{"id":"https://openalex.org/W2884579601","doi":"https://doi.org/10.1038/s41598-018-28862-4","title":"Gut Sphingolipid Composition as a Prelude to Necrotizing Enterocolitis","display_name":"Gut Sphingolipid Composition as a Prelude to Necrotizing Enterocolitis","publication_year":2018,"publication_date":"2018-07-16","ids":{"openalex":"https://openalex.org/W2884579601","doi":"https://doi.org/10.1038/s41598-018-28862-4","mag":"2884579601","pmid":"https://pubmed.ncbi.nlm.nih.gov/30030452","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6054655"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-018-28862-4","doi":"https://doi.org/10.1038/s41598-018-28862-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-28862-4","pdf_url":"https://www.nature.com/articles/s41598-018-28862-4.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-018-28862-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040380759","display_name":"Brigida A. Rusconi","orcid":"https://orcid.org/0000-0001-8422-122X","observed_orcids":["https://orcid.org/0000-0001-8422-122X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Rusconi","raw_affiliation_strings":["Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091851465","display_name":"Xuntian Jiang","orcid":"https://orcid.org/0000-0001-9048-7294","observed_orcids":["https://orcid.org/0000-0001-9048-7294"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X. Jiang","raw_affiliation_strings":["Department of Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071028184","display_name":"Rohini Sidhu","orcid":"https://orcid.org/0000-0003-1703-2167","observed_orcids":["https://orcid.org/0000-0003-1703-2167"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Sidhu","raw_affiliation_strings":["Department of Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA"],"raw_orcid":"https://orcid.org/0000-0003-1703-2167","affiliations":[{"raw_affiliation_string":"Department of Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060731094","display_name":"Daniel\u00a0S. Ory","orcid":"https://orcid.org/0000-0003-2188-2818","observed_orcids":["https://orcid.org/0000-0003-2188-2818"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. S. Ory","raw_affiliation_strings":["Department of Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002279191","display_name":"Barbara B. Warner","orcid":"https://orcid.org/0000-0002-9910-4461","observed_orcids":["https://orcid.org/0000-0002-9910-4461"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. B. Warner","raw_affiliation_strings":["Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052358059","display_name":"Phillip I. Tarr","orcid":"https://orcid.org/0000-0003-4078-7517","observed_orcids":["https://orcid.org/0000-0003-4078-7517"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"P. I. Tarr","raw_affiliation_strings":["Department of Molecular Microbiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. tarr@wustl.edu","Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. tarr@wustl.edu","Department of Molecular Microbiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. tarr@wustl.edu","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. tarr@wustl.edu","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Molecular Microbiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5052358059"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":2.0648,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.84639365,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"10984","last_page":"10984"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/necrotizing-enterocolitis","display_name":"necrotizing enterocolitis","score":1.0},{"id":"https://openalex.org/keywords/sphingolipid-metabolism","display_name":"sphingolipid metabolism","score":0.9240000247955322},{"id":"https://openalex.org/keywords/ceramide","display_name":"ceramide","score":0.652999997138977},{"id":"https://openalex.org/keywords/sphingomyelin","display_name":"sphingomyelin","score":0.8899999856948853},{"id":"https://openalex.org/keywords/gut-dysbiosis","display_name":"gut dysbiosis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/neonatal-gut-microbiota","display_name":"neonatal gut microbiota","score":0.6140000224113464},{"id":"https://openalex.org/keywords/fecal-metabolomics","display_name":"fecal metabolomics","score":0.7979999780654907},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9110000133514404}],"concepts":[{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.9569777846336365},{"id":"https://openalex.org/C2779303187","wikidata":"https://www.wikidata.org/wiki/Q10859678","display_name":"Necrotizing