{"id":"https://openalex.org/W2883789215","doi":"https://doi.org/10.1007/s00134-018-5327-1","title":"Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data","display_name":"Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data","publication_year":2018,"publication_date":"2018-07-26","ids":{"openalex":"https://openalex.org/W2883789215","doi":"https://doi.org/10.1007/s00134-018-5327-1","mag":"2883789215","pmid":"https://pubmed.ncbi.nlm.nih.gov/30051136","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6132684"},"language":"en","primary_location":{"id":"doi:10.1007/s00134-018-5327-1","doi":"https://doi.org/10.1007/s00134-018-5327-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00134-018-5327-1","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs00134-018-5327-1.pdf","source":{"id":"https://openalex.org/S198804558","display_name":"Intensive Care Medicine","issn_l":"0342-4642","issn":["0342-4642","1432-1238"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Intensive Care Medicine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007%2Fs00134-018-5327-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010790844","display_name":"Matthieu Jabaudon","orcid":"https://orcid.org/0000-0002-8121-1680","observed_orcids":["https://orcid.org/0000-0002-8121-1680"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210128870","display_name":"Centre Hospitalier Universitaire de Clermont-Ferrand","ror":"https://ror.org/02tcf7a68","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210128870"]},{"id":"https://openalex.org/I4210163188","display_name":"Institut G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement","ror":"https://ror.org/052d1cv78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210096427","https://openalex.org/I4210163188"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Matthieu Jabaudon","raw_affiliation_strings":["CNRS, UMR 6293, INSERM U1103, GReD, Universit\u00e9 Clermont Auvergne, Clermont-Ferrand, France. mjabaudon@chu-clermontferrand.fr","Department of Perioperative Medicine, CHU Clermont-Ferrand, 1 Place Lucie Aubrac, 63003, Clermont-Ferrand Cedex 1, France. mjabaudon@chu-clermontferrand.fr","CHU Clermont-Ferrand (France)","GReD - G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement (Facult\u00e9s de M\u00e9decine et de Pharmacie, TSA 50400, 28 Place Henri Dunant, 63001 Clermont-Ferrand - France)"],"raw_orcid":"https://orcid.org/0000-0002-8121-1680","affiliations":[{"raw_affiliation_string":"CNRS, UMR 6293, INSERM U1103, GReD, Universit\u00e9 Clermont Auvergne, Clermont-Ferrand, France. mjabaudon@chu-clermontferrand.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210163188"]},{"raw_affiliation_string":"Department of Perioperative Medicine, CHU Clermont-Ferrand, 1 Place Lucie Aubrac, 63003, Clermont-Ferrand Cedex 1, France. mjabaudon@chu-clermontferrand.fr","institution_ids":["https://openalex.org/I4210128870"]},{"raw_affiliation_string":"CHU Clermont-Ferrand (France)","institution_ids":["https://openalex.org/I4210128870"]},{"raw_affiliation_string":"GReD - G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement (Facult\u00e9s de M\u00e9decine et de Pharmacie, TSA 50400, 28 Place Henri Dunant, 63001 Clermont-Ferrand - France)","institution_ids":["https://openalex.org/I4210163188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057178157","display_name":"Ra\u00efko Blondonnet","orcid":"https://orcid.org/0000-0001-9881-8422","observed_orcids":["https://orcid.org/0000-0001-9881-8422"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210128870","display_name":"Centre Hospitalier Universitaire de Clermont-Ferrand","ror":"https://ror.org/02tcf7a68","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210128870"]},{"id":"https://openalex.org/I4210163188","display_name":"Institut G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement","ror":"https://ror.org/052d1cv78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210096427","https://openalex.org/I4210163188"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Raiko Blondonnet","raw_affiliation_strings":["CNRS, UMR 6293, INSERM U1103, GReD, Universit\u00e9 Clermont Auvergne, Clermont-Ferrand, France","Department of Perioperative Medicine, CHU Clermont-Ferrand, 1 Place Lucie Aubrac, 63003, Clermont-Ferrand Cedex 1, France","CHU Clermont-Ferrand (France)","GReD - G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement (Facult\u00e9s de M\u00e9decine et de Pharmacie, TSA 50400, 28 Place Henri Dunant, 63001 Clermont-Ferrand - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, UMR 6293, INSERM U1103, GReD, Universit\u00e9 