{"id":"https://openalex.org/W2883594553","doi":"https://doi.org/10.1016/j.toxrep.2018.07.001","title":"Non-clinical acute and chronic toxicity evaluations of Cissus sicyoides L. (Vitaceae) hydroalcoholic leaf extract","display_name":"Non-clinical acute and chronic toxicity evaluations of Cissus sicyoides L. (Vitaceae) hydroalcoholic leaf extract","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2883594553","doi":"https://doi.org/10.1016/j.toxrep.2018.07.001","mag":"2883594553","pmid":"https://pubmed.ncbi.nlm.nih.gov/30181957","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6120429"},"language":"en","primary_location":{"id":"doi:10.1016/j.toxrep.2018.07.001","doi":"https://doi.org/10.1016/j.toxrep.2018.07.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.toxrep.2018.07.001","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2214750018302889/pdf","source":{"id":"https://openalex.org/S2764757124","display_name":"Toxicology Reports","issn_l":"2214-7500","issn":["2214-7500"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2214750018302889/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075001895","display_name":"Margareth de F\u00e1tima Formiga Melo Diniz","orcid":"https://orcid.org/0000-0001-9896-9044","observed_orcids":["https://orcid.org/0000-0001-9896-9044"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]},{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Margareth de F\u00e1tima Formiga Melo Diniz","raw_affiliation_strings":["Departamento de Ci\u00eancias Farmac\u00eauticas, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","Laborat\u00f3rio de Ensaios Toxicol\u00f3gicos do Instituto de Pesquisa em F\u00e1rmacos e Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","Programa de P\u00f3s-Gradua\u00e7\u00e3o em Desenvolvimento e Inova\u00e7\u00e3o Tecnol\u00f3gica em Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","Programa de P\u00f3s-Gradua\u00e7\u00e3o em F\u00e1rmacos e Medicamentos da Universidade de S\u00e3o Paulo - USP, S\u00e3o Paulo, 05508-000, Brazil","Programa de P\u00f3s-Gradua\u00e7\u00e3o em Produtos Naturais e Sint\u00e9ticos Bioativos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ci\u00eancias Farmac\u00eauticas, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","institution_ids":["https://openalex.org/I169045520"]},{"raw_affiliation_string":"Laborat\u00f3rio de Ensaios Toxicol\u00f3gicos do Instituto de Pesquisa em F\u00e1rmacos e Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","institution_ids":["https://openalex.org/I169045520"]},{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Desenvolvimento e Inova\u00e7\u00e3o Tecnol\u00f3gica em Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","institution_ids":["https://openalex.org/I169045520"]},{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em F\u00e1rmacos e Medicamentos da Universidade de S\u00e3o Paulo - USP, S\u00e3o Paulo, 05508-000, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Produtos Naturais e Sint\u00e9ticos Bioativos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040254525","display_name":"Hilzeth de Luna Freire P\u00eassoa","orcid":"https://orcid.org/0000-0002-7420-2014","observed_orcids":["https://orcid.org/0000-0002-7420-2014"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Hilzeth de Luna Freire Pess\u00f4a","raw_affiliation_strings":["Laborat\u00f3rio de Ensaios Toxicol\u00f3gicos do Instituto de Pesquisa em F\u00e1rmacos e Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","Programa de P\u00f3s-Gradua\u00e7\u00e3o em Desenvolvimento e Inova\u00e7\u00e3o Tecnol\u00f3gica em Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Ensaios Toxicol\u00f3gicos do Instituto de Pesquisa em F\u00e1rmacos e Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","institution_ids":["https://openalex.org/I169045520"]},{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Desenvolvimento e Inova\u00e7\u00e3o Tecnol\u00f3gica em Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003947614","display_name":"Camila Bomfim de S\u00e1","orcid":"https://orcid.org/0000-0001-9555-488X","observed_orcids":["https://orcid.org/0000-0001-9555-488X"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Camila Bomfim de S\u00e1","raw_affiliation_strings":["Laborat\u00f3rio de Ensaios