{"id":"https://openalex.org/W2883548391","doi":"https://doi.org/10.1128/aac.00616-18","title":"Reply to Dookie et al., \u201cWhole-Genome Sequencing To Guide the Selection of Treatment for Drug-Resistant Tuberculosis\u201d","display_name":"Reply to Dookie et al., \u201cWhole-Genome Sequencing To Guide the Selection of Treatment for Drug-Resistant Tuberculosis\u201d","publication_year":2018,"publication_date":"2018-07-26","ids":{"openalex":"https://openalex.org/W2883548391","doi":"https://doi.org/10.1128/aac.00616-18","mag":"2883548391","pmid":"https://pubmed.ncbi.nlm.nih.gov/30054377","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6105783"},"language":"en","primary_location":{"id":"doi:10.1128/aac.00616-18","doi":"https://doi.org/10.1128/aac.00616-18","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.00616-18","pdf_url":"https://aac.asm.org/content/aac/62/8/e00616-18.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"letter","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aac.asm.org/content/aac/62/8/e00616-18.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043539340","display_name":"Claudio Umberto K\u00f6ser","orcid":"https://orcid.org/0000-0002-0232-846X","observed_orcids":["https://orcid.org/0000-0002-0232-846X"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE","GB"],"is_corresponding":false,"raw_author_name":"Claudio U. K\u00f6ser","raw_affiliation_strings":["Department of Genetics, University of Cambridge, Cambridge, United Kingdom","Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0232-846X","affiliations":[{"raw_affiliation_string":"Department of Genetics, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046269318","display_name":"Jan Heyckendorf","orcid":"https://orcid.org/0000-0003-4203-8421","observed_orcids":["https://orcid.org/0000-0003-4203-8421"]},"institutions":[{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan Heyckendorf","raw_affiliation_strings":["Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany","German Center for Infection Research (DZIF), Borstel, Germany","International Health/Infectious Diseases, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany","institution_ids":["https://openalex.org/I4210128097"]},{"raw_affiliation_string":"German Center for Infection Research (DZIF), Borstel, Germany","institution_ids":["https://openalex.org/I4210115305"]},{"raw_affiliation_string":"International Health/Infectious Diseases, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065671234","display_name":"S\u00f6nke Andres","orcid":"https://orcid.org/0009-0009-6063-3487","observed_orcids":["https://orcid.org/0009-0009-6063-3487"]},"institutions":[{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S\u00f6nke Andres","raw_affiliation_strings":["Division of Mycobacteriology (National Tuberculosis Reference Laboratory), Research Center Borstel, Borstel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Mycobacteriology (National Tuberculosis Reference Laboratory), Research Center Borstel, Borstel, Germany","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045146297","display_name":"Ioana Diana Olaru","orcid":"https://orcid.org/0000-0003-3392-9257","observed_orcids":["https://orcid.org/0000-0003-3392-9257"]},"institutions":[{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ioana D. Olaru","raw_affiliation_strings":["Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany","German Center for Infection Research (DZIF), Borstel, Germany"],"raw_orcid":"https://orcid.org/0000-0003-3392-9257","affiliations":[{"raw_affiliation_string":"Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany","institution_ids":["https://openalex.org/I4210128097"]},{"raw_affiliation_string":"German Center for Infection Research (DZIF), Borstel, Germany","institution_ids":["https://openalex.org/I4210115305"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004848467","display_name":"Thomas Sch\u00f6n","orcid":"https://orcid.org/0000-0003-4849-1286","observed_orcids":["https://orcid.org/0000-0003-4849-1286"]},"institutions":[{"id":"https://openalex.org/I102134673","display_name":"Link\u00f6ping University","ror":"https://ror.org/05ynxx418","country_code":"SE","type":"education","lineage":["https://openalex.org/I102134673"]},{"id":"https://openalex.org/I4210139554","display_name":"Landstinget i Kalmar l\u00e4n","ror":"https://ror.org/033bc9f34","country_code":"SE","type":"government","lineage":["https://openalex.org/I4210139554"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Thomas Sch\u00f6n","raw_affiliation_strings":["Department of Clinical and Experimental Medicine, Division of Medical Microbiology, Link\u00f6ping University, Link\u00f6ping, Sweden","Department of Infectious Diseases and Clinical Microbiology, Kalmar County Hospital, Kalmar, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Experimental Medicine, Division of Medical Microbiology, Link\u00f6ping University, Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I102134673"]},{"raw_affiliation_string":"Department of Infectious Diseases and Clinical Microbiology, Kalmar County Hospital, Kalmar, Sweden","institution_ids":["https://openalex.org/I4210139554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008180150","display_name":"Erik Stureg\u00e5rd","orcid":"https://orcid.org/0000-0003-2095-7048","observed_orcids":["https://orcid.org/0000-0003-2095-7048"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Erik Stureg\u00e5rd","raw_affiliation_strings":["Clinical Microbiology, Department of Translational Medicine, Lund University, Malm\u00f6, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Microbiology, Department of Translational Medicine, Lund University, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014425130","display_name":"Patrick Beckert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Patrick Beckert","raw_affiliation_strings":["German Center for