{"id":"https://openalex.org/W2883857562","doi":"https://doi.org/10.1021/acschembio.8b00381","title":"Chemoproteomics-Enabled Covalent Ligand Screening Reveals ALDH3A1 as a Lung Cancer Therapy Target","display_name":"Chemoproteomics-Enabled Covalent Ligand Screening Reveals ALDH3A1 as a Lung Cancer Therapy Target","publication_year":2018,"publication_date":"2018-07-13","ids":{"openalex":"https://openalex.org/W2883857562","doi":"https://doi.org/10.1021/acschembio.8b00381","mag":"2883857562","pmid":"https://pubmed.ncbi.nlm.nih.gov/30004670","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6389507"},"language":"en","primary_location":{"id":"doi:10.1021/acschembio.8b00381","doi":"https://doi.org/10.1021/acschembio.8b00381","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acschembio.8b00381","pdf_url":null,"source":{"id":"https://openalex.org/S118914585","display_name":"ACS Chemical Biology","issn_l":"1554-8929","issn":["1554-8929","1554-8937"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC6389507","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087680754","display_name":"Jessica L. Counihan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica L. Counihan","raw_affiliation_strings":["Departments of Nutritional Sciences and Toxicology, University of California, 127 Morgan Hall, Berkeley, California 94720, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Nutritional Sciences and Toxicology, University of California, 127 Morgan Hall, Berkeley, California 94720, United States","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088913110","display_name":"Amanda L. Wiggenhorn","orcid":"https://orcid.org/0000-0001-9413-690X","observed_orcids":["https://orcid.org/0000-0001-9413-690X"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda L. Wiggenhorn","raw_affiliation_strings":["Chemistry, University of California, 127 Morgan Hall, Berkeley, California 94720, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry, University of California, 127 Morgan Hall, Berkeley, California 94720, United States","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032736188","display_name":"Kimberly E. Anderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly E. Anderson","raw_affiliation_strings":["Departments of Nutritional Sciences and Toxicology, University of California, 127 Morgan Hall, Berkeley, California 94720, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Nutritional Sciences and Toxicology, University of California, 127 Morgan Hall, Berkeley, California 94720, United States","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035184259","display_name":"Daniel K. Nomura","orcid":"https://orcid.org/0000-0003-1614-8360","observed_orcids":["https://orcid.org/0000-0003-1614-8360"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel K. Nomura","raw_affiliation_strings":["Departments of Nutritional Sciences and Toxicology,\u00a0 Chemistry \u00a0and\u00a0 Molecular and Cell Biology, University of California, 127 Morgan Hall, Berkeley, California 94720, United States"],"raw_orcid":"https://orcid.org/0000-0003-1614-8360","affiliations":[{"raw_affiliation_string":"Departments of Nutritional Sciences and Toxicology,\u00a0 Chemistry \u00a0and\u00a0 Molecular and Cell Biology, University of California, 127 Morgan Hall, Berkeley, California 94720, United States","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035184259"],"corresponding_institution_ids":["https://openalex.org/I95457486"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.5881,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.90732079,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"13","issue":"8","first_page":"1970","last_page":"1977"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aldh3a1","display_name":"ALDH3A1","score":0.9700000286102295},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8259999752044678},{"id":"https://openalex.org/keywords/chemoproteomics","display_name":"chemoproteomics","score":0.9879999756813049},{"id":"https://openalex.org/keywords/chemical-genetics","display_name":"chemical genetics","score":0.7559999823570251},{"id":"https://openalex.org/keywords/activity-based-protein-profiling","display_name":"activity-based protein profiling","score":0.7730000019073486},{"id":"https://openalex.org/keywords/anticancer-drug-discovery","display_name":"anticancer drug discovery","score":0.7580000162124634},{"id":"https://openalex.org/keywords/drug-target-identification","display_name":"drug target identification","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.5332263112068176},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5302664041519165},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5147712230682373},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.5091626048088074},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.4855601489543915},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4448374807834625},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.42766398191452026},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4266882836818695},{"id":"https://openalex.org/C171852809","wikidata":"https://www.wikidata.org/wiki/Q731154","display_name":"Chemical biology","level":2,"score":0.41770264506340027},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3999260663986206},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3490567207336426},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21045300364494324},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.17124491930007935},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13898968696594238},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/acschembio.8b00381","doi":"https://doi.org/10.1021/acschembio.8b00381","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acschembio.8b00381","pdf_url":null,"source":{"id":"https://openalex.org/S118914585","display_name":"ACS