{"id":"https://openalex.org/W2884489131","doi":"https://doi.org/10.7488/ds/2352","title":"Role of accelerated ageing in limb muscle wasting of patients with Chronic Obstructive Pulmonary Disease (COPD)","display_name":"Role of accelerated ageing in limb muscle wasting of patients with Chronic Obstructive Pulmonary Disease (COPD)","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2884489131","doi":"https://doi.org/10.7488/ds/2352","mag":"2884489131"},"language":"en","primary_location":{"id":"doi:10.7488/ds/2352","doi":"https://doi.org/10.7488/ds/2352","is_oa":true,"landing_page_url":"https://doi.org/10.7488/ds/2352","pdf_url":null,"source":{"id":"https://openalex.org/S7407050748","display_name":"University of Edinburgh","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"volume":null,"type":"dataset","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.7488/ds/2352","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069939378","display_name":"Ramzi Lakhdar","orcid":"https://orcid.org/0000-0002-4749-9975","observed_orcids":["https://orcid.org/0000-0002-4749-9975"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lakhdar, Ramzi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068581160","display_name":"Dagmara McGuinness","orcid":"https://orcid.org/0000-0001-9057-3504","observed_orcids":["https://orcid.org/0000-0001-9057-3504"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"McGuinness, Dagmara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113683691","display_name":"Ellen Drost","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Drost, Ellen M","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051664610","display_name":"Paul G. Shiels","orcid":"https://orcid.org/0000-0002-7577-9843","observed_orcids":["https://orcid.org/0000-0002-7577-9843"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shiels, Paul G","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Bastos, Ricardo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bastos, Ricardo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050425677","display_name":"William MacNee","orcid":"https://orcid.org/0000-0002-3692-1448","observed_orcids":["https://orcid.org/0000-0002-3692-1448"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MacNee, William","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5002240686","display_name":"Roberto Rabinovich","orcid":"https://orcid.org/0000-0002-8653-0373","observed_orcids":["https://orcid.org/0000-0002-8653-0373"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rabinovich, Roberto A","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.04450000077486038,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.014600000344216824,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9909999966621399},{"id":"https://openalex.org/keywords/skeletal-muscle-atrophy","display_name":"skeletal muscle atrophy","score":0.7490000128746033},{"id":"https://openalex.org/keywords/accelerated-aging","display_name":"accelerated aging","score":0.9449999928474426},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.8309999704360962},{"id":"https://openalex.org/keywords/gamma-h2ax","display_name":"\u03b3H2AX","score":0.8360000252723694},{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sirt6","display_name":"SIRT6","score":1.0},{"id":"https://openalex.org/keywords/stress-induced-premature-senescence","display_name":"stress-induced premature senescence","score":0.9639999866485596},{"id":"https://openalex.org/keywords/senescence-associated-secretory-phenotype","display_name":"senescence-associated secretory phenotype","score":0.9980000257492065},{"id":"https://openalex.org/keywords/muscle-inflammation","display_name":"muscle inflammation","score":0.7400000095367432},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9940000176429749},{"id":"https://openalex.org/keywords/fat-free-mass-index","display_name":"fat-free mass index","score":0.621999979019165},{"id":"https://openalex.org/keywords/cellular-homeostasis","display_name":"cellular