{"id":"https://openalex.org/W2884489621","doi":"https://doi.org/10.1186/s12943-018-0854-5","title":"Deciphering mechanisms of brain metastasis in melanoma - the gist of the matter","display_name":"Deciphering mechanisms of brain metastasis in melanoma - the gist of the matter","publication_year":2018,"publication_date":"2018-07-27","ids":{"openalex":"https://openalex.org/W2884489621","doi":"https://doi.org/10.1186/s12943-018-0854-5","mag":"2884489621","pmid":"https://pubmed.ncbi.nlm.nih.gov/30053879","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6064184"},"language":"en","primary_location":{"id":"doi:10.1186/s12943-018-0854-5","doi":"https://doi.org/10.1186/s12943-018-0854-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12943-018-0854-5","pdf_url":"https://molecular-cancer.biomedcentral.com/track/pdf/10.1186/s12943-018-0854-5","source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://molecular-cancer.biomedcentral.com/track/pdf/10.1186/s12943-018-0854-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Torben Redmer","orcid":"https://orcid.org/0000-0002-8516-0614","observed_orcids":["https://orcid.org/0000-0002-8516-0614"]},"institutions":[{"id":"https://openalex.org/I150540706","display_name":"University of Veterinary Medicine Vienna","ror":"https://ror.org/01w6qp003","country_code":"AT","type":"education","lineage":["https://openalex.org/I150540706"]},{"id":"https://openalex.org/I4392738228","display_name":"Stiftung Charit\u00e9","ror":"https://ror.org/016rf0n60","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4392738228","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["AT","DE"],"is_corresponding":true,"raw_author_name":"Torben Redmer","raw_affiliation_strings":["Department of Dermatology, Venerology and Allergology, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, D-10117, Berlin, Germany. torben.redmer@charite.de","Department of Medical Biochemistry, University of Veterinary Medicine Vienna, Veterin\u00e4rplatz 1, 1210, Vienna, Austria. torben.redmer@charite.de","Department of Dermatology, Venerology and Allergology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, D-10117, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0002-8516-0614","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Venerology and Allergology, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, D-10117, Berlin, Germany. torben.redmer@charite.de","institution_ids":["https://openalex.org/I4392738228","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Medical Biochemistry, University of Veterinary Medicine Vienna, Veterin\u00e4rplatz 1, 1210, Vienna, Austria. torben.redmer@charite.de","institution_ids":["https://openalex.org/I150540706"]},{"raw_affiliation_string":"Department of Dermatology, Venerology and Allergology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, D-10117, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I150540706","https://openalex.org/I4392738228","https://openalex.org/I7877124"],"apc_list":{"value":5090,"currency":"USD","value_usd":5090},"apc_paid":{"value":5090,"currency":"USD","value_usd":5090},"fwci":0.7359,"has_fulltext":true,"cited_by_count":68,"citation_normalized_percentile":{"value":0.64178545,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"17","issue":"1","first_page":"106","last_page":"106"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.04309999942779541,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma-brain-metastases","display_name":"melanoma brain metastases","score":0.8870000243186951},{"id":"https://openalex.org/keywords/braf-mutation","display_name":"BRAF mutation","score":0.7250000238418579},{"id":"https://openalex.org/keywords/nras-mutation","display_name":"NRAS mutation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pten-loss","display_name":"PTEN loss","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.925000011920929},{"id":"https://openalex.org/keywords/stat3-pathway","display_name":"STAT3 pathway","score":0.8849999904632568},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9909999966621399},{"id":"https://openalex.org/keywords/p75-neurotrophin-receptor","display_name":"p75 neurotrophin