{"id":"https://openalex.org/W2883783530","doi":"https://doi.org/10.1002/ejp.1291","title":"Prescription opioid analgesic use in France: Trends and impact on morbidity\u2013mortality","display_name":"Prescription opioid analgesic use in France: Trends and impact on morbidity\u2013mortality","publication_year":2018,"publication_date":"2018-07-27","ids":{"openalex":"https://openalex.org/W2883783530","doi":"https://doi.org/10.1002/ejp.1291","mag":"2883783530","pmid":"https://pubmed.ncbi.nlm.nih.gov/30051548"},"language":"en","primary_location":{"id":"doi:10.1002/ejp.1291","doi":"https://doi.org/10.1002/ejp.1291","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ejp.1291","pdf_url":null,"source":{"id":"https://openalex.org/S143744428","display_name":"European Journal of Pain","issn_l":"1090-3801","issn":["1090-3801","1532-2149"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pain","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075029148","display_name":"Chouki Chenaf","orcid":"https://orcid.org/0009-0006-2534-3765","observed_orcids":["https://orcid.org/0009-0006-2534-3765"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210123525","display_name":"Physiopathologie et pharmacologie de la douleur et de la migraine","ror":"https://ror.org/028m9sy08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210123525","https://openalex.org/I4210155509"]},{"id":"https://openalex.org/I4210128870","display_name":"Centre Hospitalier Universitaire de Clermont-Ferrand","ror":"https://ror.org/02tcf7a68","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210128870"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C. Chenaf","raw_affiliation_strings":["Institut Analgesia Facult\u00e9 de M\u00e9decine BP38 F\u201063001 Clermont\u2010Ferrand France","Observatoire Fran\u00e7ais des M\u00e9dicaments Antalgiques (OFMA)/French Monitoring Centre for Analgesic Drugs CHU Clermont\u2010Ferrand Universit\u00e9 Clermont Auvergne F\u201063001 Clermont\u2010Ferrand France","Universit\u00e9 Clermont Auvergne CHU Clermont\u2010Ferrand Inserm, Neuro\u2010Dol Service de Pharmacologie m\u00e9dicale Centres Addictovigilance et Pharmacovigilance Centre Evaluation et Traitement de la Douleur D\u00e9l\u00e9gation \u00e0 la Recherche Clinique et \u00e0 l'Innovation F\u201063001 Clermont\u2010Ferrand France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Analgesia Facult\u00e9 de M\u00e9decine BP38 F\u201063001 Clermont\u2010Ferrand France","institution_ids":[]},{"raw_affiliation_string":"Observatoire Fran\u00e7ais des M\u00e9dicaments Antalgiques (OFMA)/French Monitoring Centre for Analgesic Drugs CHU Clermont\u2010Ferrand Universit\u00e9 Clermont Auvergne F\u201063001 Clermont\u2010Ferrand France","institution_ids":["https://openalex.org/I198244214","https://openalex.org/I4210128870"]},{"raw_affiliation_string":"Universit\u00e9 Clermont Auvergne CHU Clermont\u2010Ferrand Inserm, Neuro\u2010Dol Service de Pharmacologie m\u00e9dicale Centres Addictovigilance et Pharmacovigilance Centre Evaluation et Traitement de la Douleur D\u00e9l\u00e9gation \u00e0 la Recherche Clinique et \u00e0 l'Innovation F\u201063001 Clermont\u2010Ferrand France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210123525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017972426","display_name":"Jean\u2010Luc Kabor\u00e9","orcid":"https://orcid.org/0000-0001-7205-206X","observed_orcids":["https://orcid.org/0000-0001-7205-206X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210123525","display_name":"Physiopathologie et pharmacologie de la douleur et de la migraine","ror":"https://ror.org/028m9sy08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210123525","https://openalex.org/I4210155509"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J.