Toxicol\u00f3gicos do Instituto de Pesquisa em F\u00e1rmacos e Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","Programa de P\u00f3s-Gradua\u00e7\u00e3o em Produtos Naturais e Sint\u00e9ticos Bioativos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-9555-488X","affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Ensaios Toxicol\u00f3gicos do Instituto de Pesquisa em F\u00e1rmacos e Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","institution_ids":["https://openalex.org/I169045520"]},{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Produtos Naturais e Sint\u00e9ticos Bioativos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076353994","display_name":"Andressa Brito Lira","orcid":"https://orcid.org/0000-0003-4532-1986","observed_orcids":["https://orcid.org/0000-0003-4532-1986"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Andressa Brito Lira","raw_affiliation_strings":["Laborat\u00f3rio de Ensaios Toxicol\u00f3gicos do Instituto de Pesquisa em F\u00e1rmacos e Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","Programa de P\u00f3s-Gradua\u00e7\u00e3o em Produtos Naturais e Sint\u00e9ticos Bioativos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-4532-1986","affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Ensaios Toxicol\u00f3gicos do Instituto de Pesquisa em F\u00e1rmacos e Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","institution_ids":["https://openalex.org/I169045520"]},{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Produtos Naturais e Sint\u00e9ticos Bioativos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018239618","display_name":"Luciana da Silva Nunes Ramalho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luciana da Silva Nunes Ramalho","raw_affiliation_strings":["Laborat\u00f3rio de Ensaios Toxicol\u00f3gicos do Instituto de Pesquisa em F\u00e1rmacos e Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","Programa de P\u00f3s-Gradua\u00e7\u00e3o em Desenvolvimento e Inova\u00e7\u00e3o Tecnol\u00f3gica em Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Ensaios Toxicol\u00f3gicos do Instituto de Pesquisa em F\u00e1rmacos e Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","institution_ids":["https://openalex.org/I169045520"]},{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Desenvolvimento e Inova\u00e7\u00e3o Tecnol\u00f3gica em Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057676324","display_name":"Kardil\u00e2ndia Mendes de Oliveira","orcid":"https://orcid.org/0000-0003-4281-139X","observed_orcids":["https://orcid.org/0000-0003-4281-139X"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Kardilandia Mendes de Oliveira","raw_affiliation_strings":["Departamento de Ci\u00eancias Farmac\u00eauticas, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","Laborat\u00f3rio de Ensaios Toxicol\u00f3gicos do Instituto de Pesquisa em F\u00e1rmacos e Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","Programa de P\u00f3s-Gradua\u00e7\u00e3o em Desenvolvimento e Inova\u00e7\u00e3o Tecnol\u00f3gica em Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-4281-139X","affiliations":[{"raw_affiliation_string":"Departamento de Ci\u00eancias Farmac\u00eauticas, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","institution_ids":["https://openalex.org/I169045520"]},{"raw_affiliation_string":"Laborat\u00f3rio de Ensaios Toxicol\u00f3gicos do Instituto de Pesquisa em F\u00e1rmacos e Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","institution_ids":["https://openalex.org/I169045520"]},{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Desenvolvimento e Inova\u00e7\u00e3o Tecnol\u00f3gica em Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083192923","display_name":"Gabriela Tafaela Dias","orcid":"https://orcid.org/0000-0001-5885-172X","observed_orcids":["https://orcid.org/0000-0001-5885-172X"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gabriela Tafaela Dias","raw_affiliation_strings":["Laborat\u00f3rio de Ensaios Toxicol\u00f3gicos do Instituto de Pesquisa em F\u00e1rmacos e Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Ensaios Toxicol\u00f3gicos do Instituto de Pesquisa em F\u00e1rmacos e Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021345913","display_name":"Cinthia Rodrigues