{"id":"https://openalex.org/W2884037717","doi":"https://doi.org/10.1016/j.plefa.2018.07.014","title":"Ischemia-modified albumin: Crosstalk between fatty acid and cobalt binding","display_name":"Ischemia-modified albumin: Crosstalk between fatty acid and cobalt binding","publication_year":2018,"publication_date":"2018-07-20","ids":{"openalex":"https://openalex.org/W2884037717","doi":"https://doi.org/10.1016/j.plefa.2018.07.014","mag":"2884037717","pmid":"https://pubmed.ncbi.nlm.nih.gov/30103926","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6109191"},"language":"en","primary_location":{"id":"doi:10.1016/j.plefa.2018.07.014","doi":"https://doi.org/10.1016/j.plefa.2018.07.014","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.plefa.2018.07.014","pdf_url":"http://www.plefa.com/article/S0952327818300826/pdf","source":{"id":"https://openalex.org/S9307485","display_name":"Prostaglandins Leukotrienes and Essential Fatty Acids","issn_l":"0952-3278","issn":["0952-3278","1532-2823"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prostaglandins, Leukotrienes and Essential Fatty Acids","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.plefa.com/article/S0952327818300826/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039894660","display_name":"James P. C. Coverdale","orcid":"https://orcid.org/0000-0002-7779-6620","observed_orcids":["https://orcid.org/0000-0002-7779-6620"]},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James P.C. Coverdale","raw_affiliation_strings":["Department of Chemistry, University of Warwick, Coventry, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-7779-6620","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Warwick, Coventry, United Kingdom","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058152302","display_name":"Kondwani Katundu","orcid":"https://orcid.org/0000-0002-6635-953X","observed_orcids":["https://orcid.org/0000-0002-6635-953X"]},"institutions":[{"id":"https://openalex.org/I157591606","display_name":"University of Malawi","ror":"https://ror.org/04vtx5s55","country_code":"MW","type":"education","lineage":["https://openalex.org/I157591606"]},{"id":"https://openalex.org/I16835326","display_name":"University of St Andrews","ror":"https://ror.org/02wn5qz54","country_code":"GB","type":"education","lineage":["https://openalex.org/I16835326"]}],"countries":["GB","MW"],"is_corresponding":false,"raw_author_name":"Kondwani G.H. Katundu","raw_affiliation_strings":["School of Medicine, University of St Andrews, St Andrews, United Kingdom; College of Medicine, University of Malawi, Blantyre, Malawi","College of Medicine, University of Malawi, Blantyre, Malawi","School of Medicine, University of St Andrews, St Andrews, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, University of St Andrews, St Andrews, United Kingdom; College of Medicine, University of Malawi, Blantyre, Malawi","institution_ids":["https://openalex.org/I157591606","https://openalex.org/I16835326"]},{"raw_affiliation_string":"College of Medicine, University of Malawi, Blantyre, Malawi","institution_ids":["https://openalex.org/I157591606"]},{"raw_affiliation_string":"School of Medicine, University of St Andrews, St Andrews, United Kingdom","institution_ids":["https://openalex.org/I16835326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053513629","display_name":"Am\u00e9lie I. S. Sobczak","orcid":"https://orcid.org/0000-0003-4892-7203","observed_orcids":["https://orcid.org/0000-0003-4892-7203"]},"institutions":[{"id":"https://openalex.org/I16835326","display_name":"University of St Andrews","ror":"https://ror.org/02wn5qz54","country_code":"GB","type":"education","lineage":["https://openalex.org/I16835326"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Am\u00e9lie I.S. Sobczak","raw_affiliation_strings":["School of Medicine, University of St Andrews, St Andrews, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-4892-7203","affiliations":[{"raw_affiliation_string":"School of Medicine, University of St Andrews, St Andrews, United Kingdom","institution_ids":["https://openalex.org/I16835326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054056977","display_name":"Swati Arya","orcid":"https://orcid.org/0000-0001-7978-9507","observed_orcids":["https://orcid.org/0000-0001-7978-9507"]},"institutions":[{"id":"https://openalex.org/I16835326","display_name":"University of St