Infection Research (DZIF), Borstel, Germany","Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Infection Research (DZIF), Borstel, Germany","institution_ids":["https://openalex.org/I4210115305"]},{"raw_affiliation_string":"Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039477952","display_name":"Viola Schleusener","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Viola Schleusener","raw_affiliation_strings":["Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040272200","display_name":"Thomas Andreas Kohl","orcid":"https://orcid.org/0000-0002-1126-6803","observed_orcids":["https://orcid.org/0000-0002-1126-6803"]},"institutions":[{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas A. Kohl","raw_affiliation_strings":["German Center for Infection Research (DZIF), Borstel, Germany","Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Infection Research (DZIF), Borstel, Germany","institution_ids":["https://openalex.org/I4210115305"]},{"raw_affiliation_string":"Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090063431","display_name":"Doris Hillemann","orcid":"https://orcid.org/0000-0002-0564-8637","observed_orcids":["https://orcid.org/0000-0002-0564-8637"]},"institutions":[{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Doris Hillemann","raw_affiliation_strings":["Division of Mycobacteriology (National Tuberculosis Reference Laboratory), Research Center Borstel, Borstel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Mycobacteriology (National Tuberculosis Reference Laboratory), Research Center Borstel, Borstel, Germany","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027195068","display_name":"Danesh Moradigaravand","orcid":"https://orcid.org/0000-0001-6652-5617","observed_orcids":["https://orcid.org/0000-0001-6652-5617"]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Danesh Moradigaravand","raw_affiliation_strings":["Wellcome Trust Sanger Institute, Hinxton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Sanger Institute, Hinxton, United Kingdom","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084268602","display_name":"Julian Parkhill","orcid":"https://orcid.org/0000-0002-7069-5958","observed_orcids":["https://orcid.org/0000-0002-7069-5958"]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Julian Parkhill","raw_affiliation_strings":["Wellcome Trust Sanger Institute, Hinxton, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-7069-5958","affiliations":[{"raw_affiliation_string":"Wellcome Trust Sanger Institute, Hinxton, United Kingdom","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014626556","display_name":"Sharon J. Peacock","orcid":"https://orcid.org/0000-0002-1718-2782","observed_orcids":["https://orcid.org/0000-0002-1718-2782"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sharon J. Peacock","raw_affiliation_strings":["Department of Genetics, University of Cambridge, Cambridge, United Kingdom","London School of Hygiene & Tropical Medicine, London, United Kingdom","Wellcome Trust Sanger Institute, Hinxton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"London School of Hygiene & Tropical Medicine, London, United Kingdom","institution_ids":["https://openalex.org/I4210089966"]},{"raw_affiliation_string":"Wellcome Trust Sanger Institute, Hinxton, United Kingdom","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063438724","display_name":"Stefan Niemann","orcid":"https://orcid.org/0000-0002-6604-0684","observed_orcids":["https://orcid.org/0000-0002-6604-0684"]},"institutions":[{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Niemann","raw_affiliation_strings":["German Center for Infection Research (DZIF), Borstel, Germany","Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Infection Research (DZIF), Borstel, Germany","institution_ids":["https://openalex.org/I4210115305"]},{"raw_affiliation_string":"Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057051062","display_name":"Christoph G. Lange","orcid":"https://orcid.org/0000-0002-9691-4741","observed_orcids":["https://orcid.org/0000-0002-9691-4741"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE","SE"],"is_corresponding":false,"raw_author_name":"Christoph Lange","raw_affiliation_strings":["Department of Medicine, Karolinska Institute, Stockholm, Sweden","Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany","German Center for Infection Research (DZIF), Borstel, Germany","International Health/Infectious Diseases, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9691-4741","affiliations":[{"raw_affiliation_string":"Department of Medicine, Karolinska Institute, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany","institution_ids":["https://openalex.org/I4210128097"]},{"raw_affiliation_string":"German Center for Infection Research (DZIF), Borstel, Germany","institution_ids":["https://openalex.org/I4210115305"]},{"raw_affiliation_string":"International Health/Infectious Diseases, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063179666","display_name":"Matthias Merker","orcid":"https://orcid.org/0000-0003-1386-2331","observed_orcids":["https://orcid.org/0000-0003-1386-2331"]},"institutions":[{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Merker","raw_affiliation_strings":["German Center for Infection Research (DZIF), Borstel, Germany","Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Infection Research (DZIF), Borstel, Germany","institution_ids":["https://openalex.org/I4210115305"]},{"raw_affiliation_string":"Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany","institution_ids":["https://openalex.org/I4210128097"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"62","issue":"8","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-resistant-tuberculosis","display_name":"drug-resistant tuberculosis","score":0.9179999828338623},{"id":"https://openalex.org/keywords/whole-genome-sequencing","display_name":"whole genome