\u2010L. Kabor\u00e9","raw_affiliation_strings":["Institut Analgesia Facult\u00e9 de M\u00e9decine BP38 F\u201063001 Clermont\u2010Ferrand France","Universit\u00e9 Clermont Auvergne CHU Clermont\u2010Ferrand Inserm, Neuro\u2010Dol Service de Pharmacologie m\u00e9dicale Centres Addictovigilance et Pharmacovigilance Centre Evaluation et Traitement de la Douleur D\u00e9l\u00e9gation \u00e0 la Recherche Clinique et \u00e0 l'Innovation F\u201063001 Clermont\u2010Ferrand France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Analgesia Facult\u00e9 de M\u00e9decine BP38 F\u201063001 Clermont\u2010Ferrand France","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 Clermont Auvergne CHU Clermont\u2010Ferrand Inserm, Neuro\u2010Dol Service de Pharmacologie m\u00e9dicale Centres Addictovigilance et Pharmacovigilance Centre Evaluation et Traitement de la Douleur D\u00e9l\u00e9gation \u00e0 la Recherche Clinique et \u00e0 l'Innovation F\u201063001 Clermont\u2010Ferrand France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210123525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113987485","display_name":"J. Delorme","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210123525","display_name":"Physiopathologie et pharmacologie de la douleur et de la migraine","ror":"https://ror.org/028m9sy08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210123525","https://openalex.org/I4210155509"]},{"id":"https://openalex.org/I4210128870","display_name":"Centre Hospitalier Universitaire de Clermont-Ferrand","ror":"https://ror.org/02tcf7a68","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210128870"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J. Delorme","raw_affiliation_strings":["Institut Analgesia Facult\u00e9 de M\u00e9decine BP38 F\u201063001 Clermont\u2010Ferrand France","Observatoire Fran\u00e7ais des M\u00e9dicaments Antalgiques (OFMA)/French Monitoring Centre for Analgesic Drugs CHU Clermont\u2010Ferrand Universit\u00e9 Clermont Auvergne F\u201063001 Clermont\u2010Ferrand France","Universit\u00e9 Clermont Auvergne CHU Clermont\u2010Ferrand Inserm, Neuro\u2010Dol Service de Pharmacologie m\u00e9dicale Centres Addictovigilance et Pharmacovigilance Centre Evaluation et Traitement de la Douleur D\u00e9l\u00e9gation \u00e0 la Recherche Clinique et \u00e0 l'Innovation F\u201063001 Clermont\u2010Ferrand France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Analgesia Facult\u00e9 de M\u00e9decine BP38 F\u201063001 Clermont\u2010Ferrand France","institution_ids":[]},{"raw_affiliation_string":"Observatoire Fran\u00e7ais des M\u00e9dicaments Antalgiques (OFMA)/French Monitoring Centre for Analgesic Drugs CHU Clermont\u2010Ferrand Universit\u00e9 Clermont Auvergne F\u201063001 Clermont\u2010Ferrand France","institution_ids":["https://openalex.org/I198244214","https://openalex.org/I4210128870"]},{"raw_affiliation_string":"Universit\u00e9 Clermont Auvergne CHU Clermont\u2010Ferrand Inserm, Neuro\u2010Dol Service de Pharmacologie m\u00e9dicale Centres Addictovigilance et Pharmacovigilance Centre Evaluation et Traitement de la Douleur D\u00e9l\u00e9gation \u00e0 la Recherche Clinique et \u00e0 l'Innovation F\u201063001 Clermont\u2010Ferrand France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210123525"]}]},{"author_position":"middle","author":{"id":null,"display_name":"B. Pereira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210123525","display_name":"Physiopathologie et pharmacologie de la douleur et de la migraine","ror":"https://ror.org/028m9sy08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210123525","https://openalex.org/I4210155509"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B. Pereira","raw_affiliation_strings":["Universit\u00e9 Clermont Auvergne CHU Clermont\u2010Ferrand Inserm, Neuro\u2010Dol Service de Pharmacologie m\u00e9dicale Centres Addictovigilance et Pharmacovigilance Centre Evaluation et Traitement de la Douleur D\u00e9l\u00e9gation \u00e0 la Recherche Clinique et \u00e0 l'Innovation F\u201063001 Clermont\u2010Ferrand France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Clermont Auvergne CHU Clermont\u2010Ferrand Inserm, Neuro\u2010Dol Service de Pharmacologie m\u00e9dicale Centres Addictovigilance et Pharmacovigilance Centre Evaluation et Traitement de la Douleur D\u00e9l\u00e9gation \u00e0 la Recherche Clinique et \u00e0 l'Innovation F\u201063001 Clermont\u2010Ferrand France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210123525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011099314","display_name":"Aur\u00e9lien