Chemical Biology","issn_l":"1554-8929","issn":["1554-8929","1554-8937"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Biology","raw_type":"journal-article"},{"id":"pmid:30004670","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30004670","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS chemical biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5386952","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6389507","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6389507","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6389507","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ACS Chem Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5386952","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6389507","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1977860408","display_name":null,"funder_award_id":"RSG\u201014\u2010242\u201001\u2010TBE","funder_id":"https://openalex.org/F4320306095","funder_display_name":"American Cancer Society"},{"id":"https://openalex.org/G2912635110","display_name":null,"funder_award_id":"2015182321","funder_id":"https://openalex.org/F4320337368","funder_display_name":"Division of Graduate Education"},{"id":"https://openalex.org/G6309066425","display_name":"Annotating the Role of Dysregulated Inositol Phosphate Metabolism in Malignant Ca","funder_award_id":"R01CA172667","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000874226","display_name":"Toxic substances in the environment","funder_award_id":"P42ES004705","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000885607","display_name":"Chemical Probes to Study Formaldehyde Biology","funder_award_id":"R01ES028096","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337368","display_name":"Division of Graduate Education","ror":"https://ror.org/00whkrf32"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W2004980024","https://openalex.org/W2018339027","https://openalex.org/W2021429060","https://openalex.org/W2030953184","https://openalex.org/W2052902127","https://openalex.org/W2082395080","https://openalex.org/W2084488214","https://openalex.org/W2086575328","https://openalex.org/W2103595781","https://openalex.org/W2126593560","https://openalex.org/W2183289225","https://openalex.org/W2314348689","https://openalex.org/W2322016289","https://openalex.org/W2357535822","https://openalex.org/W2412313638","https://openalex.org/W2414755536","https://openalex.org/W2430132928","https://openalex.org/W2586539307","https://openalex.org/W2593831925","https://openalex.org/W2596709339","https://openalex.org/W2606784762","https://openalex.org/W2609087524","https://openalex.org/W2742118221","https://openalex.org/W2754208640","https://openalex.org/W2755830996"],"related_works":["https://openalex.org/W2586539307","https://openalex.org/W6997247114","https://openalex.org/W2754208640","https://openalex.org/W3001916022","https://openalex.org/W4308253407","https://openalex.org/W3173441690","https://openalex.org/W4413861595","https://openalex.org/W7214286711","https://openalex.org/W4414517765","https://openalex.org/W4238448589"],"abstract_inverted_index":{"Chemical":[0],"genetics":[1,180],"is":[2],"a":[3,44,78,130,154],"powerful":[4],"approach":[5],"for":[6,159],"identifying":[7,13],"therapeutically":[8],"active":[9],"small":[10],"molecules,":[11],"but":[12,65],"the":[14,103,110,175],"mechanisms":[15],"of":[16,36,106,177,182],"action":[17],"underlying":[18],"hit":[19,51],"compounds":[20,52],"remains":[21],"challenging.":[22],"Chemoproteomic":[23],"platforms":[24],"have":[25,42],"arisen":[26],"to":[27,49,100,189],"tackle":[28],"this":[29,74],"challenge":[30],"and":[31,57,89,128,133,143,165,194],"enable":[32],"rapid":[33],"mechanistic":[34],"deconvolution":[35],"small-molecule":[37],"screening":[38,124,181],"hits.":[39],"Here,":[40],"we":[41,76,173],"screened":[43],"cysteine-reactive":[45],"covalent":[46,79,122,136,183],"ligand":[47,80,123,184],"library":[48],"identify":[50,191],"that":[53,102,151,162],"impair":[54],"cell":[55,61],"survival":[56],"proliferation":[58],"in":[59,67,87,90,113],"nonsmall":[60],"lung":[62,92,145,160],"carcinoma":[63],"cells,":[64],"not":[66],"primary":[68,104],"human":[69],"bronchial":[70],"epithelial":[71],"cells.":[72],"Through":[73],"screen,":[75],"identified":[77,129],"hit,":[81],"DKM":[82,107],"3-42,":[83],"which":[84,139],"impaired":[85],"both":[86],"situ":[88],"vivo":[91],"cancer":[93,146],"pathogenicity.":[94,147],"We":[95,118,148],"used":[96],"activity-based":[97],"protein":[98],"profiling":[99],"discover":[101],"target":[105,158],"3-42":[108],"was":[109],"catalytic":[111],"cysteine":[112],"aldehyde":[114],"dehydrogenase":[115],"3A1":[116],"(ALDH3A1).":[117],"performed":[119],"further":[120],"chemoproteomics-enabled":[121],"directly":[125],"against":[126],"ALDH3A1,":[127],"more":[131],"potent":[132],"selective":[134,169],"lead":[135],"ligand,":[137],"EN40,":[138],"inhibits":[140],"ALDH3A1":[141,152,164,170],"activity":[142],"impairs":[144],"show":[149,174],"here":[150],"represents":[153],"potentially":[155],"novel":[156],"therapeutic":[157],"cancers":[161],"express":[163],"put":[166],"forth":[167],"two":[168],"inhibitors.":[171],"Overall,":[172],"utility":[176],"combining":[178],"chemical":[179],"libraries":[185],"with":[186],"chemoproteomic":[187],"approaches":[188],"rapidly":[190],"anticancer":[192],"leads":[193],"targets.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-08-03T00:00:00"}