","funder_display_name":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill"}],"funders":[{"id":"https://openalex.org/F4320310699","display_name":"Juvenile Diabetes Research Foundation United Kingdom","ror":"https://ror.org/0332bbh94"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332600","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337594","display_name":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W35963623","https://openalex.org/W255554239","https://openalex.org/W1524269662","https://openalex.org/W1578114463","https://openalex.org/W1963986494","https://openalex.org/W1969468597","https://openalex.org/W1970238011","https://openalex.org/W1978684572","https://openalex.org/W1992802035","https://openalex.org/W1994869675","https://openalex.org/W2010400229","https://openalex.org/W2019222105","https://openalex.org/W2020839425","https://openalex.org/W2035633748","https://openalex.org/W2035722963","https://openalex.org/W2038816020","https://openalex.org/W2041156715","https://openalex.org/W2045501299","https://openalex.org/W2047627851","https://openalex.org/W2049435279","https://openalex.org/W2057760381","https://openalex.org/W2072753827","https://openalex.org/W2077816203","https://openalex.org/W2080753451","https://openalex.org/W2085060041","https://openalex.org/W2085894034","https://openalex.org/W2092747941","https://openalex.org/W2096862996","https://openalex.org/W2098596345","https://openalex.org/W2100992652","https://openalex.org/W2104464991","https://openalex.org/W2125659714","https://openalex.org/W2126207845","https://openalex.org/W2126331122","https://openalex.org/W2135847337","https://openalex.org/W2136804237","https://openalex.org/W2146664729","https://openalex.org/W2146809820","https://openalex.org/W2149513114","https://openalex.org/W2160824801","https://openalex.org/W2260902962","https://openalex.org/W2324016220","https://openalex.org/W2325241666","https://openalex.org/W2411624427","https://openalex.org/W2418648359","https://openalex.org/W2509761201","https://openalex.org/W2594538726","https://openalex.org/W2758460412","https://openalex.org/W4248411420"],"related_works":["https://openalex.org/W4379052364","https://openalex.org/W2416795054","https://openalex.org/W2392126385","https://openalex.org/W1992848314","https://openalex.org/W2571013527","https://openalex.org/W3039146159","https://openalex.org/W2015667478","https://openalex.org/W1955721074","https://openalex.org/W4206781811","https://openalex.org/W2011724047"],"abstract_inverted_index":{"Abstract":[0],"Type":[1],"1":[2],"diabetes":[3],"(T1D)":[4],"is":[5,43,85,90],"a":[6,75,142,200],"common":[7],"autoimmune":[8],"disease":[9],"with":[10,148],"no":[11],"cure.":[12],"T1D":[13,88,197],"subjects":[14],"are":[15,32,65],"dependent":[16],"on":[17],"daily":[18],"exogenous":[19],"insulin":[20],"administration,":[21],"due":[22],"to":[23,44,48,130,185],"the":[24,69,95,99,192],"loss":[25],"of":[26,41,62,94,106,127,191,196],"functional":[27],"insulin\u2010producing":[28],"\u03b2":[29],"cells.":[30,134],"Needed":[31],"immunotherapies":[33],"that":[34],"prevent":[35,186],"and/or":[36],"treat":[37],"T1D.":[38],"One":[39],"approach":[40],"immunotherapy":[42,64],"administer":[45],"an":[46,72,124],"autoantigen":[47],"selectively":[49],"tolerize":[50],"diabetogenic":[51,100,180],"effector":[52],"T":[53,118,133,156,183],"cells":[54,119,140,184],"without":[55],"global":[56],"immunosuppression.":[57],"To":[58],"date,":[59],"however,":[60],"strategies":[61],"antigen\u2010specific":[63,73,176],"largely":[66],"ineffective":[67],"in":[68,152],"clinic.":[70],"Using":[71],"approach,":[74],"biodegradable":[76],"polymeric":[77],"delivery":[78,203],"vehicle,":[79],"acetalated":[80],"dextran":[81],"microparticles":[82],"(Ace\u2010DEX":[83],"MPs),":[84],"applied":[86],"and":[87,98,109,123,159,164],"development":[89],"prevented":[91],"through":[92],"coadministration":[93],"immunosuppressant":[96],"rapamycin":[97],"peptide":[101],"P31":[102],"(Rapa/P31/MPs),":[103],"via":[104],"alterations":[105],"both":[107],"innate":[108],"adaptive":[110],"immunity.":[111],"Ex":[112],"vivo,":[113],"adoptively":[114],"transferred":[115],"CD4":[116,154,181],"+":[117,129,132,155,182],"exhibit":[120,141],"reduced":[121,153],"proliferation":[122,158],"increased":[125],"ratio":[126],"FoxP3":[128],"IFN\u03b3":[131],"In":[135],"vitro":[136],"analysis":[137],"indicates":[138],"dendritic":[139],"less":[143],"mature":[144],"phenotype":[145],"following":[146],"coculture":[147],"Rapa/P31/MPs,":[149],"which":[150],"results":[151,172],"cell":[157],"proinflammatory":[160],"cytokine":[161],"production":[162],"(IFN\u03b3":[163],"IL\u20102),":[165],"but":[166],"promotes":[167],"PD\u20101":[168],"expression.":[169],"Together":[170],"these":[171],"demonstrate":[173],"Ace\u2010DEX":[174],"MP\u2010based":[175],"therapy":[177],"effectively":[178],"tolerizes":[179],"T1D,":[187],"thereby":[188],"demonstrating":[189],"one":[190],"first":[193],"successful":[194],"attempts":[195],"prevention":[198],"using":[199],"single\u2010formulation":[201],"particulate":[202],"platform.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}
