{"id":"https://openalex.org/W2883901424","doi":"https://doi.org/10.1016/j.celrep.2018.06.055","title":"Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression","display_name":"Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2883901424","doi":"https://doi.org/10.1016/j.celrep.2018.06.055","mag":"2883901424","pmid":"https://pubmed.ncbi.nlm.nih.gov/30021166","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6434950"},"language":"en","primary_location":{"id":"doi:10.1016/j.celrep.2018.06.055","doi":"https://doi.org/10.1016/j.celrep.2018.06.055","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2018.06.055","pdf_url":"http://www.cell.com/article/S2211124718309653/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2211124718309653/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059106502","display_name":"Kai Zhuang","orcid":"https://orcid.org/0000-0003-1724-6210","observed_orcids":["https://orcid.org/0000-0003-1724-6210","https://orcid.org/0009-0002-7152-6635"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Zhuang","raw_affiliation_strings":["Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Changquan Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Changquan Huang","raw_affiliation_strings":["Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041284688","display_name":"Lige Leng","orcid":"https://orcid.org/0000-0002-4288-4743","observed_orcids":["https://orcid.org/0000-0002-4288-4743"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lige Leng","raw_affiliation_strings":["Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060214423","display_name":"Honghua Zheng","orcid":"https://orcid.org/0000-0001-7589-2646","observed_orcids":["https://orcid.org/0000-0001-7589-2646"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Honghua Zheng","raw_affiliation_strings":["Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuehong Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuehong Gao","raw_affiliation_strings":["Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024912902","display_name":"Guimiao Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guimiao Chen","raw_affiliation_strings":["Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019955161","display_name":"Zhilin Ji","orcid":"https://orcid.org/0009-0002-2488-4632","observed_orcids":["https://orcid.org/0009-0002-2488-4632"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhilin Ji","raw_affiliation_strings":["Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061711797","display_name":"Hao Sun","orcid":"https://orcid.org/0000-0002-3670-2886","observed_orcids":["https://orcid.org/0000-0002-3670-2886"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Sun","raw_affiliation_strings":["Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041007886","display_name":"Yu Hu","orcid":"https://orcid.org/0000-0001-8367-5721","observed_orcids":["https://orcid.org/0000-0001-8367-5721"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Hu","raw_affiliation_strings":["Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Di Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Di Wu","raw_affiliation_strings":["Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103018677","display_name":"Meng Shi","orcid":"https://orcid.org/0000-0001-5502-0154","observed_orcids":["https://orcid.org/0000-0001-5502-0154"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Shi","raw_affiliation_strings":["Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100395265","display_name":"Huifang Li","orcid":"https://orcid.org/0000-0003-2268-5496","observed_orcids":["https://orcid.org/0000-0003-2268-5496","https://orcid.org/0000-0002-1806-6660"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huifang Li","raw_affiliation_strings":["Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071728727","display_name":"Yingjun Zhao","orcid":"https://orcid.org/0000-0003-2832-6590","observed_orcids":["https://orcid.org/0000-0003-2832-6590"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]},{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yingjun Zhao","raw_affiliation_strings":["Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China; Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA","Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China","Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China; Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I188891513","https://openalex.org/I191208505"]},{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043869758","display_name":"Yun\u2010wu Zhang","orcid":"https://orcid.org/0000-0002-7152-7630","observed_orcids":["https://orcid.org/0000-0002-7152-7630"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunwu Zhang","raw_affiliation_strings":["Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108534246","display_name":"Maoqiang Xue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Maoqiang Xue","raw_affiliation_strings":["Department of Basic Medical Science, Medical College, Xiamen University, Xiamen, Fujian 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Medical Science, Medical College, Xiamen University, Xiamen, Fujian 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025930339","display_name":"Guojun