{"id":"https://openalex.org/W2883696571","doi":"https://doi.org/10.1242/jcs.218610","title":"Cholera toxin inhibits SNX27-retromer-mediated delivery of cargo proteins to the plasma membrane","display_name":"Cholera toxin inhibits SNX27-retromer-mediated delivery of cargo proteins to the plasma membrane","publication_year":2018,"publication_date":"2018-07-20","ids":{"openalex":"https://openalex.org/W2883696571","doi":"https://doi.org/10.1242/jcs.218610","mag":"2883696571","pmid":"https://pubmed.ncbi.nlm.nih.gov/30030371","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6127729"},"language":"en","primary_location":{"id":"doi:10.1242/jcs.218610","doi":"https://doi.org/10.1242/jcs.218610","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.218610","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6127729","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006570436","display_name":"Varsha Singh","orcid":"https://orcid.org/0000-0003-0796-2619","observed_orcids":["https://orcid.org/0000-0003-0796-2619"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Varsha Singh","raw_affiliation_strings":["School of Medicine, Johns Hopkins University 1 Departments of Medicine and Physiology , , Baltimore, MD 21205 , USA"],"raw_orcid":"https://orcid.org/0000-0003-0796-2619","affiliations":[{"raw_affiliation_string":"School of Medicine, Johns Hopkins University 1 Departments of Medicine and Physiology , , Baltimore, MD 21205 , USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jianbo Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianbo Yang","raw_affiliation_strings":["School of Medicine, Johns Hopkins University 1 Departments of Medicine and Physiology , , Baltimore, MD 21205 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Johns Hopkins University 1 Departments of Medicine and Physiology , , Baltimore, MD 21205 , USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063993227","display_name":"Jianyi Yin","orcid":"https://orcid.org/0000-0002-1305-5399","observed_orcids":["https://orcid.org/0000-0002-1305-5399"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianyi Yin","raw_affiliation_strings":["School of Medicine, Johns Hopkins University 1 Departments of Medicine and Physiology , , Baltimore, MD 21205 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Johns Hopkins University 1 Departments of Medicine and Physiology , , Baltimore, MD 21205 , USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015933395","display_name":"Robert Norman Cole","orcid":"https://orcid.org/0000-0002-3096-4754","observed_orcids":["https://orcid.org/0000-0002-3096-4754"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Cole","raw_affiliation_strings":["School of Medicine, Johns Hopkins University 2 Department of Biological Chemistry , , Baltimore, MD 21205 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Johns Hopkins University 2 Department of Biological Chemistry , , Baltimore, MD 21205 , USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110730160","display_name":"Ming C. Tse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Tse","raw_affiliation_strings":["School of Medicine, Johns Hopkins University 1 Departments of Medicine and Physiology , , Baltimore, MD 21205 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Johns Hopkins University 1 Departments of Medicine and Physiology , , Baltimore, MD 21205 , USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043307787","display_name":"Diego E. Berman","orcid":"https://orcid.org/0000-0002-1131-3876","observed_orcids":["https://orcid.org/0000-0002-1131-3876"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diego E. Berman","raw_affiliation_strings":["Columbia University College of Physicians and Surgeons 3 , Department of Pathology , , New York, NY 10032 , USA","The Taub Institute for Research on Alzheimer's Disease and the Aging Brain 3 , Department of Pathology , , New York, NY 10032 , USA","The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University College of Physicians and Surgeons 3 , Department of Pathology , , New York, NY 10032 , USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"The Taub Institute for Research on Alzheimer's Disease and the Aging Brain 3 , Department of Pathology , , New York, NY 10032 , USA","institution_ids":[]},{"raw_affiliation_string":"The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074940166","display_name":"Scott A. Small","orcid":"https://orcid.org/0000-0002-4777-1502","observed_orcids":["https://orcid.org/0000-0002-4777-1502"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott A. Small","raw_affiliation_strings":["Columbia University College of Physicians and Surgeons 3 , Department of Pathology , , New York, NY 10032 , USA","The Taub Institute for Research on Alzheimer's Disease and the Aging Brain 3 , Department of Pathology , , New York, NY 10032 , USA","The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University College of Physicians and Surgeons 3 , Department of Pathology , , New York, NY 10032 , USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"The Taub Institute for Research on Alzheimer's Disease and the Aging Brain 3 , Department of Pathology , , New York, NY 10032 , USA","institution_ids":[]},{"raw_affiliation_string":"The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007934367","display_name":"Gregory A. Petsko","orcid":"https://orcid.org/0000-0003-3668-3694","observed_orcids":["https://orcid.org/0000-0003-3668-3694"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory Petsko","raw_affiliation_strings":["Weill Cornell Medical College 4 Helen and Robert Appel Alzheimer's Disease Research Institute and Department of Neurology , , New York, NY 10021, \u2008 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medical College 4 Helen and Robert Appel Alzheimer's Disease Research Institute and Department of Neurology , , New York, NY 10021, \u2008 USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044859707","display_name":"Mark Donowitz","orcid":"https://orcid.org/0000-0003-0477-8824","observed_orcids":["https://orcid.org/0000-0003-0477-8824"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Donowitz","raw_affiliation_strings":["School of Medicine, Johns Hopkins University 1 Departments of Medicine and Physiology , , Baltimore, MD 21205 , USA"],"raw_orcid":"https://orcid.org/0000-0003-0477-8824","affiliations":[{"raw_affiliation_string":"School of Medicine, Johns Hopkins University 1 Departments of Medicine and Physiology , , Baltimore, MD 21205 , USA","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5998,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.89173734,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"131","issue":"16","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholera-toxin","display_name":"cholera toxin","score":0.996999979019165},{"id":"https://openalex.org/keywords/snx27","display_name":"SNX27","score":0.996999979019165},{"id":"https://openalex.org/keywords/retromer-complex","display_name":"retromer complex","score":0.9070000052452087},{"id":"https://openalex.org/keywords/nhe3","display_name":"NHE3","score":0.9679999947547913},{"id":"https://openalex.org/keywords/slc9a3","display_name":"SLC9A3","score":0.8600000143051147},{"id":"https://openalex.org/keywords/protein-trafficking","display_name":"protein trafficking","score":0.5709999799728394},{"id":"https://openalex.org/keywords/plasma-membrane-delivery","display_name":"plasma membrane delivery","score":0.7269999980926514},{"id":"https://openalex.org/keywords/early-endosomes","display_name":"early endosomes","score":0.7940000295639038},{"id":"https://openalex.org/keywords/endocytic-recycling","display_name":"endocytic recycling","score":0.9760000109672546},{"id":"https://openalex.org/keywords/pharmacological-chaperones","display_name":"pharmacological chaperones","score":0.9049999713897705},{"id":"https://openalex.org/keywords/intestinal-fluid-absorption","display_name":"intestinal fluid absorption","score":0.8539999723434448},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":0.8989999890327454}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8972789645195007},{"id":"https://openalex.org/C2777006276","wikidata":"https://www.wikidata.org/wiki/Q83586","display_name":"Cholera toxin","level":2,"score":0.85643070936203},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.7076572775840759},{"id":"https://openalex.org/C145458877","wikidata":"https://www.wikidata.org/wiki/Q7317044","display_name":"Retromer","level":4,"score":0.7009661793708801},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5761365294456482},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.5400660037994385},{"id":"https://openalex.org/C2910636507","wikidata":"https://www.wikidata.org/wiki/Q4082043","display_name":"Vesicular Transport Proteins","level":5,"score":0.4376850128173828},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3347797095775604},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.33116814494132996},{"id":"https://openalex.org/C2777867350","wikidata":"https://www.wikidata.org/wiki/Q7908031","display_name":"Vacuolar protein sorting","level":4,"score":0.0},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002772","descriptor_name":"Cholera Toxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D033921","descriptor_name":"Vesicular Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D033921","descriptor_name":"Vesicular Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058305","descriptor_name":"Sorting Nexins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058305","descriptor_name":"Sorting Nexins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1242/jcs.218610","doi":"https://doi.org/10.1242/jcs.218610","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.218610","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5640843","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6127729","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6127729","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6127729","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Sci","raw_type":"Text"},{"id":"pmid:30030371","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30030371","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cell science","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:joces:131/16/jcs218610","doi":null,"is_oa":false,"landing_page_url":"http://jcs.biologists.org/cgi/content/short/131/16/jcs218610","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5640843","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6127729","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1053858726","display_name":null,"funder_award_id":"UO1-DK10316","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2535215141","display_name":"Hopkins Digestive Diseases Basic & Translational Research Core Center","funder_award_id":"P30DK089502","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5566984453","display_name":"Transporters and Trafficking in Polarized Epithelial