{"id":"https://openalex.org/W2883733158","doi":"https://doi.org/10.1016/j.nutres.2018.07.004","title":"1,25-Dihydroxyvitamin D regulates lipid metabolism and glucose utilization in differentiated 3T3-L1 adipocytes","display_name":"1,25-Dihydroxyvitamin D regulates lipid metabolism and glucose utilization in differentiated 3T3-L1 adipocytes","publication_year":2018,"publication_date":"2018-07-14","ids":{"openalex":"https://openalex.org/W2883733158","doi":"https://doi.org/10.1016/j.nutres.2018.07.004","mag":"2883733158","pmid":"https://pubmed.ncbi.nlm.nih.gov/30340817"},"language":"en","primary_location":{"id":"doi:10.1016/j.nutres.2018.07.004","doi":"https://doi.org/10.1016/j.nutres.2018.07.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.nutres.2018.07.004","pdf_url":null,"source":{"id":"https://openalex.org/S123713480","display_name":"Nutrition Research","issn_l":"0271-5317","issn":["0271-5317","1879-0739"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052983138","display_name":"Brienna Larrick","orcid":"https://orcid.org/0000-0002-5154-8098","observed_orcids":["https://orcid.org/0000-0002-5154-8098"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brienna M. Larrick","raw_affiliation_strings":["Interdepartmental Nutrition Program, Purdue University, 700 W State St, West Lafayette, Indiana 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdepartmental Nutrition Program, Purdue University, 700 W State St, West Lafayette, Indiana 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020569416","display_name":"Kee\u2010Hong Kim","orcid":"https://orcid.org/0000-0002-1124-572X","observed_orcids":["https://orcid.org/0000-0002-1124-572X"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kee-Hong Kim","raw_affiliation_strings":["Department of Food Sciences, Purdue University, 745 Agriculture Mall Dr, West Lafayette, IN 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Sciences, Purdue University, 745 Agriculture Mall Dr, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037126715","display_name":"Shawn Scott Donkin","orcid":"https://orcid.org/0000-0003-3571-4946","observed_orcids":["https://orcid.org/0000-0003-3571-4946"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shawn S. Donkin","raw_affiliation_strings":["Department of Animal Sciences, Purdue University, 915 W State St, West Lafayette, IN 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Sciences, Purdue University, 915 W State St, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026812062","display_name":"Dorothy Teegarden","orcid":"https://orcid.org/0000-0002-7045-3748","observed_orcids":["https://orcid.org/0000-0002-7045-3748"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dorothy Teegarden","raw_affiliation_strings":["Interdepartmental Nutrition Program, Purdue University, 700 W State St, West Lafayette, Indiana 47907, USA. Electronic address: teegarden@purdue.edu","Interdepartmental Nutrition Program, Purdue University, 700 W State St, West Lafayette, Indiana 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdepartmental Nutrition Program, Purdue University, 700 W State St, West Lafayette, Indiana 47907, USA. Electronic address: teegarden@purdue.edu","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Interdepartmental Nutrition Program, Purdue University, 700 W State St, West Lafayette, Indiana 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026812062"],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":{"value":4090,"currency":"USD","value_usd":4090},"apc_paid":null,"fwci":3.4225,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.92582043,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"58","issue":null,"first_page":"72","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.7124000191688538,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.7124000191688538,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.17810000479221344,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.06840000301599503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d","display_name":"1,25-dihydroxyvitamin D","score":0.9980000257492065},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.8610000014305115},{"id":"https://openalex.org/keywords/adipocyte-lipid-metabolism","display_name":"adipocyte lipid metabolism","score":0.7059999704360962},{"id":"https://openalex.org/keywords/glucose-utilization","display_name":"glucose utilization","score":0.8489999771118164},{"id":"https://openalex.org/keywords/3t3-l1-adipocytes","display_name":"3T3-L1 adipocytes","score":0.972000002861023},{"id":"https://openalex.org/keywords/triglyceride-accumulation","display_name":"triglyceride accumulation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/fatty-acid-beta-oxidation","display_name":"fatty acid beta-oxidation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/de-novo-lipogenesis","display_name":"de novo lipogenesis","score":0.875},{"id":"https://openalex.org/keywords/pyruvate-carboxylase","display_name":"pyruvate carboxylase","score":0.9580000042915344},{"id":"https://openalex.org/keywords/glucose-disposal","display_name":"glucose disposal","score":0.550000011920929},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C141359234","wikidata":"https://www.wikidata.org/wiki/Q2734301","display_name":"Lipogenesis","level":3,"score":0.8427444696426392},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.6260747909545898},{"id":"https://openalex.org/C2776941171","wikidata":"https://www.wikidata.org/wiki/Q900209","display_name":"Fatty acid synthesis","level":3,"score":0.6085283756256104},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.577168881893158},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.571652889251709},{"id":"https://openalex.org/C2779318131","wikidata":"https://www.wikidata.org/wiki/Q21199067","display_name":"Acetyl-CoA