{"id":"https://openalex.org/W2884492838","doi":"https://doi.org/10.1111/wrr.12658","title":"Involvement of calvarial stem cells in healing: A regional analysis of large cranial defects","display_name":"Involvement of calvarial stem cells in healing: A regional analysis of large cranial defects","publication_year":2018,"publication_date":"2018-07-28","ids":{"openalex":"https://openalex.org/W2884492838","doi":"https://doi.org/10.1111/wrr.12658","mag":"2884492838","pmid":"https://pubmed.ncbi.nlm.nih.gov/30054956","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6398939"},"language":"en","primary_location":{"id":"doi:10.1111/wrr.12658","doi":"https://doi.org/10.1111/wrr.12658","is_oa":false,"landing_page_url":"https://doi.org/10.1111/wrr.12658","pdf_url":null,"source":{"id":"https://openalex.org/S121715350","display_name":"Wound Repair and Regeneration","issn_l":"1067-1927","issn":["1067-1927","1524-475X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wound Repair and Regeneration","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6398939","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007810297","display_name":"Emily L. Durham","orcid":"https://orcid.org/0000-0002-6322-9393","observed_orcids":["https://orcid.org/0000-0002-6322-9393"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily L. Durham","raw_affiliation_strings":["Department of Oral Health Sciences, Medical University of South Carolina, Charleston, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Health Sciences, Medical University of South Carolina, Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109499140","display_name":"R. Nicole Howie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Nicole Howie","raw_affiliation_strings":["Department of Oral Health Sciences, Medical University of South Carolina, Charleston, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Health Sciences, Medical University of South Carolina, Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031260318","display_name":"Reed Houck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reed Houck","raw_affiliation_strings":["Department of Oral Health Sciences, Medical University of South Carolina, Charleston, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Health Sciences, Medical University of South Carolina, Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002207261","display_name":"Brayden Oakes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brayden Oakes","raw_affiliation_strings":["Department of Oral Health Sciences, Medical University of South Carolina, Charleston, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Health Sciences, Medical University of South Carolina, Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zachary Grey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary Grey","raw_affiliation_strings":["Department of Oral Health Sciences, Medical University of South Carolina, Charleston, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Health Sciences, Medical University of South Carolina, Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027650718","display_name":"SarahRose Hall","orcid":"https://orcid.org/0000-0002-4026-3118","observed_orcids":["https://orcid.org/0000-0002-4026-3118"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SarahRose Hall","raw_affiliation_strings":["Department of Oral Health Sciences, Medical University of South Carolina, Charleston, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Health Sciences, Medical University of South Carolina, Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071795573","display_name":"Martin B. Steed","orcid":"https://orcid.org/0000-0001-6340-8052","observed_orcids":["https://orcid.org/0000-0001-6340-8052"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Steed","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Medical University of South Carolina, Charleston, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Medical University of South Carolina, Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047082878","display_name":"Amanda C. LaRue","orcid":"https://orcid.org/0000-0003-4572-1496","observed_orcids":["https://orcid.org/0000-0003-4572-1496"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I4210132004","display_name":"Ralph H. Johnson VA Medical Center","ror":"https://ror.org/030ma0n95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210132004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda LaRue","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina","Ralph H. Johnson VA Medical