{"id":"https://openalex.org/W2883669998","doi":"https://doi.org/10.1083/jcb.201804171","title":"\u03b3-Secretase promotes membrane insertion of the human papillomavirus L2 capsid protein during virus infection","display_name":"\u03b3-Secretase promotes membrane insertion of the human papillomavirus L2 capsid protein during virus infection","publication_year":2018,"publication_date":"2018-07-13","ids":{"openalex":"https://openalex.org/W2883669998","doi":"https://doi.org/10.1083/jcb.201804171","mag":"2883669998","pmid":"https://pubmed.ncbi.nlm.nih.gov/30006461","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6168257"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.201804171","doi":"https://doi.org/10.1083/jcb.201804171","is_oa":true,"landing_page_url":"https://doi.org/10.1083/jcb.201804171","pdf_url":"https://rupress.org/jcb/article-pdf/217/10/3545/1377754/jcb_201804171.pdf","source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://rupress.org/jcb/article-pdf/217/10/3545/1377754/jcb_201804171.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101802708","display_name":"Takamasa Inoue","orcid":"https://orcid.org/0000-0001-5875-8808","observed_orcids":["https://orcid.org/0000-0001-5875-8808"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takamasa Inoue","raw_affiliation_strings":["Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 1","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065539835","display_name":"Pengwei Zhang","orcid":"https://orcid.org/0009-0009-5291-4238","observed_orcids":["https://orcid.org/0009-0009-5291-4238"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pengwei Zhang","raw_affiliation_strings":["Department of Genetics, Yale School of Medicine, New Haven, CT 2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Yale School of Medicine, New Haven, CT 2","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100441798","display_name":"Wei Zhang","orcid":"https://orcid.org/0000-0003-3938-1245","observed_orcids":["https://orcid.org/0000-0003-3938-1245"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["Department of Genetics, Yale School of Medicine, New Haven, CT 2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Yale School of Medicine, New Haven, CT 2","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087683979","display_name":"Kylia Goodner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kylia Goodner-Bingham","raw_affiliation_strings":["Department of Genetics, Yale School of Medicine, New Haven, CT 2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Yale School of Medicine, New Haven, CT 2","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006789972","display_name":"Allison Dupzyk","orcid":"https://orcid.org/0000-0003-1473-4489","observed_orcids":["https://orcid.org/0000-0003-1473-4489"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allison Dupzyk","raw_affiliation_strings":["Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 1","Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 6"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 1","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 6","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028430067","display_name":"Daniel DiMaio","orcid":"https://orcid.org/0000-0002-2060-5977","observed_orcids":["https://orcid.org/0000-0002-2060-5977"]},"institutions":[{"id":"https://openalex.org/I2802730090","display_name":"Yale Cancer Center","ror":"https://ror.org/03j7sze86","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802730090","https://openalex.org/I4210117499","https://openalex.org/I4210165192"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel DiMaio","raw_affiliation_strings":["Department of Genetics, Yale School of Medicine, New Haven, CT 2","Department of Molecular Biophysics and Biochemistry, Yale School of Medicine, New Haven, CT 4","Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 3","Yale Cancer Center, New Haven, CT 5"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Yale School of Medicine, New Haven, CT 2","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale School of Medicine, New Haven, CT 4","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 3","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale Cancer Center, New Haven, CT 5","institution_ids":["https://openalex.org/I2802730090"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036553460","display_name":"Billy Tsai","orcid":"https://orcid.org/0000-0003-2859-1415","observed_orcids":["https://orcid.org/0000-0003-2859-1415"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Billy Tsai","raw_affiliation_strings":["Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 1"],"raw_orcid":"https://orcid.org/0000-0003-2859-1415","affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 