Andrews","ror":"https://ror.org/02wn5qz54","country_code":"GB","type":"education","lineage":["https://openalex.org/I16835326"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Swati Arya","raw_affiliation_strings":["School of Medicine, University of St Andrews, St Andrews, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, University of St Andrews, St Andrews, United Kingdom","institution_ids":["https://openalex.org/I16835326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028198037","display_name":"Claudia Andrea Blindauer","orcid":"https://orcid.org/0000-0001-8396-9332","observed_orcids":["https://orcid.org/0000-0001-8396-9332"]},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Claudia A. Blindauer","raw_affiliation_strings":["Department of Chemistry, University of Warwick, Coventry, United Kingdom. Electronic address: c.blindauer@warwick.ac.uk","Department of Chemistry, University of Warwick, Coventry, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Warwick, Coventry, United Kingdom. Electronic address: c.blindauer@warwick.ac.uk","institution_ids":["https://openalex.org/I39555362"]},{"raw_affiliation_string":"Department of Chemistry, University of Warwick, Coventry, United Kingdom","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051578001","display_name":"Alan James Stewart","orcid":"https://orcid.org/0000-0003-4580-1840","observed_orcids":["https://orcid.org/0000-0003-4580-1840"]},"institutions":[{"id":"https://openalex.org/I16835326","display_name":"University of St Andrews","ror":"https://ror.org/02wn5qz54","country_code":"GB","type":"education","lineage":["https://openalex.org/I16835326"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Alan J. Stewart","raw_affiliation_strings":["School of Medicine, University of St Andrews, St Andrews, United Kingdom. Electronic address: ajs21@st-andrews.ac.uk","School of Medicine, University of St Andrews, St Andrews, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-4580-1840","affiliations":[{"raw_affiliation_string":"School of Medicine, University of St Andrews, St Andrews, United Kingdom. Electronic address: ajs21@st-andrews.ac.uk","institution_ids":["https://openalex.org/I16835326"]},{"raw_affiliation_string":"School of Medicine, University of St Andrews, St Andrews, United Kingdom","institution_ids":["https://openalex.org/I16835326"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5028198037","https://openalex.org/A5051578001"],"corresponding_institution_ids":["https://openalex.org/I16835326","https://openalex.org/I39555362"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":{"value":3790,"currency":"USD","value_usd":3790},"fwci":0.6626,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.55912441,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"135","issue":null,"first_page":"147","last_page":"157"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ischemia-modified-albumin","display_name":"ischemia-modified albumin","score":1.0},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.824999988079071},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.8209999799728394},{"id":"https://openalex.org/keywords/cobalt-binding","display_name":"cobalt binding","score":0.6639999747276306},{"id":"https://openalex.org/keywords/plasma-fatty-acids","display_name":"plasma fatty acids","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.7471508979797363},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.7001701593399048},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6294258832931519},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5975801348686218},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.4725075662136078},{"id":"https://openalex.org/C165616093","wikidata":"https://www.wikidata.org/wiki/Q424232","display_name":"Serum albumin","level":2,"score":0.4582355320453644},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.4216371774673462}],"mesh":[{"descriptor_ui":"D000075462","descriptor_name":"Serum Albumin, Human","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000075462","descriptor_name":"Serum Albumin, Human","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003035","descriptor_name":"Cobalt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1016/j.plefa.2018.07.014","doi":"https://doi.org/10.1016/j.plefa.2018.07.014","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.plefa.2018.07.014","pdf_url":"http://www.plefa.com/article/S0952327818300826/pdf","source":{"id":"https://openalex.org/S9307485","display_name":"Prostaglandins