receptor","score":0.996999979019165},{"id":"https://openalex.org/keywords/ccr4","display_name":"CCR4","score":0.7839999794960022},{"id":"https://openalex.org/keywords/homing-receptors","display_name":"homing receptors","score":0.8629999756813049},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7950000166893005},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cancer-stemness","display_name":"cancer stemness","score":0.8320000171661377},{"id":"https://openalex.org/keywords/dabrafenib","display_name":"dabrafenib","score":0.8539999723434448},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9559999704360962},{"id":"https://openalex.org/keywords/stereotactic-surgery","display_name":"stereotactic surgery","score":0.7960000038146973}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6991621255874634},{"id":"https://openalex.org/C2778164965","wikidata":"https://www.wikidata.org/wiki/Q1620196","display_name":"Brain metastasis","level":4,"score":0.6951921582221985},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6229647994041443},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6193684935569763},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5524970293045044},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.4994516372680664},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4876807928085327},{"id":"https://openalex.org/C21790070","wikidata":"https://www.wikidata.org/wiki/Q18030215","display_name":"Neuroblastoma RAS viral oncogene homolog","level":5,"score":0.46503064036369324},{"id":"https://openalex.org/C177504595","wikidata":"https://www.wikidata.org/wiki/Q336500","display_name":"Microphthalmia-associated transcription factor","level":4,"score":0.4397367835044861},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4271794557571411},{"id":"https://openalex.org/C151872237","wikidata":"https://www.wikidata.org/wiki/Q1410759","display_name":"Homing (biology)","level":2,"score":0.41714465618133545},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.29448002576828003},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2623395621776581},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.08779147267341614},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12943-018-0854-5","doi":"https://doi.org/10.1186/s12943-018-0854-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12943-018-0854-5","pdf_url":"https://molecular-cancer.biomedcentral.com/track/pdf/10.1186/s12943-018-0854-5","source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5022893","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6064184","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6064184","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6064184","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cancer","raw_type":"Text"},{"id":"pmid:30053879","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30053879","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:4cce68419b044ccbafe5fc924a39d965","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/4cce68419b044ccbafe5fc924a39d965","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Cancer, Vol 17, Iss 1, Pp 1-17 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12943-018-0854-5","doi":"https://doi.org/10.1186/s12943-018-0854-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12943-018-0854-5","pdf_url":"https://molecular-cancer.biomedcentral.com/track/pdf/10.1186/s12943-018-0854-5","source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4376090368","display_name":null,"funder_award_id":"RE 4210/1-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2884489621.pdf","grobid_xml":"https://content.openalex.org/works/W2884489621.grobid-xml"},"referenced_works_count":167,"referenced_works":["https://openalex.org/W40221153","https://openalex.org/W82508993","https://openalex.org/W112133451","https://openalex.org/W160155574","https://openalex.org/W193935985","https://openalex.org/W791611488","https://openalex.org/W1258373536","https://openalex.org/W1491789131","https://openalex.org/W1499083095","https://openalex.org/W1517488477","https://openalex.org/W1536495163","https://openalex.org/W1899851581","https://openalex.org/W1917632054","https://openalex.org/W1957468634","https://openalex.org/W1964154017","https://openalex.org/W1968221752","https://openalex.org/W1969082125","https://openalex.org