Center, Charleston, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Ralph H. Johnson VA Medical Center, Charleston, South Carolina","institution_ids":["https://openalex.org/I4210132004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060208102","display_name":"Robin C. Muise\u2010Helmericks","orcid":"https://orcid.org/0000-0002-8840-4661","observed_orcids":["https://orcid.org/0000-0002-8840-4661"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robin Muise\u2010Helmericks","raw_affiliation_strings":["Department of Regenerative Medicine and Cellular Biology, Medical University of South Carolina, Charleston, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Regenerative Medicine and Cellular Biology, Medical University of South Carolina, Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084705544","display_name":"James Cray","orcid":"https://orcid.org/0000-0002-8512-7005","observed_orcids":["https://orcid.org/0000-0002-8512-7005"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James Cray","raw_affiliation_strings":["Department of Oral Health Sciences, Medical University of South Carolina, Charleston, South Carolina","Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina","Department of Regenerative Medicine and Cellular Biology, Medical University of South Carolina, Charleston, South Carolina","Division of Anatomy, College of Medicine, The Ohio State University, Columbus, Ohio","Fax: 614-292-7659","James Cray Jr., Division of Anatomy, College of Medicine, The Ohio State University, 1645 Neil Ave. 279, Hamilton Hall, Columbus, OH 43210","Reprint requests:","Tel: 614-292-4831"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Health Sciences, Medical University of South Carolina, Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Department of Regenerative Medicine and Cellular Biology, Medical University of South Carolina, Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Division of Anatomy, College of Medicine, The Ohio State University, Columbus, Ohio","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Fax: 614-292-7659","institution_ids":[]},{"raw_affiliation_string":"James Cray Jr., Division of Anatomy, College of Medicine, The Ohio State University, 1645 Neil Ave. 279, Hamilton Hall, Columbus, OH 43210","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Reprint requests:","institution_ids":[]},{"raw_affiliation_string":"Tel: 614-292-4831","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5084705544"],"corresponding_institution_ids":["https://openalex.org/I153297377","https://openalex.org/I52357470"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.5992,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.61786805,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"26","issue":"5","first_page":"359","last_page":"365"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11679","display_name":"Craniofacial Disorders and Treatments","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calvarial-defect","display_name":"calvarial defect","score":0.8119999766349792},{"id":"https://openalex.org/keywords/craniofacial-defects","display_name":"craniofacial defects","score":0.8100000023841858},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.8149999976158142},{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.7239999771118164},{"id":"https://openalex.org/keywords/bone-morphogenetic-proteins","display_name":"bone morphogenetic proteins","score":0.6840000152587891},{"id":"https://openalex.org/keywords/osteoconductive-scaffolds","display_name":"osteoconductive scaffolds","score":0.7329999804496765},{"id":"https://openalex.org/keywords/critical-sized-bone-defects","display_name":"critical-size bone defect","score":0.5479999780654907},{"id":"https://openalex.org/keywords/dura-mater","display_name":"dura mater","score":0.6899999976158142},{"id":"https://openalex.org/keywords/cranial-sutures","display_name":"cranial sutures","score":0.5529999732971191},{"id":"https://openalex.org/keywords/osteoinduction","display_name":"osteoinduction","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C2776340970","wikidata":"https://www.wikidata.org/wiki/Q32838","display_name":"Mesenchyme","level":3,"score":0.7291954159736633},{"id":"https://openalex.org/C2781245598","wikidata":"https://www.wikidata.org/wiki/Q5182134","display_name":"Craniofacial","level":2,"score":0.6769578456878662},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.6594569683074951},{"id":"https://openalex.org/C30352789","wikidata":"https://www.wikidata.org/wiki/Q14903153","display_name":"Bone morphogenetic