Leukotrienes and Essential Fatty Acids","issn_l":"0952-3278","issn":["0952-3278","1532-2823"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prostaglandins, Leukotrienes and Essential Fatty Acids","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5053176","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6109191","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30103926","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30103926","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prostaglandins, leukotrienes, and essential fatty acids","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6109191","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6109191/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prostaglandins Leukot Essent Fatty Acids","raw_type":"Text"},{"id":"pmh:oai:wrap.warwick.ac.uk:107852","doi":null,"is_oa":false,"landing_page_url":"http://wrap.warwick.ac.uk/107852/1/WRAP-ischemia-modified-albumin-crosstalk-fatty-acid-cobalt-Coverdale-2018.pdf","pdf_url":"http://wrap.warwick.ac.uk/107852/1/WRAP-ischemia-modified-albumin-crosstalk-fatty-acid-cobalt-Coverdale-2018.pdf","source":{"id":"https://openalex.org/S4306400665","display_name":"Warwick Research Archive Portal (University of Warwick)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I39555362","host_organization_name":"University of Warwick","host_organization_lineage":["https://openalex.org/I39555362"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:research-repository.st-andrews.ac.uk:10023/15855","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10023/15855","pdf_url":null,"source":{"id":"https://openalex.org/S4306400230","display_name":"St Andrews Research Repository (St Andrews Research Repository)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I16835326","host_organization_name":"University of St Andrews","host_organization_lineage":["https://openalex.org/I16835326"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal item"}],"best_oa_location":{"id":"doi:10.1016/j.plefa.2018.07.014","doi":"https://doi.org/10.1016/j.plefa.2018.07.014","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.plefa.2018.07.014","pdf_url":"http://www.plefa.com/article/S0952327818300826/pdf","source":{"id":"https://openalex.org/S9307485","display_name":"Prostaglandins Leukotrienes and Essential Fatty Acids","issn_l":"0952-3278","issn":["0952-3278","1532-2823"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prostaglandins, Leukotrienes and Essential Fatty Acids","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1674948198","display_name":null,"funder_award_id":"RPG\u20102017\u2010214","funder_id":"https://openalex.org/F4320319993","funder_display_name":"Leverhulme Trust"},{"id":"https://openalex.org/G172720076","display_name":null,"funder_award_id":"BB/J006467/1","funder_id":"https://openalex.org/F4320319993","funder_display_name":"Leverhulme Trust"},{"id":"https://openalex.org/G4102477549","display_name":"Role of zinc in controlling histidine-rich glycoprotein complex formation: implications for the development of thrombotic complications","funder_award_id":"PG/15/9/31270","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G4761801404","display_name":"Characterisation of zinc-dependent heparin neutralisation by fibrinogen and histidine-rich glycoprotein","funder_award_id":"FS/15/42/31556","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G553497420","display_name":"The Dynamics of Circulatory Zinc Handling and Transport","funder_award_id":"BB/J006467/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G8641632195","display_name":null,"funder_award_id":"PG/15/9/31270","funder_id":"https://openalex.org/F4320319993","funder_display_name":"Leverhulme Trust"},{"id":"https://openalex.org/G999929898","display_name":null,"funder_award_id":"FS/15/42/31556","funder_id":"https://openalex.org/F4320319993","funder_display_name":"Leverhulme Trust"}],"funders":[{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320319993","display_name":"Leverhulme