sequencing","score":0.9760000109672546},{"id":"https://openalex.org/keywords/treatment-selection","display_name":"treatment selection","score":0.8259999752044678},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.6551718711853027},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.580443799495697},{"id":"https://openalex.org/C24432333","wikidata":"https://www.wikidata.org/wiki/Q2068526","display_name":"Whole genome sequencing","level":4,"score":0.551315426826477},{"id":"https://openalex.org/C2777107064","wikidata":"https://www.wikidata.org/wiki/Q1040214","display_name":"Extensively drug-resistant tuberculosis","level":4,"score":0.48112741112709045},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.47457340359687805},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4705869257450104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44531235098838806},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4198460876941681},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.3933868408203125},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3749198913574219},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3719848394393921},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3126554489135742},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.14075374603271484},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11306712031364441},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06749358773231506},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000073336","descriptor_name":"Whole Genome Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018088","descriptor_name":"Tuberculosis, Multidrug-Resistant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1128/aac.00616-18","doi":"https://doi.org/10.1128/aac.00616-18","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.00616-18","pdf_url":"https://aac.asm.org/content/aac/62/8/e00616-18.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5327487","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6105783","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6105783","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6105783","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:30054377","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30054377","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Letter"},{"id":"pmh:oai:DiVA.org:liu-150227","doi":null,"is_oa":false,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-150227","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:lup.lub.lu.se:b6f6ed1b-3f92-4abe-8b36-067ecaa6c64f","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/b6f6ed1b-3f92-4abe-8b36-067ecaa6c64f","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0066-4804","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/280296","doi":null,"is_oa":false,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/280296","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.17863/cam.27665","doi":"https://doi.org/10.17863/cam.27665","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.27665","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1128/aac.00616-18","doi":"https://doi.org/10.1128/aac.00616-18","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.00616-18","pdf_url":"https://aac.asm.org/content/aac/62/8/e00616-18.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2221399513","display_name":"Translating whole genome sequence technology into diagnostic and public health microbiology.","funder_award_id":"098600/Z/12/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G4039314888","display_name":null,"funder_award_id":"WT098600","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5116694684","display_name":"Translating whole genome sequence technology into diagnostic and public health microbiology","funder_award_id":"HICF-T5-342","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2883548391.pdf","grobid_xml":"https://content.openalex.org/works/W2883548391.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W2582656716","https://openalex.org/W2768676941","https://openalex.org/W2884575695"],"related_works":["https://openalex.org/W2884575695","https://openalex.org/W7213337667","https://openalex.org/W2330020730","https://openalex.org/W4310567675","https://openalex.org/W6894289364","https://openalex.org/W6950479685","https://openalex.org/W2203906141","https://openalex.org/W7094208208","https://openalex.org/W4406920387","https://openalex.org/W3024650583"],"abstract_inverted_index":{"We":[0,37],"would":[1],"like":[2],"to":[3,23,74,76,102],"thank":[4],"Dr.":[5],"Navisha":[6],"Dookie":[7],"and":[8,13,80,99],"colleagues":[9],"for":[10,14,27,45],"their":[11,16,107],"comment":[12],"sharing":[15],"view":[17],"on":[18,89],"genotypic":[19,79],"drug-susceptibility":[20,26],"testing":[21,101],"(DST)":[22],"predict":[24],"phenotypic":[25,81],"the":[28,53,71,90,104],"management":[29],"of":[30,57,92,106],"patients":[31],"with":[32],"drug-resistant":[33],"tuberculosis":[34],"(1,":[35],"2).":[36],"agree":[38],"that":[39,87],"DST":[40],"should":[41],"ideally":[42],"be":[43,75],"conducted":[44],"all":[46],"drugs":[47],"in":[48,65,83],"a":[49,67,84],"regimen,":[50],"particularly":[51],"given":[52],"severe":[54],"adverse":[55],"effects":[56],"second-line":[58],"anti-tuberculosis":[59],"drugs.":[60],"Yet,":[61],"even":[62],"whole-genome":[63],"sequencing":[64],"not":[66],"one-size-fits-all":[68],"solution.":[69],"Instead,":[70],"goal":[72],"has":[73],"optimally":[77],"combine":[78],"assays":[82],"diagnostic":[85],"algorithm":[86],"capitalises":[88],"strengths":[91],"both":[93],"approaches":[94],"whilst":[95],"including":[96,110],"appropriate":[97],"reflex":[98],"confirmatory":[100],"minimize":[103],"impact":[105],"respective":[108],"limitations,":[109],"systematic":[111],"errors":[112],"(3).":[113]},"counts_by_year":[{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2018-08-03T00:00:00"}