Clermont Auvergne, Clermont-Ferrand, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210163188"]},{"raw_affiliation_string":"Department of Perioperative Medicine, CHU Clermont-Ferrand, 1 Place Lucie Aubrac, 63003, Clermont-Ferrand Cedex 1, France","institution_ids":["https://openalex.org/I4210128870"]},{"raw_affiliation_string":"CHU Clermont-Ferrand (France)","institution_ids":["https://openalex.org/I4210128870"]},{"raw_affiliation_string":"GReD - G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement (Facult\u00e9s de M\u00e9decine et de Pharmacie, TSA 50400, 28 Place Henri Dunant, 63001 Clermont-Ferrand - France)","institution_ids":["https://openalex.org/I4210163188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013394355","display_name":"Bruno Pereira","orcid":"https://orcid.org/0000-0003-3778-7161","observed_orcids":["https://orcid.org/0000-0003-3778-7161","https://orcid.org/0000-0001-6992-4218","https://orcid.org/0000-0003-2460-6720","https://orcid.org/0000-0001-7640-1087","https://orcid.org/0000-0001-9950-3916"]},"institutions":[{"id":"https://openalex.org/I4210128870","display_name":"Centre Hospitalier Universitaire de Clermont-Ferrand","ror":"https://ror.org/02tcf7a68","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210128870"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bruno Pereira","raw_affiliation_strings":["Biostatistics Unit, Department of Clinical Research and Innovation (DRCI), CHU Clermont-Ferrand, Clermont-Ferrand, France","Service Biostatistiques, T\u00e9l\u00e9matiques, Traitement de l\u2019image [CHU Clermont-Ferrand] (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics Unit, Department of Clinical Research and Innovation (DRCI), CHU Clermont-Ferrand, Clermont-Ferrand, France","institution_ids":["https://openalex.org/I4210128870"]},{"raw_affiliation_string":"Service Biostatistiques, T\u00e9l\u00e9matiques, Traitement de l\u2019image [CHU Clermont-Ferrand] (France)","institution_ids":["https://openalex.org/I4210128870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081992519","display_name":"Rodrigo Cartin\u2010Ceba","orcid":"https://orcid.org/0000-0001-6738-9821","observed_orcids":["https://orcid.org/0000-0001-6738-9821"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rodrigo Cartin-Ceba","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA","Mayo Clinic [Rochester] (200 First St. SW\r\nRochester, MN 55905 - United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic [Rochester] (200 First St. SW\r\nRochester, MN 55905 - United States)","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033160716","display_name":"Christoph Lichtenstern","orcid":"https://orcid.org/0000-0001-5517-2174","observed_orcids":["https://orcid.org/0000-0001-5517-2174"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Lichtenstern","raw_affiliation_strings":["Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany","Heidelberg University Hospital [Heidelberg] (Im Neuenheimer Feld 400\r\n69120 Heidelberg - Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"Heidelberg University Hospital [Heidelberg] (Im Neuenheimer Feld 400\r\n69120 Heidelberg - Germany)","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050046825","display_name":"Tommaso Mauri","orcid":"https://orcid.org/0000-0002-2709-8162","observed_orcids":["https://orcid.org/0000-0002-2709-8162"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Tommaso Mauri","raw_affiliation_strings":["Department of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy","Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico (Milano - Italy)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I2803066834"]},{"raw_affiliation_string":"Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico (Milano - Italy)","institution_ids":["https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111582110","display_name":"Rogier M. Determann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105568","display_name":"OLVG","ror":"https://ror.org/01d02sf11","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210105568"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Rogier M. Determann","raw_affiliation_strings":["Department of Intensive Care Medicine, OLVG, Amsterdam, The Netherlands","OLVG - Onze Lieve Vrouwe Gasthuis (Oosterpark 9, 1091 AC Amsterdam - Netherlands)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intensive Care Medicine, OLVG, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210105568"]},{"raw_affiliation_string":"OLVG - Onze Lieve Vrouwe Gasthuis (Oosterpark 9, 1091 AC Amsterdam - Netherlands)","institution_ids":["https://openalex.org/I4210105568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038888367","display_name":"Tom\u00e1\u0161 Dr\u00e1bek","orcid":"https://orcid.org/0000-0002-5702-4498","observed_orcids":["https://orcid.org/0000-0002-5702-4498"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomas Drabek","raw_affiliation_strings":["Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","University of Pittsburgh School of Medicine (4200 Fifth Avenue\r\nPittsburgh, PA 15260 - United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"University of Pittsburgh School of Medicine (4200 Fifth Avenue\r\nPittsburgh, PA 15260 - United States)","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076906385","display_name":"Rolf D. Hubmayr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rolf D. Hubmayr","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA","Mayo Clinic [Rochester] (200 First St. SW\r\nRochester, MN 55905 - United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic [Rochester] (200 First St. SW\r\nRochester, MN 55905 - United States)","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083937518","display_name":"Ognjen Gajic","orcid":"https://orcid.org/0000-0003-4218-0890","observed_orcids":["https://orcid.org/0000-0003-4218-0890"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ognjen Gajic","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA","Mayo Clinic [Rochester] (200 First St. SW\r\nRochester, MN 55905 - United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic [Rochester] (200 First St. SW\r\nRochester, MN 55905 - United States)","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029933928","display_name":"Florian Uhle","orcid":"https://orcid.org/0000-0001-8876-7430","observed_orcids":["https://orcid.org/0000-0001-8876-7430"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Florian Uhle","raw_affiliation_strings":["Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany","Heidelberg University Hospital [Heidelberg] (Im Neuenheimer Feld 400\r\n69120 Heidelberg - Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"Heidelberg University Hospital [Heidelberg] (Im Neuenheimer Feld 400\r\n69120 Heidelberg - Germany)","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053981133","display_name":"Andrea Coppadoro","orcid":"https://orcid.org/0000-0003-1759-4071","observed_orcids":["https://orcid.org/0000-0003-1759-4071"]},"institutions":[{"id":"https://openalex.org/I4210110840","display_name":"Azienda Ospedaliera San Gerardo","ror":"https://ror.org/01xf83457","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210110840"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Coppadoro","raw_affiliation_strings":["Department of Emergency Medicine, San Gerardo Hospital, Monza, Italy","SGH - San Gerardo Hospital [Monza, Italy] (Italy)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, San Gerardo Hospital, Monza, Italy","institution_ids":["https://openalex.org/I4210110840"]},{"raw_affiliation_string":"SGH - San Gerardo Hospital [Monza, Italy] (Italy)","institution_ids":["https://openalex.org/I4210110840"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Antonio Pesenti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Pesenti","raw_affiliation_strings":["Department of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy","Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico (Milano - Italy)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I2803066834"]},{"raw_affiliation_string":"Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico (Milano - Italy)","institution_ids":["https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013315693","display_name":"Marcus Josephus Schultz","orcid":"https://orcid.org/0000-0003-3969-7792","observed_orcids":["https://orcid.org/0000-0003-3969-7792","https://orcid.org/0000-0002-4821-9955"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4210126604","display_name":"Mahidol Oxford Tropical Medicine Research Unit","ror":"https://ror.org/03fs9z545","country_code":"TH","type":"facility","lineage":["https://openalex.org/I25399158","https://openalex.org/I40120149","https://openalex.org/I4210126604","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL","TH"],"is_corresponding":false,"raw_author_name":"Marcus J. Schultz","raw_affiliation_strings":["Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands","Mahidol-Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand","AMC - Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (Meibergdreef 9 1105 AZ Amsterdam - Netherlands)","Mahidol Oxford Tropical Medicine Research Unit (420/6 Ratchawithi Road, Tungphyathai, Bangkok 