protein 2","level":3,"score":0.6298844218254089},{"id":"https://openalex.org/C2777327002","wikidata":"https://www.wikidata.org/wiki/Q2865760","display_name":"Fibrous joint","level":2,"score":0.5873820185661316},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.571167528629303},{"id":"https://openalex.org/C2779918246","wikidata":"https://www.wikidata.org/wiki/Q613203","display_name":"Calvaria","level":3,"score":0.5250696539878845},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.46910175681114197},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.46801790595054626},{"id":"https://openalex.org/C2778607769","wikidata":"https://www.wikidata.org/wiki/Q775482","display_name":"Sagittal suture","level":3,"score":0.45274975895881653},{"id":"https://openalex.org/C178596483","wikidata":"https://www.wikidata.org/wiki/Q7916472","display_name":"Vascularity","level":2,"score":0.4354114830493927},{"id":"https://openalex.org/C2779300802","wikidata":"https://www.wikidata.org/wiki/Q13147","display_name":"Skull","level":2,"score":0.43339288234710693},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42934292554855347},{"id":"https://openalex.org/C2777337764","wikidata":"https://www.wikidata.org/wiki/Q16868231","display_name":"Osteoplasty","level":2,"score":0.41818705201148987},{"id":"https://openalex.org/C2778043341","wikidata":"https://www.wikidata.org/wiki/Q5182142","display_name":"Craniofacial surgery","level":3,"score":0.41452962160110474},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.37541258335113525},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2886601686477661},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.25379490852355957},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18039527535438538},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15625795722007751},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.13610970973968506},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001861","descriptor_name":"Bone Regeneration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":true},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020341","descriptor_name":"Absorbable Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045164","descriptor_name":"Mesenchymal Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D050723","descriptor_name":"Fractures, Bone","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D050723","descriptor_name":"Fractures, Bone","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055396","descriptor_name":"Bone Morphogenetic Protein 2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/wrr.12658","doi":"https://doi.org/10.1111/wrr.12658","is_oa":false,"landing_page_url":"https://doi.org/10.1111/wrr.12658","pdf_url":null,"source":{"id":"https://openalex.org/S121715350","display_name":"Wound Repair and Regeneration","issn_l":"1067-1927","issn":["1067-1927","1524-475X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wound Repair and Regeneration","raw_type":"journal-article"},{"id":"pmid:30054956","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30054956","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6398939","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6398939","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Wound Repair Regen","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6398939","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6398939","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Wound Repair Regen","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.973800003528595,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2200386637","display_name":"The effects of pharmacological exposures on cranial suture stem cells","funder_award_id":"F31DE026684","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G2688050934","display_name":null,"funder_award_id":"I01 BX000333","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G7886057803","display_name":null,"funder_award_id":"S-16-108C","funder_id":"https://openalex.org/F4320320914","funder_display_name":"AO Foundation"},{"id":"https://openalex.org/G8892615685","display_name":"MUSC Center for Oral Health Research","funder_award_id":"P30GM103331","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000868966","display_name":"T-COHR: Training in Craniofacial and Oral Health Research","funder_award_id":"T32DE017551","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320320914","display_name":"AO