Trust","ror":"https://ror.org/012mzw131"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2884037717.pdf","grobid_xml":"https://content.openalex.org/works/W2884037717.grobid-xml"},"referenced_works_count":160,"referenced_works":["https://openalex.org/W26912437","https://openalex.org/W41840881","https://openalex.org/W73808465","https://openalex.org/W109776604","https://openalex.org/W169349588","https://openalex.org/W171252792","https://openalex.org/W571495879","https://openalex.org/W593928674","https://openalex.org/W613567032","https://openalex.org/W1430821294","https://openalex.org/W1485844398","https://openalex.org/W1516858556","https://openalex.org/W1535032604","https://openalex.org/W1559359437","https://openalex.org/W1560376606","https://openalex.org/W1570496235","https://openalex.org/W1592321796","https://openalex.org/W1596436571","https://openalex.org/W1598438402","https://openalex.org/W1605545986","https://openalex.org/W1622799587","https://openalex.org/W1901598726","https://openalex.org/W1915312313","https://openalex.org/W1932252362","https://openalex.org/W1957364659","https://openalex.org/W1964641434","https://openalex.org/W1966250940","https://openalex.org/W1968040518","https://openalex.org/W1969375661","https://openalex.org/W1969942980","https://openalex.org/W1971291382","https://openalex.org/W1972418851","https://openalex.org/W1975157741","https://openalex.org/W1977507454","https://openalex.org/W1978127615","https://openalex.org/W1980078657","https://openalex.org/W1980831385","https://openalex.org/W1981202334","https://openalex.org/W1984399732","https://openalex.org/W1986868208","https://openalex.org/W1987479195","https://openalex.org/W1991165532","https://openalex.org/W1997295916","https://openalex.org/W1998369303","https://openalex.org/W1998814242","https://openalex.org/W2000129317","https://openalex.org/W2002378742","https://openalex.org/W2004807586","https://openalex.org/W2006096143","https://openalex.org/W2007790334","https://openalex.org/W2008491823","https://openalex.org/W2008794986","https://openalex.org/W2011652269","https://openalex.org/W2013004205","https://openalex.org/W2014477053","https://openalex.org/W2017654147","https://openalex.org/W2019399271","https://openalex.org/W2019887282","https://openalex.org/W2021482300","https://openalex.org/W2025604932","https://openalex.org/W2026179388","https://openalex.org/W2026661178","https://openalex.org/W2028618127","https://openalex.org/W2028890388","https://openalex.org/W2028950712","https://openalex.org/W2032545096","https://openalex.org/W2032878070","https://openalex.org/W2033130238","https://openalex.org/W2035252935","https://openalex.org/W2035553096","https://openalex.org/W2035884057","https://openalex.org/W2037504593","https://openalex.org/W2040506379","https://openalex.org/W2046821451","https://openalex.org/W2047245081","https://openalex.org/W2048745323","https://openalex.org/W2050978313","https://openalex.org/W2051643227","https://openalex.org/W2054047714","https://openalex.org/W2061622547","https://openalex.org/W2062075717","https://openalex.org/W2065300593","https://openalex.org/W2066991797","https://openalex.org/W2070496260","https://openalex.org/W2074008646","https://openalex.org/W2075421209","https://openalex.org/W2075604188","https://openalex.org/W2079020057","https://openalex.org/W2079271683","https://openalex.org/W2080781994","https://openalex.org/W2082319637","https://openalex.org/W2082620694","https://openalex.org/W2086996948","https://openalex.org/W2087675225","https://openalex.org/W2090040797","https://openalex.org/W2090427843","https://openalex.org/W2090708652","https://openalex.org/W2092934699","https://openalex.org/W2095605519","https://openalex.org/W2099653285","https://openalex.org/W2099915928","https://openalex.org/W2101434995","https://openalex.org/W2101982331","https://openalex.org/W2108871037","https://openalex.org/W2109820048","https://openalex.org/W2110119945","https://openalex.org/W2111802384","https://openalex.org/W2112529110","https://openalex.org/W2115142726","https://openalex.org/W2115297948","https://openalex.org/W2117709279","https://openalex.org/W2131323192","https://openalex.org/W2134943028","https://openalex.org/W2135644119","https://openalex.org/W2137245183","https://openalex.org/W2138377368","https://openalex.org/W2140633499","https://openalex.org/W2142918517","https://openalex.org/W2148277095","https://openalex.org/W2148495319","https://openalex.org/W2153792189","https://openalex.org/W2157438880","https://openalex.org/W2158307047","https://openalex.org/W2159562759","https://openalex.org/W2162659272","https://openalex.org/W2165039266","https://openalex.org/W2167590372","https://openalex.org/W2170468099","https://openalex.org/W2264171151","https://openalex.org/W2283518741","https://openalex.org/W2314090418","https://openalex.org/W2326966809","https://openalex.org/W2327560853","https://openalex.org/W2329324104","https://openalex.org/W2333753404","https://openalex.org/W2339432002","https://openalex.org/W2343116046","https://openalex.org/W2394660565","https://openalex.org/W2397275266","https://openalex.org/W2419635857","https://openalex.org/W2443928013","https://openalex.org/W2470159612","https://openalex.org/W2493296989","https://openalex.org/W2495252213","https://openalex.org/W2508134361","https://openalex.org/W2518401656","https://openalex.org/W2519372331","https://openalex.org/W2520622229","https://openalex.org/W2547801125","https://openalex.org/W2561153469","https://openalex.org/W2594401612","https://openalex.org/W2606983560","https://openalex.org/W2623337612","https://openalex.org/W2624707531","https://openalex.org/W2761414505","https://openalex.org/W2763754771","https://openalex.org/W4210549250","https://openalex.org/W4299612459","https://openalex.org/W4323238414","https://openalex.org/W6606851130"],"related_works":["https://openalex.org/W1968040518","https://openalex.org/W2594401612","https://openalex.org/W2138377368","https://openalex.org/W2120026803","https://openalex.org/W7098503007","https://openalex.org/W3185320847","https://openalex.org/W2079605351","https://openalex.org/W4321447137","https://openalex.org/W1969375661","https://openalex.org/W2126663521"],"abstract_inverted_index":{"Myocardial":[0],"ischemia":[1,231],"is":[2,35,179,254],"difficult":[3],"to":[4,100,130,151,155,160,196,248],"diagnose":[5],"effectively":[6],"with":[7,268],"still":[8],"few":[9],"well-defined":[10],"biochemical":[11],"markers":[12],"for":[13,109,168,185],"identification":[14],"in":[15,18,38,145,202,205,229],"advance,":[16],"or":[17],"the":[19,42,53,57,62,88,93,102,107,117,121,131,146,161,166,175,181,197,223,243,260],"absence":[20],"of":[21,29,59,70,104,123,133,174,192,245,262,265],"myocardial":[22,230],"necrosis.":[23],"\"Ischemia-modified":[24],"albumin\"":[25],"(IMA),":[26],"a":[27,169,193,263],"form":[28],"albumin":[30,43,178,206],"displaying":[31],"reduced":[32,111],"cobalt-binding":[33,44,112],"affinity,":[34],"significantly":[36],"elevated":[37],"ischemic":[39],"patients,":[40],"and":[41,61,77,92,106,158,190,214,232,259,272],"(ACB)":[45],"assay":[46,64,148],"can":[47],"measure":[48],"its":[49,110],"level":[50],"indirectly.":[51],"Elucidating":[52],"molecular":[54,172],"mechanism":[55],"underlying":[56],"identity":[58,103],"IMA":[60,105,227],"ACB":[63,147,176,270],"hinges":[65],"on":[66,116],"understanding":[67],"metal-binding":[68],"properties":[69],"albumin.":[71],"Albumin":[72],"binds":[73],"most":[74],"metal":[75,81,209],"ions":[76,142],"harbours":[78],"four":[79],"primary":[80],"binding":[82,191,210,244],"sites:":[83],"site":[84,86,90,152,156,199,212,217],"A,":[85,157],"B,":[87,153],"N-terminal":[89,124],"(NTS),":[91],"free":[94,186],"thiol":[95],"at":[96,211,216],"Cys34.":[97],"Previous":[98],"efforts":[99],"clarify":[101],"causes":[108],"capacity":[113],"were":[114],"focused":[115],"NTS":[118],"site,":[119],"but":[120],"degree":[122],"modification":[125],"could":[126],"not":[127],"be":[128],"correlated":[129],"presence":[132],"ischemia.":[134],"More":[135],"recent":[136],"work":[137],"suggested":[138],"that":[139,225],"Co":[140,246],"2+":[141,247],"as":[143],"used":[144],"bind":[149],"preferentially":[150],"then":[154],"finally":[159],"NTS.":[162],"This":[163,253],"insight":[164],"paved":[165],"way":[167],"new":[170],"consistent":[171],"basis":[173],"assay:":[177],"also":[180],"main":[182],"plasma":[183,239,274],"carrier":[184],"fatty":[187,194],"acids":[188],"(FFAs),":[189],"acid":[195],"high-affinity":[198],"FA2":[200],"results":[201],"conformational":[203],"changes":[204],"which":[207],"prevent":[208],"A":[213,250],"partially":[215],"B.":[218,252],"Thus,":[219],"this":[220],"review":[221],"advances":[222],"hypothesis":[224],"high":[226,238,273],"levels":[228,241],"many":[233],"other":[234],"conditions":[235,267],"originate":[236],"from":[237],"FFA":[240,275],"hampering":[242],"sites":[249],"and/or":[251],"supported":[255],"by":[256],"biophysical":[257],"studies":[258],"co-association":[261],"range":[264],"pathological":[266],"positive":[269],"assays":[271],"levels.":[276]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-08-03T00:00:00"}