10400 - Thailand)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]},{"raw_affiliation_string":"Mahidol-Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand","institution_ids":["https://openalex.org/I4210126604"]},{"raw_affiliation_string":"AMC - Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (Meibergdreef 9 1105 AZ Amsterdam - Netherlands)","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Mahidol Oxford Tropical Medicine Research Unit (420/6 Ratchawithi Road, Tungphyathai, Bangkok 10400 - Thailand)","institution_ids":["https://openalex.org/I4210126604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048266377","display_name":"Vito Marco Ranieri","orcid":"https://orcid.org/0000-0002-0427-1874","observed_orcids":["https://orcid.org/0000-0002-0427-1874"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco V. Ranieri","raw_affiliation_strings":["Department of Surgical Sciences, Molinette Hospital, City of Health and Science, University of Turin, Turin, Italy","UNITO - Universit\u00e0 degli studi di Torino = University of Turin (Via Verdi, 8 \r\n10124 Torino \r\nItalie - Italy)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Sciences, Molinette Hospital, City of Health and Science, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"UNITO - Universit\u00e0 degli studi di Torino = University of Turin (Via Verdi, 8 \r\n10124 Torino \r\nItalie - Italy)","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064396992","display_name":"Helena Lahoda Brodska","orcid":"https://orcid.org/0000-0001-7962-8287","observed_orcids":["https://orcid.org/0000-0001-7962-8287"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"funder","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Helena Brodska","raw_affiliation_strings":["Institute of Clinical Biochemistry and Laboratory Diagnostics, Faculty of Medicine, General University Hospital, Charles University, Prague, Czech Republic","Medicine Charles University and General Faculty Hospital in Prague (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Biochemistry and Laboratory Diagnostics, Faculty of Medicine, General University Hospital, Charles University, Prague, Czech Republic","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210162037"]},{"raw_affiliation_string":"Medicine Charles University and General Faculty Hospital in Prague (France)","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210162037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032756872","display_name":"S\u00e9gol\u00e8ne Mrozek","orcid":"https://orcid.org/0000-0002-2370-6239","observed_orcids":["https://orcid.org/0000-0002-2370-6239"]},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S\u00e9gol\u00e8ne Mrozek","raw_affiliation_strings":["Department of Anesthesia and Intensive Care, University Hospital of Toulouse, University Toulouse 3 Paul Sabatier, Toulouse, France","P\u00f4le Anesth\u00e9sie R\u00e9animation [CHU de Toulouse] (Toulouse F-31059 - France)","UT3 - Universit\u00e9 Toulouse III - Paul Sabatier (118 route de Narbonne - 31062 Toulouse - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia and Intensive Care, University Hospital of Toulouse, University Toulouse 3 Paul Sabatier, Toulouse, France","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"raw_affiliation_string":"P\u00f4le Anesth\u00e9sie R\u00e9animation [CHU de Toulouse] (Toulouse F-31059 - France)","institution_ids":["https://openalex.org/I3019448017"]},{"raw_affiliation_string":"UT3 - Universit\u00e9 Toulouse III - Paul Sabatier (118 route de Narbonne - 31062 Toulouse - France)","institution_ids":["https://openalex.org/I134560555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077019788","display_name":"Vincent Sapin","orcid":"https://orcid.org/0000-0002-7452-315X","observed_orcids":["https://orcid.org/0000-0002-7452-315X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210128870","display_name":"Centre Hospitalier Universitaire de Clermont-Ferrand","ror":"https://ror.org/02tcf7a68","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210128870"]},{"id":"https://openalex.org/I4210163188","display_name":"Institut G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement","ror":"https://ror.org/052d1cv78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210096427","https://openalex.org/I4210163188"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Vincent Sapin","raw_affiliation_strings":["CNRS, UMR 6293, INSERM U1103, GReD, Universit\u00e9 Clermont Auvergne, Clermont-Ferrand, France","Department of Medical Biochemistry and Molecular Biology, CHU Clermont-Ferrand, Clermont-Ferrand, France","GReD - G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement (Facult\u00e9s de M\u00e9decine et de Pharmacie, TSA 50400, 28 Place Henri Dunant, 63001 Clermont-Ferrand - France)","Service Biochimie et G\u00e9n\u00e9tique Mol\u00e9culaire [CHU Clermont-Ferrand] (CHU Clermont-Ferrand - Site Gabriel-Montpied, 58 Rue Montalembert, 63000 Clermont-Ferrand - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, UMR 6293, INSERM U1103, GReD, Universit\u00e9 Clermont Auvergne, Clermont-Ferrand, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210163188"]},{"raw_affiliation_string":"Department of Medical Biochemistry and Molecular Biology, CHU Clermont-Ferrand, Clermont-Ferrand, France","institution_ids":["https://openalex.org/I4210128870"]},{"raw_affiliation_string":"GReD - G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement (Facult\u00e9s de M\u00e9decine et de Pharmacie, TSA 50400, 28 Place Henri Dunant, 63001 Clermont-Ferrand - France)","institution_ids":["https://openalex.org/I4210163188"]},{"raw_affiliation_string":"Service Biochimie et G\u00e9n\u00e9tique Mol\u00e9culaire [CHU Clermont-Ferrand] (CHU Clermont-Ferrand - Site Gabriel-Montpied, 58 Rue Montalembert, 63000 Clermont-Ferrand - France)","institution_ids":["https://openalex.org/I4210128870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052576862","display_name":"Michael A. Matthay","orcid":"https://orcid.org/0000-0003-3039-8155","observed_orcids":["https://orcid.org/0000-0003-3039-8155"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Matthay","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA","UC San Francisco - University of California [San Francisco] (505 Parnassus Ave, San Francisco, CA 94143 - United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"UC San Francisco - University of California [San Francisco] (505 Parnassus Ave, San Francisco, CA 94143 - United States)","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108113757","display_name":"Jean\u2010Michel Constantin","orcid":"https://orcid.org/0000-0001-7634-5898","observed_orcids":["https://orcid.org/0000-0001-7634-5898"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210128870","display_name":"Centre Hospitalier Universitaire de Clermont-Ferrand","ror":"https://ror.org/02tcf7a68","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210128870"]},{"id":"https://openalex.org/I4210163188","display_name":"Institut G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement","ror":"https://ror.org/052d1cv78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210096427","https://openalex.org/I4210163188"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Michel Constantin","raw_affiliation_strings":["CNRS, UMR 6293, INSERM U1103, GReD, Universit\u00e9 Clermont Auvergne, Clermont-Ferrand, France","Department of Perioperative Medicine, CHU Clermont-Ferrand, 1 Place Lucie Aubrac, 63003, Clermont-Ferrand Cedex 1, France","CHU Clermont-Ferrand (France)","GReD - G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement (Facult\u00e9s de M\u00e9decine et de Pharmacie, TSA 50400, 28 Place Henri Dunant, 63001 Clermont-Ferrand - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, UMR 6293, INSERM U1103, GReD, Universit\u00e9 Clermont Auvergne, Clermont-Ferrand, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210163188"]},{"raw_affiliation_string":"Department of Perioperative Medicine, CHU Clermont-Ferrand, 1 Place Lucie Aubrac, 63003, Clermont-Ferrand Cedex 1, France","institution_ids":["https://openalex.org/I4210128870"]},{"raw_affiliation_string":"CHU Clermont-Ferrand (France)","institution_ids":["https://openalex.org/I4210128870"]},{"raw_affiliation_string":"GReD - G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement (Facult\u00e9s de M\u00e9decine et de Pharmacie, TSA 50400, 28 Place Henri Dunant, 63001 Clermont-Ferrand - France)","institution_ids":["https://openalex.org/I4210163188"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062212651","display_name":"Carolyn S. Calfee","orcid":"https://orcid.org/0000-0001-9208-6865","observed_orcids":["https://orcid.org/0000-0001-9208-6865"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carolyn S. Calfee","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA","UC San Francisco - University of California [San Francisco] (505 Parnassus Ave, San Francisco, CA 94143 - United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"UC San Francisco - University of California [San Francisco] (505 Parnassus Ave, San Francisco, CA 94143 - United