enterocolitis","level":2,"score":0.7981594800949097},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.5496878027915955},{"id":"https://openalex.org/C61322309","wikidata":"https://www.wikidata.org/wiki/Q423143","display_name":"Sphingomyelin","level":3,"score":0.5356302857398987},{"id":"https://openalex.org/C2777851122","wikidata":"https://www.wikidata.org/wiki/Q424213","display_name":"Ceramide","level":3,"score":0.5222336053848267},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44318830966949463},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44241416454315186},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.4405529499053955},{"id":"https://openalex.org/C58017582","wikidata":"https://www.wikidata.org/wiki/Q6556376","display_name":"Lipidomics","level":2,"score":0.4279181957244873},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.3970143496990204},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3967020511627197},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38168400526046753},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.36991703510284424},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.34520551562309265},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26315850019454956},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15473389625549316},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001724","descriptor_name":"Birth Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005766","descriptor_name":"Gastrointestinal Contents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013107","descriptor_name":"Sphingolipids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020345","descriptor_name":"Enterocolitis, Necrotizing","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D020345","descriptor_name":"Enterocolitis, Necrotizing","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41598-018-28862-4","doi":"https://doi.org/10.1038/s41598-018-28862-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-28862-4","pdf_url":"https://www.nature.com/articles/s41598-018-28862-4.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5009879","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6054655","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6054655","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6054655","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:30030452","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30030452","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.wustl.edu:open_access_pubs-8005","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wustl.edu/open_access_pubs/6999","pdf_url":"https://digitalcommons.wustl.edu/open_access_pubs/6999","source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:66130f72ed26469386519c88329ae98c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/66130f72ed26469386519c88329ae98c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-018-28862-4","doi":"https://doi.org/10.1038/s41598-018-28862-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-28862-4","pdf_url":"https://www.nature.com/articles/s41598-018-28862-4.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1163197816","display_name":"Influence of the Enteric Microbiome on the Genesis of Bronchopulmonary Dysplasia","funder_award_id":"U01HL101465","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1485266116","display_name":null,"funder_award_id":"UL1TR000448","funder_id":"https://openalex.org/F4320316438","funder_display_name":"Georgia Clinical and Translational Science Alliance"},{"id":"https://openalex.org/G4114322228","display_name":null,"funder_award_id":"UL1TR000448","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G725115302","display_name":"Washington University Institute of Clinical and Translational Sciences","funder_award_id":"UL1TR000448","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7638897345","display_name":"PHYLOGENOMIC, TRANSCRIPTOMIC, VIROMIC, AND IMMUNOPROTEOMIC DETERMINANTS OF NECROTIZING ENTEROCOLITIS","funder_award_id":"R01HD092414","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G8111501821","display_name":"The Role of Host Lipids in the Onset of Necrotizing Enterocolitis","funder_award_id":"171556","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G9000868406","display_name":"Washington University Nutrition Obesity Research Center","funder_award_id":"P30DK056341","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000874565","display_name":"Pediatric Gastroenterology Research Training Program","funder_award_id":"T32DK077653","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000893777","display_name":"Washington University Institute of Clinical and Translational Sciences","funder_award_id":"UL1TR002345","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000898797","display_name":"Diabetes Research Center","funder_award_id":"P30DK020579","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000907135","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA091842","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000907878","display_name":"Host-environment interactions in the pathophysiology of digestive disease","funder_award_id":"P30DK052574","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320311176","display_name":"Children's Discovery Institute","ror":"https://ror.org/02swjdp46"},{"id":"https://openalex.org/F4320316438","display_name":"Georgia Clinical and Translational Science Alliance","ror":"https://ror.org/034hw7m59"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2884579601.pdf","grobid_xml":"https://content.openalex.org/works/W2884579601.