Mulliez","orcid":"https://orcid.org/0000-0002-9080-0444","observed_orcids":["https://orcid.org/0000-0002-9080-0444"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210123525","display_name":"Physiopathologie et pharmacologie de la douleur et de la migraine","ror":"https://ror.org/028m9sy08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210123525","https://openalex.org/I4210155509"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A. Mulliez","raw_affiliation_strings":["Universit\u00e9 Clermont Auvergne CHU Clermont\u2010Ferrand Inserm, Neuro\u2010Dol Service de Pharmacologie m\u00e9dicale Centres Addictovigilance et Pharmacovigilance Centre Evaluation et Traitement de la Douleur D\u00e9l\u00e9gation \u00e0 la Recherche Clinique et \u00e0 l'Innovation F\u201063001 Clermont\u2010Ferrand France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Clermont Auvergne CHU Clermont\u2010Ferrand Inserm, Neuro\u2010Dol Service de Pharmacologie m\u00e9dicale Centres Addictovigilance et Pharmacovigilance Centre Evaluation et Traitement de la Douleur D\u00e9l\u00e9gation \u00e0 la Recherche Clinique et \u00e0 l'Innovation F\u201063001 Clermont\u2010Ferrand France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210123525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110562212","display_name":"M. Z\u00e9nut","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210123525","display_name":"Physiopathologie et pharmacologie de la douleur et de la migraine","ror":"https://ror.org/028m9sy08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210123525","https://openalex.org/I4210155509"]},{"id":"https://openalex.org/I4210128870","display_name":"Centre Hospitalier Universitaire de Clermont-Ferrand","ror":"https://ror.org/02tcf7a68","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210128870"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M. Zenut","raw_affiliation_strings":["Institut Analgesia Facult\u00e9 de M\u00e9decine BP38 F\u201063001 Clermont\u2010Ferrand France","Observatoire Fran\u00e7ais des M\u00e9dicaments Antalgiques (OFMA)/French Monitoring Centre for Analgesic Drugs CHU Clermont\u2010Ferrand Universit\u00e9 Clermont Auvergne F\u201063001 Clermont\u2010Ferrand France","Universit\u00e9 Clermont Auvergne CHU Clermont\u2010Ferrand Inserm, Neuro\u2010Dol Service de Pharmacologie m\u00e9dicale Centres Addictovigilance et Pharmacovigilance Centre Evaluation et Traitement de la Douleur D\u00e9l\u00e9gation \u00e0 la Recherche Clinique et \u00e0 l'Innovation F\u201063001 Clermont\u2010Ferrand France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Analgesia Facult\u00e9 de M\u00e9decine BP38 F\u201063001 Clermont\u2010Ferrand France","institution_ids":[]},{"raw_affiliation_string":"Observatoire Fran\u00e7ais des M\u00e9dicaments Antalgiques (OFMA)/French Monitoring Centre for Analgesic Drugs CHU Clermont\u2010Ferrand Universit\u00e9 Clermont Auvergne F\u201063001 Clermont\u2010Ferrand France","institution_ids":["https://openalex.org/I198244214","https://openalex.org/I4210128870"]},{"raw_affiliation_string":"Universit\u00e9 Clermont Auvergne CHU Clermont\u2010Ferrand Inserm, Neuro\u2010Dol Service de Pharmacologie m\u00e9dicale Centres Addictovigilance et Pharmacovigilance Centre Evaluation et Traitement de la Douleur D\u00e9l\u00e9gation \u00e0 la Recherche Clinique et \u00e0 l'Innovation F\u201063001 Clermont\u2010Ferrand France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210123525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010795152","display_name":"No\u00e9mie Delage","orcid":"https://orcid.org/0000-0001-6671-1911","observed_orcids":["https://orcid.org/0000-0001-6671-1911"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210123525","display_name":"Physiopathologie et pharmacologie de la douleur et de la migraine","ror":"https://ror.org/028m9sy08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210123525","https://openalex.org/I4210155509"]},{"id":"https://openalex.org/I4210128870","display_name":"Centre Hospitalier Universitaire de