Cells","funder_award_id":"P01DK072084","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G60945455","display_name":"NHE3 Regulation and Signaling Complexes","funder_award_id":"R01DK061765","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7142867022","display_name":"Diarrheal Disease: Physiologic Approach to Treatment","funder_award_id":"R01DK026523","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7683699529","display_name":"Institutional Clinical and Translational Science Award","funder_award_id":"UL1TR000003","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8259535054","display_name":"Translational Approaches to Develop Drug Therapy for Diarrhea","funder_award_id":"R24DK099803","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000891685","display_name":"Pathogenesis of E. coli and Shigella infections in human enteroid models","funder_award_id":"P01AI125181","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W14738797","https://openalex.org/W1483496013","https://openalex.org/W1530007708","https://openalex.org/W1868577792","https://openalex.org/W1904012459","https://openalex.org/W1967289387","https://openalex.org/W1968578345","https://openalex.org/W1973541175","https://openalex.org/W1980269923","https://openalex.org/W1983388632","https://openalex.org/W1986415802","https://openalex.org/W1997962857","https://openalex.org/W1998311599","https://openalex.org/W1998626317","https://openalex.org/W2002513358","https://openalex.org/W2003443990","https://openalex.org/W2003731107","https://openalex.org/W2012895196","https://openalex.org/W2017326015","https://openalex.org/W2021919788","https://openalex.org/W2022394342","https://openalex.org/W2026489455","https://openalex.org/W2033713371","https://openalex.org/W2036699877","https://openalex.org/W2037199116","https://openalex.org/W2051439628","https://openalex.org/W2053210112","https://openalex.org/W2063663222","https://openalex.org/W2063690790","https://openalex.org/W2076480502","https://openalex.org/W2087548571","https://openalex.org/W2092482155","https://openalex.org/W2093084247","https://openalex.org/W2096576609","https://openalex.org/W2107429180","https://openalex.org/W2108112343","https://openalex.org/W2110337011","https://openalex.org/W2116654252","https://openalex.org/W2118098299","https://openalex.org/W2120383449","https://openalex.org/W2120419344","https://openalex.org/W2125099638","https://openalex.org/W2132771789","https://openalex.org/W2141859364","https://openalex.org/W2144603992","https://openalex.org/W2151829259","https://openalex.org/W2156374977","https://openalex.org/W2162306218","https://openalex.org/W2162829549","https://openalex.org/W2164718846","https://openalex.org/W2300594393","https://openalex.org/W2333438127","https://openalex.org/W2346732241","https://openalex.org/W2400573496","https://openalex.org/W2509816044","https://openalex.org/W2556280095","https://openalex.org/W2591860688","https://openalex.org/W2603154743","https://openalex.org/W2605950351","https://openalex.org/W2797916159","https://openalex.org/W4237892712"],"related_works":["https://openalex.org/W2164718846","https://openalex.org/W3010034984","https://openalex.org/W1606161617","https://openalex.org/W2406332580","https://openalex.org/W2043402753","https://openalex.org/W2394577813","https://openalex.org/W2086697802","https://openalex.org/W2161709410","https://openalex.org/W2168300994","https://openalex.org/W3215358904"],"abstract_inverted_index":{"exchanger":[0],"3":[1],"(NHE3;":[2],"also":[3],"known":[4],"as":[5],"SLC9A3).":[6],"The":[7],"mechanism(s)":[8],"by":[9,115,131,135,156],"which":[10,43],"CT":[11,32,111,126],"inhibits":[12,44],"NHE3":[13,48,63,151],"is":[14],"partially":[15,129],"understood,":[16],"although":[17],"no":[18],"drug":[19],"therapy":[20],"has":[21,161],"been":[22],"successful":[23],"at":[24],"reversing":[25],"this":[26,88],"inhibition.":[27],"We":[28],"now":[29],"describe":[30],"that":[31,68,84,107],"phosphorylates":[33],"an":[34,162],"amino":[35],"acid":[36],"in":[37],"the":[38,50,54,85,93,117,168,172],"PDZ":[39],"domain":[40],"of":[41,47,87,90,98,104,119,125,171],"SNX27,":[42],"SNX27-mediated":[45],"trafficking":[46,103],"from":[49],"early":[51],"endosomes":[52],"to":[53,60,81,145],"plasma":[55],"membrane":[56],"(PM),":[57],"and":[58,73,148,153],"contributes":[59],"reduced":[61,70,74],"basal":[62,147],"activity":[64,152],"through":[65],"a":[66],"mechanism":[67],"involves":[69],"PM":[71,102],"expression":[72],"endocytic":[75],"recycling.":[76],"Importantly,":[77],"mutagenesis":[78],"studies":[79],"(Ser":[80],"Asp)":[82],"showed":[83],"effect":[86],"phosphorylation":[89],"SNX27":[91,99],"phenocopies":[92],"effects":[94,124],"seen":[95],"upon":[96],"loss":[97],"function,":[100],"affecting":[101],"cargo":[105],"proteins":[106],"bind":[108],"SNX27-retromer.":[109],"Additionally,":[110],"destabilizes":[112],"retromer":[113,121,133],"function":[114],"decreasing":[116],"amount":[118],"core":[120],"proteins.":[122],"These":[123],"can":[127,142],"be":[128,143],"rescued":[130],"enhancing":[132],"stability":[134],"using":[136],"'pharmacological":[137],"chaperones'.":[138],"Moreover,":[139],"pharmacological":[140],"chaperones":[141],"used":[144],"increase":[146],"cholera":[149],"toxin-inhibited":[150],"fluid":[154],"absorption":[155],"intestinal":[157],"epithelial":[158],"cells.This":[159],"article":[160],"associated":[163],"First":[164],"Person":[165],"interview":[166],"with":[167],"first":[169],"author":[170],"paper.":[173]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-08-03T00:00:00"}