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W1480377400","https://openalex.org/W1539561890","https://openalex.org/W1608927181","https://openalex.org/W1857797615","https://openalex.org/W1963758212","https://openalex.org/W1965382258","https://openalex.org/W1969507309","https://openalex.org/W1969784469","https://openalex.org/W1978213978","https://openalex.org/W1981053070","https://openalex.org/W1981371644","https://openalex.org/W1986394981","https://openalex.org/W1989478912","https://openalex.org/W1991298714","https://openalex.org/W1994102811","https://openalex.org/W2000543170","https://openalex.org/W2010916289","https://openalex.org/W2012782636","https://openalex.org/W2015354948","https://openalex.org/W2017779727","https://openalex.org/W2022222076","https://openalex.org/W2024436717","https://openalex.org/W2037567332","https://openalex.org/W2046607062","https://openalex.org/W2060249831","https://openalex.org/W2084804585","https://openalex.org/W2101774906","https://openalex.org/W2105024467","https://openalex.org/W2107470983","https://openalex.org/W2115952302","https://openalex.org/W2116943762","https://openalex.org/W2117365118","https://openalex.org/W2126423378","https://openalex.org/W2137531873","https://openalex.org/W2145828860","https://openalex.org/W2145876349","https://openalex.org/W2151602856","https://openalex.org/W2151836397","https://openalex.org/W2152311269","https://openalex.org/W2153931548","https://openalex.org/W2156527993","https://openalex.org/W2162190649","https://openalex.org/W2168150136","https://openalex.org/W2168214421","https://openalex.org/W2171360274","https://openalex.org/W2174358501","https://openalex.org/W2256192990","https://openalex.org/W2266905719","https://openalex.org/W2267309924","https://openalex.org/W2269609486","https://openalex.org/W2289661442","https://openalex.org/W2295620997","https://openalex.org/W2302391071","https://openalex.org/W2316190485","https://openalex.org/W2325986127","https://openalex.org/W2331300001","https://openalex.org/W2338241819","https://openalex.org/W2343543833","https://openalex.org/W2343887005","https://openalex.org/W2404920363","https://openalex.org/W2517654658","https://openalex.org/W2549176487","https://openalex.org/W2550322153","https://openalex.org/W2551474347","https://openalex.org/W2565941527","https://openalex.org/W2566631381","https://openalex.org/W2577908951","https://openalex.org/W2588681363","https://openalex.org/W2592537218","https://openalex.org/W2603428400","https://openalex.org/W2605107433","https://openalex.org/W2606465135","https://openalex.org/W2616478449","https://openalex.org/W2624872662","https://openalex.org/W2731955755","https://openalex.org/W2733505187","https://openalex.org/W2743730976","https://openalex.org/W2766232071","https://openalex.org/W2766592184","https://openalex.org/W2767220660","https://openalex.org/W2767394819","https://openalex.org/W2770324303","https://openalex.org/W2782629792","https://openalex.org/W4254432455","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W4296449493","https://openalex.org/W4403784328","https://openalex.org/W3043072444","https://openalex.org/W4411075458","https://openalex.org/W4293127261","https://openalex.org/W4292080956","https://openalex.org/W7215097294","https://openalex.org/W4404447518","https://openalex.org/W4390176423","https://openalex.org/W4324376253"],"abstract_inverted_index":{"Necrotizing":[0],"enterocolitis":[1],"(NEC)":[2],"remains":[3],"a":[4,125,143],"major":[5],"challenge":[6],"in":[7,170,174],"neonatology.":[8],"Little":[9],"is":[10],"known":[11],"about":[12],"NEC":[13,35],"pathophysiology":[14],"apart":[15],"from":[16,37,99],"the":[17,87,106,133,139,157],"presence":[18],"of":[19,86,89,97,117,132,138,147,156],"pre-event":[20],"gut":[21],"dysbiosis.":[22],"Here,":[23],"we":[24],"applied":[25],"broad":[26,108],"range":[27,109],"metabolomics":[28],"to":[29,82,91,178],"stools":[30,176],"obtained":[31],"1-5":[32],"days":[33],"before":[34,185],"developed":[36],"9":[38],"cases":[39,66,74,101,134],"(9":[40],"samples)":[41,45],"and":[42,53,67,78,84,102,160],"19":[43],"(32":[44],"controls":[46,104],"matched":[47],"for":[48],"gestational":[49],"age":[50],"at":[51],"birth":[52,54],"weight.":[55],"The":[56,149],"764":[57],"identified":[58,60],"metabolites":[59,112],"six":[61],"pathways":[62],"that":[63,129,165],"differ":[64],"between":[65],"controls.":[68],"We":[69,163],"pursued":[70],"sphingolipid":[71,126,171],"metabolism":[72,172],"because":[73,85],"had":[75],"decreased":[76],"ceramides":[77],"increased":[79],"sphingomyelins":[80],"compared":[81,177],"controls,":[83,140,179],"relevance":[88],"sphingolipids":[90,187],"human":[92],"inflammatory":[93],"disorders.":[94],"Targeted":[95],"analysis":[96],"samples":[98],"23":[100],"46":[103],"confirmed":[105],"initial":[107],"observations.":[110],"While":[111],"provided":[113],"only":[114,136],"73%":[115],"accuracy":[116],"classification":[118],"by":[119],"machine":[120],"learning,":[121],"hierarchical":[122],"clustering":[123,150],"defined":[124],"associated":[127],"grouping":[128],"contained":[130],"60%":[131],"but":[135,180],"13%":[137],"possibly":[141],"identifying":[142],"pathophysiologically":[144],"distinct":[145],"subset":[146],"NEC.":[148],"did":[151],"not":[152],"associate":[153],"with":[154],"any":[155],"analyzed":[158],"clinical":[159],"sample":[161],"variables.":[162],"conclude":[164],"there":[166],"are":[167],"significant":[168],"changes":[169],"components":[173],"pre-NEC":[175],"our":[181],"data":[182],"urge":[183],"circumspection":[184],"using":[186],"as":[188],"broadly":[189],"applicable":[190],"predictive":[191],"biomarkers.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-08-03T00:00:00"}