Clermont-Ferrand","ror":"https://ror.org/02tcf7a68","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210128870"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"N. Delage","raw_affiliation_strings":["Institut Analgesia Facult\u00e9 de M\u00e9decine BP38 F\u201063001 Clermont\u2010Ferrand France","Observatoire Fran\u00e7ais des M\u00e9dicaments Antalgiques (OFMA)/French Monitoring Centre for Analgesic Drugs CHU Clermont\u2010Ferrand Universit\u00e9 Clermont Auvergne F\u201063001 Clermont\u2010Ferrand France","Universit\u00e9 Clermont Auvergne CHU Clermont\u2010Ferrand Inserm, Neuro\u2010Dol Service de Pharmacologie m\u00e9dicale Centres Addictovigilance et Pharmacovigilance Centre Evaluation et Traitement de la Douleur D\u00e9l\u00e9gation \u00e0 la Recherche Clinique et \u00e0 l'Innovation F\u201063001 Clermont\u2010Ferrand France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Analgesia Facult\u00e9 de M\u00e9decine BP38 F\u201063001 Clermont\u2010Ferrand France","institution_ids":[]},{"raw_affiliation_string":"Observatoire Fran\u00e7ais des M\u00e9dicaments Antalgiques (OFMA)/French Monitoring Centre for Analgesic Drugs CHU Clermont\u2010Ferrand Universit\u00e9 Clermont Auvergne F\u201063001 Clermont\u2010Ferrand France","institution_ids":["https://openalex.org/I198244214","https://openalex.org/I4210128870"]},{"raw_affiliation_string":"Universit\u00e9 Clermont Auvergne CHU Clermont\u2010Ferrand Inserm, Neuro\u2010Dol Service de Pharmacologie m\u00e9dicale Centres Addictovigilance et Pharmacovigilance Centre Evaluation et Traitement de la Douleur D\u00e9l\u00e9gation \u00e0 la Recherche Clinique et \u00e0 l'Innovation F\u201063001 Clermont\u2010Ferrand France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210123525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050210361","display_name":"Denis Ardid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210123525","display_name":"Physiopathologie et pharmacologie de la douleur et de la migraine","ror":"https://ror.org/028m9sy08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210123525","https://openalex.org/I4210155509"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"D. Ardid","raw_affiliation_strings":["Institut Analgesia Facult\u00e9 de M\u00e9decine BP38 F\u201063001 Clermont\u2010Ferrand France","Universit\u00e9 Clermont Auvergne CHU Clermont\u2010Ferrand Inserm, Neuro\u2010Dol Service de Pharmacologie m\u00e9dicale Centres Addictovigilance et Pharmacovigilance Centre Evaluation et Traitement de la Douleur D\u00e9l\u00e9gation \u00e0 la Recherche Clinique et \u00e0 l'Innovation F\u201063001 Clermont\u2010Ferrand France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Analgesia Facult\u00e9 de M\u00e9decine BP38 F\u201063001 Clermont\u2010Ferrand France","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 Clermont Auvergne CHU Clermont\u2010Ferrand Inserm, Neuro\u2010Dol Service de Pharmacologie m\u00e9dicale Centres Addictovigilance et Pharmacovigilance Centre Evaluation et Traitement de la Douleur D\u00e9l\u00e9gation \u00e0 la Recherche Clinique et \u00e0 l'Innovation F\u201063001 Clermont\u2010Ferrand France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210123525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075478051","display_name":"Alain Eschalier","orcid":"https://orcid.org/0000-0001-6778-1057","observed_orcids":["https://orcid.org/0000-0001-6778-1057"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210123525","display_name":"Physiopathologie et pharmacologie de la douleur et de la migraine","ror":"https://ror.org/028m9sy08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210123525","https://openalex.org/I4210155509"]},{"id":"https://openalex.org/I4210128870","display_name":"Centre Hospitalier Universitaire de Clermont-Ferrand","ror":"https://ror.org/02tcf7a68","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210128870"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"A. Eschalier","raw_affiliation_strings":["Institut Analgesia Facult\u00e9 de M\u00e9decine BP38 F\u201063001 Clermont\u2010Ferrand France","Observatoire Fran\u00e7ais des M\u00e9dicaments Antalgiques (OFMA)/French Monitoring Centre for Analgesic Drugs CHU Clermont\u2010Ferrand Universit\u00e9 Clermont Auvergne F\u201063001 Clermont\u2010Ferrand France","Universit\u00e9 Clermont Auvergne CHU Clermont\u2010Ferrand Inserm, Neuro\u2010Dol Service de Pharmacologie m\u00e9dicale Centres Addictovigilance et Pharmacovigilance Centre Evaluation et Traitement de la Douleur D\u00e9l\u00e9gation \u00e0 la Recherche Clinique et \u00e0 l'Innovation F\u201063001 Clermont\u2010Ferrand France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Analgesia Facult\u00e9 de M\u00e9decine BP38 F\u201063001 Clermont\u2010Ferrand France","institution_ids":[]},{"raw_affiliation_string":"Observatoire Fran\u00e7ais des M\u00e9dicaments Antalgiques (OFMA)/French Monitoring Centre for Analgesic Drugs CHU Clermont\u2010Ferrand Universit\u00e9 Clermont Auvergne F\u201063001 Clermont\u2010Ferrand France","institution_ids":["https://openalex.org/I198244214","https://openalex.org/I4210128870"]},{"raw_affiliation_string":"Universit\u00e9 Clermont Auvergne CHU Clermont\u2010Ferrand Inserm, Neuro\u2010Dol Service de Pharmacologie m\u00e9dicale Centres Addictovigilance et Pharmacovigilance Centre Evaluation et Traitement de la Douleur D\u00e9l\u00e9gation \u00e0 la Recherche Clinique et \u00e0 l'Innovation F\u201063001 Clermont\u2010Ferrand France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210123525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083621017","display_name":"Nicolas Authier","orcid":"https://orcid.org/0000-0002-1236-0383","observed_orcids":["https://orcid.org/0000-0002-1236-0383"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210123525","display_name":"Physiopathologie et pharmacologie de la douleur et de la migraine","ror":"https://ror.org/028m9sy08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210123525","https://openalex.org/I4210155509"]},{"id":"https://openalex.org/I4210128870","display_name":"Centre Hospitalier Universitaire de Clermont-Ferrand","ror":"https://ror.org/02tcf7a68","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210128870"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"N. Authier","raw_affiliation_strings":["Institut Analgesia Facult\u00e9 de M\u00e9decine BP38 F\u201063001 Clermont\u2010Ferrand France","Observatoire Fran\u00e7ais des M\u00e9dicaments Antalgiques (OFMA)/French Monitoring Centre for Analgesic Drugs CHU Clermont\u2010Ferrand Universit\u00e9 Clermont Auvergne F\u201063001 Clermont\u2010Ferrand France","Universit\u00e9 Clermont Auvergne CHU Clermont\u2010Ferrand Inserm, Neuro\u2010Dol Service de Pharmacologie m\u00e9dicale Centres Addictovigilance et Pharmacovigilance Centre Evaluation et Traitement de la Douleur D\u00e9l\u00e9gation \u00e0 la Recherche Clinique et \u00e0 l'Innovation F\u201063001 Clermont\u2010Ferrand France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Analgesia Facult\u00e9 de M\u00e9decine BP38 F\u201063001 Clermont\u2010Ferrand France","institution_ids":[]},{"raw_affiliation_string":"Observatoire Fran\u00e7ais des M\u00e9dicaments Antalgiques (OFMA)/French Monitoring Centre for Analgesic Drugs CHU Clermont\u2010Ferrand Universit\u00e9 Clermont Auvergne F\u201063001 Clermont\u2010Ferrand France","institution_ids":["https://openalex.org/I198244214","https://openalex.org/I4210128870"]},{"raw_affiliation_string":"Universit\u00e9 Clermont Auvergne CHU Clermont\u2010Ferrand Inserm, Neuro\u2010Dol Service de Pharmacologie m\u00e9dicale Centres Addictovigilance et Pharmacovigilance Centre Evaluation et Traitement de la Douleur D\u00e9l\u00e9gation \u00e0 la Recherche Clinique et \u00e0 l'Innovation F\u201063001 Clermont\u2010Ferrand France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210123525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5075478051"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210123525","https://openalex.org/I4210128870"],"apc_list":{"value":4310,"currency":"USD","value_usd":4310},"apc_paid":null,"fwci":23.0768,"has_fulltext":false,"cited_by_count":190,"citation_normalized_percentile":{"value":0.99763754,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"23","issue":"1","first_page":"124","last_page":"134"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/opioid-analgesics","display_name":"opioid