{"id":"https://openalex.org/W2883593119","doi":"https://doi.org/10.1186/s12943-018-0851-8","title":"Suppression of PDHX by microRNA-27b deregulates cell metabolism and promotes growth in breast cancer","display_name":"Suppression of PDHX by microRNA-27b deregulates cell metabolism and promotes growth in breast cancer","publication_year":2018,"publication_date":"2018-07-16","ids":{"openalex":"https://openalex.org/W2883593119","doi":"https://doi.org/10.1186/s12943-018-0851-8","mag":"2883593119","pmid":"https://pubmed.ncbi.nlm.nih.gov/30012170","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6048708"},"language":"en","primary_location":{"id":"doi:10.1186/s12943-018-0851-8","doi":"https://doi.org/10.1186/s12943-018-0851-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12943-018-0851-8","pdf_url":"https://molecular-cancer.biomedcentral.com/track/pdf/10.1186/s12943-018-0851-8","source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://molecular-cancer.biomedcentral.com/track/pdf/10.1186/s12943-018-0851-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039624108","display_name":"Steven C. Eastlack","orcid":"https://orcid.org/0009-0007-8787-1528","observed_orcids":["https://orcid.org/0009-0007-8787-1528"]},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven C. Eastlack","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Stanley S. Scott Cancer Center, LSUHSC School of Medicine, New Orleans, LA, 70112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Stanley S. Scott Cancer Center, LSUHSC School of Medicine, New Orleans, LA, 70112, USA","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100939059","display_name":"Shengli Dong","orcid":"https://orcid.org/0009-0005-5798-6477","observed_orcids":["https://orcid.org/0009-0005-5798-6477"]},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shengli Dong","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Stanley S. Scott Cancer Center, LSUHSC School of Medicine, New Orleans, LA, 70112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Stanley S. Scott Cancer Center, LSUHSC School of Medicine, New Orleans, LA, 70112, USA","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082498438","display_name":"Cristina Ivan","orcid":"https://orcid.org/0000-0002-4848-0168","observed_orcids":["https://orcid.org/0000-0002-4848-0168"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristina Ivan","raw_affiliation_strings":["Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049332865","display_name":"Suresh K. Alahari","orcid":"https://orcid.org/0000-0002-9651-6727","observed_orcids":["https://orcid.org/0000-0002-9651-6727"]},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Suresh K. Alahari","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Stanley S. Scott Cancer Center, LSUHSC School of Medicine, New Orleans, LA, 70112, USA. salaha@lsuhsc.edu","Department of Biochemistry and Molecular Biology, Stanley S. Scott Cancer Center, LSUHSC School of Medicine, New Orleans, LA, 70112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Stanley S. Scott Cancer Center, LSUHSC School of Medicine, New Orleans, LA, 70112, USA. salaha@lsuhsc.edu","institution_ids":["https://openalex.org/I75420490"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Stanley S. Scott Cancer Center, LSUHSC School of Medicine, New Orleans, LA, 70112, USA","institution_ids":["https://openalex.org/I75420490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5049332865"],"corresponding_institution_ids":["https://openalex.org/I75420490"],"apc_list":{"value":5090,"currency":"USD","value_usd":5090},"apc_paid":{"value":5090,"currency":"USD","value_usd":5090},"fwci":2.4029,"has_fulltext":true,"cited_by_count":65,"citation_normalized_percentile":{"value":0.8998655,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"17","issue":"1","first_page":"100","last_page":"100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.032099999487400055,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna-27b","display_name":"microRNA-27b","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pdhx","display_name":"PdHx","score":0.9350000023841858},{"id":"https://openalex.org/keywords/pyruvate-dehydrogenase-e1-beta-subunit","display_name":"pyruvate dehydrogenase E1 beta subunit","score":0.906000018119812},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.8450000286102295},{"id":"https://openalex.org/keywords/warburg-effect","display_name":"Warburg effect","score":0.9049999713897705},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8610000014305115},{"id":"https://openalex.org/keywords/mitochondrial-oxidation","display_name":"mitochondrial