Bu","orcid":"https://orcid.org/0000-0003-3491-1016","observed_orcids":["https://orcid.org/0000-0003-3491-1016"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Guojun Bu","raw_affiliation_strings":["Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA","Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA","Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I191208505"]},{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060805677","display_name":"Timothy Y. Huang","orcid":"https://orcid.org/0000-0002-3504-9459","observed_orcids":["https://orcid.org/0000-0002-3504-9459"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Y. Huang","raw_affiliation_strings":["Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010227886","display_name":"Huaxi Xu","orcid":"https://orcid.org/0000-0001-7031-7853","observed_orcids":["https://orcid.org/0000-0001-7031-7853"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]},{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Huaxi Xu","raw_affiliation_strings":["Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China; Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA","Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China","Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China; Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I188891513","https://openalex.org/I191208505"]},{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100436636","display_name":"Jie Zhang","orcid":"https://orcid.org/0000-0001-7683-3971","observed_orcids":["https://orcid.org/0000-0001-7683-3971"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jie Zhang","raw_affiliation_strings":["Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China. Electronic address: jiezhang@xmu.edu.cn","Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China. Electronic address: jiezhang@xmu.edu.cn","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China","institution_ids":["https://openalex.org/I191208505"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100436636"],"corresponding_institution_ids":["https://openalex.org/I191208505"],"apc_list":{"value":5620,"currency":"USD","value_usd":5620},"apc_paid":{"value":5620,"currency":"USD","value_usd":5620},"fwci":1.4667,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.79829845,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"24","issue":"3","first_page":"701","last_page":"712"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.6791999936103821,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.6791999936103821,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.298799991607666,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/menin","display_name":"menin","score":0.9610000252723694},{"id":"https://openalex.org/keywords/men1","display_name":"MEN1","score":0.8009999990463257},{"id":"https://openalex.org/keywords/p35","display_name":"p35","score":0.734000027179718},{"id":"https://openalex.org/keywords/cdk5","display_name":"cyclin-dependent kinase 5","score":0.9909999966621399},{"id":"https://openalex.org/keywords/dendritic-spine-formation","display_name":"dendritic spine formation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/dendritic-branching","display_name":"dendritic branching","score":0.906000018119812},{"id":"https://openalex.org/keywords/synaptic-dysfunction","display_name":"synaptic dysfunction","score":0.9810000061988831},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.7480000257492065},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8100000023841858},{"id":"https://openalex.org/keywords/cortex","display_name":"cortex","score":0.7440000176429749},{"id":"https://openalex.org/keywords/multiple-endocrine-neoplasia-type-1","display_name":"multiple endocrine neoplasia type 1","score":0.9390000104904175}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6236184239387512},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.604200541973114},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5140165090560913},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.44189831614494324},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4183821976184845},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.41714999079704285},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3220271170139313}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010770","descriptor_name":"Phosphotransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010770","descriptor_name":"Phosphotransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056426","descriptor_name":"Genetic Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1016/j.celrep.2018.06.055","doi":"https://doi.org/10.1016/j.celrep.2018.06.055","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2018.06.055","pdf_url":"http://www.cell.com/article/S2211124718309653/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},{"id":"pmid:30021166","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30021166","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5415307","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6434950","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6434950","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6434950/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cell Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:bd9432cb7fdd48ec980406a951818154","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/bd9432cb7fdd48ec980406a951818154","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports, Vol 24, Iss 3, Pp 701-712 (2018)","raw_type":"article"},{"id":"pmh:oai:repository.hkust.edu.hk:1783.1-130468","doi":null,"is_oa":false,"landing_page_url":"http://lbdiscover.ust.hk/uresolver?