homeostasis","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.8772562742233276},{"id":"https://openalex.org/C2779764123","wikidata":"https://www.wikidata.org/wiki/Q7972881","display_name":"Wasting","level":2,"score":0.8644815683364868},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.8619434833526611},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.7613910436630249},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6692103147506714},{"id":"https://openalex.org/C2776214593","wikidata":"https://www.wikidata.org/wiki/Q1787939","display_name":"Sarcopenia","level":2,"score":0.5147243142127991},{"id":"https://openalex.org/C2992644362","wikidata":"https://www.wikidata.org/wiki/Q692536","display_name":"Muscle disease","level":3,"score":0.5129606127738953},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5034856200218201},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.45890918374061584},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.44751760363578796},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4004855751991272},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3741397559642792},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36796778440475464}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.7488/ds/2352","doi":"https://doi.org/10.7488/ds/2352","is_oa":true,"landing_page_url":"https://doi.org/10.7488/ds/2352","pdf_url":null,"source":{"id":"https://openalex.org/S7407050748","display_name":"University of Edinburgh","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"mag:2884489131","doi":null,"is_oa":false,"landing_page_url":"https://datashare.ed.ac.uk/handle/10283/3086","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.7488/ds/2352","doi":"https://doi.org/10.7488/ds/2352","is_oa":true,"landing_page_url":"https://doi.org/10.7488/ds/2352","pdf_url":null,"source":{"id":"https://openalex.org/S7407050748","display_name":"University of Edinburgh","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2809130290","https://openalex.org/W2565574576","https://openalex.org/W7099955613","https://openalex.org/W2312962973","https://openalex.org/W179879772","https://openalex.org/W4281629217","https://openalex.org/W2045886232","https://openalex.org/W3031389212","https://openalex.org/W2242318452","https://openalex.org/W2066636563"],"abstract_inverted_index":{"Skeletal":[0],"muscle":[1,46,68,135,167],"wasting":[2,47,69],"is":[3],"an":[4,37,149,196],"independent":[5],"predictor":[6],"of":[7,10,19,63,70,97,156,162,168,199,201],"health-related":[8],"quality":[9],"life,":[11],"and":[12,48,91,122,128,134,160,184,194,204],"survival":[13],"in":[14,53,66,106,109,113,120,126,141,146,165],"COPD,":[15],"but":[16],"the":[17,20,49,60,166,190],"complexity":[18],"molecular":[21],"mechanisms":[22],"associated":[23,185],"with":[24,55,72,115,148,171],"this":[25],"process":[26],"have":[27],"not":[28],"been":[29],"fully":[30],"elucidated.":[31],"We":[32,102],"aimed":[33],"to":[34,40,45,118],"determine":[35],"whether":[36],"impaired":[38,157],"ability":[39],"repair":[41,159],"DNA":[42,158],"damage":[43,133],"contributes":[44],"accelerated":[50,64,150],"ageing":[51,65,151],"phenotype":[52,152,193],"patients":[54,71,170],"COPD.":[56],"These":[57,143,175],"data":[58,144,176],"support":[59],"publication:":[61],"Role":[62],"limb":[67],"Chronic":[73],"Obstructive":[74],"Pulmonary":[75],"Disease":[76],"(COPD).":[77],"Ramzi":[78],"Lakhdar,":[79],"Dagmara":[80],"McGuinness,":[81],"Ellen":[82],"M":[83],"Drost,":[84],"Paul":[85],"G":[86],"Shiels,Ricardo":[87],"Bastos,":[88],"William":[89],"MacNee":[90],"Roberto":[92],"A":[93],"Rabinovich.":[94],"International":[95],"Journal":[96],"COPD":[98,169],"2018":[99],"(Accepted":[100],"manuscript).":[101],"observed":[103],"a":[104,116,123,154,172],"decrease":[105,125],"\u03b3H2AX":[107],"expression":[108,198],"COPDL,":[110],"which":[111],"occurred":[112],"association":[114],"tendency":[117],"increase":[119],"CDKN2A/p16ink4a":[121],"significant":[124],"SIRT1":[127],"SIRT6":[129],"protein":[130],"levels.":[131],"Cellular":[132],"inflammatory":[136,186],"markers":[137,200],"were":[138],"also":[139],"increased":[140,197],"COPDL.":[142],"are":[145],"keeping":[147],"as":[153],"result":[155],"dysregulation":[161],"cellular":[163,178],"homeostasis":[164],"low":[173],"FFMI.":[174],"indicate":[177],"degeneration":[179],"via":[180],"stress-induced":[181],"premature":[182],"senescence":[183],"responses":[187],"abetted":[188],"by":[189],"senescence-associated":[191],"secretory":[192],"reflected":[195],"oxidative":[202],"stress":[203],"inflammation.":[205]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2018-08-03T00:00:00"}