1","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5036553460"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"],"apc_list":null,"apc_paid":null,"fwci":4.3692,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.95148343,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"217","issue":"10","first_page":"3545","last_page":"3559"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.8285999894142151,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.8285999894142151,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.11180000007152557,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gamma-secretase","display_name":"gamma-secretase","score":0.9549999833106995},{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.9909999966621399},{"id":"https://openalex.org/keywords/l2-capsid-protein","display_name":"L2 capsid protein","score":0.9679999947547913},{"id":"https://openalex.org/keywords/membrane-insertion","display_name":"membrane insertion","score":0.8659999966621399},{"id":"https://openalex.org/keywords/virus-entry","display_name":"viral entry","score":0.6610000133514404},{"id":"https://openalex.org/keywords/endosomal-membrane","display_name":"endosomal membrane","score":0.5899999737739563},{"id":"https://openalex.org/keywords/retromer-complex","display_name":"retromer complex","score":0.8610000014305115},{"id":"https://openalex.org/keywords/retrograde-transport","display_name":"retrograde transport","score":0.9729999899864197},{"id":"https://openalex.org/keywords/golgi-apparatus","display_name":"Golgi apparatus","score":0.8500000238418579},{"id":"https://openalex.org/keywords/chaperone-activity","display_name":"chaperone activity","score":0.7459999918937683},{"id":"https://openalex.org/keywords/proteolytic-processing","display_name":"proteolytic processing","score":0.7250000238418579},{"id":"https://openalex.org/keywords/low-ph","display_name":"low pH","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.7608568668365479},{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.6932193040847778},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5996536612510681},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.5944960713386536},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5502302646636963},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.47970646619796753},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.47432324290275574},{"id":"https://openalex.org/C145458877","wikidata":"https://www.wikidata.org/wiki/Q7317044","display_name":"Retromer","level":4,"score":0.4667739272117615},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.46600422263145447},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.45822465419769287},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.4334694445133209},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.42092758417129517},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.2167762815952301},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12002766132354736},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.11689046025276184},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09141978621482849},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08970651030540466},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006056","descriptor_name":"Golgi Apparatus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006056","descriptor_name":"Golgi Apparatus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006056","descriptor_name":"Golgi Apparatus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006056","descriptor_name":"Golgi Apparatus","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009856","descriptor_name":"Oncogene Proteins, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009856","descriptor_name":"Oncogene Proteins, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D052162","descriptor_name":"Human papillomavirus 16","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052162","descriptor_name":"Human papillomavirus 16","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1083/jcb.201804171","doi":"https://doi.org/10.1083/jcb.201804171","is_oa":true,"landing_page_url":"https://doi.org/10.1083/jcb.201804171","pdf_url":"https://rupress.org/jcb/article-pdf/217/10/3545/1377754/jcb_201804171.pdf","source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5423543","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6168257","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6168257","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6168257","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:30006461","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30006461","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1083/jcb.201804171","doi":"https://doi.org/10.1083/jcb.201804171","is_oa":true,"landing_page_url":"https://doi.org/10.1083/jcb.201804171","pdf_url":"https://rupress.org/jcb/article-pdf/217/10/3545/1377754/jcb_201804171.pdf","source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1099537107","display_name":"The essential role of gamma-secretase in human papillomavirus infection","funder_award_id":"F32AI114132","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1835437302","display_name":"How polyomaviruses penetrate the ER membrane","funder_award_id":"R01AI064296","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8537180639","display_name":"Role of Retromer-mediated Retrograde Transport in HPV Entry","funder_award_id":"R01AI102876","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8624074680","display_name":"Molecular