{"id":"https://openalex.org/W2884562811","doi":"https://doi.org/10.3233/jad-180384","title":"Decreased Parietal Beta Power as a Sign of Disease Progression in Patients with Mild Cognitive Impairment","display_name":"Decreased Parietal Beta Power as a Sign of Disease Progression in Patients with Mild Cognitive Impairment","publication_year":2018,"publication_date":"2018-07-21","ids":{"openalex":"https://openalex.org/W2884562811","doi":"https://doi.org/10.3233/jad-180384","mag":"2884562811","pmid":"https://pubmed.ncbi.nlm.nih.gov/30056426"},"language":"en","primary_location":{"id":"doi:10.3233/jad-180384","doi":"https://doi.org/10.3233/jad-180384","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-180384","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer\u2019s Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008332911","display_name":"Christian Sand\u00f8e Musaeus","orcid":"https://orcid.org/0000-0002-6442-2910","observed_orcids":["https://orcid.org/0000-0002-6442-2910"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Christian Sand\u00f8e Musaeus","raw_affiliation_strings":["Department of Neurology, Danish Dementia Research Centre (DDRC), Rigshospitalet, University of Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Danish Dementia Research Centre (DDRC), Rigshospitalet, University of Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035900720","display_name":"Malene Schj\u00f8nning Nielsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087803","display_name":"Zealand University Hospital","ror":"https://ror.org/00363z010","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799668677","https://openalex.org/I2802567020","https://openalex.org/I4210087803"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Malene Schj\u00f8nning Nielsen","raw_affiliation_strings":["Department of Neurology, Regional Dementia Research Centre, Zealand University Hospital, Roskilde, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Regional Dementia Research Centre, Zealand University Hospital, Roskilde, Denmark","institution_ids":["https://openalex.org/I4210087803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010597330","display_name":"Natascha Nellum \u00d8sterbye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087803","display_name":"Zealand University Hospital","ror":"https://ror.org/00363z010","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799668677","https://openalex.org/I2802567020","https://openalex.org/I4210087803"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Natascha Nellum \u00d8sterbye","raw_affiliation_strings":["Department of Neurology, Regional Dementia Research Centre, Zealand University Hospital, Roskilde, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Regional Dementia Research Centre, Zealand University Hospital, Roskilde, Denmark","institution_ids":["https://openalex.org/I4210087803"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048020632","display_name":"Peter H\u00f8gh","orcid":"https://orcid.org/0000-0002-8478-8098","observed_orcids":["https://orcid.org/0000-0002-8478-8098"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I4210087803","display_name":"Zealand University Hospital","ror":"https://ror.org/00363z010","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799668677","https://openalex.org/I2802567020","https://openalex.org/I4210087803"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Peter H\u00f8gh","raw_affiliation_strings":["Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark","Department of Neurology, Regional Dementia Research Centre, Zealand University Hospital, Roskilde, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Department of Neurology, Regional Dementia Research Centre, Zealand University Hospital, Roskilde, Denmark","institution_ids":["https://openalex.org/I4210087803"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5008332911"],"corresponding_institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802709434"],"apc_list":null,"apc_paid":null,"fwci":2.5154,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.88970011,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"65","issue":"2","first_page":"475","last_page":"487"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":0.984000027179718},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.6990413665771484},{"id":"https://openalex.org/C139676723","wikidata":"https://www.wikidata.org/wiki/Q1193832","display_name":"Sign (mathematics)","level":2,"score":0.6623459458351135},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.6029142141342163},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5058341026306152},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.482472687959671},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46982264518737793},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4514528512954712},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.3831908702850342},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37418150901794434},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.311045378446579},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0718177855014801},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.058408498764038086},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001611","descriptor_name":"Beta Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010296","descriptor_name":"Parietal