analgesics","score":0.8610000014305115},{"id":"https://openalex.org/keywords/opioid-use-trends","display_name":"opioid use trends","score":0.7350000143051147},{"id":"https://openalex.org/keywords/opioid-related-deaths","display_name":"opioid-related deaths","score":0.765999972820282},{"id":"https://openalex.org/keywords/opioid-related-hospitalizations","display_name":"opioid-related hospitalizations","score":0.9120000004768372},{"id":"https://openalex.org/keywords/oxycodone","display_name":"oxycodone","score":0.7590000033378601},{"id":"https://openalex.org/keywords/fentanyl","display_name":"fentanyl","score":0.9449999928474426},{"id":"https://openalex.org/keywords/chronic-non-cancer-pain","display_name":"chronic non-cancer pain","score":0.8939999938011169},{"id":"https://openalex.org/keywords/codeine","display_name":"codeine","score":0.8309999704360962},{"id":"https://openalex.org/keywords/tramadol","display_name":"tramadol","score":0.9959999918937683},{"id":"https://openalex.org/keywords/opium","display_name":"opium","score":0.8289999961853027},{"id":"https://openalex.org/keywords/prescription-drug-misuse","display_name":"prescription drug misuse","score":0.4650000035762787},{"id":"https://openalex.org/keywords/france","display_name":"France","score":0.8759999871253967},{"id":"https://openalex.org/keywords/opioid-crisis","display_name":"opioid epidemic","score":0.5419999957084656},{"id":"https://openalex.org/keywords/hospital-discharge-data","display_name":"hospital discharge data","score":0.4869999885559082},{"id":"https://openalex.org/keywords/mortality-registry","display_name":"mortality registry","score":0.9049999713897705},{"id":"https://openalex.org/keywords/claims-data","display_name":"claims data","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C2776029756","wikidata":"https://www.wikidata.org/wiki/Q407535","display_name":"Oxycodone","level":4,"score":0.8750715255737305},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8711949586868286},{"id":"https://openalex.org/C508975757","wikidata":"https://www.wikidata.org/wiki/Q2268608","display_name":"Propoxyphene","level":3,"score":0.7349907159805298},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.6719127893447876},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.6677035689353943},{"id":"https://openalex.org/C2779777798","wikidata":"https://www.wikidata.org/wiki/Q407592","display_name":"Tramadol","level":3,"score":0.6185869574546814},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5621708631515503},{"id":"https://openalex.org/C2777866328","wikidata":"https://www.wikidata.org/wiki/Q174723","display_name":"Codeine","level":3,"score":0.5469362139701843},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5097679495811462},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.47086942195892334},{"id":"https://openalex.org/C104863432","wikidata":"https://www.wikidata.org/wiki/Q614304","display_name":"Pharmacy","level":2,"score":0.4681796133518219},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.42977431416511536},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.37917834520339966},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.34734728932380676},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32765573263168335},{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.24913829565048218},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.17020070552825928},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.10591432452201843},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.09637695550918579},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003061","descriptor_name":"Codeine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005283","descriptor_name":"Fentanyl","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005602","descriptor_name":"France","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009026","descriptor_name":"Mortality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009293","descriptor_name":"Opioid-Related