Foundation","ror":"https://ror.org/04v7vb598"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1595761687","https://openalex.org/W1894490659","https://openalex.org/W1963555074","https://openalex.org/W1970893419","https://openalex.org/W1980051005","https://openalex.org/W1997526887","https://openalex.org/W1998734250","https://openalex.org/W2000444871","https://openalex.org/W2001546027","https://openalex.org/W2004594210","https://openalex.org/W2006505645","https://openalex.org/W2014680491","https://openalex.org/W2042245118","https://openalex.org/W2043070543","https://openalex.org/W2049069390","https://openalex.org/W2050107109","https://openalex.org/W2053816672","https://openalex.org/W2060174229","https://openalex.org/W2066749771","https://openalex.org/W2081199190","https://openalex.org/W2093114427","https://openalex.org/W2095132685","https://openalex.org/W2101542036","https://openalex.org/W2139586508","https://openalex.org/W2155104677","https://openalex.org/W2261324366","https://openalex.org/W2264070708","https://openalex.org/W2297139832","https://openalex.org/W2317745141","https://openalex.org/W2328577922","https://openalex.org/W2413262766","https://openalex.org/W2494321118","https://openalex.org/W2543966630","https://openalex.org/W4295850198","https://openalex.org/W4296816736"],"related_works":["https://openalex.org/W2096826910","https://openalex.org/W1975463875","https://openalex.org/W2728836061","https://openalex.org/W2896545834","https://openalex.org/W2054598108","https://openalex.org/W2276932119","https://openalex.org/W1894490659","https://openalex.org/W2126173958","https://openalex.org/W2423209135","https://openalex.org/W2005872612"],"abstract_inverted_index":{"Large":[0],"craniofacial":[1,213],"defects":[2],"present":[3],"a":[4,34,72,92,134],"substantial":[5],"clinical":[6,32],"challenge":[7],"that":[8,69,170,178,222],"often":[9],"requires":[10],"the":[11,39,43,45,50,82,89,161,182,187,204,245],"use":[12],"of":[13,37,91,139,158,167,212,234,254],"osteoconductive":[14,223],"matrices":[15,224],"and":[16,49,118,121,149,177,256],"osteoinductive":[17,228],"cues":[18],"(i.e.,":[19],"bone":[20,65,74,154],"morphogenetic":[21],"proteins":[22],"[BMP2])":[23],"to":[24,55,59,63,146,152],"augment":[25],"healing.":[26],"While":[27],"these":[28,219],"methods":[29],"have":[30],"improved":[31],"outcomes,":[33],"better":[35,232],"understanding":[36],"how":[38],"osteogenic":[40],"fronts":[41],"surrounding":[42],"defect,":[44,206],"underlying":[46],"dura":[47],"mater,":[48],"cranial":[51],"suture":[52,86,192],"area":[53],"contribute":[54],"healing":[56,70,168,174,179,205,233,239],"may":[57],"lead":[58],"more":[60],"targeted":[61],"therapies":[62],"enhance":[64],"regeneration.":[66],"We":[67],"hypothesized":[68],"within":[71,81,160,203],"large":[73,235],"defect":[75,162],"will":[76],"be":[77],"precipitated":[78],"from":[79,181,186,244],"cells":[80,215],"remaining":[83],"or":[84,111,128,216],"available":[85],"mesenchyme":[87],"abutting":[88],"edges":[90],"murine":[93],"critical":[94],"sized":[95],"defect.":[96],"To":[97],"investigate":[98],"this":[99],"hypothesis,":[100],"39":[101],"adult,":[102],"wild-type":[103],"mice":[104],"were":[105,143],"randomly":[106],"arranged":[107],"into":[108],"groups":[109],"(9":[110],"10":[112],"per":[113],"group)":[114],"by":[115],"time":[116],"(4":[117],"8":[119],"weeks)":[120],"treatment":[122,196],"(control,":[123],"acellular":[124,129],"collagen":[125,130],"sponge":[126,131],"alone,":[127],"loaded":[132],"with":[133,190,227],"clinically":[135],"relevant":[136],"scaled":[137],"dosage":[138],"BMP2).":[140],"The":[141],"skulls":[142],"then":[144],"subjected":[145],"microcomputed":[147],"tomography":[148],"histological":[150],"analysis":[151],"assess":[153],"regeneration":[155],"in":[156,200,225,231],"regions":[157],"interest":[159],"area.":[163],"A":[164],"regional":[165,210],"assessment":[166],"indicated":[169],"BMP2":[171,195],"drives":[172],"greater":[173],"than":[175],"control":[176],"emanates":[180],"surgical":[183,246],"margin,":[184],"particularly":[185],"margin":[188,247],"associated":[189],"undisrupted":[191],"mesenchyme.":[193],"Though":[194],"drove":[197],"an":[198,251],"increase":[199],"cell":[201],"presence":[202],"there":[207,249],"was":[208],"no":[209],"orientation":[211],"stem":[214],"vascularity.":[217],"Overall,":[218],"data":[220],"reinforce":[221],"conjunction":[226],"peptides":[229],"result":[230],"calvarial":[236],"defects.":[237],"This":[238],"is":[240,250],"characterized":[241],"as":[242],"emanating":[243],"where":[248],"abundant":[252],"supply":[253],"vasculature":[255],"progenitor":[257],"cells.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-08-03T00:00:00"}