carboxylase","level":4,"score":0.5618332624435425},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5567168593406677},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.549338161945343},{"id":"https://openalex.org/C82714985","wikidata":"https://www.wikidata.org/wiki/Q306213","display_name":"Beta oxidation","level":3,"score":0.5431789755821228},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.5431756377220154},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.5158828496932983},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.5112793445587158},{"id":"https://openalex.org/C140137476","wikidata":"https://www.wikidata.org/wiki/Q21114968","display_name":"Pyruvate carboxylase","level":3,"score":0.5104998350143433},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4998152256011963},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4991307258605957},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4767811596393585},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35894161462783813},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.23610714077949524},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.09715977311134338},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005990","descriptor_name":"Glycerol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008066","descriptor_name":"Lipolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011766","descriptor_name":"Pyruvate Carboxylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011766","descriptor_name":"Pyruvate Carboxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019308","descriptor_name":"Palmitic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D041721","descriptor_name":"3T3-L1 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050155","descriptor_name":"Lipogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050156","descriptor_name":"Adipogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.nutres.2018.07.004","doi":"https://doi.org/10.1016/j.nutres.2018.07.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.nutres.2018.07.004","pdf_url":null,"source":{"id":"https://openalex.org/S123713480","display_name":"Nutrition Research","issn_l":"0271-5317","issn":["0271-5317","1879-0739"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition Research","raw_type":"journal-article"},{"id":"pmid:30340817","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30340817","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition research (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2560545833","display_name":"Indiana Clinical and Translational Sciences Institute","funder_award_id":"UL1TR001108","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333194","display_name":"Office of the Executive Vice President for Research and Partnerships, Purdue University","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W28171545","https://openalex.org/W1242222040","https://openalex.org/W1615702087","https://openalex.org/W1752951489","https://openalex.org/W1887767379","https://openalex.org/W1891706576","https://openalex.org/W1954270231","https://openalex.org/W1963619735","https://openalex.org/W1963773375","https://openalex.org/W1968136207","https://openalex.org/W1971352128","https://openalex.org/W1973268693","https://openalex.org/W1973986499","https://openalex.org/W1984182813","https://openalex.org/W1986860566","https://openalex.org/W1989020172","https://openalex.org/W1992694688","https://openalex.org/W1993959456","https://openalex.org/W1995392366","https://openalex.org/W1997909566","https://openalex.org/W1998154781","https://openalex.org/W2001332479","https://openalex.org/W2006433855","https://openalex.org/W2013950118","https://openalex.org/W2022292907","https://openalex.org/W2025479029","https://openalex.org/W2039156823","https://openalex.org/W2044373321","https://openalex.org/W2045934903","https://openalex.org/W2046745564","https://openalex.org/W2048919754","https://openalex.org/W2049122246","https://openalex.org/W2051827443","https://openalex.org/W2060925506","https://openalex.org/W2068466840","https://openalex.org/W2073724566","https://openalex.org/W2073901631","https://openalex.org/W2075145089","https://openalex.org/W2076553311","https://openalex.org/W2079234794","https://openalex.org/W2079993449","https://openalex.org/W2080030121","https://openalex.org/W2081418782","https://openalex.org/W2084286724","https://openalex.org/W2086825927","https://openalex.org/W2086891038","https://openalex.org/W2092543665","https://openalex.org/W2093034724","https://openalex.org/W2102655490","https://openalex.org/W2103506340","https://openalex.org/W2104868811","https://openalex.org/W2106192637","https://openalex.org/W2109549328","https://openalex.org/W2110330424","https://openalex.org/W2114647414","https://openalex.org/W2115496586","https://openalex.org/W2128900719","https://openalex.org/W2144741116","https://openalex.org/W2151576515","https://openalex.org/W2152296863","https://openalex.org/W2157304718","https://openalex.org/W2158553989","https://openalex.org/W2158589848","https://openalex.org/W2158721638","https://openalex.org/W2166608053","https://openalex.org/W2199079318","https://openalex.org/W2284494825","https://openalex.org/W2558655274","https://openalex.org/W6642261425","https://openalex.org/W6668862492","https://openalex.org/W6676447656"],"related_works":["https://openalex.org/W4389024701","https://openalex.org/W2554160200","https://openalex.org/W2156807491","https://openalex.org/W2284494825","https://openalex.org/W1020198532","https://openalex.org/W2548833706","https://openalex.org/W1977239388","https://openalex.org/W2081418782","https://openalex.org/W7096787085","https://openalex.org/W2371857021"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-08-03T00:00:00"}