States)","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":7,"institutions_distinct_count":22,"corresponding_author_ids":["https://openalex.org/A5010790844"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210128870","https://openalex.org/I4210163188"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":2.3412,"has_fulltext":true,"cited_by_count":145,"citation_normalized_percentile":{"value":0.9240458,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"44","issue":"9","first_page":"1388","last_page":"1399"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soluble-receptor-for-advanced-glycation-end-products","display_name":"soluble receptor for advanced glycation end products","score":0.921999990940094},{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mortality-prediction","display_name":"mortality prediction","score":0.6399999856948853},{"id":"https://openalex.org/keywords/alveolar-fluid-clearance","display_name":"alveolar fluid clearance","score":0.9279999732971191},{"id":"https://openalex.org/keywords/lung-epithelial-injury","display_name":"lung epithelial injury","score":0.9089999794960022},{"id":"https://openalex.org/keywords/driving-pressure","display_name":"driving pressure","score":0.875},{"id":"https://openalex.org/keywords/tidal-volume","display_name":"tidal volume","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ventilator-induced-lung-injury","display_name":"ventilator-induced lung injury","score":0.9409999847412109},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7250000238418579},{"id":"https://openalex.org/keywords/mediation-analysis","display_name":"mediation analysis","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8805966377258301},{"id":"https://openalex.org/C2779526319","wikidata":"https://www.wikidata.org/wiki/Q615057","display_name":"Anesthesiology","level":2,"score":0.8658114075660706},{"id":"https://openalex.org/C2991975920","wikidata":"https://www.wikidata.org/wiki/Q621261","display_name":"Pain medicine","level":3,"score":0.8374069929122925},{"id":"https://openalex.org/C2776348555","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"ARDS","level":3,"score":0.8282394409179688},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.6841049194335938},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5257278680801392},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.4461360275745392},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.441158264875412},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4099860191345215},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.13781175017356873},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.11131975054740906},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000067759","descriptor_name":"Receptor for Advanced Glycation End Products","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013990","descriptor_name":"Tidal Volume","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014939","descriptor_name":"Work of Breathing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018806","descriptor_name":"APACHE","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064887","descriptor_name":"Observational Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1007/s00134-018-5327-1","doi":"https://doi.org/10.1007/s00134-018-5327-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00134-018-5327-1","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs00134-018-5327-1.pdf","source":{"id":"https://openalex.org/S198804558","display_name":"Intensive Care Medicine","issn_l":"0342-4642","issn":["0342-4642","1432-1238"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Intensive Care Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5086071","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6132684","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6132684","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6132684","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Intensive Care Med","raw_type":"Text"},{"id":"pmid:30051136","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30051136","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Intensive care medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/f8b3ec0e-41ee-41d2-a093-d28575ba6876","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/f8b3ec0e-41ee-41d2-a093-d28575ba6876","pdf_url":"https://pure.amsterdamumc.nl/files/158500309/Plasma-srage-is-independently-associated-with-increased-mortality-in-ards-a-meta-analysis-of-individual-patient-data.