Basis of Cancer Virus Replication, Transformation, and Innate Defense","funder_award_id":"P01CA016038","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8718966553","display_name":null,"funder_award_id":"AI120486","funder_id":"https://openalex.org/F4320311255","funder_display_name":"Israel National Road Safety Authority"},{"id":"https://openalex.org/G8804894181","display_name":"Mechanism of endosomal membrane penetration by Human Papillomavirus 16","funder_award_id":"F31AI120486","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8862638037","display_name":"A novel cytosolic chaperone complex in polyomavirus ER membrane transport","funder_award_id":"R01GM113722","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000132752","display_name":null,"funder_award_id":"CA016038","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320311255","display_name":"Israel National Road Safety Authority","ror":"https://ror.org/03zqvfs52"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2883669998.pdf","grobid_xml":"https://content.openalex.org/works/W2883669998.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W46899889","https://openalex.org/W1552188451","https://openalex.org/W1875899284","https://openalex.org/W1933856345","https://openalex.org/W1941700947","https://openalex.org/W1965015341","https://openalex.org/W1971200157","https://openalex.org/W1976338165","https://openalex.org/W1992461042","https://openalex.org/W1994373739","https://openalex.org/W1997283942","https://openalex.org/W2007245430","https://openalex.org/W2012616842","https://openalex.org/W2019708706","https://openalex.org/W2033546933","https://openalex.org/W2037754405","https://openalex.org/W2040839560","https://openalex.org/W2041725513","https://openalex.org/W2048162805","https://openalex.org/W2070164943","https://openalex.org/W2074766470","https://openalex.org/W2075829521","https://openalex.org/W2081758487","https://openalex.org/W2091046596","https://openalex.org/W2092790680","https://openalex.org/W2099104401","https://openalex.org/W2106682089","https://openalex.org/W2111312569","https://openalex.org/W2113166966","https://openalex.org/W2119010277","https://openalex.org/W2128681927","https://openalex.org/W2137458535","https://openalex.org/W2138224402","https://openalex.org/W2142973505","https://openalex.org/W2143158562","https://openalex.org/W2146581496","https://openalex.org/W2150088870","https://openalex.org/W2159872486","https://openalex.org/W2160107586","https://openalex.org/W2167294127","https://openalex.org/W2248874440","https://openalex.org/W2314207955","https://openalex.org/W2329336071","https://openalex.org/W2339855837","https://openalex.org/W2444052028","https://openalex.org/W2559911659","https://openalex.org/W2610886919","https://openalex.org/W2611626290","https://openalex.org/W2619962752","https://openalex.org/W2626576440","https://openalex.org/W2769973950","https://openalex.org/W6640558792"],"related_works":["https://openalex.org/W4224036389","https://openalex.org/W2099104401","https://openalex.org/W3094207589","https://openalex.org/W7098628719","https://openalex.org/W2040839560","https://openalex.org/W4378345776","https://openalex.org/W1933856345","https://openalex.org/W3176264890","https://openalex.org/W7098849916","https://openalex.org/W3179126517"],"abstract_inverted_index":{"Despite":[0],"their":[1],"importance":[2],"as":[3],"human":[4,8],"pathogens,":[5],"entry":[6],"of":[7,28,34,41,62,105,136],"papillomaviruses":[9],"(HPVs)":[10],"into":[11,68],"cells":[12],"is":[13,108,126],"poorly":[14],"understood.":[15],"The":[16],"transmembrane":[17],"protease":[18],"\u03b3-secretase":[19,35,51,125],"executes":[20],"a":[21,53,102],"crucial":[22],"function":[23],"during":[24],"the":[25,32,39,63,76,81,88,95,140,143],"early":[26],"stages":[27],"HPV":[29,64,119],"infection,":[30],"but":[31],"role":[33],"in":[36],"infection":[37],"and":[38,92],"identity":[40],"its":[42],"critical":[43],"substrate":[44],"are":[45],"unknown.":[46],"Here":[47],"we":[48],"demonstrate":[49,123],"that":[50,124,131],"harbors":[52],"previously":[54],"uncharacterized":[55],"chaperone":[56],"function,":[57],"promoting":[58],"low":[59],"pH-dependent":[60],"insertion":[61,135],"L2":[65,74,82,107],"capsid":[66],"protein":[67],"endosomal":[69],"membranes.":[70],"Upon":[71],"membrane":[72,134],"insertion,":[73],"recruits":[75],"cytosolic":[77],"retromer,":[78],"which":[79],"enables":[80],"viral":[83],"genome":[84],"complex":[85],"to":[86,94,142],"enter":[87],"retrograde":[89],"transport":[90],"pathway":[91],"traffic":[93],"Golgi":[96],"en":[97],"route":[98],"for":[99,118],"infection.":[100,120],"Although":[101],"small":[103],"fraction":[104],"membrane-inserted":[106],"also":[109],"cleaved":[110],"by":[111],"\u03b3-secretase,":[112],"this":[113],"proteolytic":[114],"event":[115],"appears":[116],"dispensable":[117],"Our":[121],"findings":[122],"endowed":[127],"with":[128],"an":[129],"activity":[130],"can":[132],"promote":[133],"L2,":[137],"thereby":[138],"targeting":[139],"virus":[141],"productive":[144],"infectious":[145],"pathway.":[146]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-08-03T00:00:00"}