oxidation","score":0.7039999961853027},{"id":"https://openalex.org/keywords/extracellular-acidification","display_name":"extracellular acidification","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/oncogenic-microrna","display_name":"oncogenic microRNA","score":0.7689999938011169},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.5649999976158142},{"id":"https://openalex.org/keywords/citrate","display_name":"citrate","score":0.5090000033378601},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.9150000214576721}],"concepts":[{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.6905322074890137},{"id":"https://openalex.org/C109156525","wikidata":"https://www.wikidata.org/wiki/Q56770304","display_name":"Warburg effect","level":4,"score":0.6694468855857849},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6401658654212952},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.546563982963562},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5450092554092407},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5000979900360107},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49228253960609436},{"id":"https://openalex.org/C2910680157","wikidata":"https://www.wikidata.org/wiki/Q18028499","display_name":"Lactate dehydrogenase A","level":4,"score":0.4712189733982086},{"id":"https://openalex.org/C55885012","wikidata":"https://www.wikidata.org/wiki/Q4750801","display_name":"Anaerobic glycolysis","level":4,"score":0.41901981830596924},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.41363027691841125},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4101366698741913},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37503767013549805},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3333379030227661},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2630390524864197},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10785022377967834},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05346783995628357}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011768","descriptor_name":"Pyruvate Dehydrogenase Complex","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011768","descriptor_name":"Pyruvate Dehydrogenase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019289","descriptor_name":"Pyruvic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019343","descriptor_name":"Citric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12943-018-0851-8","doi":"https://doi.org/10.1186/s12943-018-0851-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12943-018-0851-8","pdf_url":"https://molecular-cancer.biomedcentral.com/track/pdf/10.1186/s12943-018-0851-8","source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5006116","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6048708","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6048708","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6048708","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cancer","raw_type":"Text"},{"id":"pmid:30012170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30012170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:326a716502c74f5e853a8e3d4b83dba5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/326a716502c74f5e853a8e3d4b83dba5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Cancer, Vol 17, Iss 1, Pp 1-16 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12943-018-0851-8","doi":"https://doi.org/10.1186/s12943-018-0851-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12943-018-0851-8","pdf_url":"https://molecular-cancer.biomedcentral.com/track/pdf/10.1186/s12943-018-0851-8","source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2883593119.pdf","grobid_xml":"https://content.openalex.org/works/W2883593119.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W4864661","https://openalex.org/W144423133","https://openalex.org/W1517812011","https://openalex.org/W1553978925","https://openalex.org/W1978119925","https://openalex.org/W1982107902","https://openalex.org/W1983107759","https://openalex.org/W1984941589","https://openalex.org/W1991429659","https://openalex.org/W2002869675","https://openalex.org/W2005972711","https://openalex.org/W2014946489","https://openalex.org/W2017408113","https://openalex.org/W2022223655","https://openalex.org/W2026570544","https://openalex.org/W2026967508","https://openalex.org/W2040608814","https://openalex.org/W2041094651","https://openalex.org/W2046638220","https://openalex.org/W2052543023","https://openalex.org/W2058691572","https://openalex.org/W2059920458","https://openalex.org/W2060669952","https://openalex.org/W2062188669","https://openalex.org/W2069300693","https://openalex.org/W2102322990","https://openalex.org/W2105665764","https://openalex.org/W2110015442","https://openalex.org/W2115431