/W1969717303","https://openalex.org/W1970195561","https://openalex.org/W1973172185","https://openalex.org/W1974499786","https://openalex.org/W1982532675","https://openalex.org/W1985577088","https://openalex.org/W1985649889","https://openalex.org/W1985928174","https://openalex.org/W1988957846","https://openalex.org/W1990376228","https://openalex.org/W1990675339","https://openalex.org/W1990757263","https://openalex.org/W1997733193","https://openalex.org/W1998038367","https://openalex.org/W1999018351","https://openalex.org/W2003402062","https://openalex.org/W2006741643","https://openalex.org/W2007436843","https://openalex.org/W2008878539","https://openalex.org/W2009334802","https://openalex.org/W2011755139","https://openalex.org/W2013996063","https://openalex.org/W2015129158","https://openalex.org/W2015541518","https://openalex.org/W2016254755","https://openalex.org/W2020185423","https://openalex.org/W2023121881","https://openalex.org/W2024117515","https://openalex.org/W2025130458","https://openalex.org/W2028092387","https://openalex.org/W2029094642","https://openalex.org/W2032211985","https://openalex.org/W2035296213","https://openalex.org/W2036905020","https://openalex.org/W2039202448","https://openalex.org/W2042204087","https://openalex.org/W2043166238","https://openalex.org/W2043746859","https://openalex.org/W2045196113","https://openalex.org/W2048508307","https://openalex.org/W2056199226","https://openalex.org/W2056362223","https://openalex.org/W2060551076","https://openalex.org/W2064442490","https://openalex.org/W2065626916","https://openalex.org/W2073971491","https://openalex.org/W2074515925","https://openalex.org/W2080878900","https://openalex.org/W2084659308","https://openalex.org/W2085363039","https://openalex.org/W2086303392","https://openalex.org/W2090134577","https://openalex.org/W2090360494","https://openalex.org/W2091100650","https://openalex.org/W2091600673","https://openalex.org/W2091714475","https://openalex.org/W2094105868","https://openalex.org/W2097995306","https://openalex.org/W2098395271","https://openalex.org/W2098508336","https://openalex.org/W2102978104","https://openalex.org/W2103220202","https://openalex.org/W2105012597","https://openalex.org/W2105986003","https://openalex.org/W2107484016","https://openalex.org/W2108175127","https://openalex.org/W2109387929","https://openalex.org/W2110478149","https://openalex.org/W2114847324","https://openalex.org/W2117086282","https://openalex.org/W2118471749","https://openalex.org/W2119569174","https://openalex.org/W2121886536","https://openalex.org/W2122200359","https://openalex.org/W2127199535","https://openalex.org/W2128542677","https://openalex.org/W2129330002","https://openalex.org/W2129349376","https://openalex.org/W2129553803","https://openalex.org/W2131281381","https://openalex.org/W2131329324","https://openalex.org/W2132390180","https://openalex.org/W2133492954","https://openalex.org/W2133857293","https://openalex.org/W2136474966","https://openalex.org/W2136731993","https://openalex.org/W2137672944","https://openalex.org/W2140293999","https://openalex.org/W2145990138","https://openalex.org/W2148291345","https://openalex.org/W2152140971","https://openalex.org/W2152353759","https://openalex.org/W2154468380","https://openalex.org/W2156323704","https://openalex.org/W2163188200","https://openalex.org/W2163845360","https://openalex.org/W2164626076","https://openalex.org/W2166071065","https://openalex.org/W2166262263","https://openalex.org/W2166606798","https://openalex.org/W2168143310","https://openalex.org/W2169465106","https://openalex.org/W2171902538","https://openalex.org/W2175940415","https://openalex.org/W2177518191","https://openalex.org/W2213900452","https://openalex.org/W2281478723","https://openalex.org/W2292305777","https://openalex.org/W2311385685","https://openalex.org/W2346727850","https://openalex.org/W2396385691","https://openalex.org/W2406863140","https://openalex.org/W2412290775","https://openalex.org/W2413728677","https://openalex.org/W2415629219","https://openalex.org/W2416333308","https://openalex.org/W2416791964","https://openalex.org/W2467571845","https://openalex.org/W2500279326","https://openalex.org/W2509811343","https://openalex.org/W2512420471","https://openalex.org/W2529270648","https://