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Jabaudon, M, Blondonnet, R, Pereira, B, Cartin-Ceba, R, Lichtenstern, C, Mauri, T, Determann, R M, Drabek, T, Hubmayr, R D, Gajic, O, Uhle, F, Coppadoro, A, Pesenti, A, Schultz, M J, Ranieri, M V, Brodska, H, Mrozek, S G, Sapin, V, Matthay, M A, Constantin, J-M & Calfee, C S 2018, 'Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data', Intensive care medicine, vol. 44, no. 9, pp. 1388-1399. https://doi.org/10.1007/s00134-018-5327-1","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/116bafd6-b6b7-48fa-96c9-8d28d464e1bb","doi":null,"is_oa":true,"landing_page_url":"https://pure.amc.nl/en/publications/plasma-srage-is-independently-associated-with-increased-mortality-in-ards-a-metaanalysis-of-individual-patient-data(116bafd6-b6b7-48fa-96c9-8d28d464e1bb).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Intensive care medicine, 44(9), 1388 - 1399. Springer Verlag","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-03023663v1","doi":null,"is_oa":true,"landing_page_url":"https://uca.hal.science/hal-03023663v1/document","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Intensive Care Medicine, 2018, 44 (9), pp.1388-1399. ⟨10.1007/s00134-018-5327-1⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:air.unimi.it:2434/586831","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2434/586831","pdf_url":null,"source":{"id":"https://openalex.org/S4306400516","display_name":"Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189158943","host_organization_name":"University of Milan","host_organization_lineage":["https://openalex.org/I189158943"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:cris.unibo.it:11585/663676","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11585/663676","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:ricerca.uniba.it:11586/474529","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11586/474529","pdf_url":null,"source":{"id":"https://openalex.org/S4377196296","display_name":"CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5561750","host_organization_name":"University of Bari Aldo Moro","host_organization_lineage":["https://openalex.org/I5561750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1007/s00134-018-5327-1","doi":"https://doi.org/10.1007/s00134-018-5327-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00134-018-5327-1","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs00134-018-5327-1.pdf","source":{"id":"https://openalex.org/S198804558","display_name":"Intensive Care Medicine","issn_l":"0342-4642","issn":["0342-4642","1432-1238"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Intensive Care Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[{"id":"https://openalex.org/G1181304126","display_name":"Translational Approach to Understanding RAGE pathway in Acute respiratory distress syndrome : physiopathologic, diagnostic and therapeutic implications","funder_award_id":"ANR-13-PRTS-0010","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G3335243318","display_name":"ARDS Endotypes: Expanded Analysis of Clinical and Biological Phenotypes and Evolution Over Time","funder_award_id":"K24HL133390","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3429402575","display_name":null,"funder_award_id":"HL-51856","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G375247153","display_name":"RESOLUTION OF CLINICAL LUNG INJURY","funder_award_id":"R01HL051856","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G749329918","display_name":"Precision Medicine in the Acute Respiratory Distress Syndrome","funder_award_id":"R35HL140026","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8920118733","display_name":null,"funder_award_id":"ANR-13-PRTS-0010","funder_id":"https://openalex.org/F4320323038","funder_display_name":"Conseil R\u00e9gional d'Auvergne"},{"id":"https://openalex.org/G904655290","display_name":"Resolution of Clinical Lung Injury","funder_award_id":"R37HL051856","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320323038","display_name":"Conseil R\u00e9gional d'Auvergne","ror":"https://ror.org/03b7vrw33"},{"id":"https://openalex.org/F4320325668","display_name":"Direction G\u00e9n\u00e9rale de l\u2019offre de Soins","ror":null},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2883789215.pdf","grobid_xml":"https://content.openalex.org/works/W2883789215.