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rfr_id=info:sid/HKUST:SPI&rft.genre=article&rft.issn=2211-1247&rft.volume=24&rft.issue=3&rft.date=2018&rft.spage=701&rft.aulast=Zhuang&rft.aufirst=Kai&rft.atitle=Neuron-Specific+Menin+Deletion+Leads+to+Synaptic+Dysfunction+and+Cognitive+Impairment+by+Modulating+p35+Expression&rft.title=Cell+Reports","pdf_url":null,"source":{"id":"https://openalex.org/S4306401796","display_name":"Rare & Special e-Zone (The Hong Kong University of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I200769079","host_organization_name":"Hong Kong University of Science and Technology","host_organization_lineage":["https://openalex.org/I200769079"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1016/j.celrep.2018.06.055","doi":"https://doi.org/10.1016/j.celrep.2018.06.055","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2018.06.055","pdf_url":"http://www.cell.com/article/S2211124718309653/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1410627402","display_name":"Molecular pathobiology of soluble TREM2 in Alzheimer's disease","funder_award_id":"RF1AG056130","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1534905169","display_name":"Roles of SN27 in regulating glutamate receptors during neurodegeneration","funder_award_id":"R01AG044420","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1851188853","display_name":null,"funder_award_id":"2016YFC1305903","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G1981720942","display_name":null,"funder_award_id":"20720180049","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G2282850689","display_name":"The Role of Appoptosin in Alzheimer's Disease and Other Tauopathies","funder_award_id":"R01AG038710","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2435716591","display_name":"Cdk5 \u78f7\u9178\u5316Bag3 \u53ca\u5176\u5728\u795e\u7ecf\u5143\u7a81\u89e6\u529f\u80fd\u548c\u51cb\u4ea1\u4e2d\u7684\u4f5c\u7528\u4e0e\u673a\u5236\u7814\u7a76","funder_award_id":"31571055","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2790957610","display_name":"Regulation of Protein Trafficking in Neurodegeneration","funder_award_id":"R01NS046673","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3452454666","display_name":null,"funder_award_id":"81771163","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G358263164","display_name":null,"funder_award_id":"U1405222","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4835707079","display_name":"The Role of DLG5 in Alzheimer's Disease","funder_award_id":"R21AG048519","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4880680867","display_name":null,"funder_award_id":"2016J01411","funder_id":"https://openalex.org/F4320321878","funder_display_name":"Natural Science Foundation of Fujian Province"},{"id":"https://openalex.org/G4985621903","display_name":"Menin\u901a\u8fc7IGFs\u4fe1\u53f7\u901a\u8def\u8c03\u63a7\u80da\u80ce\u795e\u7ecf\u7cfb\u7edf\u53d1\u80b2\u7684\u7ec4\u86cb\u767d\u7532\u57fa\u5316\u4fee\u9970\u673a\u5236","funder_award_id":"81100842","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5027862427","display_name":null,"funder_award_id":"81771164","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5741465425","display_name":"Characterizing neuroprotective roles for SNX27 signaling pathways in AD and DS","funder_award_id":"RF1AG044420","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G62269212","display_name":null,"funder_award_id":"20720150062","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G6741903323","display_name":"A role for TREM2/Abeta interactions in microglia-regulated AD pathogenesis","funder_award_id":"R21AG059217","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6870282530","display_name":null,"funder_award_id":"81271421","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7040251284","display_name":null,"funder_award_id":"2014J01375","funder_id":"https://openalex.org/F4320321878","funder_display_name":"Natural Science Foundation of Fujian Province"},{"id":"https://openalex.org/G714008154","display_name":"Identifying and characterizing gene(s) involved in beta-amyloid production.","funder_award_id":"R01AG021173","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8067859611","display_name":"BAC Transgenic Mouse Models of TREM2 to Study Neuroprotective Mechanisms in AD","funder_award_id":"RF1AG056114","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8118044435","display_name":null,"funder_award_id":"2013J01147","funder_id":"https://openalex.org/F4320321878","funder_display_name":"Natural Science Foundation of Fujian