openalex.org/W2560367415","https://openalex.org/W2562656839","https://openalex.org/W2572174216","https://openalex.org/W2579190971","https://openalex.org/W2580923676","https://openalex.org/W2592722082","https://openalex.org/W2603647816","https://openalex.org/W2604400807","https://openalex.org/W2615907969","https://openalex.org/W2617489830","https://openalex.org/W2618369933","https://openalex.org/W2620651944","https://openalex.org/W2662390570","https://openalex.org/W2725029513","https://openalex.org/W2739436552","https://openalex.org/W2741094414","https://openalex.org/W2744131715","https://openalex.org/W2745845089","https://openalex.org/W2755251092","https://openalex.org/W2761851330","https://openalex.org/W2766903152","https://openalex.org/W2770795622","https://openalex.org/W2784022064","https://openalex.org/W2794627893","https://openalex.org/W2890815045","https://openalex.org/W4237979552","https://openalex.org/W4285719527","https://openalex.org/W4301912147"],"related_works":["https://openalex.org/W4416713969","https://openalex.org/W2038286991","https://openalex.org/W2963114976","https://openalex.org/W1964181793","https://openalex.org/W2618369933","https://openalex.org/W3083457883","https://openalex.org/W4243486169","https://openalex.org/W7204247485","https://openalex.org/W3121204061","https://openalex.org/W160155574"],"abstract_inverted_index":{"Metastasis":[0],"to":[1,22,24,44,70,142,171],"distant":[2],"organs":[3],"and":[4,27,57,86,112,167,199],"particularly":[5],"the":[6,10,25,49,65,72,76,158,206,243],"brain":[7,26,66,96,122,134,164,211,247],"still":[8],"represents":[9],"most":[11],"serious":[12],"obstacle":[13],"in":[14,88,129,249],"melanoma":[15,124,146],"therapies.":[16],"Melanoma":[17],"cells":[18,136,147,161,166,196],"acquire":[19],"a":[20,58,99,173,186,191,238],"phenotype":[21,68],"metastasize":[23],"successfully":[28],"grow":[29],"there":[30],"through":[31],"complex":[32],"mechanisms":[33,244],"determined":[34],"by":[35,133,189,215],"microenvironmental":[36],"than":[37],"rather":[38],"genetic":[39],"cues.":[40],"There":[41],"do":[42],"appear":[43,69],"be":[45,71],"some":[46],"prerequisites,":[47],"including":[48],"presence":[50],"of":[51,60,64,75,84,95,102,104,121,178,242],"oncogenic":[52],"BRAF":[53,218],"or":[54,78,81,151,226],"NRAS":[55],"mutations":[56],"loss":[59],"PTEN.":[61],"Further":[62,229],"mediators":[63],"metastatic":[67,89,123],"high":[73,82,100],"activation":[74],"PI3K/AKT":[77],"STAT3":[79],"pathway":[80],"levels":[83],"PLEKHA5":[85],"MMP2":[87],"cells.":[90,125],"A":[91],"yet":[92],"undefined":[93],"subset":[94],"metastases":[97,212],"exhibit":[98],"level":[101],"expression":[103,116],"CD271":[105,115],"that":[106,148,181,193,245],"is":[107],"associated":[108],"with":[109,163,223],"stemness,":[110],"migration":[111],"survival.":[113],"Hence,":[114],"may":[117,184],"determine":[118],"specific":[119],"properties":[120],"Environmental":[126],"cues":[127],"-":[128,140],"particular":[130],"those":[131],"provided":[132],"parenchymal":[135],"such":[137,220],"as":[138,221],"astrocytes":[139],"seem":[141],"help":[143],"specifically":[144],"guide":[145],"express":[149],"CCR4":[150],"CD271,":[152],"potential":[153],"\"homing":[154],"receptors\".":[155],"Upon":[156],"entering":[157],"brain,":[159],"these":[160],"interact":[162],"parenchyma":[165],"are":[168],"thereby":[169],"reprogrammed":[170],"adopt":[172],"neurological":[174],"phenotype.":[175],"Several":[176],"lines":[177],"evidence":[179],"suggest":[180],"current":[182],"therapies":[183],"have":[185,204],"negative":[187],"effect":[188],"activating":[190],"program":[192],"drives":[194],"tumor":[195],"toward":[197,231],"stemness":[198],"metastasis.":[200],"Yet":[201],"significant":[202],"improvements":[203],"expanded":[205],"therapeutic":[207,234],"options":[208],"for":[209],"treating":[210],"from":[213],"melanoma,":[214],"combining":[216],"potent":[217],"inhibitors":[219,225],"dabrafenib":[222],"checkpoint":[224],"stereotactic":[227],"surgery.":[228],"progress":[230],"developing":[232],"new":[233],"strategies":[235],"will":[236],"require":[237],"more":[239],"profound":[240],"understanding":[241],"underlie":[246],"metastasis":[248],"melanoma.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-08-03T00:00:00"}