Melo","orcid":"https://orcid.org/0000-0002-7251-9616","observed_orcids":["https://orcid.org/0000-0002-7251-9616"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Cinthia Rodrigues Melo","raw_affiliation_strings":["Laborat\u00f3rio de Ensaios Toxicol\u00f3gicos do Instituto de Pesquisa em F\u00e1rmacos e Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-7251-9616","affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Ensaios Toxicol\u00f3gicos do Instituto de Pesquisa em F\u00e1rmacos e Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070440335","display_name":"Josu\u00e9 do Amaral Ramalho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Josu\u00e9 do Amaral Ramalho","raw_affiliation_strings":["Laborat\u00f3rio de Ensaios Toxicol\u00f3gicos do Instituto de Pesquisa em F\u00e1rmacos e Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Ensaios Toxicol\u00f3gicos do Instituto de Pesquisa em F\u00e1rmacos e Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011351920","display_name":"Caliandra Maria Bezerra Luna Lima","orcid":"https://orcid.org/0000-0001-5478-4435","observed_orcids":["https://orcid.org/0000-0001-5478-4435","https://orcid.org/0000-0002-3569-9638"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Caliandra Maria Bezerra Luna Lima","raw_affiliation_strings":["Departamento de Fisiologia e Patologia, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","Laborat\u00f3rio de Ensaios Toxicol\u00f3gicos do Instituto de Pesquisa em F\u00e1rmacos e Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","Programa de P\u00f3s-Gradua\u00e7\u00e3o em Modelos de DecisP\u00e3o e Sa\u00fade, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-900, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Fisiologia e Patologia, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","institution_ids":["https://openalex.org/I169045520"]},{"raw_affiliation_string":"Laborat\u00f3rio de Ensaios Toxicol\u00f3gicos do Instituto de Pesquisa em F\u00e1rmacos e Medicamentos, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-970, Brazil","institution_ids":["https://openalex.org/I169045520"]},{"raw_affiliation_string":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Modelos de DecisP\u00e3o e Sa\u00fade, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, 58051-900, Brazil","institution_ids":["https://openalex.org/I169045520"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5075001895"],"corresponding_institution_ids":["https://openalex.org/I169045520","https://openalex.org/I17974374"],"apc_list":{"value":2530,"currency":"USD","value_usd":2530},"apc_paid":{"value":2530,"currency":"USD","value_usd":2530},"fwci":0.6449,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.69162752,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"5","issue":null,"first_page":"890","last_page":"896"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12756","display_name":"Plant Toxicity and Pharmacological Properties","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cissus-sicyoides","display_name":"Cissus sicyoides","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hydroalcoholic-leaf-extract","display_name":"hydroalcoholic leaf extract","score":0.781000018119812},{"id":"https://openalex.org/keywords/acute-toxicity","display_name":"acute toxicity","score":0.8510000109672546},{"id":"https://openalex.org/keywords/chronic-toxicity","display_name":"chronic toxicity","score":0.9620000123977661},{"id":"https://openalex.org/keywords/hematological-parameters","display_name":"hematological parameters","score":0.7039999961853027},{"id":"https://openalex.org/keywords/biochemical-parameters","display_name":"biochemical parameters","score":0.8949999809265137},{"id":"https://openalex.org/keywords/glycemia","display_name":"glycemia","score":0.859000027179718},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.5049999952316284},{"id":"https://openalex.org/keywords/erythrocytes","display_name":"erythrocytes","score":0.5899999737739563},{"id":"https://openalex.org/keywords/aspartate-aminotransferase","display_name":"aspartate aminotransferase","score":0.8360000252723694},{"id":"https://openalex.org/keywords/uric-acid","display_name":"uric