Lobe","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3233/jad-180384","doi":"https://doi.org/10.3233/jad-180384","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-180384","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer\u2019s Disease","raw_type":"journal-article"},{"id":"pmid:30056426","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30056426","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's disease : JAD","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/d005f64f-27ee-42f1-a2c1-1e9ba9f52c31","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/d005f64f-27ee-42f1-a2c1-1e9ba9f52c31","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Musaeus, C S, Nielsen, M S, \u00d8sterbye, N N & H\u00f8gh, P 2018, 'Decreased parietal beta power as a sign of disease progression in patients with mild cognitive impairment', Journal of Alzheimer's Disease, vol. 65, no. 2, pp. 475-487. https://doi.org/10.3233/JAD-180384","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1534513493","https://openalex.org/W1921388971","https://openalex.org/W1975165119","https://openalex.org/W1978324806","https://openalex.org/W1984828228","https://openalex.org/W1996446023","https://openalex.org/W2002204158","https://openalex.org/W2002272109","https://openalex.org/W2003109983","https://openalex.org/W2012785000","https://openalex.org/W2016158653","https://openalex.org/W2018335290","https://openalex.org/W2028436804","https://openalex.org/W2029162491","https://openalex.org/W2055649795","https://openalex.org/W2057629466","https://openalex.org/W2061095322","https://openalex.org/W2066044108","https://openalex.org/W2068499600","https://openalex.org/W2068671431","https://openalex.org/W2083015405","https://openalex.org/W2085032083","https://openalex.org/W2087964262","https://openalex.org/W2090048242","https://openalex.org/W2096970998","https://openalex.org/W2102536066","https://openalex.org/W2105909330","https://openalex.org/W2109236382","https://openalex.org/W2115017507","https://openalex.org/W2124114508","https://openalex.org/W2128495200","https://openalex.org/W2130087615","https://openalex.org/W2134876067","https://openalex.org/W2136194794","https://openalex.org/W2142202785","https://openalex.org/W2142464155","https://openalex.org/W2144631174","https://openalex.org/W2151393950","https://openalex.org/W2152284561","https://openalex.org/W2154900811","https://openalex.org/W2159122349","https://openalex.org/W2166073443","https://openalex.org/W2168760269","https://openalex.org/W2572249372","https://openalex.org/W2763282512","https://openalex.org/W2769639544","https://openalex.org/W2781170536"],"related_works":["https://openalex.org/W2028668525","https://openalex.org/W2090048242","https://openalex.org/W2617502228","https://openalex.org/W2389229201","https://openalex.org/W3031718462","https://openalex.org/W2092860011","https://openalex.org/W2077545887","https://openalex.org/W1551747696","https://openalex.org/W2080331087","https://openalex.org/W2334445218"],"abstract_inverted_index":{"BACKGROUND:":[0],"Electroencephalography":[1],"(EEG)":[2],"power":[3,70,118,142,178,192],"has":[4],"previously":[5],"been":[6,226],"used":[7],"to":[8,17,54,60,77,206,241],"compare":[9],"mild":[10],"cognitive":[11,78,128],"impairment":[12],"(MCI)":[13],"patients":[14,22,85,89],"who":[15,25],"progress":[16],"Alzheimer's":[18],"disease":[19],"(pMCI)":[20],"with":[21,23,86,90,181,228],"MCI":[24],"remain":[26],"stable":[27],"(sMCI)":[28],"by":[29],"using":[30,68],"beta":[31,35,162,220],"power.":[32,245],"However,":[33],"the":[34,49,144,148,168,194,198,213,218],"band":[36,150,200],"is":[37],"very":[38],"broad":[39,219],"and":[40,66,71,92,103,116,130,183,210],"smaller":[41],"frequency":[42],"bands":[43,163],"may":[44,201],"improve":[45],"accuracy.":[46],"OBJECTIVE:":[47],"In":[48,171,232],"present":[50],"study,":[51],"we":[52,156,173,234],"wanted":[53],"investigate":[55],"whether":[56,72],"it":[57],"was":[58,119,179,239],"possible":[59],"find":[61],"any":[62],"differences":[63,74],"between":[64,208],"pMCI":[65,137,209],"sMCI":[67,211],"relative":[69,117,141,191],"these":[73],"were":[75,97,109],"correlated":[76,180,240],"function":[79],"or":[80],"neuropathology":[81],"markers.":[82],"METHODS:":[83],"17":[84],"AD,":[87],"27":[88],"MCI,":[91],"38":[93],"older":[94],"healthy":[95],"controls":[96],"recruited":[98],"from":[99],"two":[100],"memory":[101,238],"clinics":[102],"followed":[104],"for":[105,113],"three":[106],"years.":[107],"EEGs":[108],"recorded":[110],"at":[111,212],"baseline":[112,140,161],"all":[114,160],"participants":[115,122],"calculated.":[120],"All":[121],"underwent":[123],"adjusted":[124],"batteries":[125],"of":[126,215],"standardized":[127],"tests":[129],"lumbar":[131],"puncture.":[132],"RESULTS:":[133],"We":[134],"found":[135,157,174,227,235],"that":[136,175,190,236],"showed":[138],"decreased":[139],"in":[143,147,159,167,193,197],"parietal":[145,177,195,243],"electrodes":[146,196],"beta1":[149,169,199,244],"(13-17.99":[151],"Hz).":[152],"At":[153],"2-year":[154],"follow-up,":[155],"changes":[158],"but":[164],"most":[165],"pronounced":[166],"band.":[170,221],"addition,":[172,233],"qEEG":[176,242],"amyloid-\u03b242":[182],"anterograde":[184,237],"memory.":[185],"CONCLUSION:":[186],"These":[187],"findings":[188,223],"suggests":[189],"be":[202],"a":[203],"better":[204],"way":[205],"discriminate":[207],"time":[214],"diagnosis":[216],"than":[217],"Similar":[222],"have":[224],"also":[225],"resting":[229],"state":[230],"fMRI.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-08-03T00:00:00"}