016","https://openalex.org/W2117692326","https://openalex.org/W2123079914","https://openalex.org/W2124756133","https://openalex.org/W2126737563","https://openalex.org/W2128578138","https://openalex.org/W2137734450","https://openalex.org/W2137937088","https://openalex.org/W2138110344","https://openalex.org/W2138213364","https://openalex.org/W2138664009","https://openalex.org/W2140824212","https://openalex.org/W2160467221","https://openalex.org/W2162674813","https://openalex.org/W2216910489","https://openalex.org/W2223535266","https://openalex.org/W2231088500","https://openalex.org/W2235523093","https://openalex.org/W2252382072","https://openalex.org/W2331669280","https://openalex.org/W2566200459","https://openalex.org/W2580194908","https://openalex.org/W2748544035","https://openalex.org/W2762723870","https://openalex.org/W2783867527","https://openalex.org/W4234042459","https://openalex.org/W4250090323"],"related_works":["https://openalex.org/W2592313801","https://openalex.org/W6977292656","https://openalex.org/W2512720239","https://openalex.org/W2059920458","https://openalex.org/W2028388552","https://openalex.org/W2610089667","https://openalex.org/W4412890694","https://openalex.org/W7020749156","https://openalex.org/W2993146265","https://openalex.org/W2492808536"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"disruption":[2],"of":[3,22,62,91,100,116,144,180,201,213,250],"normal":[4],"gene":[5],"regulation":[6,90],"due":[7],"to":[8,38,112,137,272],"microRNA":[9],"dysfunction":[10],"is":[11,19,28,95,104,197,269],"a":[12,86,96,141,161,198],"common":[13],"event":[14],"in":[15,31,50,118,183,203,263],"cancer":[16,120,282],"pathogenesis.":[17],"MicroRNA-27b":[18,259],"an":[20,23,76,232,264],"example":[21],"oncogenic":[24],"miRNA,":[25],"and":[26,103,134,159,216,224,247,276],"it":[27],"frequently":[29],"upregulated":[30],"breast":[32,119,185,204,240,281],"cancer.":[33,205],"MicroRNAs":[34],"have":[35],"been":[36],"found":[37],"deregulate":[39],"tumor":[40,186,241],"metabolism,":[41,84],"which":[42],"typically":[43],"manifests":[44],"as":[45,70,140,218,220],"heightened":[46],"cellular":[47],"glucose":[48],"uptake":[49],"consort":[51],"with":[52,81,231,254],"increased":[53,233],"flux":[54],"through":[55],"glycolysis,":[56],"followed":[57],"by":[58,121,130,207],"the":[59,71,114,168,178],"preferential":[60],"conversion":[61],"glycolytic":[63],"pyruvate":[64],"into":[65],"lactate":[66,215],"(a":[67],"phenomenon":[68],"known":[69],"Warburg":[72],"Effect).":[73],"Pyruvate":[74,193],"Dehydrogenase,":[75],"enzyme":[77],"complex":[78,102],"linking":[79],"glycolysis":[80],"downstream":[82],"oxidative":[83],"represents":[85],"key":[87,97],"location":[88],"where":[89],"metabolism":[92,153,170],"occurs;":[93],"PDHX":[94,139,243,251],"structural":[98],"component":[99],"this":[101],"essential":[105],"for":[106,235],"its":[107,126],"function.":[108],"METHODS:":[109],"We":[110,128,146,164],"sought":[111],"characterize":[113],"role":[115],"miR-27b":[117,150,202,210],"identifying":[122],"novel":[123,142],"transcripts":[124],"under":[125],"control.":[127],"began":[129],"utilizing":[131],"luciferase,":[132],"RNA,":[133],"protein":[135],"assays":[136],"establish":[138],"target":[143,200],"miR-27b.":[145],"then":[147],"tested":[148],"whether":[149],"could":[151],"alter":[152],"using":[154],"several":[155],"metabolite":[156],"assay":[157],"kits":[158],"performed":[160],"seahorse":[162],"analysis.":[163],"also":[165],"examined":[166],"how":[167],"altered":[169,211,265],"might":[171],"affect":[172],"cell":[173,236,277],"proliferation.":[174,237],"Lastly,":[175],"we":[176],"confirmed":[177],"relevance":[179],"our":[181],"findings":[182],"human":[184,239],"samples.":[187],"RESULTS:":[188],"Our":[189],"data":[190],"indicate":[191],"that":[192,268],"Dehydrogenase":[194],"Protein":[195],"X":[196],"credible":[199],"Mechanistically,":[206],"suppressing":[208],"PDHX,":[209,261],"levels":[212,249],"pyruvate,":[214],"citrate,":[217],"well":[219],"reducing":[221],"mitochondrial":[222],"oxidation":[223],"promoting":[225,280],"extracellular":[226],"acidification.":[227],"These":[228],"changes":[229],"corresponded":[230],"capacity":[234],"In":[238],"samples,":[242],"expression":[244],"was":[245],"deficient,":[246],"low":[248],"were":[252],"associated":[253],"reduced":[255],"patient":[256],"survival.":[257],"CONCLUSIONS:":[258],"targets":[260],"resulting":[262],"metabolic":[266],"configuration":[267],"better":[270],"suited":[271],"fuel":[273],"biosynthetic":[274],"processes":[275],"proliferation,":[278],"thereby":[279],"progression.":[283]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":8}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2018-08-03T00:00:00"}