acid","score":0.9010000228881836},{"id":"https://openalex.org/keywords/amylase","display_name":"amylase","score":0.6940000057220459},{"id":"https://openalex.org/keywords/histopathology","display_name":"histopathology","score":0.5709999799728394},{"id":"https://openalex.org/keywords/herbal-medicine-safety","display_name":"herbal medicine safety","score":0.5920000076293945},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C2779371508","wikidata":"https://www.wikidata.org/wiki/Q26220","display_name":"Vitaceae","level":3,"score":0.8500477075576782},{"id":"https://openalex.org/C162156334","wikidata":"https://www.wikidata.org/wiki/Q473420","display_name":"Dose","level":2,"score":0.7649915814399719},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.7146445512771606},{"id":"https://openalex.org/C116263406","wikidata":"https://www.wikidata.org/wiki/Q3299024","display_name":"Acute toxicity","level":3,"score":0.7086878418922424},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6589999794960022},{"id":"https://openalex.org/C53164099","wikidata":"https://www.wikidata.org/wiki/Q5114007","display_name":"Chronic toxicity","level":3,"score":0.5036856532096863},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.48414215445518494},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.4816804826259613},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.4146011471748352},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.39447587728500366},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3810915946960449},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.35342973470687866},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2798861563205719},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26331883668899536},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21987587213516235},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1412612497806549},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.11268728971481323},{"id":"https://openalex.org/C2992143071","wikidata":"https://www.wikidata.org/wiki/Q30046","display_name":"Vitis vinifera","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.toxrep.2018.07.001","doi":"https://doi.org/10.1016/j.toxrep.2018.07.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.toxrep.2018.07.001","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2214750018302889/pdf","source":{"id":"https://openalex.org/S2764757124","display_name":"Toxicology Reports","issn_l":"2214-7500","issn":["2214-7500"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5074260","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6120429","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30181957","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30181957","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6120429","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6120429/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicol Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:91db007699344c8abedd8b87993655a6","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/91db007699344c8abedd8b87993655a6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Toxicology Reports, Vol 5, Iss , Pp 890-896 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.toxrep.2018.07.001","doi":"https://doi.org/10.1016/j.toxrep.2018.07.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.toxrep.2018.07.001","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2214750018302889/pdf","source":{"id":"https://openalex.org/S2764757124","display_name":"Toxicology Reports","issn_l":"2214-7500","issn":["2214-7500"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2883594553.pdf","grobid_xml":"https://content.openalex.org/works/W2883594553.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W18059750","https://openalex.org/W1523749459","https://openalex.org/W1529534524","https://openalex.org/W1539904063","https://openalex.org/W1544761525","https://openalex.org/W1666287743","https://openalex.org/W1920912273","https://openalex.org/W1928219841","https://openalex.org/W1979500594","https://openalex.org/W1989954292","https://openalex.org/W1996485351","https://openalex.org/W2016431808","https://openalex.org/W2026156396","https://openalex.org/W2034643854","https://openalex.org/W2074352356","https://openalex.org/W2075666907","https://openalex.org/W2076320739","https://openalex.org/W2165863947","https://openalex.org/W2283795933","https://openalex.org/