Province"},{"id":"https://openalex.org/G8295456792","display_name":null,"funder_award_id":"81522016","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G9000377538","display_name":null,"funder_award_id":"NCET-13-0508","funder_id":"https://openalex.org/F4320334924","funder_display_name":"Program for New Century Excellent Talents in University"},{"id":"https://openalex.org/G9000379379","display_name":null,"funder_award_id":"2014J06019","funder_id":"https://openalex.org/F4320321878","funder_display_name":"Natural Science Foundation of Fujian Province"}],"funders":[{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320309944","display_name":"Cure Alzheimer's Fund","ror":"https://ror.org/05ewr7t48"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321878","display_name":"Natural Science Foundation of Fujian Province","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334924","display_name":"Program for New Century Excellent Talents in University","ror":"https://ror.org/01mv9t934"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2883901424.pdf"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1555206224","https://openalex.org/W1593105928","https://openalex.org/W1737683501","https://openalex.org/W1745050920","https://openalex.org/W1760380374","https://openalex.org/W1761323037","https://openalex.org/W1918417411","https://openalex.org/W1964830067","https://openalex.org/W1971468364","https://openalex.org/W1973822970","https://openalex.org/W1979566060","https://openalex.org/W1981695027","https://openalex.org/W1983601892","https://openalex.org/W1988011192","https://openalex.org/W2002008745","https://openalex.org/W2011616541","https://openalex.org/W2016024994","https://openalex.org/W2017398815","https://openalex.org/W2017446931","https://openalex.org/W2023373446","https://openalex.org/W2024532072","https://openalex.org/W2025570007","https://openalex.org/W2033971511","https://openalex.org/W2036681136","https://openalex.org/W2055630164","https://openalex.org/W2055697619","https://openalex.org/W2071904720","https://openalex.org/W2073739130","https://openalex.org/W2078037618","https://openalex.org/W2083829293","https://openalex.org/W2090521738","https://openalex.org/W2101974166","https://openalex.org/W2102087601","https://openalex.org/W2105263951","https://openalex.org/W2116702160","https://openalex.org/W2124607109","https://openalex.org/W2127976626","https://openalex.org/W2128500531","https://openalex.org/W2128514286","https://openalex.org/W2130496784","https://openalex.org/W2133659563","https://openalex.org/W2133938268","https://openalex.org/W2140422012","https://openalex.org/W2145060259","https://openalex.org/W2150056778","https://openalex.org/W2151459094","https://openalex.org/W2153043611","https://openalex.org/W2154213460","https://openalex.org/W2157212789","https://openalex.org/W2158590037","https://openalex.org/W2159663149","https://openalex.org/W2161675086","https://openalex.org/W2162583663","https://openalex.org/W2320983896","https://openalex.org/W2335026293","https://openalex.org/W2462932269","https://openalex.org/W2508569780","https://openalex.org/W2588474297","https://openalex.org/W2610352112","https://openalex.org/W2697903199","https://openalex.org/W6684209755"],"related_works":["https://openalex.org/W6959643063","https://openalex.org/W6884664877","https://openalex.org/W3160003532","https://openalex.org/W2159663149","https://openalex.org/W4311156291","https://openalex.org/W1593105928","https://openalex.org/W4225015696","https://openalex.org/W2508569780","https://openalex.org/W2002498062","https://openalex.org/W2744994999"],"abstract_inverted_index":{"Menin":[0],"(MEN1)":[1,23],"is":[2,27,35,91,97],"a":[3,86,130],"critical":[4,98,131],"modulator":[5],"of":[6,52,106,114],"tissue":[7],"development":[8,101],"and":[9,58,68,96,102,112,120,137],"maintenance.":[10],"As":[11,85],"such,":[12],"MEN1":[13],"mutations":[14],"are":[15],"associated":[16,123],"with":[17,37,124],"multiple":[18],"endocrine":[19],"neoplasia":[20],"type":[21],"1":[22],"syndrome.":[24],"Although":[25],"menin":[26,74,134],"abundantly":[28],"expressed":[29,92],"in":[30,42,62,64,94,109,135],"the":[31,43,77,110,142],"nervous":[32],"system,":[33],"little":[34],"known":[36],"regard":[38],"to":[39,76,81],"its":[40],"function":[41,139],"adult":[44],"brain.":[45],"Here,":[46],"we":[47,71],"demonstrate":[48],"that":[49,73],"neuron-specific":[50],"deletion":[51],"Men1":[53,115,125],"(CcKO)":[54],"affects":[55],"dendritic":[56],"branching":[57],"spine":[59],"formation,":[60],"resulting":[61],"defects":[63],"synaptic":[65,103,119,136],"function,":[66],"learning,":[67],"memory.":[69],"Furthermore,":[70],"find":[72],"binds":[75],"p35":[78,83,90,107],"promoter":[79],"region":[80],"facilitate":[82],"transcription.":[84],"primary":[87],"Cdk5":[88],"activator,":[89],"mainly":[93],"neurons":[95],"for":[99,133],"brain":[100],"plasticity.":[104],"Restoration":[105],"expression":[108],"hippocampus":[111],"cortex":[113],"CcKO":[116],"mice":[117],"rescues":[118],"cognitive":[121,138],"deficits":[122],"deletion.":[126],"These":[127],"results":[128],"reveal":[129],"role":[132],"by":[140],"modulating":[141],"p35-Cdk5":[143],"pathway.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-08-03T00:00:00"}