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1529866008","https://openalex.org/W1549965729","https://openalex.org/W1620542608","https://openalex.org/W1803784511","https://openalex.org/W1888618913","https://openalex.org/W1892829132","https://openalex.org/W1898928487","https://openalex.org/W1921068641","https://openalex.org/W1982209837","https://openalex.org/W1982613382","https://openalex.org/W1990202497","https://openalex.org/W1991940875","https://openalex.org/W1992644453","https://openalex.org/W1999525648","https://openalex.org/W2007473062","https://openalex.org/W2011966143","https://openalex.org/W2020821849","https://openalex.org/W2027386447","https://openalex.org/W2027812057","https://openalex.org/W2032705278","https://openalex.org/W2033925475","https://openalex.org/W2050118439","https://openalex.org/W2067423028","https://openalex.org/W2071637551","https://openalex.org/W2073083940","https://openalex.org/W2077726738","https://openalex.org/W2080564894","https://openalex.org/W2088326435","https://openalex.org/W2093758142","https://openalex.org/W2093852073","https://openalex.org/W2104057213","https://openalex.org/W2109334664","https://openalex.org/W2115672224","https://openalex.org/W2116580258","https://openalex.org/W2120156715","https://openalex.org/W2124519382","https://openalex.org/W2129925362","https://openalex.org/W2132575282","https://openalex.org/W2138839431","https://openalex.org/W2142332363","https://openalex.org/W2144304154","https://openalex.org/W2162001089","https://openalex.org/W2281274792","https://openalex.org/W2286228001","https://openalex.org/W2291900475","https://openalex.org/W2294383798","https://openalex.org/W2302682587","https://openalex.org/W2515625652","https://openalex.org/W2552328820","https://openalex.org/W2620241325","https://openalex.org/W2758688195","https://openalex.org/W4293242440","https://openalex.org/W4294658238"],"related_works":["https://openalex.org/W3162591531","https://openalex.org/W2805040489","https://openalex.org/W2392141635","https://openalex.org/W2390727860","https://openalex.org/W1982613382","https://openalex.org/W2088326435","https://openalex.org/W7214127612","https://openalex.org/W1990097165","https://openalex.org/W1921068641","https://openalex.org/W4406873159"],"abstract_inverted_index":{"The":[0,100],"soluble":[1],"receptor":[2],"for":[3,23,135,151,166],"advanced":[4],"glycation":[5],"end-products":[6],"(sRAGE)":[7],"is":[8,38,46],"a":[9,71,191],"marker":[10],"of":[11,61,65,73,122,194,197,206,226,237],"lung":[12,27,67],"epithelial":[13,239],"injury":[14,28,240],"and":[15,26,45,84,108,119,125,162,229],"alveolar":[16,238],"fluid":[17],"clearance":[18],"(AFC),":[19],"with":[20,43,48,180,217,223],"promising":[21],"values":[22],"assessing":[24],"prognosis":[25],"severity":[29],"in":[30,40,80,87,93,184,221,246],"acute":[31],"respiratory":[32],"distress":[33],"syndrome":[34],"(ARDS).":[35],"Because":[36],"AFC":[37],"impaired":[39],"most":[41],"patients":[42,78,222],"ARDS":[44,94],"associated":[47,179,216],"higher":[49,181,198,207,218],"mortality,":[50,59,120],"we":[51,111],"hypothesized":[52],"that":[53,205],"baseline":[54,116,129,212],"plasma":[55,89,117,130,188,213],"sRAGE":[56,90,118,131,189,214],"would":[57],"predict":[58],"independently":[60,121,178,225],"two":[62],"key":[63],"mediators":[64],"ventilator-induced":[66],"injury.":[68],"We":[69],"conducted":[70],"meta-analysis":[72],"individual":[74],"data":[75],"from":[76],"746":[77],"enrolled":[79],"eight":[81],"prospective":[82],"randomized":[83],"observational":[85],"studies":[86],"which":[88],"was":[91,103,215],"measured":[92],"articles":[95],"published":[96],"through":[97],"March":[98],"2016.":[99],"primary":[101],"outcome":[102],"90-day":[104,182,219],"mortality.":[105],"Using":[106],"multivariate":[107,185],"mediation":[109],"analyses,":[110],"tested":[112],"the":[113,195,234],"association":[114],"between":[115],"driving":[123,148,227],"pressure":[124,149,228],"tidal":[126,163,230],"volume.":[127],"Higher":[128,211],"[odds":[132],"ratio":[133],"(OR)":[134],"each":[136,152,167],"one-log":[137,168],"increment,":[138,154,169],"1.18;":[139],"95%":[140,156,171],"confidence":[141],"interval":[142],"(CI)":[143],"1.01\u20131.38;":[144],"P":[145,159,174,200],"=":[146,160,175],"0.04],":[147],"(OR":[150,165],"one-point":[153],"1.04;":[155],"CI":[157,172],"1.02\u20131.07;":[158],"0.002),":[161],"volume":[164],"1.98;":[170],"1.07\u20133.64;":[173],"0.03)":[176],"were":[177],"mortality":[183,202,220],"analysis.":[186],"Baseline":[187],"mediated":[190],"small":[192],"fraction":[193],"effect":[196],"\u0394":[199],"on":[201],"but":[203],"not":[204],"V":[208],"T":[209],".":[210],"ARDS,":[224],"volume,":[231],"thus":[232],"reinforcing":[233],"likely":[235],"contribution":[236],"as":[241],"an":[242],"important":[243],"prognostic":[244],"factor":[245],"ARDS.":[247],"Registration:":[248],"PROSPERO":[249],"(ID:":[250],"CRD42018100241).":[251]},"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":32},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2018-08-03T00:00:00"}