W2465908331","https://openalex.org/W2505718079","https://openalex.org/W2572222530","https://openalex.org/W2596736177","https://openalex.org/W4235361508","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2596736177","https://openalex.org/W4412687313","https://openalex.org/W1539904063","https://openalex.org/W1979500594","https://openalex.org/W1879735667","https://openalex.org/W2739439425","https://openalex.org/W4300716714","https://openalex.org/W3165979116","https://openalex.org/W2755290951","https://openalex.org/W2931324710"],"abstract_inverted_index":{"Cissus":[0,40],"sicyoides":[1,41],"(Cs)":[2],"has":[3],"been":[4],"traditionally":[5],"used":[6],"to":[7,12,25,65],"treat":[8],"diabetes":[9],"and":[10,16,29,77,79,89,99,112,132,169,208,210,230,233,244,268,272,319,325,356],"belongs":[11],"the":[13,27,37,85,129,138,141,144,148,185,191,215,226,240,277,296,304,315,329,335,352],"family":[14],"Vitaceae,":[15],"is":[17],"known":[18],"as":[19,351],"\u201cvegetable":[20],"insulin\".":[21],"This":[22],"study":[23],"aimed":[24],"evaluate":[26],"acute":[28,44,158],"chronic":[30,103,216],"non-clinical":[31],"toxicity":[32,217,312],"of":[33,39,55,68,74,97,109,152,190,197,228,242,279,331],"hydroalcoholic":[34],"extract":[35],"from":[36],"leaves":[38],"(EHA-Cs).":[42],"The":[43,102,115,299],"test":[45],"was":[46,177,221,288],"performed":[47],"in":[48,107,167,181,201,206,212,266,270,283,303,323,347],"Wistar":[49],"rats,":[50],"administering":[51],"a":[52,178,309],"single":[53],"dose":[54,278,330],"40.5":[56,113,231,237],"mg/kg.":[57,114],"Behavioral":[58],"parameters":[59,117,327],"for":[60,94,184,223,234,250,253,274],"pharmacological":[61],"screening":[62],"were":[63,87,92,105,118,155,161,301],"observed":[64,119],"detect":[66],"signs":[67],"Central":[69],"Nervous":[70],"System":[71],"activity;":[72],"consumption":[73,220,248],"daily":[75],"food":[76,170],"water,":[78],"weight":[80,182,259],"evaluation.":[81],"After":[82],"day":[83],"14,":[84],"animals":[86,193],"euthanized":[88],"blood":[90],"samples":[91],"collected":[93],"laboratory":[95],"analyses":[96,189],"hematological":[98,324],"biochemical":[100,326],"parameters.":[101,174],"tests":[104,136],"administered":[106],"doses":[108],"4.5,":[110],"13.5":[111,229,245,280,332],"same":[116],"together":[120],"with":[121,258],"body":[122],"temperature,":[123],"glucose,":[124],"exploration":[125],"activity":[126,134],"(test":[127],"on":[128,137],"open":[130],"field),":[131],"motor":[133],"(diagnostic":[135],"Rota-rod).":[139],"For":[140,157],"group":[142],"given":[143],"highest":[145],"dosage":[146],"during":[147],"study,":[149],"histopathological":[150],"examinations":[151],"vital":[153,348],"organs":[154,349],"performed.":[156],"toxicity,":[159],"there":[160,176],"no":[162],"CNS":[163],"level":[164],"effects,":[165],"changes":[166,269,300,322,346],"water":[168,219],"consumption,":[171],"or":[172],"hematologic":[173],"However,":[175],"significant":[179],"decrease":[180],"gain":[183],"treated":[186,192],"females.":[187],"Biochemical":[188],"presented":[194,263],"increased":[195,249],"levels":[196,205],"AST":[198],"(aspartate":[199],"aminotransferase)":[200],"females,":[202,251],"uric":[203],"acid":[204],"females":[207,224,284],"males,":[209],"amylase":[211],"males.":[213],"In":[214,339],"tests,":[218],"higher":[222],"(at":[225,236,276,314],"dosages":[227,241],"mg/kg)":[232],"males":[235,254,275],"mg/kg).":[238,281],"At":[239],"4.5":[243],"mg/kg,":[246],"feed":[247],"while":[252],"it":[255],"decreased":[256],"along":[257],"gain.":[260],"Blood":[261],"analysis":[262],"an":[264],"increase":[265],"albumin":[267],"erythrocytes":[271],"hemoglobin":[273],"Glycemia":[282],"(13.5":[285],"mg/kg":[286,333],"dose)":[287],"significantly":[289],"less,":[290],"presenting":[291],"only":[292,320],"slight":[293],"drops":[294],"at":[295,328],"other":[297],"doses.":[298],"reversible":[302],"satellite":[305],"group.":[306],"EHA-Cs":[307,341],"revealed":[308],"relatively":[310],"low":[311],"profile":[313],"popular":[316,336],"use":[317,337],"dose),":[318],"small":[321],"(3x":[334],"dosage).":[338],"addition,":[340],"did":[342],"not":[343],"promote":[344],"histological":[345],"such":[350],"heart,":[353],"lungs,":[354],"liver":[355],"kidneys.":[357]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-08-03T00:00:00"}