Disorders","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D009892","descriptor_name":"Opium","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010098","descriptor_name":"Oxycodone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011431","descriptor_name":"Dextropropoxyphene","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014147","descriptor_name":"Tramadol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059350","descriptor_name":"Chronic Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1002/ejp.1291","doi":"https://doi.org/10.1002/ejp.1291","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ejp.1291","pdf_url":null,"source":{"id":"https://openalex.org/S143744428","display_name":"European Journal of Pain","issn_l":"1090-3801","issn":["1090-3801","1532-2149"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pain","raw_type":"journal-article"},{"id":"pmid:30051548","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30051548","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pain (London, England)","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-01926154v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.archives-ouvertes.fr/hal-01926154","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1090-3801","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-02323031v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-02323031","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Journal of Pain, 2019, 23 (1), pp.124-134. &#x27E8;10.1002/ejp.1291&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-04317229v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-04317229","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1090-3801","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9912999868392944}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320324526","display_name":"Agence Nationale de S\u00e9curit\u00e9 du M\u00e9dicament et des Produits de Sant\u00e9","ror":"https://ror.org/01g80gk13"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W40152349","https://openalex.org/W87803556","https://openalex.org/W97547660","https://openalex.org/W100098653","https://openalex.org/W1500489880","https://openalex.org/W1565376005","https://openalex.org/W1584890869","https://openalex.org/W1757854360","https://openalex.org/W1869851070","https://openalex.org/W1918215063","https://openalex.org/W1982173905","https://openalex.org/W1986692293","https://openalex.org/W1995188972","https://openalex.org/W1995209972","https://openalex.org/W1997699648","https://openalex.org/W2000445173","https://openalex.org/W2007379992","https://openalex.org/W2016895882","https://openalex.org/W2024150610","https://openalex.org/W2028238067","https://openalex.org/W2045583249","https://openalex.org/W2045707303","https://openalex.org/W2054317009","https://openalex.org/W2061326496","https://openalex.org/W2062111202","https://openalex.org/W2068968575","https://openalex.org/W2077322745","https://openalex.org/W2106148191","https://openalex.org/W2117063553","https://openalex.org/W2126791898","https://openalex.org/W2133228717","https://openalex.org/W2133900227","https://openalex.org/W2139044430","https://openalex.org/W2149560262","https://openalex.org/W2156613964","https://openalex.org/W2157406381","https://openalex.org/W2163607991","https://openalex.org/W2168667510","https://openalex.org/W2266710787","https://openalex.org/W2269501814","https://openalex.org/W2275737843","https://openalex.org/W2288528566","https://openalex.org/W2292748019","https://openalex.org/W2296986887","https://openalex.org/W2300421333","https://openalex.org/W2323221475","https://openalex.org/W2330130766","https://openalex.org/W2330874792","https://openalex.org/W2340078511","https://openalex.org/W2425287903","https://openalex.org/W2429408914","https://openalex.org/W2514357007","https://openalex.org/W2561663951","https://openalex.org/W2725503094","https://openalex.org/W2733037038","https://openalex.org/W2771401986","https://openalex.org/W2774111693","https://openalex.org/W2775796391","https://openalex.org/W2790470440","https://openalex.org/W2791970879","https://openalex.org/W2800358689","https://openalex.org/W3132839697","https://openalex.org/W4406467019"],"related_works":["https://openalex.org/W2969815372","https://openalex.org/W2999354848","https://openalex.org/W3029058208","https://openalex.org/W2791970879","https://openalex.org/W3215803960","https://openalex.org/W4402638754","https://openalex.org/W2200418254","https://openalex.org/W4229048215","https://openalex.org/W2559786992","https://openalex.org/W3087166120"],"abstract_inverted_index":{"BACKGROUND:":[0],"While":[1],"data":[2],"from":[3,86,123,155,179,191],"USA":[4],"and":[5,43,71,78,107,113,148,188,234,237,272],"Canada":[6],"demonstrate":[7],"an":[8,290],"opioid":[9,54,103,120,136,265,300],"overdose":[10],"epidemic,":[11],"very":[12],"little":[13],"nation-wide":[14],"European":[15,206],"studies":[16],"have":[17],"been":[18],"published":[19],"on":[20],"this":[21],"topical":[22],"subject.":[23],"METHODS:":[24],"Using":[25],"a":[26,204,209,279],"nationally":[27],"representative":[28],"sample":[29],"of":[30,75,83,101,299],"the":[31,37,98],"French":[32],"Claims":[33],"database":[34],"(>700,000":[35],"patients),":[36],"exhaustive":[38],"nationwide":[39,210],"hospital":[40],"discharge":[41],"database,":[42],"national":[44,217],"mortality":[45,166],"registry,":[46],"all":[47],"patients":[48],"dispensed":[49,89],"at":[50,269],"least":[51,270],"one":[52],"prescription":[53,264],"(PO)":[55],"in":[56,63,138,221,232,241,252,258,267,282],"2004-2017":[57,220],"were":[58],"identified,":[59],"to":[60,125,157,181,193,208,215,247,254],"describe":[61],"trends":[62],"PO":[64,76,223,250],"analgesic":[65],"use,":[66,236],"shopping":[67,79,153],"behaviour,":[68],"opioid-related":[69,189,242,259,283],"hospitalizations":[70,177],"deaths.":[72],"Annual":[73],"prevalence":[74,100],"use":[77,104,121,137,224,266,274],"behaviour":[80],"(\u22651":[81],"day":[82],"overlapping":[84],"prescriptions":[85],"\u22652":[87],"prescribers,":[88],"by":[90,110,143],"\u22653":[91],"pharmacies)":[92],"was":[93],"estimated.":[94],"RESULTS:":[95],"In":[96,219,262],"2004-2017,":[97,263],"annual":[99],"weak":[102],"codeine,":[105],"tramadol":[106],"opium":[108],"rose":[109,142],"150%,":[111],"123%,":[112],"244%,":[114],"respectively":[115],"(p":[116,145],"<":[117,129,146,161],"0.05).":[118],"Strong":[119,135],"increased":[122,154,178,275],"0.54%":[124],"1.1%":[126],"(+104%,":[127],"p":[128,160],"0.05),":[130,162],"significantly":[131],"for":[132,150,289,296],"oxycodone":[133,233,273],"(+1950%).":[134],"chronic":[139],"noncancer":[140],"pain":[141],"88%":[144],"0.05)":[147],"1180%":[149],"oxycodone.":[151],"Opioid":[152],"0.50%":[156],"0.67%":[158],"(+34%,":[159],"associated":[163,277],"with":[164,212,278],"higher":[165],"risk":[167],"HR":[168],"=":[169],"2.8":[170],"[95%":[171],"confidence":[172],"interval":[173],"(CI):":[174],"1.2-6.4].":[175],"Opioid-related":[176],"15":[180],"40":[182],"per":[183,195],"1,000,000":[184,196],"population":[185,197],"(+167%,":[186],"2000-2017),":[187],"deaths":[190],"1.3":[192],"3.2":[194],"(+146%,":[198],"2000-2015).":[199],"CONCLUSIONS:":[200],"This":[201],"study":[202],"provided":[203],"first":[205],"approach":[207],"estimation":[211],"complete":[213],"access":[214],"several":[216],"registries.":[218],"France,":[222],"excluding":[225],"dextropropoxyphene":[226],"more":[227],"than":[228],"doubled.":[229],"The":[230],"increase":[231,281],"fentanyl":[235],"nontrivial":[238,280],"increasing":[239],"trend":[240],"morbidity-mortality":[243],"should":[244],"prompt":[245],"authorities":[246],"closely":[248],"monitor":[249],"consumption":[251],"order":[253],"prevent":[255],"alarming":[256],"increases":[257],"morbidity-mortality.":[260,284],"SIGNIFICANCE:":[261],"France":[268],"doubled":[271],"particularly,":[276],"Although":[285],"giving":[286],"no":[287],"indication":[288],"'opioid":[291],"epidemic,'":[292],"these":[293],"findings":[294],"call":[295],"proper":[297],"monitoring":[298],"use.":[301]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":25},{"year":2021,"cited_by_count":34},{"year":2020,"cited_by_count":43},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-08-03T00:00:00"}